Impact of aging on dendritic cell functions in humans
Open accessAbstract
Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subsets in aged subjects; nevertheless, their capacity to phagocytose antigens and migrate is impaired with age. There is aberrant cytokine secretion by various DC subsets with CDCs secreting increased basal level of pro-inflammatory cytokines but the response on stimulation to foreign antigens is decreased. In contrast, the response to self-antigens is increased suggesting erosion of peripheral self tolerance. PDC subset also secretes reduced IFN-α in response to viruses. The capacity of DCs to prime T cell responses is also affected. Aging thus has a profound affect on DC functions. Present review summarizes the effect of advancing age on DC functions in humans in the context of both immunity and tolerance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Functions of dendritic cells such as antigen presentation, endocytosis, and IFN production are reduced in aged individuals.
“Moreover, their functions such as antigen presentation, endocytosis, and IFN production, are also reduced in aged individuals [145, 146].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [145]
Despite comparable cell numbers, differentiation, and morphology in the young and aged, DCs from older persons exhibit impaired phagocytosis of antigen.
“Despite comparable cell numbers, differentiation, and morphology in the young and aged, DCs from older persons exhibit impaired phagocytosis of antigen (113, 114).”
From Aging and Lung Disease (2020) · cites this paper as [113]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,244 · see citing works
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works
Immunobiology of Dendritic Cells
Banchereau, J., Brière, F., Caux, C., Davoust, J. M., Lebecque, S., Liu, Y., Pulendran, B., & Palucka, K. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.767 · Cited by 6,612 · see citing works
Steinman, R. M., Hawiger, D., & Nussenzweig, M. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141040 · Cited by 3,124 · see citing works
Förster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner‐Müller, I., Wolf, E., & Lipp, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80059-8 · Cited by 2,348 · see citing works
Regulation of Adaptive Immunity by the Innate Immune System
Iwasaki, A., & Medzhitov, R. M. (2010) · Science · doi:10.1126/science.1183021 · Cited by 2,139 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
Kotenko, S. V., Gallagher, G. E., Baurin, V. V., Lewis-Antes, A., Shen, M., Shah, N. K., Langer, J. A., Sheikh, F. G., Dickensheets, H. L., & Donnelly, R. P. (2002) · Nature Immunology · doi:10.1038/ni875 · Cited by 1,867 · see citing works
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M. N., Ravetch, J. V., Steinman, R. M., & Nussenzweig, M. C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.769 · Cited by 1,848 · see citing works
Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579 · see citing works
A blast from the past: clearance of apoptotic cells regulates immune responses
Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574 · see citing works
Plasticity of CD4+ T Cell Lineage Differentiation
Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551 · see citing works
Dendritic-cell control of pathogen-driven T-cell polarization
Kapsenberg, M. L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1246 · Cited by 1,440 · see citing works
Signalling through C-type lectin receptors: shaping immune responses
Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,380 · see citing works
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357 · see citing works
Origin, maturation and antigen presenting function of dendritic cells
Cella, M., Sallusto, F., & Lanzavecchia, A. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80153-7 · Cited by 1,339 · see citing works
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
Steinman, R., & Nussenzweig, M. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.231606698 · Cited by 1,278 · see citing works
The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells
Steinman, R. M., Turley, S. J., Mellman, I., & Inaba, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.411 · Cited by 1,172 · see citing works
The who, how and where of antigen presentation to B cells
Batista, F. D., & Harwood, N. E. (2008) · Nature reviews. Immunology · doi:10.1038/nri2454 · Cited by 775 · see citing works
Agrawal, S., Agrawal, A., Doughty, B. L., Gerwitz, A., Blenis, J., Dyke, T. E. V., & Pulendran, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.4984 · Cited by 726 · see citing works
Self-citationβ‐glucan recognition by the innate immune system
Goodridge, H. S., Wolf, A. J., & Underhill, D. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00793.x · Cited by 693 · see citing works
Inaba, K., Metlay, J. P., Crowley, M. T., & Steinman, R. M. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.2.631 · Cited by 657 · see citing works
Cohen, P. L., Caricchio, R., Abraham, V., Camenisch, T. D., Jennette, J. C., Roubey, R. A. S., Earp, H. S., Matsushima, G. K., & Reap, E. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012094 · Cited by 637 · see citing works
Ank, N., West, H., Bartholdy, C., Eriksson, K., Thomsen, A. R., & Paludan, S. R. (2006) · Journal of Virology · doi:10.1128/jvi.80.9.4501-4509.2006 · Cited by 598 · see citing works
Antigen presentation in the thymus for positive selection and central tolerance induction
Klein, L., Hinterberger, M., Wirnsberger, G., & Kyewski, B. (2009) · Nature reviews. Immunology · doi:10.1038/nri2669 · Cited by 588 · see citing works
Ohnmacht, C., Pullner, A., King, S. B. S., Drexler, I., Meier, S., Brocker, T., & Voehringer, D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082394 · Cited by 578 · see citing works
Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production
Mevorach, D., Zhou, J. L., Song, X., & Elkon, K. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.387 · Cited by 567 · see citing works
Dillon, S. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27203 · Cited by 550 · see citing works
Panda, A., Qian, F., Mohanty, S., van Duin, D., Newman, F. K., Zhang, L., Chen, S., Towle, V., Belshe, R. B., Fikrig, E., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901022 · Cited by 548 · see citing works
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 531 · see citing works
Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells
Qi, H., Egen, J. G., Huang, A. Y.-C., & Germain, R. N. (2006) · Science · doi:10.1126/science.1125703 · Cited by 521 · see citing works
Mechanisms maintaining peripheral tolerance
Mueller, D. L. (2009) · Nature Immunology · doi:10.1038/ni.1817 · Cited by 461 · see citing works
Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works
Self-citationThe ageing immune system: is it ever too old to become young again?
Dorshkind, K. A., Montecino‐Rodriguez, E., & Signer, R. A. J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2471 · Cited by 412 · see citing works
Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
Burgdorf, S., Scholz, C. W., Kautz, A., Tampé, R., & Kurts, C. (2008) · Nature Immunology · doi:10.1038/ni.1601 · Cited by 404 · see citing works
Cell Surface Recycling of Internalized Antigen Permits Dendritic Cell Priming of B Cells
Bergtold, A., Desai, D. D., Gavhane, A., & Clynes, R. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.013 · Cited by 401 · see citing works
Biology of Lung Dendritic Cells at the Origin of Asthma
Lambrecht, B. N., & Hammad, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.008 · Cited by 372 · see citing works
Schmitt, N., Morita, R., Bourdery, L., Bentebibel, S.-E., Zurawski, S., Banchereau, J., & Ueno, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.016 · Cited by 357 · see citing works
Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism
Onoguchi, K., Yoneyama, M., Takemura, A., Akira, S., Taniguchi, T., Namiki, H., & Fujita, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608618200 · Cited by 354 · see citing works
Immunosenescence: what does it mean to health outcomes in older adults?
McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.023 · Cited by 340 · see citing works
Paleolog, E. M., Young, S., Stark, A. C., McCloskey, R. V., Feldmann, M., & Maini, R. N. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199807)41:7 · Cited by 318 · see citing works
Pattern recognition: recent insights from Dectin-1
Reid, D. M., Gow, N. A. R., & Brown, G. D. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.003 · Cited by 291 · see citing works
Dumoutier, L., Tounsi, A., Michiels, T., Sommereyns, C., Kotenko, S. V., & Renauld, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404789200 · Cited by 291 · see citing works
Jing, Y., Shaheen, E., Drake, R. R., Chen, N., Gravenstein, S., & Deng, Y. (2009) · Human Immunology · doi:10.1016/j.humimm.2009.07.005 · Cited by 284 · see citing works
Peripheral blood dendritic cells and monocytes are differently regulated in the elderly
Bella, S. D., Bierti, L., Presicce, P., Arienti, R., Valenti, M., Saresella, M., Vergani, C., & Villa, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.09.012 · Cited by 280 · see citing works
Autophagy and its role in MHC-mediated antigen presentation
Crotzer, V. L., & Blum, J. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0803458 · Cited by 279 · see citing works
IFN? induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein
Opitz, B., Rejaibi, A., Dauber, B., Eckhard, J., Vinzing, M., Schmeck, B., Hippenstiel, S., Suttorp, N., & Wolff, T. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00841.x · Cited by 278 · see citing works
Okabe, Y., Kawane, K., Akira, S., Taniguchi, T., & Nagata, S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051654 · Cited by 275 · see citing works
Immunosenescence and vaccine failure in the elderly
Grubeck-Loebenstein, B., Della Bella, S., Iorio, A. M., Michel, J.-P., Pawelec, G., & Solana, R. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03324904 · Cited by 269 · see citing works
Impaired immune responses in the lungs of aged mice following influenza infection
Toapanta, F. R., & Ross, T. M. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-112 · Cited by 259 · see citing works
Modulation of adaptive immunity with Toll-like receptors
Manicassamy, S., & Pulendran, B. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.05.005 · Cited by 255 · see citing works
Intracellular mechanisms of antigen cross presentation in dendritic cells
Amigorena, S., & Savina, A. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.022 · Cited by 246 · see citing works
Kellermann, S., Hudak, S. A., Oldham, E. R., Liu, Y.-J., & McEvoy, L. M. (1999) · PubMed · Cited by 244 · see citing works
Insufficient protection for healthy elderly adults by tetanus and TBE vaccines
Hainz, U., Jenewein, B., Asch, E., Pfeiffer, K.-P., Berger, P., & Grubeck-Loebenstein, B. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.01.085 · Cited by 224 · see citing works
Inflamm-aging: autoimmunity, and the immune-risk phenotype
Boren, E. J., & Gershwin, M. E. (2004) · Autoimmunity Reviews · doi:10.1016/j.autrev.2004.03.004 · Cited by 222 · see citing works
Biological activity of interleukins-28 and -29: Comparison with type I interferons
Meager, A., Visvalingam, K., Dilger, P., BRYAN, D., & Wadhwa, M. (2005) · Cytokine · doi:10.1016/j.cyto.2005.04.003 · Cited by 220 · see citing works
Khaitov, M. R., Laza‐Stanca, V., Edwards, M. R., Walton, R. P., Rohde, G. G. U., Contoli, M., Papi, A. A., Stanciu, L. A., Kotenko, S. V., & Johnston, S. L. (2009) · Allergy · doi:10.1111/j.1398-9995.2008.01826.x · Cited by 209 · see citing works
Kellermann, S., Hudak, S. A., Oldham, E. R., Liu, Y.-J., & McEvoy, L. M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3859 · Cited by 205 · see citing works
The Immune System in the Elderly: Activation-Induced and Damage-Induced Apoptosis
Ginaldi, L., Martinis, M. D., Monti, D., & Franceschi, C. (2004) · Immunologic Research · doi:10.1385/ir:30:1:081 · Cited by 202 · see citing works
Circulating, Interferon‐Producing Plasmacytoid Dendritic Cells Decline During Human Ageing
Shodell, M., & Siegal, F. P. (2002) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2002.01148.x · Cited by 189 · see citing works
Harnessing human dendritic cell subsets for medicine
Ueno, H., Schmitt, N., Klechevsky, E., Pedroza‐González, A., Matsui, T., Zurawski, G., Oh, S., Fay, J. W., Pascual, V., Banchereau, J., et al. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00884.x · Cited by 166 · see citing works
Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA
Agrawal, A., Tay, J., Ton, S., Agrawal, S., & Gupta, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1138 · Cited by 165 · see citing works
Self-citationDC subsets in positive and negative regulation of immunity
Coquerelle, C., & Moser, M. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00887.x · Cited by 164 · see citing works
Immunosenescence, autoimmunity, and rheumatoid arthritis
Weyand, C. M., Fulbright, J. W., & Goronzy, J. J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00090-1 · Cited by 161 · see citing works
Lung, T. L., Saurwein-Teissl, M., Parson, W., Schönitzer, D., & Grubeck-Loebenstein, B. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00494-6 · Cited by 161 · see citing works
Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c mice
Zhao, L., Sun, L., Wang, H., Ma, H., Liu, G., & Zhao, Y. X. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0506364 · Cited by 154 · see citing works
Baba, T., Nakamoto, Y., & Mukaida, N. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900438 · Cited by 153 · see citing works
Apoptotic Cells Deliver Processed Antigen to Dendritic Cells for Cross-Presentation
Blachère, N. E., Darnell, R. B., & Albert, M. L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030185 · Cited by 153 · see citing works
Impaired Dendritic Cell Function in Aging Leads to Defective Antitumor Immunity
Grolleau‐Julius, A., Harning, E. K., Close, L. A., & Yung, R. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5769 · Cited by 151 · see citing works
Luckashenak, N. A., Schroeder, S., Endt, K., Schmidt, D., Mahnke, K., Bachmann, M., Marconi, P., Deeg, C., & Brocker, T. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.018 · Cited by 151 · see citing works
Toll or Toll-Free Adjuvant Path Toward the Optimal Vaccine Development
Ishii, K. J., & Akira, S. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9087-x · Cited by 149 · see citing works
Stout-Delgado, H. W., Yang, X. T., Walker, W. E., Tesar, B. M., & Goldstein, D. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.6747 · Cited by 148 · see citing works
Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly
Ramos‐Casals, M., García‐Carrasco, M., Brito, M. P., López‐Soto, A., & Font, J. (2003) · Lupus · doi:10.1191/0961203303lu383ed · Cited by 146 · see citing works
Dendritic Cells Control B Cell Growth and Differentiation
Jégo, G., Pascual, V., Palucka, A. K., & Banchereau, J. (2004) · KARGER eBooks · doi:10.1159/000082101 · Cited by 144 · see citing works
Steger, M. M., Maczek, C., & Grubeck-Loebenstein, B. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.d01-790.x · Cited by 138 · see citing works
Bhushan, M., Cumberbatch, M., Dearman, R. J., Andrew, S. M., Kimber, I., & Griffiths, C. E. M. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04549.x · Cited by 126 · see citing works
Mucosal immunosenescence: new developments and vaccines to control infectious diseases
Fujihashi, K., & Kiyono, H. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.004 · Cited by 116 · see citing works
Intrinsic versus environmental influences on T‐cell responses in aging
Linton, P., Li, S. P., Zhang, Y., Bautista, B., Huynh, Q. L., & Trinh, T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00266.x · Cited by 115 · see citing works
Chronological ageing and photoageing of dendritic cells
Grewe, M. (2001) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2001.00898.x · Cited by 106 · see citing works
Kaml, M., Weiskirchner, I., Keller, M., Luft, T., Hoster, E., Hasford, J., Young, L., Bartlett, B., Neuner, C., Fischer, K.-H., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.06.037 · Cited by 98 · see citing works
Murine myeloid dendritic cell‐dependent toll‐like receptor immunity is preserved with aging
Tesar, B. M., Walker, W. E., Unternaehrer, J., Joshi, N. S., Chandele, A., Haynes, L., Kaech, S. M., & Goldstein, D. R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00245.x · Cited by 93 · see citing works
Pagliaccetti, N. E., Eduardo, R., Kleinstein, S. H., Mu, X. J., Bandi, P., & Robek, M. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804296200 · Cited by 93 · see citing works
The role of NOD-like Receptors in shaping adaptive immunity
Williams, A., Flavell, R. A., & Eisenbarth, S. C. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.004 · Cited by 92 · see citing works
Effect of Aging on Epidermal Dendritic Cell Populations in C57BL/6J Mice
Sprecher, E., Becker, Y., Kraal, G., Hall, E. J., Harrison, D. G., & Shultz, L. D. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12874586 · Cited by 91 · see citing works
Effect of Aging on Cytokine Production in Response to Respiratory Syncytial Virus Infection
Looney, R. J., Falsey, A. R., Walsh, E. E., & Campbell, D. (2002) · The Journal of Infectious Diseases · doi:10.1086/339008 · Cited by 90 · see citing works
Influenza-Induced Production of Interferon-Alpha is Defective in Geriatric Individuals
Canaday, D. H., Amponsah, N. A., Jones, L., Tisch, D. J., Hornick, T. R., & Ramachandra, L. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9374-9 · Cited by 89 · see citing works
The Multifaceted Influence of the Mucosal Microflora on Mucosal Dendritic Cell Responses
Strober, W. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.001 · Cited by 87 · see citing works
Age-associated epigenetic modifications in human DNA increase its immunogenicity
Agrawal, A., Tay, J., Yang, G., Agrawal, S., & Gupta, S. (2010) · Aging · doi:10.18632/aging.100121 · Cited by 84 · see citing works
Self-citationPotential adjuvantic properties of innate immune stimuli
Warshakoon, H. J., Hood, J. D., Kimbrell, M. R., Malladi, S. S., Wu, W. Y., Shukla, N. M., Agnihotri, G., Sil, D., & David, S. A. (2009) · Human Vaccines · doi:10.4161/hv.5.6.8175 · Cited by 83 · see citing works
Chemokine mediated control of dendritic cell migration and function
Gunn, M. D. (2003) · Seminars in Immunology · doi:10.1016/j.smim.2003.08.004 · Cited by 82 · see citing works
Reduced numbers of plasmacytoid dendritic cells in aged blood donors
Pérez-Cabezas, B., Naranjo-Gómez, M., Fernández, M. A., Grífols, J. R., Pujol-Borrell, R., & Borràs, F. E. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.010 · Cited by 80 · see citing works
Wong, C. P., Magnusson, K. R., & Ho, E. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.005 · Cited by 74 · see citing works
Effect of Aging on Bone Marrow-Derived Murine CD11c+CD4-CD8 - Dendritic Cell Function
Grolleau‐Julius, A., Garg, M. R., Mo, R., Stoolman, L. L., & Yung, R. L. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.10.1039 · Cited by 69 · see citing works
Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions
Kato, H. (2003) · International Immunology · doi:10.1093/intimm/dxg011 · Cited by 69 · see citing works
Surface markers and transendothelial migration of dendritic cells from elderly subjects
Pietschmann, P., Hahn, P., Kudlacek, S., Thomas, R., & Peterlik, M. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00089-3 · Cited by 68 · see citing works
Chiu, B., Stolberg, V. R., Zhang, H., & Chensue, S. W. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.09.002 · Cited by 68 · see citing works
Donnini, A., Argentati, K., Mancini, R., Smorlesi, A., Bartozzi, B., Bernardini, G., & Provinciali, M. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00087-6 · Cited by 65 · see citing works
Elmezayen, R., Gazzar, M. E., Myer, R. G., & High, K. P. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00502.x · Cited by 54 · see citing works
Weksler, M. E., & Goodhardt, M. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00091-8 · Cited by 54 · see citing works
Faria, A. M. C., Garcia, G., Rios, M. J., Michalaros, C. L., & Vaz, N. M. (1993) · PubMed Central · Cited by 52 · see citing works
Epidermal langerhans cell density and contact sensitivity in young and aged BALB/c mice
Choi, K. L., & Sauder, D. N. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90087-x · Cited by 51 · see citing works
Abnormalities of B cells and dendritic cells in SAMP1 mice
Haruna, H., Inaba, M., Inaba, K., Taketani, S., Sugiura, K., Fukuba, Y., Doi, H., Toki, J., Tokunaga, R., & Ikehara, S. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250528 · Cited by 51 · see citing works
Aging affects oral tolerance induction but not its maintenance in mice
Faria, A. M. C., Ficker, S. M., Speziali, E., Menezes, J. S., Stransky, B., Rodrigues, V. S., & Vaz, N. M. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00024-4 · Cited by 50 · see citing works
Age‐dependent changes in thymic macrophages and dendritic cells
Varas, A., Sacedón, R., Hernández‐López, C., Jiménez, E., García‐Ceca, J., Arias‐Díaz, J., Zapata, A. G., & Vicente, Á. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10411 · Cited by 49 · see citing works
Ultrastructural study of thymic microenvironment involution in aging mice
Nabarra, B., & Andrianarison, I. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02038-1 · Cited by 43 · see citing works
The role of Toll-like receptors and C-type lectins for vaccination against Candida albicans
Ferwerda, G., Netea, M. G., Joosten, L. A. B., van der Meer, J. W. M., Romani, L. R., & Kullberg, B. J. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.10.082 · Cited by 42 · see citing works
Microbe–dendritic cell dialog controls regulatory T‐cell fate
Grainger, J. R., Hall, J. A., Bouladoux, N. J., Oldenhove, G., & Belkaid, Y. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00880.x · Cited by 41 · see citing works
Directing Autoimmunity to Nucleoprotein Particles
Hardin, J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030130 · Cited by 39 · see citing works
Disposal of dying cells: A balancing act between infection and autoimmunity
Gaipl, U. S., Brunner, J., Beyer, T. D., Voll, R. E., Kalden, J. R., & i, M. H. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10744 · Cited by 37 · see citing works
Chapter 5 Dysregulation of T Cell Peripheral Tolerance in Type 1 Diabetes
Tisch, R., & Wang, B. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00805-5 · Cited by 31 · see citing works
Wakabayashi, A., Utsuyama, M., Hosoda, T., Sato, K., & Hirokawa, K. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00036-6 · Cited by 26 · see citing works
Increase of gingival matured dendritic cells number in elderly patients with chronic periodontitis
Bodineau, A., Coulomb, B., Tedesco, A. C., & Séguier, S. (2008) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2008.06.014 · Cited by 23 · see citing works
Shoshan, Y., & Mevorach, D. (2004) · Autoimmunity · doi:10.1080/08916930410001666622 · Cited by 21 · see citing works
Do Langerhans cells behave similarly in elderly and younger patients with chronic periodontitis?
Bodineau, A., Coulomb, B., Folliguet, M., Changotade, S., Godeau, G., Brousse, N., & Séguier, S. (2006) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2006.09.007 · Cited by 19 · see citing works
Regeneration of dendritic cells in aged mice
van Dommelen, S. L. H., Rizzitelli, A., Chidgey, A. P., Boyd, R. L., Shortman, K., & Wu, L. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.114 · Cited by 16 · see citing works
Gebe, J. A., Unrath, K. A., Falk, B. A., Ito, K., Li, W., Daniels, T. L., Lernmark, Å., & Nepom, G. T. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.08.002 · Cited by 15 · see citing works
Benito, M. J., López‐Hoyos, M., Fernández‐Fresnedo, G., Ruiz, J. C., Benito, A., Segundo, D. S., Gómez-Alamillo, C., & Arias, M. (2008) · Transplantation Proceedings · doi:10.1016/j.transproceed.2008.09.018 · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 119 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [2]Agrawal S Agrawal A Doughty B Gerwitz A Van Dyke T Pulendran B Cutting edge, Different TLR Agonist Instruct Dendritic Cells to Induce Diverse T helper Responses, via Differential Activation of MAP Kinases J Immunol 2003 171 4984 4989 14607893
Cited by
Sorted by citations
Immunosenescence: molecular mechanisms and diseases
Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,023 · see citing works
Causes, consequences, and reversal of immune system aging
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works
How sex and age affect immune responses, susceptibility to infections, and response to vaccination
Giefing, C., Berger, P., Lepperdinger, G., & Grubeck‐Loebenstein, B. (2015) · Aging Cell · doi:10.1111/acel.12326 · Cited by 768 · see citing works
Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.008 · Cited by 567 · see citing works
Immunosenescence: a key player in cancer development
Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458 · see citing works
The immune system and aging: A review
Castelo-Branco, C., & Soveral, I. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.852531 · Cited by 449 · see citing works
Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 436 · see citing works
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works
Human T Cell Aging and the Impact of Persistent Viral Infections
Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347 · see citing works
Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Faner, R., Rojas, M., MacNee, W., & Agustí, A. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0282pp · Cited by 268 · see citing works
Immune System Dysfunction in the Elderly
Eduardo Fuentes, Q., FUENTES, M., Alarcón, M. A., & Palomo, I. F. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160487 · Cited by 234 · see citing works
Immunosenescence, aging and successful aging
Wang, Y., Chen, D., Han, Y., Gu, Z., & Sun, C. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.942796 · Cited by 215 · see citing works
Ageing and the border between health and disease
MacNee, W., Rabinovich, R., & Choudhury, G. (2014) · European Respiratory Journal · doi:10.1183/09031936.00134014 · Cited by 188 · see citing works
Hallmarks of aging and immunosenescence: Connecting the dots
Rodrigues, L. P., Teixeira, V. R., Alencar‐Silva, T., Simonassi-Paiva, B., Pereira, R. W., Pogue, R. E., & Carvalho, J. L. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.006 · Cited by 187 · see citing works
Aging, inflammation and cancer
Bottazzi, B., Ríboli, E., & Mantovani, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.10.011 · Cited by 167 · see citing works
Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases
Bleve, A., Motta, F., Durante, B., Pandolfo, C., Selmi, C., & Sica, A. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08909-7 · Cited by 179 · see citing works
Innate immune responses in the ageing lung.
Boe, D. M., Boule, L. A., & Kovacs, E. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12881 · Cited by 156 · see citing works
On the immunological theory of aging
Fulop, T., Witkowski, J. M., Pawelec, G., Alan, C., & Larbi, A. (2014) · Interdisciplinary topics in gerontology and geriatrics · doi:10.1159/000358904 · Cited by 157 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03048-x · Cited by 156 · see citing works
Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly
Agrawal, A., Agrawal, S., & Gupta, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00896 · Cited by 154 · see citing works
Self-citationActivation of immunosuppressive network in the aging process
Salminen, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100998 · Cited by 153 · see citing works
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110632 · Cited by 143 · see citing works
Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases
Saint‐Criq, V., Lugo‐Villarino, G., & Thomas, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101235 · Cited by 143 · see citing works
The Role of Immunosenescence in Neurodegenerative Diseases
Costantini, E., D’Angelo, C., & Reale, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/6039171 · Cited by 133 · see citing works
Cancer Vaccines: Adjuvant Potency, Importance of Age, Lifestyle, and Treatments
Cuzzubbo, S., Mangsbo, S. M., Nagarajan, D., Habra, K., Pockley, A. G., & McArdle, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615240 · Cited by 130 · see citing works
The conundrum of human immune system “senescence”
Pawelec, G., Bronikowski, A. M., Cunnane, S. C., Ferrucci, L., Franceschi, C., Fülöp, T., Gaudreau, P., Gladyshev, V. N., Gonos, E. S., Gorbunova, V. A., et al. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111357 · Cited by 119 · see citing works
Salminen, A. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02123-w · Cited by 124 · see citing works
Schulz, A. R., Mälzer, J. N., Domingo, C., Jürchott, K., Grützkau, A., Babel, N., Nienen, M., Jelinek, T., Niedrig, M., & Thiel, A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500598 · Cited by 112 · see citing works
Weinberger, B., & Grubeck-Loebenstein, B. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.03944.x · Cited by 104 · see citing works
Overcoming immune dysfunction in the elderly: trained immunity as a novel approach
Bulut, O., Kilic, G., Domínguez-Andrés, J., & Netea, M. G. (2020) · International Immunology · doi:10.1093/intimm/dxaa052 · Cited by 99 · see citing works
ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01904-z · Cited by 98 · see citing works
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors
Zhivaki, D., Kennedy, S. N., Park, J., Borriello, F., Devant, P., Cao, A., Bahleda, K. M., Murphy, S. M., Aubin, C., Evavold, C. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.026 · Cited by 101 · see citing works
Targeting immunosenescence and inflammaging: advancing longevity research
Nguyen, T. Q. T., & Cho, K. A. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01527-9 · Cited by 94 · see citing works
Linton, P., & Thoman, M. L. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.017 · Cited by 86 · see citing works
Karagiannis, T. T., Dowrey, T. W., Villacorta-Martín, C., Montano, M. A., Reed, E. R., Belkina, A. C., Andersen, S. L., Perls, T. T., Monti, S., Murphy, G. J., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104514 · Cited by 86 · see citing works
Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis
Grifoni, A., Alonzi, T., Alter, G., Noonan, D. M., LANDAY, A. L., Albini, A., & Goletti, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1146704 · Cited by 87 · see citing works
Implications of the Immune Landscape in COPD and Lung Cancer: Smoking Versus Other Causes
Taucher, E., Mykoliuk, I., Lindenmann, J., & Smolle-Jüettner, F.-M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.846605 · Cited by 79 · see citing works
Impact of aging on viral infections
Leng, J., & Goldstein, D. R. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.08.009 · Cited by 76 · see citing works
Bigley, A. B., Spielmann, G., LaVoy, E. C. P., & Simpson, R. J. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.06.010 · Cited by 75 · see citing works
Immunosenescence, Inflammaging, and Lung Senescence in Asthma in the Elderly
Soma, T., & Nagata, M. (2022) · Biomolecules · doi:10.3390/biom12101456 · Cited by 71 · see citing works
Zacca, E. R., Crespo, M. I., Acland, R. P., Roselli, E., Núñez, N. G., Maccioni, M., Maletto, B. A., Pistoresi-Palencia, M. C., & Morón, G. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140672 · Cited by 66 · see citing works
Immunosenescence, Aging, and Systemic Lupus Erythematous
Montoya-Ortiz, G. (2013) · Autoimmune Diseases · doi:10.1155/2013/267078 · Cited by 65 · see citing works
Borges, R. C., Hohmann, M. S., & Borghi, S. M. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1844195 · Cited by 62 · see citing works
Food nutrients as inherent sources of immunomodulation during COVID-19 pandemic
Vishwakarma, S., Panigrahi, C., Barua, S., Sahoo, M., & Mandliya, S. (2022) · LWT · doi:10.1016/j.lwt.2022.113154 · Cited by 63 · see citing works
Targeting Immune Senescence in Atherosclerosis
Vellasamy, D. M., Lee, S.-J., Goh, K. W., Goh, B. H., Tang, Y.-Q., Ming, L. C., & Yap, W. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113059 · Cited by 60 · see citing works
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells
Bian, F., Xiao, Y., Barbosa, F. L., de Souza, R. G., Hernandez, H., Yu, Z., Pflugfelder, S. C., & de Paiva, C. S. (2019) · Mucosal Immunology · doi:10.1038/s41385-018-0127-z · Cited by 58 · see citing works
Wang, L., Li, X., Liu, M., Zhou, H., & Shao, J. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1372731 · Cited by 60 · see citing works
Natural Compounds and Aging: Between Autophagy and Inflammasome
Chuang, S.-Y., Lin, C.-H., & Fang, J. (2014) · BioMed Research International · doi:10.1155/2014/297293 · Cited by 57 · see citing works
Zhou, Q., Gu, H., Sun, S., Zhang, Y., Hou, Y., Li, C., Zhao, Y., Ma, P., Lv, L., Aji, S., et al. (2021) · Advanced Materials · doi:10.1002/adma.202102528 · Cited by 57 · see citing works
Aging and chronic kidney disease: epidemiology, therapy, management and the role of immunity
Tang, Y., Jiang, J., Zhao, Y., & Du, D. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae235 · Cited by 65 · see citing works
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59 · see citing works
Age‐mediated gut microbiota dysbiosis promotes the loss of dendritic cells tolerance
Bashir, H., Singh, S., Singh, R. P., Agrewala, J. N., & Kumar, R. (2023) · Aging Cell · doi:10.1111/acel.13838 · Cited by 55 · see citing works
Immunotherapy in older patients with cancer
Granier, C., Gey, A., Roncelin, S., Weiss, L., Paillaud, É., & Tartour, É. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.07.009 · Cited by 56 · see citing works
Ageing and respiratory infections: The airway of ageing
Haq, K., & McElhaney, J. E. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.009 · Cited by 52 · see citing works
Derhovanessian, E., & Pawelec, G. (2012) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2011.00283.x · Cited by 51 · see citing works
The impact of aging-induced gut microbiome dysbiosis on dendritic cells and lung diseases
Malik, J. A., Zafar, M. A., Lamba, T., Nanda, S., Khan, M. A., & Agrewala, J. N. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2290643 · Cited by 51 · see citing works
Human Intestinal Dendritic Cells in Inflammatory Bowel Diseases
Bernardo, D., Chaparro, M., & Gisbert, J. P. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700931 · Cited by 46 · see citing works
Ross, K. A., Senapati, S., Alley, J., Darling, R. J., Goodman, J., Jefferson, M. A., Uz, M., Guo, B., Yoon, K. J., Verhoeven, D. E., et al. (2019) · Biomaterials Science · doi:10.1039/c8bm01443d · Cited by 47 · see citing works
Vallejo, A. N., Hamel, D. L., Mueller, R. G., Ives, D. G., Michel, J. J., Boudreau, R. M., & Newman, A. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026558 · Cited by 44 · see citing works
Effect of age on surface molecules and cytokine expression in human dendritic cells
Ciaramella, A., Spalletta, G., Bizzoni, F., Salani, F., Caltagirone, C., & Bossù, P. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.04.010 · Cited by 43 · see citing works
The aging lung: microenvironment, mechanisms, and diseases
Wang, Y., Huang, X., Luo, G., Xu, Y., Deng, X., Lin, Y., Wang, Z., Zhou, S., Wang, S., Chen, H., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1383503 · Cited by 46 · see citing works
Probiotic modulation of dendritic cell function is influenced by ageing
You, J., Dong, H., Mann, E. R., Knight, S. C., & Yaqoob, P. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.08.012 · Cited by 41 · see citing works
Donor Age-Specific Injury and Immune Responses
Oberhuber, R., Ge, X., & Tullius, S. G. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03798.x · Cited by 41 · see citing works
Gardner, J. K., Mamotte, C. D. S., Jackaman, C., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.07.002 · Cited by 40 · see citing works
The diseased kidney: aging and senescent immunology
Chi, M., Tian, Z., Ma, K., Li, Y., Wang, L., Nasser, M. I., & Liu, C. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00313-9 · Cited by 41 · see citing works
The role of dendritic cells in cancer immunity and therapeutic strategies
Tai, Y., Chen, M., Wang, F., Fan, Y., Zhang, J., Cai, B., Lin, Y., Luo, Y., & Li, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111548 · Cited by 41 · see citing works
Senescence, NK cells, and cancer: navigating the crossroads of aging and disease
Gergues, M., Bari, R., Koppisetti, S., Gosiewska, A., Kang, L., & HARIRI, R. J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1565278 · Cited by 42 · see citing works
Prakash, S., Agrawal, S., Vahed, H., Ngyuen, M., BenMohamad, L., Gupta, S., & Agrawal, A. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.28 · Cited by 40 · see citing works
Self-citationAgrawal, S., Ganguly, S., Tran, A., Sundaram, P., & Agrawal, A. (2016) · Aging · doi:10.18632/aging.100973 · Cited by 38 · see citing works
Self-citationKynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
Solvang, S.-E. H., Hodge, A. M., Watne, L. O., Cabral-Marques, O., Nordrehaug, J. E., Giles, G. G., Dugué, P., Nygard, O. K., Ueland, P. M., McCann, A., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5019752 · Cited by 36 · see citing works
Cellular Senescence in Immunity against Infections
Marrella, V., Facoetti, A., & Cassani, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911845 · Cited by 37 · see citing works
Immunological hurdles of ageing: Indispensable research of the human model
Vallejo, A. N. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.01.005 · Cited by 36 · see citing works
Immunosenescence as a convergence pathway in neurodegeneration
Mohapatra, L., Mishra, D. K., Tripathi, A. S., & Parida, S. K. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110521 · Cited by 36 · see citing works
Immunosenescence and cancer: Opportunities and challenges
Fu, Z., Xu, H., Yue, L., Zheng, W., Pan, L., Gao, F., & Liu, X. (2023) · Medicine · doi:10.1097/md.0000000000036045 · Cited by 36 · see citing works
The role of DNA methylation and hydroxymethylation in immunosenescence
Johnson, N. D., & Conneely, K. N. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.011 · Cited by 35 · see citing works
Immunosenescence in renal transplantation
Seyda, M., Quante, M., Uehara, H., Slegtenhorst, B. R., Elkhal, A., & Tullius, S. G. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000210 · Cited by 35 · see citing works
Rahmatpanah, F. B., Agrawal, S., Scarfone, V. M., Kapadia, S., Mercola, D., & Agrawal, A. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly106 · Cited by 34 · see citing works
Self-citationImmune response to SARS-CoV-2 in severe disease and long COVID-19
Sumi, T., & Harada, K. (2022) · iScience · doi:10.1016/j.isci.2022.104723 · Cited by 33 · see citing works
Phenotype and functions of conventional dendritic cells are not compromised in aged mice
Tan, S., Cavanagh, L. L., d'Advigor, W., Shackel, N. A., Groth, B. F. D. S., & Weninger, W. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2011.104 · Cited by 32 · see citing works
Salminen, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102694 · Cited by 33 · see citing works
Immune aging and infectious diseases
Chen, R., Zou, J., Chen, J., Wang, L., Kang, R., & Tang, D. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003410 · Cited by 33 · see citing works
The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines
Cianci, R., Franza, L., Massaro, M. G., Borriello, R., Vito, F., & Gambassi, G. (2020) · Vaccines · doi:10.3390/vaccines8040636 · Cited by 31 · see citing works
Immunosenescence promotes cancer development: from mechanisms to treatment strategies
Wang, L., & Tang, D. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02082-6 · Cited by 30 · see citing works
Agrawal, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061206 · Cited by 29 · see citing works
Self-citationAvivi, I. M., Zisman‐Rozen, S., Naor, S., Dai, I., Benhamou, D., Shahaf, G. L., Tabibian‐Keissar, H., Rosenthal, N., Rakovsky, A., Ammuri, H., et al. (2019) · Aging Cell · doi:10.1111/acel.12959 · Cited by 30 · see citing works
IgM response against amyloid-beta in aging: a potential peripheral protective mechanism
Agrawal, S., Abud, E. M., Snigdha, S., & Agrawal, A. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0412-9 · Cited by 29 · see citing works
Self-citationAgeing impairs the T cell response to dendritic cells
You, J., Dong, H., Mann, E. R., Knight, S. C., & Yaqoob, P. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.02.002 · Cited by 28 · see citing works
T-cell Senescence in the Tumor Microenvironment
Huang, L., Zhang, C., Jiang, A., Lin, A., Zhu, L., Mou, W., Zeng, D., Liu, Z., Tang, B., Zhang, J., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0894 · Cited by 27 · see citing works
Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?
Hieber, C., Grabbe, S., & Bros, M. (2023) · Biomolecules · doi:10.3390/biom13071085 · Cited by 28 · see citing works
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation
Gardner, J. K., Cornwall, S. M. J., Musk, A. W., Alvarez, J., Mamotte, C. D. S., Jackaman, C., Nowak, A. K., & Nelson, D. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195313 · Cited by 26 · see citing works
The aging of the immune system and its implications for transplantation
McGovern, K. E., Sonar, S. A., Watanabe, M., Coplen, C. P., Bradshaw, C. M., & Nikolich‐Žugich, J. (2023) · GeroScience · doi:10.1007/s11357-022-00720-2 · Cited by 25 · see citing works
Xiao, J., Zhou, H., Wu, N., & Wu, L. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.39 · Cited by 25 · see citing works
Optimising vaccine immunogenicity in ageing populations: key strategies
Jiang, G., Zou, Y., Zhao, D., & Yu, J. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00497-3 · Cited by 26 · see citing works
Vaccine-preventable diseases: From paediatric to adult targets
Esposito, S., Durando, P., Bosis, S., Ansaldi, F., Tagliabue, C., & Icardi, G. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.12.004 · Cited by 24 · see citing works
Chronic Pruritus in the Geriatric Population
Cao, T., Tey, H. L., & Yosipovitch, G. (2018) · Dermatologic Clinics · doi:10.1016/j.det.2018.02.004 · Cited by 24 · see citing works
The Innate Immune System and Aging: What is the Contribution to Immunosenescence ?
Fülöp, T. (2012) · Open Longevity Science · doi:10.2174/1876326x01206010121 · Cited by 22 · see citing works
Risk Factors for 28-Day Mortality in a Surgical ICU: A Retrospective Analysis of 347 Cases
Zhang, Y., Zhang, J., Du, Z., Ren, Y., Nie, J.-M., Wu, Z., Lv, Y., Bi, J., & Wu, R. (2021) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s303514 · Cited by 21 · see citing works
Innate immune cell activation by adjuvant AS01 in human lymph node explants is age independent
Stylianou, V. V., Bertram, K. M., Vo, V. A., Dunn, E. B., Baharlou, H., Terre, D. D., Elhindi, J., Elder, E. E., French, J. R., Meybodi, F., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci174144 · Cited by 21 · see citing works
Oxidized phospholipid damage signals as modulators of immunity
Choi, J. H., & Kagan, J. C. (2025) · Open Biology · doi:10.1098/rsob.240391 · Cited by 21 · see citing works
- Authors
- Agrawal, A., & Gupta, S.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Agrawal, Anshu
- Gupta, Sudhir
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 10
- Issue
- 3
- Pages
- 336-345
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC3030666
- OpenAlex
- W2035279182
- Cited by
- 246
- References
- 119
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 17 · 2023: 22 · 2022: 23 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 6 · 2015: 12 · 2014: 14 · 2013: 15 · 2012: 10
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ellison Medical Foundation
- National Institutes of Health
- National Institute on Aging (AG-027512, R21AG027512)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- dendritic cells, aging, immunosenescence, chronic inflammation, dendritic cell migration, cytokine production, inflammatory cytokines, self-tolerance, plasmacytoid dendritic cells, interferon-alpha, T cell priming, dendritic cell subsets
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Cell Movement, Dendritic Cells, Humans, Signal Transduction, Cytokines, Models, Animal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
