Cited by 702Asthma and respiratory diseasesIL-33, ST2, and ILC PathwaysGenetic Associations and Epidemiology

The DOI matches its Crossref record; 286 of the 287 references it cites were found in a registry or an index.

The genetics of asthma and allergic disease: a 21st century perspective

Open access

Ober, Carole, Yao, Tsung‐Chieh·2011·Immunological Reviews

DOI 10.1111/j.1600-065x.2011.01029.xPMC PMC3151648

Open this paper in CoChat — free account

Abstract

Summary: Asthma and allergy are common conditions with complex etiologies involving both genetic and environmental contributions. Recent genome‐wide association studies (GWAS) and meta‐analyses of GWAS have begun to shed light on both common and distinct pathways that contribute to asthma and allergic diseases. Associations with variation in genes encoding the epithelial cell‐derived cytokines, interleukin‐33 (IL‐33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL‐33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T‐helper 2 cells in the pathogenesis of both asthma and allergic diseases. In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma. These and other genetic findings are providing a list of well‐validated asthma and allergy susceptibility genes that are expanding our understanding of the common and unique biological pathways that are dysregulated in these related conditions. Ongoing studies will continue to broaden our understanding of asthma and allergy and unravel the mechanisms for the development of these complex traits.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1600-065x.2011.01029.x

Cites

286 of 286 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336
Sequencing technologies – the next generation
Metzker, M. L. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2626 · Cited by 7,066
The International HapMap Project
†The International HapMap Consortium, Genotyping centres: Baylor College of Medicine and ParAllele BioScience, Gibbs, R. A., Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Chinese HapMap Consortium, Yang, H., Ch'ang, L.-Y., et al. (2003) · Nature · doi:10.1038/nature02168 · Cited by 6,057
The Future of Genetic Studies of Complex Human Diseases
Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC
Beasley, R. W. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07302-9 · Cited by 3,794
The global burden of asthma: executive summary of the GINA Dissemination Committee Report
Masoli, M., Fabian, D., Holt, S., Beasley, R. W., & Program, G. I. F. A. (. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00526.x · Cited by 3,521
Genetic Dissection of Complex Traits
Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,425

Show all 287 references

Research works printed but not linked: 1

10.1034/j.1399-3003.1999.13a04.x · DOI

Sorted by citations

Items 201–300 of 702

The Role of Sphingolipids in Allergic Disorders
Díaz‐Perales, A., Escribese, M. M., Garrido‐Arandia, M., Obeso, D., Izquierdo, E., Tomé‐Amat, J., & Barber, D. (2021) · Frontiers in Allergy · doi:10.3389/falgy.2021.675557 · Cited by 32
Identification of a new locus at 16q12 associated with time to asthma onset
Sarnowski, C., Sugier, P., Granell, R., Jarvis, D., Dizier, M., Ege, M. J., Imboden, M., Laprise, C., Хуснутдинова, Э. К., Freidin, M. B., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.03.018 · Cited by 33
Polygenic prediction of atopic dermatitis improves with atopic training and filaggrin factors
Arehart, C. H., Daya, M., Campbell, M., Boorgula, M. P., Rafaels, N. M., Chavan, S., David, G. L., Hanifin, J. M., Slifka, M. K., Gallo, R. L., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.05.034 · Cited by 31
A pathway‐based association study reveals variants from Wnt signalling genes contributing to asthma susceptibility
Barreto-Luis, A., Corrales, A., Acosta‐Herrera, M., González-Colino, C., Cumplido, J., Martínez-Tadeo, J. A., Carracedo, Á., Villar, J., Carrillo, T., Pino-Yanes, M. D. M., et al. (2017) · Clinical & Experimental Allergy · doi:10.1111/cea.12883 · Cited by 29
Der p 1 Disrupts the Epithelial Barrier and Induces IL-6 Production in Patients With House Dust Mite Allergic Rhinitis
Ogi, K., Ramezanpour, M., Liu, S., Tuli, J. F., Bennett, C. A., Suzuki, M., Fujieda, S., Psaltis, A. J., Wormald, P., & Vreugde, S. (2021) · Frontiers in Allergy · doi:10.3389/falgy.2021.692049 · Cited by 29
Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers
Illi, S., Depner, M., Pfefferle, P. I., Renz, H. E., Roduit, C., Taft, D. H., Kalanetra, K. M., Mills, D. A., Farquharson, F. M., Louis, P., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202106-1458oc · Cited by 29
Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme
Cooper, P. J., Figueiredo, C. A., Rodríguez, A., dos Santos, L. M., Ribeiro‐Silva, R. C., Carneiro, V. L., Costa, G., da Silva, T. M., de Jesus, T. D. S., Rios, R., et al. (2023) · Clinical and Translational Allergy · doi:10.1002/clt2.12232 · Cited by 29
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
Granell, R., Curtin, J. A., Haider, S., Kitaba, N. T., Mathie, S. A., Gregory, L. G., Yates, L. L., Tutino, M., Hankinson, J., Perretti, M., et al. (2023) · eLife · doi:10.7554/elife.84315 · Cited by 29
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans
Myers, R. A., Himes, B. E., Gignoux, C. R., Yang, J. J., Gauderman, W. J., Rebordosa, C., Xie, J., Torgerson, D. G., Levin, A. M., Baurley, J. W., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.054 · Cited by 29
Self-citation
The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice
Sécher, T., Maillet, I., Mackowiak, C., Bérichel, J. L., Philippeau, A., Panek, C., Boury, M., Oswald, É., Saoudi, A., Erard, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29689-9 · Cited by 29
Replicated methylation changes associated with eczema herpeticum and allergic response
Boorgula, M. P., Taub, M. A., Rafaels, N., Daya, M., Campbell, M., Chavan, S., Shetty, A., Cheadle, C., Barkataki, S., Fan, J., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0714-1 · Cited by 28
Identifying patients at risk of anaphylaxis
du Toit, G., Smith, P., Muraro, A., Fox, A. T., Roberts, G., Ring, J., & Worm, M. (2024) · The World Allergy Organization Journal · doi:10.1016/j.waojou.2024.100904 · Cited by 23
Impact of Probiotic Bacteria on Respiratory Allergy Disorders
Jakubczyk, D., & Górska, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.688137 · Cited by 29
Polymorphisms in recent GWA identified asthma genes CA10, SGK493, and CTNNA3 are associated with disease severity and treatment response in childhood asthma
Perin, P., & Potočnik, U. (2014) · Immunogenetics · doi:10.1007/s00251-013-0755-0 · Cited by 28
Trajectories of childhood immune development and respiratory health relevant to asthma and allergy
Tang, H. H. F., Teo, S. M., Belgrave, D. C. M., Evans, M. D., Jackson, D. J., Brożyńska, M., Kusel, M. M. H., Johnston, S. L., Gern, J. E., Lemanske, R. F., et al. (2018) · eLife · doi:10.7554/elife.35856 · Cited by 30
Interleukin 4 gene polymorphism (−589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies
Kousha, A., Gorabi, A. M., Forouzesh, M., Hosseini, M., Alexander, M., Imani, D., Razi, B., Mousavi, M. J., Aslani, S., & Mikaeili, H. (2020) · BMC Immunology · doi:10.1186/s12865-020-00384-7 · Cited by 28
Genetic Variation in Genes Encoding Airway Epithelial Potassium Channels Is Associated with Chronic Rhinosinusitis in a Pediatric Population
Purkey, M. T., Li, J., Mentch, F. D., Grant, S. F. A., Desrosiers, M. Y., Hakonarson, H. H., & Toskala, E. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089329 · Cited by 27
Twins' risk of childhood asthma mediated by gestational age and birthweight
Ullemar, V., Lundholm, C., & Almqvist, C. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12547 · Cited by 27
Inhalant Mediated Allergy: Immunobiology, Clinical Manifestations and Diagnosis
Lam, K., Au, E. Y. L., Ip, W., Tam, J. K., & Leung, P. S. C. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09053-2 · Cited by 26
Update on the role of endoplasmic reticulum stress in asthma.
Miao, K., Zhang, L., Pan, T. S., & Wang, Y. (2020) · PubMed Central · Cited by 26
A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies
Shi, X., Chai, X., Yang, Y., Cheng, Q., Jiao, Y., Chen, H., Huang, J., Yang, C., & Liu, J. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa767 · Cited by 26
Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis
Ndika, J., Airaksinen, L. K., Suojalehto, H., Karisola, P., Fyhrquist, N., Puustinen, A., & Alenius, H. T. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.040 · Cited by 26
Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for “Omics” Technology?
Galeone, C., Scelfo, C., Bertolini, F., Caminati, M., Ruggiero, P., Facciolongo, N. C., & Menzella, F. (2018) · BioMed Research International · doi:10.1155/2018/4617565 · Cited by 26
Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma
Zhu, Z., Shibata, R., Hoffman, K. L., Cormier, J., Mansbach, J. M., Liang, L., Camargo, C. A., & Hasegawa, K. (2024) · European Respiratory Journal · doi:10.1183/13993003.01130-2024 · Cited by 25
Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets
Dong, Z., Ma, Y., Zhou, H., Shi, L., Ye, G., Yang, L., Liu, P., & Zhou, L. P. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-01303-7 · Cited by 25
The interleukin-4 −589C/T polymorphism and the risk of asthma: A meta-analysis including 7345 cases and 7819 controls
Nie, W., Zhu, Z., Pan, X., & Xiu, Q. (2013) · Gene · doi:10.1016/j.gene.2013.02.027 · Cited by 25
Antioxidant Defense Enzyme Genes and Asthma Susceptibility: Gender-Specific Effects and Heterogeneity in Gene-Gene Interactions between Pathogenetic Variants of the Disease
Polonikov, A., Ivanov, V. P., Bogomazov, A. D., Freidin, M. B., Illig, T., & Solodilova, M. A. (2014) · BioMed Research International · doi:10.1155/2014/708903 · Cited by 26
The pertussis hypothesis: Bordetella pertussis colonization in the etiology of asthma and diseases of allergic sensitization
Rubin, K., & Glazer, S. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.08.006 · Cited by 25
Metabolomics in the prevention and management of asthma
Zhu, Z., Camargo, C. A., & Hasegawa, K. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1674650 · Cited by 25
Association between Green Space Structure and the Prevalence of Asthma: A Case Study of Toronto
Dong, Y., Liu, H., & Zheng, T. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115852 · Cited by 24
Identifying Shared Risk Genes for Asthma, Hay Fever, and Eczema by Multi-Trait and Multiomic Association Analyses
Guo, H., An, J., & Yu, Z. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00270 · Cited by 24
Asthma Endophenotypes and Polymorphisms in the Histamine Receptor HRH4 Gene
Simon, T., Semsei, Á. F., Ungvári, I., Hadadi, É., Virág, V., Nagy, A., Vangor, M. S., László, V., Szalai, C., & Falus, A. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000335919 · Cited by 24
CXC chemokine superfamily induced by Interferon-γ in asthma: a cross-sectional observational study
Takaku, Y., Soma, T., Uchida, Y., Kobayashi, T., Nakagome, K., & Nagata, M. (2016) · Asthma Research and Practice · doi:10.1186/s40733-016-0021-y · Cited by 24
Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma
Toraih, E. A., Hussein, M. H., Ageeli, E. A., Riad, E., AbdAllah, N. B., Helal, G. M., & Fawzy, M. S. (2017) · Respiratory Research · doi:10.1186/s12931-017-0648-0 · Cited by 24
Microbial interactions in the atopic march
Nibbering, B., & Ubags, N. D. J. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13398 · Cited by 24
Sensitization to common aeroallergens in a population of young adults in a sub-Saharan Africa setting: a cross-sectional study
Ngahane, B. H. M., Noah, D., Nganda, M. M., Njankouo, Y. M., & Njock, L. R. (2016) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-015-0107-8 · Cited by 24
Genome-wide expression profiling of B lymphocytes reveals IL4R increase in allergic asthma
Pascual, M., Roa, S., Garcı́a-Sánchez, A., Sanz, C., Hernández-Hernández, L., Greally, J. M., Lorente, F., Davila, I. J., & Isidoro‐García, M. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.015 · Cited by 23
Urinary Metabolomic Profiling Reveals Biological Pathways and Predictive Signatures Associated with Childhood Asthma
Li, S., Liu, J., Zhou, J., Wang, Y., Jin, F., Chen, X., Yang, J. J., & Chen, Z. (2020) · Journal of Asthma and Allergy · doi:10.2147/jaa.s281198 · Cited by 23
IL-1 receptor–associated kinase 3 gene (IRAK3) variants associate with asthma in a replication study in the Spanish population
Pino-Yanes, M. D. M., Sánchez‐Machín, I., Cumplido, J., Figueroa, J., Torres-Galván, M. J., González‐Pérez, R., Corrales, A., Fernández, O. A., García-Robaina, J. C., Carrillo, T., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.001 · Cited by 23
The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma
Dizier, M., Margaritte‐Jeannin, P., Madore, A., Esparza-Gordillo, J., Moffatt, M. F., Corda, E., Monier, F., GUILLOUD-BATAILLE, M., Franke, A., Weidinger, S., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.04.010 · Cited by 23
Epidemiology of bronchial asthma in school children (10–16 years) in Srinagar
Qureshi, U., Qureshi, U., Bilquees, S., Haq, I. U., Khan, M., & Qurieshi, M. (2016) · Lung India · doi:10.4103/0970-2113.177442 · Cited by 23
The puzzle of immune phenotypes of childhood asthma
Landgraf‐Rauf, K., Anselm, B., & Schaub, B. (2016) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-016-0057-3 · Cited by 26
Linking hearing impairment, employment and education
Garramiola-Bilbao, I., & Rodrı́guez-Álvarez, A. (2016) · Public Health · doi:10.1016/j.puhe.2016.09.013 · Cited by 23
Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search
Kogan, V., Millstein, J., London, S. J., Ober, C., White, S. R., Naureckas, E. T., Gauderman, W. J., Jackson, D. J., Barraza‐Villarreal, A., Romieu, I., et al. (2018) · Human Heredity · doi:10.1159/000489765 · Cited by 23
Self-citation
Atopic diseases by filaggrin mutations and birth year
Thyssen, J. P., Linneberg, A. R., Johansen, J. D., Carlsen, B. C., Zachariae, C. O. C., Meldgaard, M., Szecsi, P. B., Stender, S., & Menné, T. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02804.x · Cited by 22
Polymorphism of the rs1800896 IL10 promoter gene protects children from post-bronchiolitis asthma
Koponen, P. S., Nuolivirta, K., Virta, M., Helminen, M., Hurme, M., & Korppi, M. O. (2013) · Pediatric Pulmonology · doi:10.1002/ppul.22909 · Cited by 22
Asthma and risk of lethal prostate cancer in the Health Professionals Follow-Up Study
Platz, E. A., Drake, C. G., Wilson, K. M., Sutcliffe, S. S., Kenfield, S. A., Mucci, L. A., Stampfer, M. J., Willett, W. C., Camargo, C. A., & Giovannucci, E. L. (2015) · International Journal of Cancer · doi:10.1002/ijc.29463 · Cited by 22
Perspectives on immunomodulation early in life
Diesner, S. C., Förster‐Waldl, E., Olivera, A., Pollak, A. J., Jensen‐Jarolim, E., & Untersmayr, E. (2012) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2011.01259.x · Cited by 22
Respiratory medicine – genetic base for allergy and asthma
Binia, A., & Kabesch, M. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13612 · Cited by 22
Prevalence and risk factors associated with wheezing in the first year of life
Bessa, O. A. A. C., Leite, Á. J. M., Solé, D., & Mallol, J., V (2013) · Jornal de Pediatria · doi:10.1016/j.jped.2013.08.007 · Cited by 21
The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype
Dizier, M., Margaritte‐Jeannin, P., Madore, A., Moffatt, M. F., Brossard, M., Lavielle, N., Sarnowski, C., Just, J., Cookson, W., Lathrop, M. G., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.12.1074 · Cited by 21
B Cell Intrinsic Mechanisms Constraining IgE Memory
Laffleur, B., Debeaupuis, O., Dalloul, Z., & Cogné, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01277 · Cited by 21
Pharmacogenetics of inhaled corticosteroids and exacerbation risk in adults with asthma
Edris, A., de Roos, E. W., McGeachie, M. J., Verhamme, K. M. C., Brusselle, G., Tantisira, K. G., Iribarren, C., Lü, M., Wu, A. C., Stricker, B. H. C., et al. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.13829 · Cited by 21
Early postnatal exposure to traffic-related air pollution and asthma in adolescents: vulnerability factors in the PARIS birth cohort
Citerne, A., Roda, C., Viola, M., Rancière, F., & Momas, I. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111473 · Cited by 21
Extracellular Vesicles as Unique Signaling Messengers: Role in Lung Diseases
Gao, Y., & Raj, J. U. (2020) · Comprehensive physiology · doi:10.1002/cphy.c200006 · Cited by 21
Sputum IL-25, IL-33 and TSLP, IL-23 and IL-36 in airway obstructive diseases. Reduced levels of IL-36 in eosinophilic phenotype
Moermans, C., Damas, K., Guiot, J., Njock, M., Corhay, J. L., Henket, M., Schleich, F., & Louis, R. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155421 · Cited by 20
Group 2 innate lymphoid cells and their surrounding environment
Naito, M., & Kumanogoh, A. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00272-8 · Cited by 21
Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder
Pan, P., Taylor, M. J., Larsson, H., Almqvist, C., Lichtenstein, P., Lundström, S., & Bölte, S. (2023) · Molecular Autism · doi:10.1186/s13229-023-00548-3 · Cited by 22
Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model
Menzel, M., Akbarshahi, H., Persson, I. M., Puthia, M., Bjermer, L. H., & Uller, L. (2017) · ERJ Open Research · doi:10.1183/23120541.00047-2017 · Cited by 21
Genetic Mechanisms of Asthma and the Implications for Drug Repositioning
Huo, Y., & Zhang, H. (2018) · Genes · doi:10.3390/genes9050237 · Cited by 22
Effect of Farming on Asthma
Pechlivanis, S., & von Mutius, E. (2020) · Acta Medica Academica · doi:10.5644/ama2006-124.293 · Cited by 20
Genetic polymorphisms of the TNF-α-308G/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China.
Yang, Y., Liu, Y., Zhang, L., Li, H., Li, X.-B., Ouyang, Q., & Zhu, G. (2015) · PubMed Central · Cited by 20
Filaggrin sequencing and bioinformatics tools
Margolis, D. J., Mitra, N., Wubbenhorst, B. S., & Nathanson, K. L. (2019) · Archives of Dermatological Research · doi:10.1007/s00403-019-01956-3 · Cited by 20
Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma
Djeddi, S., Fernandez‐Salinas, D., Huang, G. X., Aguiar, V. R. C., Mohanty, C., Kendziorski, C. M., Gazal, S., Boyce, J. A., Ober, C., Gern, J. E., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100636 · Cited by 20
Self-citation
Immune monitoring for precision medicine in allergy and asthma
Boyd, S. D., Hoh, R. A., Nadeau, K. C., & Galli, S. J. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.08.007 · Cited by 19
Second‐hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity
Johansson, E., Martin, L. J., He, H., Chen, X., Weirauch, M. T., Kroner, J. W., Hershey, G. K. K., & Myers, J. M. B. (2020) · Clinical & Experimental Allergy · doi:10.1111/cea.13815 · Cited by 19
Association between exposure to greenness and atopic march in children and adults—A systematic review and meta-analysis
Wang, X., Zhou, N., & Zhi, Y. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1097486 · Cited by 20
Association between fine mapping thymic stromal lymphopoietin and atopic dermatitis onset and persistence
Lou, C., Mitra, N., Wubbenhorst, B. S., D'Andrea, K. P., Hoffstad, O., Kim, B., Yan, A. C., Zaenglein, A. L., Fuxench, Z. C. C., Nathanson, K. L., et al. (2019) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2019.08.018 · Cited by 19
The Prevention of House Dust Mite Allergies in Pediatric Asthma
Klain, A., Senatore, A. A., Licari, A., Galletta, F., Bettini, I., Tomei, L., Manti, S., Mori, F., del Giudice, M. M., & Indolfi, C. (2024) · Children · doi:10.3390/children11040469 · Cited by 18
Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population
Wang, D. Y. (2011) · Asia Pacific Allergy · doi:10.5415/apallergy.2011.1.3.152 · Cited by 18
Interference of miR-943-3p with secreted frizzled-related proteins4 (SFRP4) in an asthma mouse model
Shen, J. H., Zhao, J., Ye, Q.-Y., & Gu, X. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03026-6 · Cited by 18
Environment and Host-Genetic Determinants in Early Development of Allergic Asthma: Contribution of Fungi
Hadebe, S., & Brombacher, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02696 · Cited by 18
Current status and perspectives regarding the association between allergic disorders and cancer
Fereidouni, M., Ferns, G. A., & Bahrami, A. (2020) · IUBMB Life · doi:10.1002/iub.2285 · Cited by 18
Mechanistic and Therapeutic Approaches to Occupational Exposure-Associated Allergic and Non-Allergic Asthmatic Disease
Schwab, A. D., & Poole, J. A. (2023) · Current Allergy and Asthma Reports · doi:10.1007/s11882-023-01079-w · Cited by 17
A time-varying group sparse additive model for genome-wide association studies of dynamic complex traits
Marchetti-Bowick, M., Yin, J., Howrylak, J. A., & Xing, E. P. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw347 · Cited by 17
Exposure to tobacco smoke and childhood rhinitis: a population-based study
Yao, T., Chang, S.-W., Chang, W., Tsai, M., Liao, S., Hua, M., Lai, S., Yeh, K., Tseng, Y.-L., Lin, W.-C., et al. (2017) · Scientific Reports · doi:10.1038/srep42836 · Cited by 19
Self-citation
Role of the TSLP–DC–OX40L pathway in asthma pathogenesis and airway inflammation in mice
Feng, S., Zhang, L., Bian, X.-H., Luo, Y., Qin, G.-H., & Shi, R. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0126 · Cited by 17
Retracted
Single nucleotide polymorphisms in asthma candidate genes TBXA2R, ADAM33 FCER1B and ORMDL3 in Pakistani asthmatics a case control study
Saba, N., Yusuf, O. M., Rehman, S., Munir, S., Noor, A., Saqlain, M., Mansoor, A., & Raja, G. K. (2018) · Asthma Research and Practice · doi:10.1186/s40733-018-0039-4 · Cited by 17
Thunderstorms, Pollen, and Severe Asthma in a Midwestern, USA, Urban Environment, 2007–2018
Smith, M. L., MacLehose, R. F., Chandler, J., & Berman, J. D. (2022) · Epidemiology · doi:10.1097/ede.0000000000001506 · Cited by 17
Genetic variants with gene regulatory effects are associated with diisocyanate-induced asthma
Bernstein, D. I., Lummus, Z. L., Kesavalu, B., Yao, J., Kottyan, L. C., Miller, D., Cartier, A., Cruz, M. J., Lemière, C., Muñoz, X., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.06.022 · Cited by 18
Association of group‐specific component exon 11 polymorphisms with bronchial asthma in children and adolescents
Fawzy, M. S., Elgazzaz, M., Ibrahim, A., Hussein, M. H., Khashana, M. S., & Toraih, E. A. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12740 · Cited by 17
Physiopathology of Allergic Asthma: A Comprehensive Review
Ghrairi, N., & Elhechmi, Y. Z. (2025) · Scandinavian Journal of Immunology · doi:10.1111/sji.70032 · Cited by 18
Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies
Lessard, S., Chao, M. J., Reis, K., FinnGen, Rajpal, D. K., Shankara, S., Sloane, J., Palta, P., Klinger, K. W., de Rinaldis, E., et al. (2024) · BMC Genomics · doi:10.1186/s12864-024-10971-2 · Cited by 17
Advances and Evolving Concepts in Allergic Asthma
Tung, H.-Y., Li, E., Landers, C. T., Nguyen, A., Kheradmand, F., Knight, J., & Corry, D. B. (2018) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0037-1607981 · Cited by 16
A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity
Maazi, H., Hartiala, J., Suzuki, Y., Crow, A. L., Shafiei-Jahani, P., Lam, J., Patel, N., Rigas, D., Han, Y. Y., Huang, P., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008528 · Cited by 16
Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank
Fawcett, K. A., Demidov, G. M., Shrine, N. R. G., Paynton, M. L., Ossowski, S., Sayers, I., Wain, L. V., & Hollox, E. J. (2022) · BMC Medical Genomics · doi:10.1186/s12920-022-01268-y · Cited by 16
Association of genetic risk and lifestyle with incident adult-onset asthma in the UK Biobank cohort
Liang, H., Jing, D., Zhu, Y., Li, D., Zhou, X., Tu, W. Y., Liu, H., Pan, P., & Zhang, Y. (2023) · ERJ Open Research · doi:10.1183/23120541.00499-2022 · Cited by 16
Is the Relationship Between Breastfeeding and Childhood Risk of Asthma and Obesity Mediated by Infant Antibiotic Treatment?
Krenz‐Niedbała, M., Kościński, K., Puch, E. A., Zelent, A., & Bręborowicz, A. (2015) · Breastfeeding Medicine · doi:10.1089/bfm.2014.0173 · Cited by 16
Association Between Gasdermin A and Gasdermin B Polymorphisms and Susceptibility to Adult and Childhood Asthma Among Jordanians
Zihlif, M., Obeidat, N. M., Zihlif, N., Mahafza, T. M., Froukh, T. J., Ghanim, M. T., Beano, H. M., Al-Akhras, F. M., & Naffa, R. G. (2016) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2015.0174 · Cited by 16
Interaction Between Helminths and Toll-Like Receptors: Possibilities and Potentials for Asthma Therapy
Zakeri, A., Borji, H., & Haghparast, A. (2016) · International Reviews of Immunology · doi:10.3109/08830185.2015.1096936 · Cited by 16
A passenger strand variant in miR-196a2 contributes to asthma severity in children and adolescents: A preliminary study
Hussein, M. H., Toraih, E. A., Aly, N. M., Riad, E., & Fawzy, M. S. (2016) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0010 · Cited by 16
A Comprehensive Look at the Development of Asthma in Children
Diaconu, I.-D., Gheorman, V., Grigorie, G. A., Gheonea, C., Ţenea-Cojan, T.-Ş., Mahler, B., Voropanov, I. A., Firoiu, M. C., Pîrvu, A. S., Popescu, A. B., et al. (2024) · Children · doi:10.3390/children11050581 · Cited by 15
Developmental Origins of Health and Disease: Impact of environmental dust exposure in modulating microbiome and its association with non-communicable diseases
Ooi, D. S. Q., Tan, C. P. T., Tay, M. J. Y., Ong, S. G., Tham, E. H., Siah, K. T. H., Eriksson, J. G., Godfrey, K. M., Shek, L. P., & Loo, E. X. L. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420000549 · Cited by 15
Factors and mechanisms contributing to the development of preschool wheezing disorders
Bonner, K., Scotney, E., & Saglani, S. (2021) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1913057 · Cited by 16
Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals
Song, Y., Li, X., Liu, F., Zhu, H., & Shen, Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12340 · Cited by 15
A meta-analysis of the association between CTLA-4 genetic polymorphism and susceptibility of asthma
Zheng, Y., Wang, H., Luo, L., Liao, L., You, L., Wang, J., & Li, Q. (2018) · Medicine · doi:10.1097/md.0000000000011380 · Cited by 15
Genome‐Wide Association Studies in Asthma
Portelli, M. A., & Sayers, I. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0024639 · Cited by 15
Indoor air pollution effects on pediatric asthma are submicron aerosol particle–dependent
Juskiene, I., Prokopčiuk, N., Franck, U. F., Valiulis, A., Valskys, V., Mesceriakova, V., Kvedarienė, V., Valiulyte, I., Poluziorovienė, E., Šaulienė, I., et al. (2022) · European Journal of Pediatrics · doi:10.1007/s00431-022-04443-6 · Cited by 14
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population
Costa, R. D. S., Figueiredo, C. A., Barreto, M. L., Alcântara‐Neves, N. M., Rodrigues, L. C., Cruz, Á. A., Vergara, C., Rafaels, N. M., Foster, C., Potee, J., et al. (2017) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.01.028 · Cited by 14
Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation
Song, D. J., Miller, M., Beppu, A., Rosenthal, P., Das, S., Karta, M. R., Vuong, C., Mehta, A. K., Croft, M., & Broide, D. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601412 · Cited by 14

Authors: Ober, C., & Yao, T.
Affiliations: University of Chicago (US)
Chang Gung University (TW)
Corresponding author: Ober, Carole
ORCID: Ober, Carole
Yao, Tsung‐Chieh
Venue: Immunological Reviews
Publisher: Wiley
Published: 2011-06-20
Volume: 242
Issue: 1
Pages: 10-30
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2011.01029.x
PMC: PMC3151648
OpenAlex: W1808276465
Cited by: 698
References: 287
Citations by year: 2026: 32 · 2025: 46 · 2024: 33 · 2023: 38 · 2022: 42 · 2021: 46 · 2020: 46 · 2019: 53 · 2018: 58 · 2017: 47 · 2016: 54 · 2015: 57 · 2014: 56 · 2013: 50 · 2012: 33
FWCI: 4.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL101543, RC2HL101651, HL85197, HL 70831, HL101651, RC2HL101543, R01HL085197, P01HL070831)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: asthma genetics, allergic diseases, genome-wide association study, IL-33, thymic stromal lymphopoietin, ST2, innate immunity, Th2 cells, ORMDL3, childhood asthma, susceptibility genes, cytokines
MeSH terms: Interleukin-33, Interleukin-1 Receptor-Like 1 Protein, Gasdermins, Thymic Stromal Lymphopoietin, Adult, Asthma, Child, Chromosomes, Human, Pair 17, Gene Expression Regulation, Humans, Hypersensitivity, Immediate, Immunity, Innate, Infant, Interleukins, Genetic Linkage, Lymphocyte Activation, Membrane Proteins, Neoplasm Proteins, Receptors, Cell Surface, Genetic Variation, Meta-Analysis as Topic, Cytokines, Th2 Cells, Genetic Predisposition to Disease, Genome-Wide Association Study, Genetic Loci

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The genetics of asthma and allergic disease: a 21st century perspective

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks