Cited by 702Asthma and respiratory diseasesIL-33, ST2, and ILC PathwaysGenetic Associations and Epidemiology

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The genetics of asthma and allergic disease: a 21st century perspective

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Ober, Carole, Yao, Tsung‐Chieh·2011·Immunological Reviews

DOI 10.1111/j.1600-065x.2011.01029.xPMC PMC3151648

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Abstract

Summary: Asthma and allergy are common conditions with complex etiologies involving both genetic and environmental contributions. Recent genome‐wide association studies (GWAS) and meta‐analyses of GWAS have begun to shed light on both common and distinct pathways that contribute to asthma and allergic diseases. Associations with variation in genes encoding the epithelial cell‐derived cytokines, interleukin‐33 (IL‐33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL‐33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T‐helper 2 cells in the pathogenesis of both asthma and allergic diseases. In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma. These and other genetic findings are providing a list of well‐validated asthma and allergy susceptibility genes that are expanding our understanding of the common and unique biological pathways that are dysregulated in these related conditions. Ongoing studies will continue to broaden our understanding of asthma and allergy and unravel the mechanisms for the development of these complex traits.

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Authors: Ober, C., & Yao, T.
Affiliations: University of Chicago (US)
Chang Gung University (TW)
Corresponding author: Ober, Carole
ORCID: Ober, Carole
Yao, Tsung‐Chieh
Venue: Immunological Reviews
Publisher: Wiley
Published: 2011-06-20
Volume: 242
Issue: 1
Pages: 10-30
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2011.01029.x
PMC: PMC3151648
OpenAlex: W1808276465
Cited by: 698
References: 287
Citations by year: 2026: 32 · 2025: 46 · 2024: 33 · 2023: 38 · 2022: 42 · 2021: 46 · 2020: 46 · 2019: 53 · 2018: 58 · 2017: 47 · 2016: 54 · 2015: 57 · 2014: 56 · 2013: 50 · 2012: 33
FWCI: 4.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL101543, RC2HL101651, HL85197, HL 70831, HL101651, RC2HL101543, R01HL085197, P01HL070831)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: asthma genetics, allergic diseases, genome-wide association study, IL-33, thymic stromal lymphopoietin, ST2, innate immunity, Th2 cells, ORMDL3, childhood asthma, susceptibility genes, cytokines
MeSH terms: Interleukin-33, Interleukin-1 Receptor-Like 1 Protein, Gasdermins, Thymic Stromal Lymphopoietin, Adult, Asthma, Child, Chromosomes, Human, Pair 17, Gene Expression Regulation, Humans, Hypersensitivity, Immediate, Immunity, Innate, Infant, Interleukins, Genetic Linkage, Lymphocyte Activation, Membrane Proteins, Neoplasm Proteins, Receptors, Cell Surface, Genetic Variation, Meta-Analysis as Topic, Cytokines, Th2 Cells, Genetic Predisposition to Disease, Genome-Wide Association Study, Genetic Loci

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