Cited by 702Asthma and respiratory diseasesIL-33, ST2, and ILC PathwaysGenetic Associations and Epidemiology

The DOI matches its Crossref record; 286 of the 287 references it cites were found in a registry or an index.

The genetics of asthma and allergic disease: a 21st century perspective

Open access

Ober, Carole, Yao, Tsung‐Chieh·2011·Immunological Reviews

DOI 10.1111/j.1600-065x.2011.01029.xPMC PMC3151648

Open this paper in CoChat — free account

Abstract

Summary: Asthma and allergy are common conditions with complex etiologies involving both genetic and environmental contributions. Recent genome‐wide association studies (GWAS) and meta‐analyses of GWAS have begun to shed light on both common and distinct pathways that contribute to asthma and allergic diseases. Associations with variation in genes encoding the epithelial cell‐derived cytokines, interleukin‐33 (IL‐33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL‐33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T‐helper 2 cells in the pathogenesis of both asthma and allergic diseases. In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma. These and other genetic findings are providing a list of well‐validated asthma and allergy susceptibility genes that are expanding our understanding of the common and unique biological pathways that are dysregulated in these related conditions. Ongoing studies will continue to broaden our understanding of asthma and allergy and unravel the mechanisms for the development of these complex traits.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1600-065x.2011.01029.x

Cites

286 of 286 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336
Sequencing technologies – the next generation
Metzker, M. L. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2626 · Cited by 7,066
The International HapMap Project
†The International HapMap Consortium, Genotyping centres: Baylor College of Medicine and ParAllele BioScience, Gibbs, R. A., Belmont, J. W., Hardenbol, P., Willis, T. D., Yu, F., Chinese HapMap Consortium, Yang, H., Ch'ang, L.-Y., et al. (2003) · Nature · doi:10.1038/nature02168 · Cited by 6,057
The Future of Genetic Studies of Complex Human Diseases
Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Bousquet, J., Khaltaev, N., Cruz, A. A., Denburg, J., Fokkens, W. J., Togias, A., Zuberbier, T., Baena‐Cagnani, C. E., Canonica, G. W., Van Weel, C., et al. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01620.x · Cited by 4,729
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC
Beasley, R. W. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07302-9 · Cited by 3,794
The global burden of asthma: executive summary of the GINA Dissemination Committee Report
Masoli, M., Fabian, D., Holt, S., Beasley, R. W., & Program, G. I. F. A. (. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00526.x · Cited by 3,521
Genetic Dissection of Complex Traits
Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,425

Show all 287 references

Research works printed but not linked: 1

10.1034/j.1399-3003.1999.13a04.x · DOI

Sorted by citations

Items 601–700 of 702

Determinants and Impact of Childhood Asthma in Outpatient Clinics of Family Medicine Centers of New Minia City
Elsherif, M., Sadek, R. R., Mahfouz, E. M., & Farouk, R. (2020) · Minia Journal of Medical Research · doi:10.21608/mjmr.2022.221582
Το εκπνεόμενο ΝΟ ως μη επεμβατικός δείκτης για την εκτίμηση ανάπτυξης αποφρακτικού συνδρόμου μετά από άσκηση και σύγχρονη έκθεση σε χλώριο σε νεαρούς κολυμβητές εσωτερικής πισίνας
Peletidou, S. (2020) · doi:10.12681/eadd/47619
Allergische Krankheiten
Hamelmann, E. H. (2020) · Springer Reference Medizin · doi:10.1007/978-3-662-60300-0_112
Effect of mobile phone radiofrequency on Cognitive function among children users.
Sayed, S. Z., Reyad, A., Ali, L., Khalaf, M. A., & Ali, E. (2019) · Minia Journal of Medical Research · doi:10.21608/mjmr.2022.221758
Severe Asthma
Wong, R., & Maffei, F. A. (2021) · Springer eBooks · doi:10.1007/978-3-030-53363-2_10
Asthma
(2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44306-7.50074-8
Peer Review #1 of "IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma (v0.1)"
(2022) · PeerJ · doi:10.7287/peerj.13444v0.1/reviews/1
Peer Review #1 of "IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma (v0.2)"
(2022) · PeerJ · doi:10.7287/peerj.13444v0.2/reviews/1
Peer Review #2 of "IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma (v0.2)"
(2022) · PeerJ · doi:10.7287/peerj.13444v0.2/reviews/2
Peer Review #2 of "IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma (v0.1)"
(2022) · PeerJ · doi:10.7287/peerj.13444v0.1/reviews/2
One Health: Flächen im Lebensumfeld von Mensch und Tier und ihre Auswirkungen auf Allergie und Asthma
Zednik, K., & Pali‐Schöll, I. (2022) · Allergo Journal · doi:10.1007/s15007-022-5015-x
Inmunoterapia con alérgenos para enfermedades alérgicas de las vías respiratorias: Aprovechar las lecciones del pasado para diseñar un futuro mejor
Hesse, L., Elberink, J. N. G. O., van Oosterhout, A. J. M., & Nawijn, M. C. (2022) · Kompass Neumología · doi:10.1159/000525293
Studying the Causes of Acute Asthma Attacks at Damascus Hospital, Treatment, Hospitalization, and DeathsPreprint
Alkhaled, O. S., Alshurbaji, R. E., & Al-bardan, H. (2022) · Research Square · doi:10.21203/rs.3.rs-2124815/v1
Asthma and COPD: distinct diseases or components of a continuum?
Martin, C., Chassagnon, G., Günther, S., Habib, S., Pastré, J., Burgel, P., & Roche, N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85419-1.00010-4
Genetics and epigenetics
Zeliger, H. I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91890-9.00022-2
Environment-Based Asthma Trigger Detection (ATD)
Chourasiya, S., Panchal, L., Dangra, M., Bhandari, M., Charkha, V., & Dhale, I. (2022) · Lecture notes in networks and systems · doi:10.1007/978-981-19-5221-0_51
Avaliação do uso de vitamina D em pacientes com asma: uma revisão integrativa
Pinto, A. R. H., dos Santos, G. P., da Costa, S. P., Santos, P. H. F. P., Lacerda, G. P., Almeida, N. C. C. D. S., Arruda, M. P. D. S., Paz, B. R., Oliveira, M. D. J., & Zanoni, R. D. (2022) · Research Society and Development · doi:10.33448/rsd-v11i17.39045
Peer Review #1 of "Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma (v0.2)"
(2023) · PeerJ · doi:10.7287/peerj.14760v0.2/reviews/1
Peer Review #2 of "Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma (v0.2)"
(2023) · PeerJ · doi:10.7287/peerj.14760v0.2/reviews/2
Peer Review #2 of "Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma (v0.1)"
(2023) · PeerJ · doi:10.7287/peerj.14760v0.1/reviews/2
Peer Review #1 of "Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma (v0.1)"
(2023) · PeerJ · doi:10.7287/peerj.14760v0.1/reviews/1
Evidence on the Impact of Pharmacogenetics to Treat and Manage Asthma
Nie, X., Zhao, Y., & Lu, C. Y. (2022) · Springer eBooks · doi:10.1007/978-3-030-50247-8_136-1
Study of Vitamin D Level in Paediatric Asthma at a Tertiary care Center
Kumar, P., Kumar, R., & Singh, P. B. (2022) · Journal of Nepal Paediatric Society · doi:10.3126/jnps.v42i3.47355
Author response: A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
Granell, R., Curtin, J. A., Haider, S., Kitaba, N. T., Mathie, S. A., Gregory, L. G., Yates, L. L., Tutino, M., Hankinson, J., Perretti, M., et al. (2023) · eLife · doi:10.7554/elife.84315.sa2
The Role of miRNAs in Asthma
Tosun, H., & Ceylan, H. (2023) · International Conference on Applied Engineering and Natural Sciences · doi:10.59287/icaens.1066
Evidence on the Impact of Pharmacogenetics to Treat and Manage Asthma
Nie, X., Zhao, Y., & Lu, C. Y. (2023) · Springer eBooks · doi:10.1007/978-3-030-64477-2_136
Epigenetics of allergic diseases
Karmaus, W., Ziyab, A. H., & Mukherjee, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-21863-7.00002-0
Relationship between effectiveness of asthma management and genetic variants in asthmatic Egyptian children
Ahmed, H. H., Farid, T. M., Hashish, M. M. A. A., Ibrahim, A. R., Mustafa, A., Wahby, A. A., Hassan, M., Elsebaie, E. H., Ramadan, A., & Mansour, S. A. (2024) · Egyptian Pediatric Association Gazette · doi:10.1186/s43054-023-00242-2
Advances in Genome-Wide Association Study on Asthma Pharmacogenomics
王, 钦. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.143900
Risk factors for the prevalence and development of allergic diseases
Turkalj, M., & Banić, I. (2024) · Liječnički vjesnik · doi:10.26800/lv-146-supl1-3
Genetics of asthma
Миронова, Ж. А., Трофимов, В. И., Karunas, A. S., Babadzhanova, G. Y., & Хуснутдинова, Э. К. (2024) · doi:10.18093/978-5-6048754-6-9-2024-2-38-57
Prevalence and CCR3-T51C genotype–phenotype correlation of bronchial asthma among basic education school children: an observational study
Zedan, M. M. E., Wassefy, M. E., Zareif, I. E., ElTahan, H., & Wahba, Y. (2024) · Egyptian Pediatric Association Gazette · doi:10.1186/s43054-024-00306-x
Genetic Association of Asthma: A Synoptic Review Based on Indian Population
Dey, D., Moitra, S., & Saha, G. K. (2024) · Proceedings of the Zoological Society · doi:10.1007/s12595-024-00550-4
NÍVEIS DE IgG1, IgG2, IgG3 E IgG4 ESPECÍFICOS A ANTÍGENOS DE POLÉN DE Lolium multiflorum EM PACIENTES COM POLINOSE NO SUL DO BRASIL
Silva, K. (2024) · doi:10.14393/ufu.di.2024.5238
An Analytical Study Using Biochemical Markers to Assess the Effect of Emissions on Workers’ Health in Nineveh at Badoush Cement Factory
Khalil, M. (2024) · Tikrit Journal of Pure Science · doi:10.25130/tjps.v29i6.1670
Migración interna y su asociación con el asma infantil en Ecuador: un estudio transversal
Cruz-Mariño, A., Cooper, P. J., Chico, M., Romero-Sandoval, N. C., & Rodríguez, A. (2024) · Colombia medica · doi:10.25100/cm.v55i2.5929
Microbiome: The One Health Connecting Link
Ramanathan, J. (2025) · Springer eBooks · doi:10.1007/978-3-031-80029-0_1
INNOVATIVE SCIENTIFIC RESEARCH: LATEST THEORIES, MODERN METHODS AND PRACTICES
Vladlenov, D. (2025) · doi:10.46299/isg.p.2025.1.20
Proceedings of the XX International Scientific and Practical Conference
(2025) · doi:10.46299/isg.2025.1.20
Shared loci but distinct variants underlie genetic architecture of allergic diseasesPreprint
Salamone, I. M., Zhong, X., Sakabe, N. J., Mitchell, R., Wentworth-Sheilds, W., Zhang, L., Thompson, E. E., Decker, D. C., Rische, C. H., Liu, X., et al. (2025) · medRxiv · doi:10.1101/2025.06.06.25329154 · Cited by 2
Self-citation
Disentangling the comorbidity between allergic disease and type 1 diabetes using genetically informative designs
Smew, A. I., Gong, T., Kuja‐Halkola, R., Lundholm, C., Harder, A., Lu, Y., Savendahl, L. S., Lichtenstein, P., Brew, B. K., & Almqvist, C. (2025) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2025.100519
Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure
Strohm, A. N., Civello, B., Badrani, J. H., Lacasa, L., Cavagnero, K. J., Portillo, A., Amadeo, M. B., Naji, L. H., Leng, A., Baum, R. E., et al. (2026) · F1000Research · doi:10.12688/f1000research.186491.1
Sun Exposure on the Incidence of Allergies in Adult Women
Pertiwi, F. D., Damayanthi, E., & Rimbawan, R. (2025) · Jurnal Kesehatan Masyarakat · doi:10.15294/kemas.v20i4.31230
The Immunobiology of Asthma
Cho, J. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00252-0
Multi-ancestry fine-mapping of the chromosome 17q12-q21 asthma locus identifies independent associations implicating lymphocyte and eosinophil levels in the causal pathwayPreprint
Ben-Eghan, C., Munter, M., Terao, C., Diaz-Papkovich, A., Gravel, S., Lathrop, M. G., & Grant, A. V. (2025) · medRxiv · doi:10.1101/2025.08.05.25333026
Prevalence of Asthma and Allergic Rhinitis and Their Association With Chronotype Among Adolescents in Ernakulam District: A School-Based Cross-Sectional Study
Sureshkumar, P., Mohandas, S., Rose, B. M., & Sreedevi, A. (2025) · Cureus · doi:10.7759/cureus.89928
Emerging roles of the gasdermin family in asthma
Miller, M., & Choi, G. (2025) · Kosin Medical Journal · doi:10.7180/kmj.25.121
Computationally efficient methods for estimating phenome—wide coheritability of multi-type phenotypes using biobank data
Deng, Y., Zeng, D., & Wang, Y. (2025) · Communications Biology · doi:10.1038/s42003-025-08180-y
Gene–environment interaction at 17q12–q21 locus and its role in asthma pathogenesis
Zhu, Z., Liu, C., Ober, C., & Camargo, C. A. (2025) · European Respiratory Journal · doi:10.1183/13993003.01232-2025
Self-citation
Genetic Variation in the ADRB2 Gene and Selected Immune Markers in Asthma Patients in Baghdad
Alkhamessi, R. N., Abdal-Wahab, S. T., Esam, B., Qasim, S. R., & Kadham, M. J. (2025) · The Egyptian Journal of Medical Microbiology · doi:10.21608/ejmm.2025.422964.1867
Preliminary Research on Early-Stage Preventive Strategies in Allergic Rhinitis
杨, 浩. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15113333
Variants in the Glucocorticoid Receptor gene (NR3C1), asthma control and serum cytokine levels
de Santana, M. B. R., Cruz, Á. A., de Araújo, J. L. F., Tugores, R., Teixeira, H. M. P., de Jesus, T. D. S., Pimentel, G., Santana, C. V. N., Kermani, N. Z., Chung, K. F., et al. (2025) · Respiratory Medicine · doi:10.1016/j.rmed.2025.108553
IL-18 receptor axis in allergic conjunctivitis: a multi-omics study
Yuan, L., Su, W., Li, L., Xiang, Y., Xu, Z., Wang, Y., Hua, X., & Yuan, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1704591
Additional file 1 of Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank
Fawcett, K. A., Demidov, G., Shrine, N. R. G., Paynton, M. L., Ossowski, S., Sayers, I., Wain, L. V., & Hollox, E. J. (2022) · Figshare · doi:10.6084/m9.figshare.19817792
Additional file 2 of Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets
Dong, Z., Ma, Y., Zhou, H., Shi, L., Ye, G., Yang, L., Liu, P., & Zhou, L. (2020) · Figshare · doi:10.6084/m9.figshare.13106283
Additional file 1 of DNA methylation and aeroallergen sensitization: The chicken or the egg?
Kilanowski, A., Merid, S. K., Abrishamcar, S., Feil, D., Thiering, E., Waldenberger, M., Melén, E., Peters, A., Standl, M., & Hüls, A. (2022) · Figshare · doi:10.6084/m9.figshare.21151399
Additional file 1 of Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder
Pan, P.-Y., Taylor, M. J., Larsson, H., Almqvist, C., Lichtenstein, P., Lundström, S., & Bölte, S. (2024) · Figshare · doi:10.6084/m9.figshare.26584179
Additional file 2 of Identification of asthma-related genes using asthmatic blood eQTLs of Korean patients
Kim, D. J., Lim, J. E., Jung, H.-U., Chung, J. Y., Baek, E. J., Jung, H., Kwon, S. Y., Kim, H. K., Kang, J.-O., Park, K., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24432122
Additional file 1 of Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets
Dong, Z., Ma, Y., Zhou, H., Shi, L., Ye, G., Yang, L., Liu, P., & Zhou, L. (2020) · Figshare · doi:10.6084/m9.figshare.13106280
Additional file 2 of Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder
Pan, P.-Y., Taylor, M. J., Larsson, H., Almqvist, C., Lichtenstein, P., Lundström, S., & Bölte, S. (2024) · Figshare · doi:10.6084/m9.figshare.26584182
Epigenetics and Allergic Diseases
Andrenacci, B., Licari, A., & Marseglia, G. L. (2025) · Rare diseases of the immune system · doi:10.1007/978-3-032-02902-7_9
Characterization of genetic loci associated with allergic conjunctivitis
Koskimäki, F., Ruokamo-Korva, K., Ahokas, O., Liinamaa, J., Reis, K., Reigo, A., Palta, P., Kettunen, J., Karjalainen, M. K., & Saarela, V. O. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.12.1000
Disentangling childhood asthma risk structure via Bayesian network topology
Gu, C., Ge, H., Wang, H., Sun, C., & Yang, H. (2026) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2026.131306
Association Of IL-4 Gene Polymorphism with Serum Ige And Eosinophil Levels in Asthma Patients
Hadi, H. S. (2026) · International Journal of Medical Science and Dental Health · doi:10.55640/ijmsdh-12-01-14
Two-Level Meta-Analysis of Genetic and Epigenetic Markers of Asthma in Preschool Children
Rsovac, S., Cukanovic, N., Zekovic, L., Selaković, V., & Milosevic, K. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15031229
Single-cell multi-omic profiling of lung immune cells identifies novel asthma risk genes and cell-type specific functionsPreprint
Gu, J., Decker, D. C., Zhong, X., Sperling, A. I., Ober, C., Nóbrega, M. A., He, X., & Schoettler, N. (2026) · Research Square · doi:10.21203/rs.3.rs-8914109/v1
Self-citation
VDR (Apa 1) Gene Polymorphism in Asthma in Karachi Population
Baig, S., Asim, H., & Anum, F. (2025) · Academic researcher. · doi:10.70349/ar.v2i2.36
NEBULIZED BUDESONIDE AS ADD-ON TO STANDARD THERAPY IN CHILDREN AGED 5-14 YEARS WITH ACUTE EXACERBATION OF ASTHMA
Deb, R., NARWAT, A., & Verma, S. (2026) · International Journal of Current Pharmaceutical Research · doi:10.22159/ijcpr.2026v18i2.8083
Role of IL-13 in allergic rhinitis inflammation: Preliminary results
Miteva, D., Naydenova, K., Dimitrov, V. D., & Velikova, T. V. (2026) · Pharmacia · doi:10.3897/pharmacia.73.e167296
Clinical Profile and Hematologic Parameters of Children Under Five Years Presenting With Wheeze
Tripathy, S. K., Medhagopal, R. G., Das, S., & Malik, A. (2026) · Cureus · doi:10.7759/cureus.106066
Interactions gène-gène et gène-environnement dans les études génétiques de maladies multifactorielles : application à l’asthme et l’atopie
Sugier, P. (2018) · theses.fr (ABES) · doi:10.70675/123d2373z6e08z4413z97bez1dd3c88e63a0
Context-specific genetic effects inform endotypes and treatment in asthma
Dahl, A. W., Sajuthi, S. P., Rappaport, N., Galanter, J., Gignoux, C. R., Burchard, E. G., Seibold, M. A., & Zaitlen, N. (2026) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2026.03.017
La prééminence du droit en droit positif
Lauraire, T. (2018) · doi:10.70675/550373e6zf0c7z4110zb145z4cce798201e3
Rôle de l’IL-33 et des cellules lymphoïdes innées de type 2 dans l’inflammation allergique pulmonaire
Schmitt, P. (2019) · theses.fr (ABES) · doi:10.70675/910c14fdzc720z4a3fza364z6abf25ce9c20
Vers une démocratisation de l’utilisation de la cytométrie en flux pour le diagnostic et le suivi de l’allergie
Arif‐Lusson, R. (2022) · doi:10.70675/278ff4c6zd2a4z41e8z90b0z379748702a07
Predictors of prognosis in children under six years of age with recurrent croup: a retrospective cohort study
Yaşar, A., Yılmaz, Ö., Eres, M., Tatar, A. A., & Yüksel, H. (2026) · BMC Pediatrics · doi:10.1186/s12887-026-06894-4
Phytotherapeutic Strategies for Bronchial Asthma: A Comprehensive Review of Anti-Inflammatory Medicinal Plants, Bioactive Compounds, and Molecular Mechanisms
A., M. K., N., K. S., D., G. D., & R., T. P. (2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.21s.24
Translating Asthma Pharmacogenomics into Practice: Evidence Synthesis, Clinical Implementation, and Future Directions
Buddhadev, S. S., Prajapati, B., Gadavala, S., KAYAMBO, D., & Vediya, P. (2026) · Asthma Allergy Immunology · doi:10.21911/aai.2026.1162
BOLALARDA BRONXIAL ASTMA KASALIKLARINI ERTA TASHXISLASH VA PROFILAKTIKA CHORALARI
Alisherova, M. A., & Bo'ronboyev, D. (2026) · Science and Innovation: Republican Scientific and Practical Conference · doi:10.70413/si-v04-i37-s40833
Shared Genetic Susceptibility Between Asthma and Immune‐Mediated Inflammatory Diseases
Zhou, L., & Sun, K. (2026) · Canadian Respiratory Journal · doi:10.1155/carj/4534431
Integrative multi-omics reveals that downregulation of HLA-DPA1/DPB1 drives macrophage immune-metabolic dysregulation in pediatric asthma
Wen, Y., Du, Z., Zhong, Z., Yuan, Q., Lin, L., Yao, R., He, J., Huang, Q., Li, L., Ouyang, C., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1835475
The role of estrogen receptors and house dust mite-induced DNA methylation in a mouse model
Commodore, S., Ekpruke, C. D., Alford, R., Borges-Sosa, O. A., Rousselle, D., Babayev, M., Igwe, C. E., Hemmerich, C. M., Rusch, D. B., & Silveyra, P. (2026) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00102.2026
Exposure to coal-fired power plant emissions, unconventional natural gas development, and salivary miRNA profiles and asthma in children
Reho, P., Jackson, G. L., Wang, F., Flores, N. M., Henneman, L., Mercer, D. G., Schwartz, B. S., Baccarelli, A., Wu, H., & (5172998), J. A. C. (2026) · Environmental Research · doi:10.1016/j.envres.2026.124856
Asthma
Ali, H., Brooks, C., Pearce, N. E., & Douwes, J. E. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45863-7.00083-4
Multimodal gene prioritization reveals nonlinear regulatory architecture in childhood-onset asthmaPreprint
Huang, N., Ragsac, M. F., Gui, X., Tantisira, K. G., & Amariuta, T. (2026) · medRxiv · doi:10.64898/2026.07.14.26357983
Pediatric asthma: Epidemiology, pathophysiology, clinical manifestations, diagnosis, and contemporary management approaches
Singh, A. K., Sharma, Y., & Rathore, S. (2026) · Indian Journal of Tuberculosis · doi:10.1016/j.ijtb.2026.07.024
Exercise-Induced Bronchoconstriction in Non-Asthmatic Children with Moderate-to-Severe Persistent Allergic Rhinitis Undergoing Subcutaneous Allergen Immunotherapy: Prevalence and Risk Factors
Yılmaz, E., Köker, N., & Topal, E. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15155944
Features of hereditary allergic history in different phenotypes of bronchial asthma in children under 5 years of age
Bolshakova, O. V., Malyuzhinskaya, N. V., Polyakova, O. V., Akulova, E. A., & Akhmatova, D. O. (2026) · Allergology and Immunology in Pediatrics · doi:10.53529/2500-1175-2026-2-15-27
Parental asthma and childhood asthma phenotypes: maternal associations with persistent asthma
Grefslie, M. R., Håberg, S. E., Magnus, M. C., Omsland, T. K., & Magnus, P. M. (2026) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2026-004245
Targeting the gut-nasal axis: probiotic-induced intestinal immune homeostasis for allergic rhinitis management
Han, Z., Li, X., Guo, J., Wang, J., Fang, S., Wu, Y., & Gu, S. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109755
Asthma: Pathogenesis, Etiology, and Risk Factors
Abdulla, A. A., & Mahmood, N. S. (2026) · Medical Journal of Babylon · doi:10.4103/mjbl.mjbl_284_24
The Role of Socioeconomic Factors in Severity, Diagnosis and Management of Childhood Asthma: A Scoping Review
Dhumal, P. I., Jadhav, S. J., & Muraleedharan, M. (2026) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-026-02592-5
Establishment of H1R-SNAP-tag/CMC and screening for anti-allergic active ingredients targeting H1R
Zhang, Q., Jiang, Y., Chen, W., Wang, J., Zhang, X., Wang, Y., Xu, Z., Dong, H., & Han, S. (2026) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-026-06799-2
HLA Polymorphism and Allergenicity
Doytchinova, I. A. (2026) · Allergies · doi:10.3390/allergies6030035
Big Problems, Big Data, Big Answers
Rider, N. L. (2026) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2026.08.010
Fungi in Asthma: From Epidemiology and Airway Mycobiome to Molecular Mechanisms and Novel Allergenic Phytopathogens
Krasowska-Kunach, M., Sułek, M., & Szuster‐Ciesielska, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198639
Gene-environment interactions of ORMDL3, IL4, IL13, ADAM33, IL10, and IL6 polymorphisms with bacterial infections in relation to asthma susceptibility
Mohsen, R. T., Al-Aboosi, I. T. S., & Hadi, K. A. (2026) · Regulatory Mechanisms in Biosystems · doi:10.15421/0226145
The Role of Epigenetics in Inner City Asthma (ICAC-15)
Schwartz, D., Liu, A., & Mitchell, H. (2017) · ImmPort · doi:10.21430/m3sxdbhqts
BindingDB Entry 50045562: Exploration of benzamidochromenone derivatives with conformational restrictor as interleukin-5 inhibitors.
BindingDB (2016) · UC San Diego · doi:10.7270/q25d8tjf
35th Multicenter Airway Research Collaboration (MARC-35): airway metagenome endotyping in infancy
Camargo, C. A., & Zhu, Z. (2024) · ImmPort · doi:10.21430/m35ond33v5

Authors: Ober, C., & Yao, T.
Affiliations: University of Chicago (US)
Chang Gung University (TW)
Corresponding author: Ober, Carole
ORCID: Ober, Carole
Yao, Tsung‐Chieh
Venue: Immunological Reviews
Publisher: Wiley
Published: 2011-06-20
Volume: 242
Issue: 1
Pages: 10-30
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2011.01029.x
PMC: PMC3151648
OpenAlex: W1808276465
Cited by: 698
References: 287
Citations by year: 2026: 32 · 2025: 46 · 2024: 33 · 2023: 38 · 2022: 42 · 2021: 46 · 2020: 46 · 2019: 53 · 2018: 58 · 2017: 47 · 2016: 54 · 2015: 57 · 2014: 56 · 2013: 50 · 2012: 33
FWCI: 4.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL101543, RC2HL101651, HL85197, HL 70831, HL101651, RC2HL101543, R01HL085197, P01HL070831)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: asthma genetics, allergic diseases, genome-wide association study, IL-33, thymic stromal lymphopoietin, ST2, innate immunity, Th2 cells, ORMDL3, childhood asthma, susceptibility genes, cytokines
MeSH terms: Interleukin-33, Interleukin-1 Receptor-Like 1 Protein, Gasdermins, Thymic Stromal Lymphopoietin, Adult, Asthma, Child, Chromosomes, Human, Pair 17, Gene Expression Regulation, Humans, Hypersensitivity, Immediate, Immunity, Innate, Infant, Interleukins, Genetic Linkage, Lymphocyte Activation, Membrane Proteins, Neoplasm Proteins, Receptors, Cell Surface, Genetic Variation, Meta-Analysis as Topic, Cytokines, Th2 Cells, Genetic Predisposition to Disease, Genome-Wide Association Study, Genetic Loci

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The genetics of asthma and allergic disease: a 21st century perspective

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks