The DOI matches its Crossref record; 169 of the 170 references it cites were found in a registry or an index.
Rethinking inflammation: neural circuits in the regulation of immunity
Open accessAbstract
Summary: Neural reflex circuits regulate cytokine release to prevent potentially damaging inflammation and maintain homeostasis. In the inflammatory reflex, sensory input elicited by infection or injury travels through the afferent vagus nerve to integrative regions in the brainstem, and efferent nerves carry outbound signals that terminate in the spleen and other tissues. Neurotransmitters from peripheral autonomic nerves subsequently promote acetylcholine‐release from a subset of CD4+T cells that relay the neural signal to other immune cells, e.g. through activation of α7 nicotinic acetylcholine receptors on macrophages. Here, we review recent progress in the understanding of the inflammatory reflex and discuss potential therapeutic implications of current findings in this evolving field.
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“the CNS is not a 'passive recipient' of information, but actively modulates aspects of peripheral immunity”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Olofsson et al, 2012
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Host-Bacterial Mutualism in the Human Intestine
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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
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Self-citationNicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
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Metadata
- Authors
- Olofsson, P. S., Rosas‐Ballina, M., Levine, Y. A., & Tracey, K. J.
- Affiliations
- Feinstein Institute for Medical Research (US)
- University of Basel (CH)
- Corresponding author
- Tracey, Kevin J.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2012-06-21
- Volume
- 248
- Issue
- 1
- Pages
- 188-204
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC4536565
- OpenAlex
- W1901457319
- Cited by
- 393
- References
- 170
- Citations by year
- 2026: 16 · 2025: 11 · 2024: 17 · 2023: 29 · 2022: 28 · 2021: 30 · 2020: 14 · 2019: 28 · 2018: 34 · 2017: 35 · 2016: 32 · 2015: 44 · 2014: 42 · 2013: 22 · 2012: 10
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM057226)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- cholinergic anti-inflammatory pathway, vagus nerve, brainstem, acetylcholine, CD4+ T cells, alpha7 nicotinic acetylcholine receptor, macrophages, spleen, neuroimmune regulation, cytokine production, anti-inflammatory therapy
- MeSH terms
- Acetylcholine, Animals, Choline O-Acetyltransferase, Humans, Inflammation, Reflex, T-Lymphocytes, Vagus Nerve, Neuroimmunomodulation
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