Cited by 393Vagus Nerve Stimulation ResearchHeart Rate Variability and Autonomic ControlCancer, Stress, Anesthesia, and Immune Response

The DOI matches its Crossref record; 169 of the 170 references it cites were found in a registry or an index.

Rethinking inflammation: neural circuits in the regulation of immunity

Open access

Olofsson, Peder S., Rosas‐Ballina, Mauricio, Levine, Yaakov A., Tracey, Kevin J.·2012·Immunological Reviews

DOI 10.1111/j.1600-065x.2012.01138.xPMC PMC4536565

Open this paper in CoChat — free account

Abstract

Summary: Neural reflex circuits regulate cytokine release to prevent potentially damaging inflammation and maintain homeostasis. In the inflammatory reflex, sensory input elicited by infection or injury travels through the afferent vagus nerve to integrative regions in the brainstem, and efferent nerves carry outbound signals that terminate in the spleen and other tissues. Neurotransmitters from peripheral autonomic nerves subsequently promote acetylcholine‐release from a subset of CD4+T cells that relay the neural signal to other immune cells, e.g. through activation of α7 nicotinic acetylcholine receptors on macrophages. Here, we review recent progress in the understanding of the inflammatory reflex and discuss potential therapeutic implications of current findings in this evolving field.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1600-065x.2012.01138.x

Cites

169 of 169 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats*
Mioni, C., Bazzani, C., Giuliani, D., Altavilla, D., Leone, S., Ferrari, A., Minutoli, L., Bitto, A., Marini, H., Zaffe, D., et al. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000186762.05301.13 · Cited by 148
Retracted
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Self-citation
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
The inflammatory reflex
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Self-citation
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
Self-citation
Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120
The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252
Resolvins
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650

Show all 170 references

Sorted by citations

The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome
Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell · doi:10.1016/j.cell.2014.11.047 · Cited by 1,014
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813
Inflammation, Immunity, and Hypertensive End-Organ Damage
McMaster, W. G., Kirabo, A., Madhur, M. S., & Harrison, D. G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303697 · Cited by 708
Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees
Prisco, G. D., Cavaliere, V., Annoscia, D., Varricchio, P., Caprio, E., Nazzi, F., Gargiulo, G., & Pennacchio, F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314923110 · Cited by 708
Sleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624
The resolution of inflammation
Buckley, C. D., Gilroy, D. W., Serhan, C. N., Stockinger, B., & Tak, P. P. (2012) · Nature reviews. Immunology · doi:10.1038/nri3362 · Cited by 602
Nicotinic ACh receptors as therapeutic targets in CNS disorders
Dineley, K. T., Pandya, A. A., & Yakel, J. L. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.12.002 · Cited by 460
The sympathetic nervous response in inflammation
Pongratz, G., & Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0504-2 · Cited by 427
Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity
Locati, M., Mantovani, A., & Sica, A. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00006-5 · Cited by 418
The cholinergic anti-inflammatory pathway: A critical review
Martelli, D., McKinley, M. J., & McAllen, R. M. (2013) · Autonomic Neuroscience · doi:10.1016/j.autneu.2013.12.007 · Cited by 398
The vagus nerve in appetite regulation, mood, and intestinal inflammation
Browning, K. N., Verheijden, S., & Boeckxstaens, G. E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.046 · Cited by 361
Vagus nerve stimulation: from epilepsy to the cholinergic anti‐inflammatory pathway
Bonaz, B., Picq, C., Sinniger, V., Mayol, J., & Clarencon, D. (2013) · Neurogastroenterology and Motility · doi:10.1111/nmo.12076 · Cited by 302
A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin
Baganz, N. L., & Blakely, R. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300186b · Cited by 316
Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes
Inoue, T., Abe, C., Sung, S. J., Moscalu, S., Jankowski, J., Huang, L., Ye, H., Rosin, D. L., Guyenet, P. G., & Okusa, M. D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83658 · Cited by 316
Psychological Stress and Mitochondria: A Conceptual Framework
Picard, M. A., & McEwen, B. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000544 · Cited by 328
Cholinergic modulation of the immune system presents new approaches for treating inflammation
Hoover, D. B. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.002 · Cited by 306
C1 neurons: the body's EMTs
Guyenet, P. G., Stornetta, R. L., Bochorishvili, G., DePuy, S. D., Burke, P. G. R., & Abbott, S. B. G. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00054.2013 · Cited by 269
Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders
Singh, R., Zogg, H., Wei, L., Bartlett, A., Ghoshal, U. C., Rajender, S., & Ro, S. (2020) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm20149 · Cited by 274
Neural circuitry and immunity
Pavlov, V. A., & Tracey, K. J. (2015) · Immunologic Research · doi:10.1007/s12026-015-8718-1 · Cited by 254
Self-citation
Microbes, immunity, and behavior: psychoneuroimmunology meets the microbiome
Dinan, T. G., & Cryan, J. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.103 · Cited by 246
Long-Term Exposure to Concentrated Ambient PM2.5 Increases Mouse Blood Pressure through Abnormal Activation of the Sympathetic Nervous System: A Role for Hypothalamic Inflammation
Ying, Z., Xu, X., Bai, Y., Zhong, J., Chen, M., Liang, Y., Zhao, J., Liu, D., Morishita, M., Sun, Q., et al. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1307151 · Cited by 235
Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease
Bonaz, B., Sinniger, V., & Pellissier, S. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12611 · Cited by 213
Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication
El Aidy, S., Dinan, T. G., & Cryan, J. F. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.002 · Cited by 215
α7 Nicotinic Acetylcholine Receptor Signaling Inhibits Inflammasome Activation by Preventing Mitochondrial DNA Release
Lü, B., Kwan, K., Levine, Y. A., Olofsson, P. S., Yang, H., Li, J., Joshi, S., Wang, H., Andersson, U., Chavan, S. S., et al. (2014) · Molecular Medicine · doi:10.2119/molmed.2013.00117 · Cited by 209
Self-citation
Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity
Zanos, T. P., Silverman, H. A., Levy, T. J., Tsaava, T., Battinelli, E., Lorraine, P. W., Ashe, J. M., Chavan, S. S., Tracey, K. J., & Bouton, C. E. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719083115 · Cited by 203
Self-citation
Crosstalk between the nociceptive and immune systems in host defence and disease
McMahon, S. B., Russa, F. L., & Bennett, D. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3946 · Cited by 196
C1 neurons mediate a stress-induced anti-inflammatory reflex in mice
Abe, C., Inoue, T., Inglis, M. A., Viar, K. E., Huang, L., Ye, H., Rosin, D. L., Stornetta, R. L., Okusa, M. D., & Guyenet, P. G. (2017) · Nature Neuroscience · doi:10.1038/nn.4526 · Cited by 188
Neuroendocrine regulation of inflammation
Padro, C. J., & Sanders, V. M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.01.003 · Cited by 192
Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
Öhman, L., Törnblom, H., & Simrén, M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.200 · Cited by 185
Mechanisms of Fever Production and Lysis: Lessons from Experimental LPS Fever
Roth, J., & Blatteis, C. M. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130033 · Cited by 206
The immune system and hypertension
Singh, M. V., Chapleau, M. W., Harwani, S. C., & Abboud, F. M. (2014) · Immunologic Research · doi:10.1007/s12026-014-8548-6 · Cited by 176
Vagus nerve controls resolution and pro-resolving mediators of inflammation
Mirakaj, V., Dalli, J., Granja, T., Rosenberger, P., & Serhan, C. N. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132103 · Cited by 176
From Probiotics to Psychobiotics: Live Beneficial Bacteria Which Act on the Brain-Gut Axis
Bermúdez‐Humarán, L. G., Salinas, E., Ortíz, G. G., Ramírez-Jirano, L. J., Morales, J. A., & Bitzer-Quintero, O. K. (2019) · Nutrients · doi:10.3390/nu11040890 · Cited by 184
Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage
Zhao, X., Ting, S., Liu, C.-H., Sun, G., Kruzel, M. L., Roy-O’Reilly, M. A., & Aronowski, J. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00770-7 · Cited by 171
Connection between Systemic Inflammation and Neuroinflammation Underlies Neuroprotective Mechanism of Several Phytochemicals in Neurodegenerative Diseases
Wang, J., Song, Y., Zheng, C., & Leng, S. X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1972714 · Cited by 158
Epidemiological and Experimental Links between Air Pollution and Type 2 Diabetes
Liu, C., Ying, Z., Harkema, J. R., Sun, Q., & Rajagopalan, S. (2012) · Toxicologic Pathology · doi:10.1177/0192623312464531 · Cited by 149
Abandon the Mouse Research Ship? Not Just Yet!
Osuchowski, M. F., Remick, D. G., Lederer, J. A., Lang, C. H., Aasen, A. O., Aibiki, M., Azevedo, L. C. P., Bahrami, S., Boros, M., Cooney, R. N., et al. (2014) · Shock · doi:10.1097/shk.0000000000000153 · Cited by 148
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
Bertrand, D., Lee, C., Flood, D. G., Marger, F., & Donnelly‐Roberts, D. L. (2015) · Pharmacological Reviews · doi:10.1124/pr.113.008581 · Cited by 142
Brain-Reactive Antibodies and Disease
Diamond, B., Honig, G., Mader, S., Brimberg, L., & Volpe, B. T. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075041 · Cited by 138
Molecular Mechanisms of Neuroinflammation in ME/CFS and Long COVID to Sustain Disease and Promote Relapses
Tate, W. P., Walker, M., Sweetman, E., Helliwell, A., Peppercorn, K., Edgar, C. D., Blair, A., & Chatterjee, A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.877772 · Cited by 131
Posttraumatic stress disorder: does the gut microbiome hold the key?
Leclercq, S., Forsythe, P., & Bienenstock, J. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716635535 · Cited by 121
Alpha7 nicotinic receptors as therapeutic targets for Parkinson’s disease
Quik, M., Zhang, D., McGregor, M., & Bordia, T. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.014 · Cited by 113
Lifestyle Effects on Hematopoiesis and Atherosclerosis
Nahrendorf, M., & Świrski, F. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.303550 · Cited by 124
Heart-rate-variability (HRV), predicts outcomes in COVID-19
Mol, M. B. A., Strous, M. T. A., van Osch, F., Vogelaar, F. J., Barten, D. G., Farchi, M. U., Foudraine, N. A., & Gidron, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258841 · Cited by 118
Dynamics of T cell responses after stroke.
Gill, D., & Veltkamp, R. (2016) · Current opinion in pharmacology (Print) · doi:10.1016/j.coph.2015.09.009 · Cited by 116
Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway
Schneider, N., Chandran, P., Sundby, M., Visioli, F., Gonçalves, F. D. C., Burks, S. R., Paz, A. H. D. R., & Frank, J. A. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.033 · Cited by 117
The autonomic nervous system in septic shock and its role as a future therapeutic target: a narrative review
Carrara, M., Ferrario, M., Pinto, B. B., & Herpain, A. (2021) · Annals of Intensive Care · doi:10.1186/s13613-021-00869-7 · Cited by 118
Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase
Olofsson, P. S., Steinberg, B. E., Sobbi, R., Cox, M. A., Ahmed, M. N., Oswald, M., Szekeres, F. L. M., Hanes, W. M., Introini, A., Liu, S. F., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3663 · Cited by 118
Self-citation
Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence
Lai, N. Y., Mills, K. R., & Chiu, I. M. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12591 · Cited by 116
GABA ergic signalling in the immune system
Barragán, A., Weidner, J. M., Jin, Z., Korpi, E. R., & Birnir, B. (2015) · Acta Physiologica · doi:10.1111/apha.12467 · Cited by 110
Low-Level Vagus Nerve Stimulation Suppresses Post-Operative Atrial Fibrillation and Inflammation
Stavrakis, S., Humphrey, M. B., Scherlag, B. J., Iftikhar, O., Parwani, P. J., Abbas, M., Filiberti, A., Fleming, C., Hu, Y., Garabelli, P. J., et al. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.02.019 · Cited by 112
GABAergic signaling by cells of the immune system: more the rule than the exception
Bhandage, A. K., & Barragán, A. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03881-z · Cited by 114
Innervation of cervical carcinoma is mediated by cancer-derived exosomes
Lucido, C. T., Wynja, E., Madeo, M., Williamson, C. S., Schwartz, L. E., Imblum, B. A., Drapkin, R., & Vermeer, P. D. (2019) · Gynecologic Oncology · doi:10.1016/j.ygyno.2019.04.651 · Cited by 112
Sex differences in how inflammation affects behavior: what we can learn from experimental inflammatory models in humans
Lasselin, J., Lekander, M., Axelsson, J., & Karshikoff, B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.005 · Cited by 106
Hyperoxia and the Immature Brain
Reich, B., Hoeber, D., Bendix, I., & Felderhoff‐Mueser, U. (2016) · Developmental Neuroscience · doi:10.1159/000454917 · Cited by 112
Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke
Engel, O., Akyüz, L., Gonçalves, A. C. D. C., Winek, K., Dames, C., Thielke, M., Herold, S., Böttcher, C., Priller, J., Volk, H., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.008989 · Cited by 103
Modulation of experimental arthritis by vagal sensory and central brain stimulation
Bassi, G. S., Dias, D. P. M., Franchin, M., Talbot, J., dos Reis, D. G., Menezes, G. B., Castania, J. A., Garcia‐Cairasco, N., Resstel, L. B. M., Salgado, H. C., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.04.003 · Cited by 99
Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes
Liu, C., Fonken, L. K., Wang, A., Maiseyeu, A., Bai, Y., Wang, T.-Y., Maurya, S. K., Ko, Y.-A., Periasamy, M., Dvonch, T. J., et al. (2014) · Particle and Fibre Toxicology · doi:10.1186/s12989-014-0053-5 · Cited by 96
Acetylcholinesterase Inhibitors Reduce Neuroinflammation and -Degeneration in the Cortex and Hippocampus of a Surgery Stress Rat Model
Kalb, A., von Haefen, C., Sifringer, M., Tegethoff, A., Paeschke, N., Kostova, M. H., Feldheiser, A., & Spies, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062679 · Cited by 94
The Gut's Little Brain in Control of Intestinal Immunity.
Jonge, D., & Wouter, J. (2013) · ISRN Gastroenterology · doi:10.1155/2013/630159 · Cited by 36
Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood–Brain Barrier Permeability following Experimental Traumatic Brain Injury
Dash, P. K., Zhao, J., Kobori, N., Redell, J. B., Hylin, M. J., Hood, K. N., & Moore, A. N. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3197-15.2016 · Cited by 93
Drosophila as a model for the two myeloid blood cell systems in vertebrates
Gold, K. S., & Brückner, K. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.06.002 · Cited by 99
Higher Vagal Activity as Related to Survival in Patients With Advanced Breast Cancer
Giese‐Davis, J., Wilhelm, F. H., Tamagawa, R., Palesh, O. G., Neri, E., Taylor, C. B., KRAEMER, H. C., & Spiegel, D. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000167 · Cited by 96
Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit
Caravaca, A. S., Gallina, A. L., Tarnawski, L., Shavva, V. S., Colas, R. A., Dalli, J., Malin, S., Hult, H., Arnardottir, H. H., & Olofsson, P. S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023285119 · Cited by 94
Self-citation
Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release
Hecker, A., Küllmar, M., Wilker, S., Richter, K., Zakrzewicz, A., Atanasova, S., Mathes, V., Timm, T., Lerner, S., Klein, J., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1400974 · Cited by 91
Disentangling multiple interactions in the hive ecosystem
Nazzi, F., & Pennacchio, F. (2014) · Trends in Parasitology · doi:10.1016/j.pt.2014.09.006 · Cited by 90
Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear
Addorisio, M. E., Imperato, G. H., de Vos, A. F., Forti, S., Goldstein, R. S., Pavlov, V. A., van der Poll, T., Yang, H., Diamond, B., Tracey, K. J., et al. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0020-4 · Cited by 93
Self-citation
Adrenergic β2 Receptor Activation Stimulates Anti-Inflammatory Properties of Dendritic Cells In Vitro
Nijhuis, L., Olivier, B. J., Dhawan, S., Hilbers, F. W., Boon, L., Wolkers, M. C., Samsom, J. N., & de Jonge, W. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085086 · Cited by 88
Single-pulse and unidirectional electrical activation of the cervical vagus nerve reduces tumor necrosis factor in endotoxemia
Olofsson, P. S., Levine, Y. A., Caravaca, A., Chavan, S. S., Pavlov, V. A., Faltys, M., & Tracey, K. J. (2015) · Bioelectronic Medicine · doi:10.15424/bioelectronmed.2015.00006 · Cited by 81
Self-citation
Regulation of bitter taste responses by tumor necrosis factor
Feng, P., Jyotaki, M., Kim, A. S., Chai, J., Simon, N., Zhou, M., Bachmanov, A. A., Huang, L., & Wang, H. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.001 · Cited by 83
Chronic Morphine-Induced MicroRNA-124 Promotes Microglial Immunosuppression by Modulating P65 and TRAF6
Qiu, S., Feng, Y., LeSage, G., Zhang, Y., Stuart, C. A., He, L., Li, Y., Caudle, Y., Peng, Y., & Yin, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400106 · Cited by 82
Perioperative Inflammation and Its Modulation by Anesthetics
Rossaint, J., & Zarbock, A. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002484 · Cited by 80
Stimulation of the α7 Nicotinic Acetylcholine Receptor Protects against Neuroinflammation after Tibia Fracture and Endotoxemia in Mice
Terrando, N., Yang, T., Ryu, J. K., Newton, P. T., Monaco, C. G., Feldmann, M., Ma, D., Akassoglou, K., & Maze, M. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00143 · Cited by 80
Glutamatergic Neurotransmission between the C1 Neurons and the Parasympathetic Preganglionic Neurons of the Dorsal Motor Nucleus of the Vagus
DePuy, S. D., Stornetta, R. L., Bochorishvili, G., Deisseroth, K. A., Witten, I. B., Coates, M. B., & Guyenet, P. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4269-12.2013 · Cited by 77
Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation
Rosas‐Ballina, M., Valdés‐Ferrer, S. I., Dancho, M. E., Ochani, M., Katz, D., Cheng, K. F., Olofsson, P. S., Chavan, S. S., Al‐Abed, Y., Tracey, K. J., et al. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.07.010 · Cited by 79
Self-citation
The Neuromodulation of the Intestinal Immune System and Its Relevance in Inflammatory Bowel Disease
Giovangiulio, M. D., Verheijden, S., Bosmans, G., Stakenborg, N., Boeckxstaens, G. E., & Matteoli, G. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00590 · Cited by 81
Neural control of the immune system
Sundman, E., & Olofsson, P. S. (2014) · Advances in Physiology Education · doi:10.1152/advan.00094.2013 · Cited by 74
Self-citation
Research progress of vagus nerve stimulation in the treatment of epilepsy
Fan, J., Shan, W., Wu, J., & Wang, Q. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13209 · Cited by 76
The mouse autonomic nervous system modulates inflammation and epithelial renewal after corneal abrasion through the activation of distinct local macrophages
Xue, Y., He, J., Xiao, C., Guo, Y., Fu, T., Liu, J., Lin, C., Wu, M., Yang, Y., Dong, D., et al. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0031-6 · Cited by 75
Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10
Zakrzewicz, A., Richter, K., Agné, A. M., Wilker, S., Siebers, K., Fink, C. B., Krasteva‐Christ, G., Althaus, M., Padberg, W. M., Hone, A. J., et al. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00189 · Cited by 76
Immune dysfunction in Niemann‐Pick disease type C
Platt, N., Speak, A. O., Colaço, A., Gray, J., Smith, D. A., Williams, I. M., Wallom, K., & Platt, F. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13138 · Cited by 73
Association between corrected QT interval and inflammatory cytokines in rheumatoid arthritis
Adlan, A. M., Panoulas, V. F., Smith, J. P., Fisher, J. P., & Kitas, G. D. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.140861 · Cited by 71
Dysfunction of Inflammation-Resolving Pathways Is Associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of the Metabolic Syndrome
Su, X., Feng, X., Terrando, N., Yan, Y., Chawla, A., Koch, L. G., Britton, S. L., Matthay, M. A., & Maze, M. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00351 · Cited by 72
Cholinergic Modulation of the Immune System in Neuroinflammatory Diseases
Reale, M., & Costantini, E. (2021) · Diseases · doi:10.3390/diseases9020029 · Cited by 76
Tolerance of infection: A role for animal behavior, potential immune mechanisms, and consequences for parasite transmission
Adelman, J. S., & Hawley, D. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.10.013 · Cited by 72
Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats
Lataro, R. M., Silva, C. A. A., Tefé‐Silva, C., Prado, C. M., & Salgado, H. C. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv017 · Cited by 71
Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature
Irwin, M. R. (2022) · Temperature · doi:10.1080/23328940.2022.2109932 · Cited by 80
Neuroimmune Modulation Through Vagus Nerve Stimulation Reduces Inflammatory Activity in Crohn’s Disease Patients: A Prospective Open-label Study
D’Haens, G., Eberhardson, M., Čabrijan, Ž., Danese, S., van den Berg, R., Löwenberg, M., Fiorino, G., Schuurman, P. R., Lind, G., Almqvist, P. M., et al. (2023) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad151 · Cited by 75
Self-citation
An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation
Caravaca, A. S., Gallina, A. L., Tarnawski, L., Tracey, K. J., Pavlov, V. A., Levine, Y. A., & Olofsson, P. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00877 · Cited by 66
Self-citation
Causes and Consequences of Degeneration of the Dorsal Motor Nucleus of the Vagus Nerve in Parkinson's Disease
Greene, J. G. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5859 · Cited by 69
A Neuroinflammatory Model for Acute Fatigue During Exercise
Vargas, N. T., & Marino, F. E. (2014) · Sports Medicine · doi:10.1007/s40279-014-0232-4 · Cited by 65
Microbiome to Brain: Unravelling the Multidirectional Axes of Communication
Aidy, S. E., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-20215-0_15 · Cited by 65
Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor
Teng, P., Liu, Y., Dai, Y., Zhang, H., Liu, W., & Hu, J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801513 · Cited by 63
Towards a Better Understanding of the Complexities of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID
Tate, W. P., Walker, M., Peppercorn, K., Blair, A., & Edgar, C. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065124 · Cited by 62
Nicotinic ACh receptors in the hippocampal circuit; functional expression and role in synaptic plasticity
Yakel, J. L. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.273896 · Cited by 61
Fetal cholinergic anti-inflammatory pathway and necrotizing enterocolitis: the brain-gut connection begins in utero
Garzoni, L., Faure, C. C., & Frasch, M. G. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00057 · Cited by 57
A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve
Caravaca, A. S., Tsaava, T., Goldman, L., Silverman, H., Riggott, G., Chavan, S. S., Bouton, C., Tracey, K. J., Desimone, R., Boyden, E. S., et al. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa7a42 · Cited by 57
Self-citation
Neural Control of Inflammation
Steinberg, B. E., Sundman, E., Terrando, N., Eriksson, L. I., & Olofsson, P. S. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001083 · Cited by 59
Self-citation

Authors: Olofsson, P. S., Rosas‐Ballina, M., Levine, Y. A., & Tracey, K. J.
Affiliations: Feinstein Institute for Medical Research (US)
University of Basel (CH)
Corresponding author: Tracey, Kevin J.
ORCID: Olofsson, Peder S.
Levine, Yaakov A.
Tracey, Kevin J.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2012-06-21
Volume: 248
Issue: 1
Pages: 188-204
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.1600-065x.2012.01138.x
PMC: PMC4536565
OpenAlex: W1901457319
Cited by: 393
References: 170
Citations by year: 2026: 16 · 2025: 11 · 2024: 17 · 2023: 29 · 2022: 28 · 2021: 30 · 2020: 14 · 2019: 28 · 2018: 34 · 2017: 35 · 2016: 32 · 2015: 44 · 2014: 42 · 2013: 22 · 2012: 10
FWCI: 3.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM057226)
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Keywords: cholinergic anti-inflammatory pathway, vagus nerve, brainstem, acetylcholine, CD4+ T cells, alpha7 nicotinic acetylcholine receptor, macrophages, spleen, neuroimmune regulation, cytokine production, anti-inflammatory therapy
MeSH terms: Acetylcholine, Animals, Choline O-Acetyltransferase, Humans, Inflammation, Reflex, T-Lymphocytes, Vagus Nerve, Neuroimmunomodulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Rethinking inflammation: neural circuits in the regulation of immunity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks