An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model: A pilot study
Abstract
Chronic ultraviolet B (UVB) exposure of human or murine skin is known to induce cutaneous photoaging and enhanced carcinogenic risk. An extract of Polypodium leucotomos (PL), a tropical fern plant, has been known to exhibit interesting antioxidant and photoprotective properties against acute exposure to ultraviolet radiation. The objective of this preliminary (or pilot) study was to determine the photoprotective role of topically applied Polypodium leucotomos extract in the prevention or amelioration of cutaneous changes of photoaging in hairless mice. PL‐treated mice showed significant reduction of skinfold thickness than those observed in PL‐untreated controls. Additionally, PL‐treated mice showed a significantly lower degree of histologic parameters of photoaging damage, including dermal elastosis, compared with positive control mice. Interestingly, PL treatment also showed reduction in the number of mice showing skin tumors at 8 weeks after the cessation of the UVB exposure protocol. The results of this preliminary study illustrate that PL treatment helped to ameliorate and to partially inhibit some of the histologic damage associated with photoaging of skin and appeared to contribute to a decrease in the prevalence of UVB‐induced skin tumors in mice.
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Polypodium leucotomos protects against photocarcinogenesis.
“| | leucotomos | Photocarcinogenesis | | + | (101) |”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [101]
Cites
Dermatology in General Medicine
Anderson, P. C. (1994) · JAMA · doi:10.1001/jama.1994.03510370097045 · Cited by 1,213 · see citing works
A review of skin ageing and its medical therapy
GILCHREST, B. A. (1996) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1996.d01-1088.x · Cited by 444 · see citing works
Bissett, D., Hannonand, D., & Orr, T. (1987) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1987.tb04783.x · Cited by 314 · see citing works
Prevention of Ultraviolet Damage to the Dermis of Hairless Mice by Sunscreens
Kligman, L. H., Akin, F. J., & Kligman, A. M. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12506359 · Cited by 236 · see citing works
(1997) · PubMed · Cited by 177 · see citing works
González, S., Pathak, M. A., Cuevas, J., Villarrubia, V. G., & Fitzpatrick, T. B. (1997) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1997.tb00108.x · Cited by 131 · see citing works
Self-citationGonzález, S., & Pathak, M. A. (1996) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1996.tb00175.x · Cited by 127 · see citing works
Self-citationRole of Oxygen Intermediates in UV-Induced Epidermal Cell Injury
Danno, K., Horio, T., Takigawa, M., & Imamura, S. (1984) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12263506 · Cited by 126 · see citing works
The ultraviolet-irradiated hairless mouse: A model for photoaging
Kligman, L. H. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70229-2 · Cited by 124 · see citing works
Sunscreens Promote Repair of Ultraviolet Radiation-Induced Dermal Damage
Kligman, L. H., Akin, F. J., & Kligman, A. M. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12542169 · Cited by 115 · see citing works
Elastic fibres in normal and sun-damaged skin: an immunohistochemical study
Mera, S. L., Lovell, C. R., Jones, R. R., & Davies, J. D. (1987) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1987.tb04086.x · Cited by 99 · see citing works
Snyder, D. S., & May, M. (1975) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12610349 · Cited by 81 · see citing works
Differential Protection by Two Sunscreens from UV Radiation–Induced Immunosuppression
Reeve, V. E., Bosnic, M., Boehm‐Wilcox, C., & Ley, R. D. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12483006 · Cited by 71 · see citing works
FISHER, M. S., Menter, J. M., & Willis, I. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12277156 · Cited by 70 · see citing works
CHRONIC ULTRAVIOLET B RADIATION‐INDUCED BIOCHEMICAL CHANGES IN THE SKIN OF HAIRLESS MICE*
Chatterjee, R., Benzinger, M. J., Ritter, J. L., & Bissett, D. L. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb01688.x · Cited by 66 · see citing works
Photoaging therapy with topical tretinoin: an evidence-based analysis
Kang, S., & Voorhees, J. J. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70446-3 · Cited by 64 · see citing works
Kligman, L. H., & Gebre, M. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02011.x · Cited by 59 · see citing works
Ho, K. K.-L., Halliday, G. M., & Barnetson, R. S. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12499926 · Cited by 58 · see citing works
Metabolic Effects of Calagualine, an Antitumoral Saponine of Polypodium leucotomos
Horvath, A., ALVARADO, F., de Szöcs, J., ALVARADO, Z. N. D., & Padilla, G. (1967) · Nature · doi:10.1038/2141256a0 · Cited by 51 · see citing works
Role of UVB-Induced Serum Factor(s) in Suppression of Contact Hypersensitivity in Mice
Swartz, R. P. (1984) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12340434 · Cited by 50 · see citing works
Experimental elastosis induced by chronic ultraviolet exposure
Berger, H., Tsambaos, D., & Mahrle, G. (1980) · Archives of Dermatological Research · doi:10.1007/bf00404456 · Cited by 44 · see citing works
Narrow-band UV radiation and induction of dermal elastosis and skin cancer.
Hc, W., Poulsen, T., Re, D., & Urbach, F. (1989) · PubMed · Cited by 44 · see citing works
Photochemistry and photobiology of actinic erythema: defensive and reparative cutaneous mechanisms
Tedesco, A. C., Martínez, L., & González, S. (1997) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1997000500002 · Cited by 39 · see citing works
Self-citationKochevar, I. E., Moran, M. N., Lyon, N., Flotte, T. J., Siebert, E. P., & Gange, R. W. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12462804 · Cited by 32 · see citing works
POULSEN, J. T., STABERG, B., Wulf, H. C., & Brodthagen, H. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1984.tb04675.x · Cited by 28 · see citing works
Bissett, D. L., McBride, J. F., Hannon, D. P., & Patrick, L. F. (1991) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(91)80169-i · Cited by 21 · see citing works
Kligman, L. H., Agin, P. P., & Sayre, R. M. (1996) · Journal of the Society of Cosmetic Chemists · Cited by 15 · see citing works
Mast cells and elastosis in ultraviolet‐irradiated hairless mice
Kaarsen, L. L., Poulsen, T. D., Olivarius, F. D. F., & Wulf, H. C. (1995) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1995.tb00128.x · Cited by 12 · see citing works
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Cited by
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The role of antioxidants in photoprotection: A critical review
Chen, L., Hu, J. Y., & Wang, S. Q. (2012) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.02.009 · Cited by 402 · see citing works
The latest on skin photoprotection
González, S., Fernández-Lorente, M., & Gilaberte, Y. (2008) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2007.09.010 · Cited by 307 · see citing works
Self-citationPhotoprotection: a Review of the Current and Future Technologies
Wang, S. Q., Balagula, Y., & Osterwalder, U. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2009.01289.x · Cited by 294 · see citing works
Phytochemicals from fern species: potential for medicine applications
Cao, H., Chai, T., Wang, X., Morais‐Braga, M. F. B., Yang, J., Wong, F., Wang, R., Yao, H., Cao, J., Cornara, L., et al. (2017) · Phytochemistry Reviews · doi:10.1007/s11101-016-9488-7 · Cited by 181 · see citing works
Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin
Middelkamp-Hup, M. A., Pathak, M. A., Parrado, C., Goukassian, D. A., Ríus, F., Mihm, M. C., Fitzpatrick, T. B., & González, S. (2004) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.06.027 · Cited by 171 · see citing works
Self-citationMiddelkamp-Hup, M. A., Pathak, M. A., Parrado, C., García‐Caballero, T., Ríus, F., Fitzpatrick, T. B., & González, S. (2003) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(03)02732-4 · Cited by 137 · see citing works
Self-citationLess-known botanical cosmeceuticals
Baumann, L. (2007) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2007.00147.x · Cited by 114 · see citing works
Philips, N. E., Smith, J. C., Keller, T., & González, S. (2003) · Journal of Dermatological Science · doi:10.1016/s0923-1811(03)00042-2 · Cited by 99 · see citing works
Self-citationParrado, C., Mascaraque, M., Gilaberte, Y., Juarranz, Á., & González, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071026 · Cited by 97 · see citing works
Self-citationPhilips, N. E., Conte, J., Chen, Y., Natrajan, P., Taw, M. N., Keller, T., Givant, J., Tuason, M., Dulaj, L., Leonardi, D., et al. (2009) · Archives of Dermatological Research · doi:10.1007/s00403-009-0950-x · Cited by 91 · see citing works
Self-citationPolypodium leucotomos extract: Antioxidant activity and disposition
Gombau, L., Garcı́a, F., Lahoz, A., Fabre, M., Roda‐Navarro, P., Majano, P. L., Alonso-Lebrero, J. L., Pivel, J. P., Castell, J. V., Gómez‐Lechón, M. J., et al. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.09.008 · Cited by 83 · see citing works
Self-citationda Silva, A. C. P., Paiva, J. P., Diniz, R. R., dos Anjos, V. M., Silva, A. B. S. M., Pinto, A. V., dos Santos, E. P., Leitão, A. C., Cabral, L. M., Rodrigues, C. R., et al. (2019) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2019.03.003 · Cited by 74 · see citing works
Papular scars: an addition to the acne scar classification scheme.
Nestor, M. S., Berman, B., & Swenson, N. (2015) · Europe PMC (PubMed Central) · Cited by 72 · see citing works
Reyes, E., Jaén, P., Heras, E. D. L., de Eusebio, E., Carrión, F., Cuevas, J., González, S., Villarrubia, V. G., & Álvarez‐Mon, M. (2006) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.12.006 · Cited by 67 · see citing works
Self-citationPolypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition
Capote, R., Alonso-Lebrero, J. L., Garcı́a, F., Brieva, A., Pivel, J. P., & González, S. (2006) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2005.11.005 · Cited by 67 · see citing works
Self-citationGilaberte, Y., & González, S. (2010) · Actas Dermo-Sifiliográficas · doi:10.1016/s1578-2190(10)70696-x · Cited by 64 · see citing works
Self-citationJańczyk, A., Garcia‐Lopez, M. A., Fernandez‐Peñas, P., Alonso‐Lebrero, J. L., Benedicto, I., López‐Cabrera, M., & Gonzalez, S. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00603.x · Cited by 60 · see citing works
Self-citationGonzález, S., Gilaberte, Y., Philips, N. E., & Juarranz, Á. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12128466 · Cited by 59 · see citing works
Self-citationAlonso-Lebrero, J. L., Domı&#x;nguez-Jiménez, C., Tejedor, R., Brieva, A., & Pivel, J. P. (2003) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(03)00051-4 · Cited by 58 · see citing works
Practical and experimental consideration of sun protection in dermatology
Ting, W. W., Vest, C. D., & Sontheimer, R. D. (2003) · International Journal of Dermatology · doi:10.1046/j.1365-4362.2003.01867.x · Cited by 58 · see citing works
Goh, C., Chuah, S. Y., Tien, S., Thng, G., Vitale, M. A., & Delgado-Rubin, A. (2018) · Europe PMC (PubMed Central) · Cited by 53 · see citing works
Gilaberte, Y., & González, S. (2010) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2010.04.003 · Cited by 48 · see citing works
Self-citationGonzález, S., Gilaberte, Y., & Philips, N. E. (2010) · Photochemical & Photobiological Sciences · doi:10.1039/b9pp00156e · Cited by 46 · see citing works
Self-citationMulero, M., Rodríguez‐Yanes, E., Nogués, M. R., Giralt, M., Romeu, M., González, S., & Mallol, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00684.x · Cited by 46 · see citing works
Self-citationEffect of pre-treatment of almond oil on ultraviolet B-induced cutaneous photoaging in mice
Sultana, Y., Kohli, K., Athar, M., Khar, R. K., & Aqil, M. (2007) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2007.00293.x · Cited by 45 · see citing works
Benefits of oral Polypodium Leucotomos extract in MM high‐risk patients
Aguilera, P., Carrera, C., Puig‐Butillé, J. A., Bádenas, C., Lecha, M., González, S., Malvehy, J., & Puig, S. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2012.04659.x · Cited by 43 · see citing works
Self-citationPolypodium Leucotomos--An Overview of Basic Investigative Findings.
Berman, B., Ellis, C. N., & Elmets, C. A. (2016) · PubMed · Cited by 36 · see citing works
Oral and Systemic Photoprotection
González, S., Gilaberte, Y., & Juarranz, Á. (2016) · Springer eBooks · doi:10.1007/978-3-319-29382-0_22 · Cited by 34 · see citing works
Self-citationPolypodium leucotomos inhibits ultraviolet B radiation‐induced immunosuppression
Siscovick, J. R., Zapolanski, T., MAGRO, C. M. J., Carrington, K., Prograis, S., Nussbaum, M., González, S., Ding, W., & Granstein, R. D. (2008) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2008.00352.x · Cited by 33 · see citing works
Self-citationCurrent Trends in Photoprotection - A New Generation of Oral Photoprotectors
González, S., Gilaberte, Y., Philips, N., & Juarranz, Á. (2011) · The Open Dermatology Journal · doi:10.2174/1874372201105010006 · Cited by 33 · see citing works
Self-citationSun protection in a pill: the photoprotective properties of P olypodium leucotomos extract
El‐Haj, N., & Goldstein, N. P. (2014) · International Journal of Dermatology · doi:10.1111/ijd.12611 · Cited by 28 · see citing works
The role of the aqueous extract Polypodium leucotomos in photoprotection
Parrado, C., Nicolás, J., Juarranz, Á., & González, S. (2020) · Photochemical & Photobiological Sciences · doi:10.1039/d0pp00124d · Cited by 27 · see citing works
Self-citationRodríguez‐Yanes, E., Cuevas, J., González, S., & Mallol, J. (2014) · Experimental Dermatology · doi:10.1111/exd.12454 · Cited by 25 · see citing works
Self-citationPourang, A., Dourra, M., Ezekwe, N., Kohli, I., Hamzavi, I. H., & Lim, H. W. (2021) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-021-00087-x · Cited by 24 · see citing works
Polypodium leucotomos extract: A nutriceutical with photoprotective properties
González, S., Alonso-Lebrero, J. L., Rio, R. D., & Jaén, P. (2007) · Drugs of today · doi:10.1358/dot.2007.43.7.1062667 · Cited by 20 · see citing works
Self-citationSunscreens and Antioxidants as Photo-protective Measures: An update
Hassan, I., Dorjay, K., Sami, A., & Anwar, P. (2013) · Our Dermatology Online · doi:10.7241/ourd.20133.92 · Cited by 19 · see citing works
Pihl, C., Togsverd‐Bo, K., Andersen, F., Hædersdal, M., Bjerring, P., & Lerche, C. M. (2021) · Cancers · doi:10.3390/cancers13153684 · Cited by 19 · see citing works
Villarrubia, V. G., Costa, L. A. M. D., & Diez, R. A. (2004) · Medicina Clínica · doi:10.1016/s0025-7753(04)74656-4 · Cited by 19 · see citing works
Immunomodulatory properties of a hydrophilic extract of Polypodium leucotomos
Brieva, A., Guerrero, A. F., & Pivel, J. P. (2001) · Inflammopharmacology · doi:10.1163/156856001320290624 · Cited by 19 · see citing works
Lee, S. J., Kim, J. E., Choi, Y. J., Gong, J. E., Park, S. H., Douangdeuane, B., Souliya, O., Park, J. M., Lee, H. S., Kim, B.-H., et al. (2021) · Antioxidants · doi:10.3390/antiox10050791 · Cited by 16 · see citing works
Manna, S. K., Bueso-Ramos, C., Alvarado, F., & Aggarwal, B. B. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00618-3 · Cited by 15 · see citing works
Primary and Secondary Chemoprevention of Malignant Melanoma
Mounessa, J. S., Buntinx-Krieg, T., Qin, R., Dunnick, C. A., & Dellavalle, R. P. (2016) · American Journal of Clinical Dermatology · doi:10.1007/s40257-016-0221-5 · Cited by 13 · see citing works
Nutraceutical strategies for alleviation of UVB phototoxicity
McCarty, M. F., Benzvi, C., Vojdani, A., & Lerner, A. (2023) · Experimental Dermatology · doi:10.1111/exd.14777 · Cited by 12 · see citing works
Gilaberte, Y., Coscojuela, C., Esguevillas, M. A. C. S. D. S., & González, S. (2003) · Actas Dermo-Sifiliográficas · doi:10.1016/s0001-7310(03)76688-5 · Cited by 11 · see citing works
Self-citationA 28-day oral toxicology study of an aqueous extract of Polypodium leucotomos (Fernblock ® )
Murbach, T. S., Glávits, R., Hirka, G., Endres, J. R., Clewell, A. E., & Szakonyiné, I. P. (2017) · Toxicology Reports · doi:10.1016/j.toxrep.2017.09.002 · Cited by 10 · see citing works
de Carvalho, V. M. S., Covre, J. L., Correia-Silva, R. D., Lice, I., Corrêa, M. P., Leopoldino, A. M., & Gil, C. D. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112247 · Cited by 9 · see citing works
Fern extract, oxidative stress, and skin cancer
Parrado, C., Gilaberte, Y., Philips, N. E., Juarranz, Á., & González, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819547-5.00034-1 · Cited by 6 · see citing works
Self-citationChapter 21 Cutaneous photosensitivity and photoprotection for photodynamic therapy patients
Trehan, M., & Taylor, C. R. (2001) · Comprehensive series in photosciences · doi:10.1016/s1568-461x(01)80125-3 · Cited by 5 · see citing works
İli, P., & Keskin, N. (2013) · Biotechnic & Histochemistry · doi:10.3109/10520295.2013.773077 · Cited by 5 · see citing works
Fern Extract, Oxidative Stress, and Skin Cancer
Parrado, C., Juarranz, Á., Gilaberte, Y., Philips, N. E., & González, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405205-5.00025-8 · Cited by 5 · see citing works
Self-citationMohamad, A. F., Philipsen, P. A., Lerche, C. M., Douki, T., Laursen, F. S. W., Granborg, J. R., Bjerring, P., Hædersdal, M., & Wiegell, S. R. (2025) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-025-00807-7 · Cited by 4 · see citing works
Villarrubia, V. G., Tarazona, R., Solana, R., & González, S. (2001) · Piel · doi:10.1016/s0213-9251(01)72511-7 · Cited by 4 · see citing works
Self-citationİli, P. (2016) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2016.04.025 · Cited by 2 · see citing works
Selbstbräuner und Lichtschutzmittel: Möglichkeiten und Gefahren
Hölzle, E. (2003) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-55661-6_67 · Cited by 2 · see citing works
Proteins and Cytokines Used for Rejuvenation
Beer, K. R. (2010) · CRC Press eBooks · doi:10.3109/9781841847450-3 · Cited by 1 · see citing works
Estrategias farmacológicas y no farmacológicas para la prevención del cáncer cutáneo no melanoma
Morgado‐Carrasco, D., Piquero‐Casals, J., & Bosch‐Amate, X. (2021) · Piel · doi:10.1016/j.piel.2020.10.016 · Cited by 1 · see citing works
Ultrapotent Antioxidants and Anti-inflammatories
Geraghty, L. N., Berson, D. S., & HIRSCH, R. J. (2010) · CRC Press eBooks · doi:10.3109/9781841847450.001 · Cited by 1 · see citing works
Sunscreens, Photoimmunosuppression, and Photoaging
Halliday, G. M., & Hönigsmann, H. (2008) · Basic and clinical dermatology · doi:10.3109/9781420080858.008 · Cited by 1 · see citing works
Modelo biológico para evaluar la acción fotoprotectora de un extracto de cordón umbilical humano
Barca, I. H., Gómez-Barry, H., & Cao, C. M. M. (2003) · Revista cubana de farmacia
Cruz, S. M., Solis, N. D., Solís, P. N., Gupta, M. P., & Cáceres, A. (2005) · Revista Científica · doi:10.54495/rev.cientifica.edicionespecial2005.201
Oral and Other Non-sunscreen Photoprotective Agents
González, S., & Gilaberte, Y. (2008) · Basic and clinical dermatology · doi:10.3109/9781420080858.016
Self-citationBoostani, M., Kuraitis, D., Herbold, E. D., Tracy, E., Purizhansky, B., Murphy, S. C., Bozsányi, S., Rodrigues, R. C. G., Vien, M., Carman, A. F., et al. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2026.08.020
- Authors
- Alcaraz, M. V., Pathak, M. A., Rius, F., Kollias, N., & González, S.
- Affiliations
- Harvard University (US)
- Universidad de Málaga (ES)
- Corresponding author
- González, S.
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 1999-06-08
- Volume
- 15
- Issue
- 3-4
- Pages
- 120-126
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W2051658147
- Cited by
- 63
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2021: 6 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- Polypodium leucotomos, UV-B radiation, photoprotection, topical herbal extract, skinfold thickness, skin carcinogenesis, antioxidant activity
- MeSH terms
- Animals, Mice, Hairless, Pilot Projects, Plant Extracts, Skin, Ultraviolet Rays, Skin Aging, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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