Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens
Abstract
Olive leaves contain higher amount of polyphenols than olive oil and represent a waste product from olive harvest and pruning of olive trees. The most abundant compound in olive leaves is oleuropein. Benefits of the topical application of olive leaves extract were previously reported, but little information is available on its photoprotective potential and the result of the association of this extract with organic UV filters in topical sunscreen formulations. The olive leaves extract photoprotective potential is less explored for both oral and topical photoprotection in comparison with other plants extracts and polyphenols, such as Polypodium leucotomos extract and resveratrol. There are increasing efforts towards developing more efficient sunscreens and a photoprotection assessement along with a better understanding of the photochemistry of naturally occurring sunscreens could aid the design of new and improved commercial sunscreen formulations. This study was designed to investigate the photoprotective potential of olive leaves extract standardized for oleuropein performing a set of in vitro and in silico tools as an innovative approach, highlighting yeast assays, in vitro Sun Protection Factor (SPF) and molecular modelling studies of UV absorption. This study supports the use of olive leaves extract for photoprotection, as an effective photoprotective, anti-mutagenic and antioxidant active, also showing a synergistic effect in association with UV filters with an improvemen…
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A commercial Olea europaea extract with 20% oleuropein displays DPPH radical scavenging (IC50 = 11.75 μg/mL) and photoprotective activity with SPF 22 and λmax 376 nm.
“This extract displayed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (IC50 = 11.75 μg/mL) and photoprotective activity exhibiting a SPF value of 22 and a maximum wavelength (λmax) of 376 nm [101].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [101]
V. vinifera grape extracts have higher radical scavenging capacity than commercial olive leaf extract, probably due to higher phenolic content.
“It is noteworthy to mention that V. vinifera grape extracts [100] revealed a higher radical scavenging capacity than the commercial extract of olive leaves [101], probably due to the highest content in phenolic compounds.”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [101]
Cites
Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves
Pereira, A. P., Ferreira, I. C., Marcelino, F., Valentão, P., Andrade, P. B., Seabra, R., Estevinho, L., Bento, A., & Pereira, J. A. (2007) · Molecules · doi:10.3390/12051153 · Cited by 519 · see citing works
Sunlight damage to cellular DNA: focus on oxidatively generated lesions
Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works
Afaq, F., Adhami, V. M., & Ahmad, N. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(02)00014-5 · Cited by 262 · see citing works
Kostyuk, V., Potapovich, A., Albuhaydar, A. R., Mayer, W., De Luca, C., & Korkina, L. (2018) · Rejuvenation Research · doi:10.1089/rej.2017.1931 · Cited by 85 · see citing works
Photostability evaluation of five UV-filters, trans-resveratrol and beta-carotene in sunscreens
Freitas, J. V., Lopes, N. P., & Gaspar, L. R. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.07.004 · Cited by 66 · see citing works
Alcaraz, M. V., Pathak, M. A., Rius, F., Kollias, N., & González, S. (1999) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.1999.tb00071.x · Cited by 63 · see citing works
Buonocore, D., Nobile, Cestone, Santin, Bottone, Marzatico, Lazzeretti, & Tocabens (2012) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s36102 · Cited by 57 · see citing works
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UV Filters: Challenges and Prospects
Jesus, A., Sousa, E., Cruz, M., Cidade, H., Lobo, J., & Almeida, I. (2022) · Pharmaceuticals · doi:10.3390/ph15030263 · Cited by 132 · see citing works
Hübner, A. A., Sarruf, F. D., Oliveira, C. A., Neto, A. V., Fischer, D. C. H., Kato, E. T. M., Lourenço, F. R., Baby, A. R., & Bacchi, E. M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121148 · Cited by 46 · see citing works
Potential therapeutic of olive oil industry by-products in skin health: A review
Nunes, A., Marto, J., Gonçalves, L., Martins, A. M., Fraga, C., & Ribeiro, H. M. (2022) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15384 · Cited by 24 · see citing works
- Authors
- da Silva, A. C. P., Paiva, J. P., Diniz, R. R., dos Anjos, V. M., Silva, A. B. S. M., Pinto, A. V., dos Santos, E. P., Leitão, A. C., Cabral, L. M., Rodrigues, C. R., de Pádula, M., & Santos, B. A. M. C.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Instituto Nacional de Controle de Qualidade em Saúde (BR)
- Corresponding author
- Santos, Bianca Aloise M.C.
- ORCID
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 193
- Pages
- 162-171
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W2921265393
- Cited by
- 74
- References
- 7
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 10 · 2023: 14 · 2022: 16 · 2021: 8 · 2020: 7 · 2019: 3
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro
- Universidade Federal do Rio de Janeiro
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- oleuropein, photoprotection, sunscreen formulation, organic UV filters, sun protection factor, antioxidant activity, polyphenols, synergistic effect, olive by-products
- MeSH terms
- Antioxidants, Models, Molecular, Plant Extracts, Quantum Theory, Sunscreening Agents, Ultraviolet Rays, Plant Leaves, Olea, Iridoids, Iridoid Glucosides, Sun Protection Factor
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