The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Overnight human plasma melatonin, Cortisol, prolactin, TSH, under conditions of normal sleep, sleep deprivation, and sleep recovery
Abstract
Abstract: Early investigations of the effect of sleep deprivation on plasma melatonin reported no major changes. Recently, 36 hrs of sleep deprivation was reported to elevate melatonin levels on the post‐sleep deprivation night. Given these contradictions melatonin, Cortisol, prolactin, and thyroid stimulating hormone before, during, and, after sleep deprivation were examined in nine healthy young males following one night of sleep deprivation. Hormone levels at hourly intervals, for each night, were statistically analyzed by a repeated measures, two‐way factorial ANOVA. ANOVA was also performed for measures of area under the curve (AUC). No significant differences were observed for melatonin levels. Cortisol was significantly higher on the sleep deprivation night presumably reflecting the aroused state accompanying being awake; however, there were several time points on the control night when it was elevated also. Prolactin was higher on the post‐sleep deprivation and control nights but did not rise on the deprivation night, indicating a useful nonpolysomnographic index for discriminating overnight sleep and awake states. TSH levels showed a similar rise during the control and sleep deprivation nights, but remained flat on the post‐sleep deprivation night. It appears that the pineal is insulated against feedback from changes to the level of arousal accompanying sleep and wakefulness. In comparison, Cortisol, prolactin, and TSH levels vary with these states and are, therefore, useful indices of arousal and sleep‐wake.
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“Several studies have reported an elevation of cortisol levels both during the night of total sleep deprivation [13, 35, 72] and, if wakefulness was further prolonged, during the following day, particularly in the afternoon and evening [63, 73].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [72]
Citations
Cites
Light Suppresses Melatonin Secretion in Humans
Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Markey, S. P. (1980) · Science · doi:10.1126/science.7434030 · Cited by 1,913
Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects
WEITZMAN, E. D., FUKUSHIMA, D., NOGEIRE, C., ROFFWARG, H., GALLAGHER, T. F., & HELLMAN, L. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-1-14 · Cited by 1,258
Direct radioimmunoassay for melatonin in plasma.
Fraser, S., Cowen, P. J., Franklin, M., Franey, C. S., & Arendt, J. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.2.396 · Cited by 578
Cortisol Is Secreted Episodically by Normal Man
HELLMAN, L., Nakada, F., Curti, J. T., Weitzman, E. D., Kream, J., Roffwarg, H. P., Ellman, S. J., Fukushima, D. K., & Gallagher, T. F. (1970) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-30-4-411 · Cited by 394
A behavioural method for accelerating re-entrainment of rhythms to new light—dark cycles
Mrosovsky, N., & Salmon, P. A. (1987) · Nature · doi:10.1038/330372a0 · Cited by 241
WEITZMAN, E. D., NOGEIRE, C., PERLOW, M., FUKUSHIMA, D., SASSIN, J., MCGREGOR, P., GALLAGHER, T. F., & HELLMAN, L. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-6-1018 · Cited by 235
Vaughan, G. M., Pelham, R. W., Pang, S. F., LOUGHLIN, L. L., WILSON, K. M., Sandock, K. L., Vaughan, M. K., Koslow, S. H., & Reiter, R. J. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-4-752 · Cited by 199
Melatonin excretion, body temperature and subjective arousal during 64 hours of sleep deprivation
Åkerstedt, T., Fröberg, J. E., Friberg, Y., & Wetterberg, L. (1979) · Psychoneuroendocrinology · doi:10.1016/0306-4530(79)90005-2 · Cited by 178
Sleep and activity: their relation to the 24-hour clock.
Cp, R. (1967) · PubMed · Cited by 167
Effects of Stimulated Physical Activity on the Circadian Pacemaker of Vertebrates 1
Turek, F. W. (1989) · Journal of Biological Rhythms · doi:10.1177/074873048900400204 · Cited by 163
Research works printed but not linked: 5
- Armstrong S. M., 1989, Melatonin: The internal Zeitgeber in mammals, Pineal Res. Rev., 7, 157
- Dunn J. D., 1974, Biological Rhythms in Neurendocrine Activity, 119
- Klein D. C., 1985, Ciba Function Symposium 117. Photperiodism, Melatonin and the Pineal, 51
- Moore R. Y., 1978, Biological Rhythms and Their Central Mechanism. A Naito Foundation Symposium, 343
- Weitzman E. D., 1968, Trans. Amer. Neurol. Assoc., 93, 153
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Sorted by citations
Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948
Wright, K. P., Drake, A. L., Frey, D. J., Fleshner, M., Desouza, C. A., Gronfier, C., & Czeisler, C. A. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.01.004 · Cited by 567
Human pineal physiology and functional significance of melatonin
Macchi, M. M., & Bruce, J. N. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.08.001 · Cited by 545
Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity
Balbo, M., Leproult, R., & Van Cauter, E. (2010) · International Journal of Endocrinology · doi:10.1155/2010/759234 · Cited by 408
“Several studies have reported an elevation of cortisol levels both during the night of total sleep deprivation [13, 35, 72] and, if wakefulness was further prolonged, during the following day, particularly in the afternoon and evening [63, 73].”
BackgroundMelatonin and sleep in aging population
Pandi-Perumal, S. R., Zisapel, N., Srinivasan, V. J., & Cardinali, D. P. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.08.009 · Cited by 367
Metadata
- Authors
- von Treuer, K., Norman, T. R., & Armstrong, S. M.
- Affiliations
- The University of Melbourne (AU)
- La Trobe University (AU)
- Corresponding author
- Armstrong, Stuart Maxwell
- ORCID
- Norman, Trevor R.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 1996-01
- Volume
- 20
- Issue
- 1
- Pages
- 7-14
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W1989059017
- Cited by
- 116
- References
- 31
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 4
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, melatonin, cortisol, prolactin, thyroid-stimulating hormone, pineal gland, arousal, sleep-wake states, sleep recovery
- MeSH terms
- Adult, Analysis of Variance, Humans, Hydrocortisone, Male, Melatonin, Pineal Gland, Prolactin, Radioimmunoassay, Sleep, Sleep Deprivation, Thyrotropin, Wakefulness
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