The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Melatonin and its precursors scavenge nitric oxide
Abstract
Abstract:Nitric oxide (NO) scavenging activity of melatonin, N‐acetyl‐5‐hydroxytryptamine, serotonin, 5‐hydroxytryptophan and L‐tryptophan was examined by the Griess reaction using flow injection analysis. l‐Hydroxy‐2‐oxo‐3‐(N‐methyl‐3‐aminopropyl)‐3‐methyl‐1 ‐ triazene (NOC‐7) was used as NO generator. The Griess reagent stoichiometrically reacts with NO 2, which was converted by a cadmium‐copper reduction column from the stable end products of NO oxidation. Except for tryptophan, all the compounds examined scavenged NO in a dose‐dependent manner. Melatonin, which has a methoxy group in the 5‐position and an acetyl side chain, exhibited the most potent scavenging activity among the compounds tested. Serotonin. N‐acetyl‐5 hydroxytryptamine, and 5‐hydroxytryptophan, respectively, showed moderate scavenging activity compared to melatonin. Tryptophan, which has neither a methoxy nor a hydroxyl group in the 5‐position, exhibited the least NO scavenging activity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Cited by
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875
Reiter, R. J., Tan, D.-X., Manchester, L. C., & Qi, W. (2001) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:34:2:237 · Cited by 696
Melatonin: reducing the toxicity and increasing the efficacy of drugs
Reiter, R. J., Tan, D.-X., Sainz, R. M., Mayo, J. C., & Lopez-Burillo, S. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235702760345374 · Cited by 417
Cardiovascular diseases: protective effects of melatonin
Tengattini, S., Reiter, R. J., Tan, D., Terron, M. P., Rodella, L. F., & Rezzani, R. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00518.x · Cited by 337
Neurotoxins: Free radical mechanisms and melatonin protection
J. Reiter, R., C. Manchester, L., & Tan, D.-X. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246236 · Cited by 179
Metadata
- Authors
- Noda, Y., Mori, A., Liburdy, R., & Packer, L.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 1999-10
- Volume
- 27
- Issue
- 3
- Pages
- 159-163
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W1995600680
- Cited by
- 185
- References
- 1
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Melatonin and its precursors scavenge nitric oxide. https://app.cochat.ai/papers/10.1111/j.1600-079x.1999.tb00611.x
- The paper
- Noda, Y., Mori, A., Liburdy, R., & Packer, L. (1999). Melatonin and its precursors scavenge nitric oxide. Journal of Pineal Research. https://doi.org/10.1111/j.1600-079x.1999.tb00611.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
