The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Cardiovascular diseases: protective effects of melatonin
Open accessAbstract
Abstract: This brief review considers some of the cardiac diseases and conditions where free radicals and related reactants are believed to be causative. The report also describes the beneficial actions of melatonin against oxidative cardiovascular disorders. Based on the data available, melatonin seems to have cardioprotective properties via its direct free radical scavenger and its indirect antioxidant activity. Melatonin efficiently interacts with various reactive oxygen and reactive nitrogen species (receptor independent actions) and it also upregulates antioxidant enzymes and downregulates pro‐oxidant enzymes (receptor‐dependent actions). Moreover, melatonin enters all cells and subcellular compartments and crosses morphophysiologic barriers. These findings have implications for the protective effects of melatonin against cardiac diseases induced by oxidative stress. Melatonin attenuates molecular and cellular damages resulting from cardiac ischemia/reperfusion in which destructive free radicals are involved. Anti‐inflammatory and antioxidative properties of melatonin are also involved in the protection against a chronic vascular disease, atherosclerosis. The administration of melatonin, as a result of its antioxidant features, has been reported to reduce hypertension and cardiotoxicity induced by clinically used drugs. The results described herein help to clarify the beneficial effects of melatonin against these conditions and define the potential clinical applicability of melatonin in cardiovascular diseases.
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Cites
Free radicals, metals and antioxidants in oxidative stress-induced cancer
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Regulation of antioxidant enzymes: a significant role for melatonin
Rodriguez, C., Mayo, J. C., Sainz, R. M., Antolín, I., Herrera, F., Martín, V., & Reiter, R. J. (2004) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,987
Self-citationTan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601
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Self-citationRole of Oxidative Stress in Cardiac Hypertrophy and Remodeling
Takimoto, E., & Kass, D. A. (2007) · Hypertension · doi:10.1161/01.hyp.0000254415.31362.a7 · Cited by 770
Oxidant and antioxidant balance in the airways and airway diseases
Rahman, I., Biswas, S. K., & Kode, A. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.12.087 · Cited by 727
The chemistry of melatonin's interaction with reactive species
Allegra, M., Reiter, R. J., Tan, D. ‐., Gentile, C., Tesoriere, L., & Livrea, M. A. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02112.x · Cited by 718
Self-citationHardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 671
A Review of the Multiple Actions of Melatonin on the Immune System
Carrillo-Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 666
Self-citationMelatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
Reiter, R. J., Tan, D.-X., Mayo, J. C., Sainz, R. M., Leon, J., & Czarnocki, Z. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3637 · Cited by 621
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Cited by
Melatonin—A pleiotropic, orchestrating regulator molecule
Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843
Koziróg, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., & Broncel, M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00835.x · Cited by 299
Rotating Night Shift Work and the Risk of Ischemic Stroke
Brown, D. L., Feskanich, D., Sanchez, B. N., Rexrode, K. M., Schernhammer, E. S., & Lisabeth, L. D. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp056 · Cited by 297
Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00649.x · Cited by 291
Self-citationEffects of circadian disruption on the cardiometabolic system
Rüger, M., & Scheer, F. A. J. L. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9122-8 · Cited by 232
Metadata
- Authors
- Tengattini, S., Reiter, R. J., Tan, D., Terron, M. P., Rodella, L. F., & Rezzani, R.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2007-10-31
- Volume
- 44
- Issue
- 1
- Pages
- 16-25
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2019384027
- Cited by
- 337
- References
- 87
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tengattini, S., Reiter, R. J., Tan, D., Terron, M. P., Rodella, L. F., & Rezzani, R. (2008). Cardiovascular diseases: protective effects of melatonin. Journal of Pineal Research. https://doi.org/10.1111/j.1600-079x.2007.00518.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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