Neurotoxins: Free radical mechanisms and melatonin protection

Metals, Toxicity and Oxidative Stress

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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Oxidative Stress, Glutamate, and Neurodegenerative Disorders

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Regulation of antioxidant enzymes: a significant role for melatonin

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Melatonin : a potent, endogenous hydroxyl radical scavenger

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One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?

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Biochemistry of oxidative stress

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Actions of Melatonin in the Reduction of Oxidative Stress

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Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography‐mass spectrometry

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Chemical and Physical Properties and Potential Mechanisms: Melatonin as a Broad Spectrum Antioxidant and Free Radical Scavenger

Tan, D., Reiter, R. J., Manchester, L. C., Yan, M.-T., El-Sawi, M. R., Sainz, R. M., Mayo, J. C., Kohen, R., Allegra, M., & Hardelan, R. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394443 · Cited by 1,065 · see citing works

Reactions of oxyl radicals with DNA

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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide

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Oxidative damage in the central nervous system: protection by melatonin

Reiter, R. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00052-5 · Cited by 836 · see citing works

Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates.

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Functional MT1 and MT2 Melatonin Receptors in Mammals

Dubocovich, M. L., & Markowska, M. (2005) · Endocrine · doi:10.1385/endo:27:2:101 · Cited by 816 · see citing works

A highly reproducible rotenone model of Parkinson's disease

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Oxidative processes and antioxidative defense mechanisms in the aging brain 1

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Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation

Sherer, T., Kim, J.-H., Betarbet, R. S., & Greenamyre, J. T. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.8072 · Cited by 707 · see citing works

Kainic acid: a powerful neurotoxic analogue of glutamate

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Kainic acid seizures in the rat

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Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

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A Review of the Multiple Actions of Melatonin on the Immune System

Carrillo‐Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 664 · see citing works

Melatonin: A Coordinating Signal for Mammalian Reproduction?

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Aluminium and lead: molecular mechanisms of brain toxicity

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Melatonin stimulates brain glutathione peroxidase activity

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Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin

Tan, D., Manchester, L. C., Hardeland, R., López‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02111.x · Cited by 541 · see citing works

Melatonin mitigates mitochondrial malfunction

León, J., Acuña-Castroviejo, D., Escames, G., Tan, D. X., & Reiter, R. J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00181.x · Cited by 515 · see citing works

A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes

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Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: A hypothesis

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Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study

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Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

Reiter, R. J., Paredes, S. D., Manchester, L. C., & Tan, D.-X. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230903044914 · Cited by 477 · see citing works

Melatonin-Immune System Relationships

Guerrero, J. M., & Reiter, R. J. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394335 · Cited by 476 · see citing works

Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation

Tan, D., Manchester, L. C., Reiter, R. J., Plummer, B. F., Limson, J. L., Weintraub, S. T., & Qi, W. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00435-4 · Cited by 474 · see citing works

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

Hardeland, R., Tan, D., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00701.x · Cited by 474 · see citing works

Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes

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Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension

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Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress

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Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain.

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Chronic Exposure to Rotenone Models Sporadic Parkinson's Disease in Drosophila melanogaster

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Melatonin and Reproduction Revisited

Reiter, R. J., Tan, D. X., Manchester, L. C., Paredes, S. D., Mayo, J. C., & Sainz, R. M. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.075655 · Cited by 422 · see citing works

Melatonin: reducing the toxicity and increasing the efficacy of drugs

Reiter, R. J., Tan, D., Sainz, R. M., Mayo, J. C., & López‐Burillo, S. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235702760345374 · Cited by 418 · see citing works

Human Melatonin Production Decreases With Age

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Protective effect of melatonin against chlorophyll degradation during the senescence of barley leaves

Arnao, M. B., & Hernández‐Ruíz, J. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00625.x · Cited by 405 · see citing works

Non‐vertebrate melatonin

Hardeland, R., & Pöeggeler, B. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00040.x · Cited by 400 · see citing works

Melatonin as a Chronobiotic / Anticancer Agent: Cellular, Biochemical, and Molecular Mechanisms of Action and their Implications for Circadian-Based Cancer Therapy

Blask, D. E., Sauer, L. A., & Dauchy, R. T. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394407 · Cited by 381 · see citing works

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

Paradies, G., Petrosillo, G., Paradies, V., Reiter, R. J., & Ruggiero, F. M. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00759.x · Cited by 378 · see citing works

Melatonin in walnuts: Influence on levels of melatonin and total antioxidant capacity of blood

Reiter, R. J., Manchester, L. C., & Tan, D. (2005) · Nutrition · doi:10.1016/j.nut.2005.02.005 · Cited by 372 · see citing works

High levels of melatonin in the seeds of edible plants

Manchester, L. C., Tan, D. X., Reiter, R. J., Park, W., Monis, K., & Qi, W. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00896-1 · Cited by 367 · see citing works

The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness

Tan, D. X., Hardeland, R., Manchester, L. C., Paredes, S. D., Korkmaz, A., Sainz, R. M., Mayo, J. C., Fuentes‐Broto, L., & Reiter, R. J. (2009) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2009.00118.x · Cited by 365 · see citing works

Oxygen free radicals and human disease

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Phytomelatonin: a review

Paredes, S. D., Korkmaz, A., Manchester, L. C., Tan, D., & Reiter, R. J. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern284 · Cited by 349 · see citing works

Melatonin but not vitamins C and E maintains glutathione homeostasis in t‐butyl hydroperoxide‐induced mitochondrial oxidative stress

Martı́n, M., Macías, M. J., Escames, G., León, J., & Acuña-Castroviejo, D. (2000) · The FASEB Journal · doi:10.1096/fj.99-0865fje · Cited by 347 · see citing works

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

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Physiology and pharmacology of melatonin in relation to biological rhythms

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Oxidative stress and antioxidant therapy in Parkinson's disease

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Melatonin induces γ-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells

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Medical implications of melatonin: receptor-mediated and receptor-independent actions.

Reiter, R. J., Tan, D. X., Manchester, L. C., Terrón, M. P., Flores, L. J., & Koppisepi, S. (2007) · PubMed · Cited by 331 · see citing works

A Novel Melatonin Metabolite, Cyclic 3-Hydroxymelatonin: A Biomarker ofin VivoHydroxyl Radical Generation

Tan, D., Manchester, L. C., Reiter, R. J., Plummer, B. F., Hardies, L. J., Weintraub, S. T., Vijayalaxmi, V., & Shepherd, A. M. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9826 · Cited by 319 · see citing works

Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials

Korkmaz, A., Reiter, R. J., Topal, T., Manchester, L. C., Öter, Ş., & Tan, D. (2009) · Molecular Medicine · doi:10.2119/molmed.2008.00117 · Cited by 319 · see citing works

Presowing seed treatment with melatonin protects red cabbage seedlings against toxic copper ion concentrations

Posmyk, M. M., Kuran, H., Marciniak, K., et al. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00552.x · Cited by 318 · see citing works

Melatonin is a scavenger of peroxynitrite

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Melatonin: Lowering the High Price of Free Radicals

Reiter, R. J. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.5.246 · Cited by 305 · see citing works

Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species

Peyrot, F., & Ducrocq, C. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00580.x · Cited by 292 · see citing works

Oxidative stress of the newborn in the pre‐ and postnatal period and the clinical utility of melatonin

Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00649.x · Cited by 291 · see citing works

Reaction of Melatonin and Related Indoles With Hydroxyl Radicals: EPR and Spin Trapping Investigations

Matuszak, Z., Reszka, K. J., & Chignell, C. F. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00614-4 · Cited by 288 · see citing works

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

López, A., García, J. A., Escames, G., Venegas, C., Ortiz, F., López, L. C., & Acuña-Castroviejo, D. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00647.x · Cited by 277 · see citing works

Melatonin applied to cucumber (Cucumis sativus L.) seeds improves germination during chilling stress

Posmyk, M. M., Bałabusta, M., Wieczorek, M., et al. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00652.x · Cited by 275 · see citing works

On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals*

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Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress‐induced apoptosis of rat brain astrocytes

Jou, M., Peng, T., Reiter, R. J., Jou, S., WU, H., & Wen, S. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00140.x · Cited by 265 · see citing works

Rapid Communication: Attenuation of Methamphetamine‐Induced Neurotoxicity in Copper/Zinc Superoxide Dismutase Transgenic Mice

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A randomized, placebo‐controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities

Wasdell, M. B., Jan, J. E., Bomben, M. M., Fréeman, R. D., Rietveld, W. J., Tai, J., Hamilton, D., & Weiss, M. D. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00528.x · Cited by 261 · see citing works

Protection against cognitive deficits and markers of neurodegeneration by long‐term oral administration of melatonin in a transgenic model of Alzheimer disease

Olcese, J., Cao, C., Mori, T., Mamcarz, M. B., Maxwell, A. K., Runfeldt, M. J., Wang, L., Zhang, C., Lin, X., Zhang, G., et al. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00692.x · Cited by 260 · see citing works

Melatonin protects against common deletion of mitochondrial DNA‐augmented mitochondrial oxidative stress and apoptosis

Jou, M., Peng, T.-I., Yu, P., Jou, S., Reiter, R. J., Chen, J., WU, H., Chen, C., & Hsu, L. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00490.x · Cited by 258 · see citing works

Pineal Melatonin Rhythm: Reduction in Aging Syrian Hamsters

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An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

Pappolla, M. A., Chyan, Y., Pöeggeler, B., Frangione, B., Wilson, G. L., Ghiso, J. A., & Reiter, R. J. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050018 · Cited by 239 · see citing works

Putting Cancer to Sleep at Night: The Neuroendocrine/Circadian Melatonin Signal

Blask, D. E., Dauchy, R. T., & Sauer, L. A. (2005) · Endocrine · doi:10.1385/endo:27:2:179 · Cited by 238 · see citing works

Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction

Ressmeyer, A., Mayo, J. C., Zelosko, V., Sainz, R. M., Tan, D., Pöeggeler, B., Antolı́n, I., Zsizsik, B. K., Reiter, R. J., & Hardeland, R. (2003) · Redox Report · doi:10.1179/135100003225002709 · Cited by 238 · see citing works

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

Jung-Hynes, B. D., Reiter, R. J., & Ahmad, N. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00729.x · Cited by 234 · see citing works

Novel rhythms of N 1 ‐acetyl‐N 2 ‐formyl‐5‐methoxykynuramine and its precursor melatonin in water hyacinth: importance for phytoremediation

Tan, D. X., Manchester, L. C., Mascio, P. D., Martinez, G. R., Prado, F. M., & Reiter, R. J. (2007) · The FASEB Journal · doi:10.1096/fj.06-7745com · Cited by 232 · see citing works

Regional brain trace-element studies in Alzheimer's disease.

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Melatonin–estrogen interactions in breast cancer

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Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice

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The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc: An adsorptive voltammetric study

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AFMK, a melatonin metabolite, attenuates X‐ray‐induced oxidative damage to DNA, proteins and lipids in mice

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A novel strategy for the treatment of cocaine addiction

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Calmodulin mediates melatonin cytoskeletal effects

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High Melatonin Concentrations in Third Ventricular Cerebrospinal Fluid Are Not due to Galen Vein Blood Recirculating through the Choroid Plexus1

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The modulatory role of melatonin on immune responsiveness.

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AGE-ASSOCIATED REDUCTION IN NOCTURNAL PINEAL MELATONIN LEVELS IN FEMALE RATS1

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Comparative Physiology: Pineal Gland

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Melatonin as a potential antihypertensive treatment

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Melatonin reduces nitric oxide synthase activity in rat hypothalamus

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Melatonin Enters the Cerebrospinal Fluid through the Pineal Recess

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Molecular Mechanisms of Melatonin Anticancer Effects

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Melatonin immunoreactivity in the photosynthetic prokaryote Rhodospirillum rubrum: implications for an ancient antioxidant system.

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Melatonin as a hydroxyl radical scavenger

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Melatonin treatment normalizes plasma pro‐inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy

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Current investigational drugs for major depression

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