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Cited by 26Muscle metabolism and nutritionMetabolism, Diabetes, and CancerCardiovascular and exercise physiology

Glycogen concentration in human skeletal muscle: effect of prolonged insulin and glucose infusion

Hansen, B. F., Asp, S., Kim, B., Richter, E. A.·1999·Scandinavian Journal of Medicine & Science in Sports
DOI 10.1111/j.1600-0838.1999.tb00235.x
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Abstract

To study the upper limit of glycogen storage in human muscle, two healthy male subjects were infused with glucose and insulin for 8 h reaching plasma concentrations of about 21 mM glucose and approximately 2000 μU/ml insulin. Prior to the infusion subjects performed for 1 h one‐legged knee‐extensor exercise at 75% of their maximum one‐legged work capacity in order to lower muscle glycogen stores in one leg. During the 8‐h hyperglycemic clamp procedure, glycogen concentrations increased and levelled off at 2‐ and 5‐fold above the pre‐infusion levels in the resting and the working leg, respectively. However, the absolute glycogen levels reached in both legs were quite similar, close to 4 g per 100 g wet muscle (about 1000 μmol/g d.w.), independent of prior exercise. Previous studies have shown that glycogen levels, after a bout of glycogen‐depleting exercise and subsequent ingestion of a carbohydrate‐rich diet for 3 days, can be increased to values around 3–4 g per 100 g wet muscle. It appears that the maximal attainable glycogen concentration in human muscle seems to be close to 4 g per 100 g wet muscle. This glycogen level can thus be reached either by a prolonged infusion of supra‐physiological concentrations of glucose and insulin or by glycogen‐depleting exercise followed by ingestion of a carbohydrate‐rich diet.

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Crossref · 10.1111/j.1600-0838.1999.tb00235.x

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  • Intravenous delivery of supra-physiological concentrations of glucose and insulin can increase rates of post-exercise glycogen synthesis over 8 h to levels achieved by glycogen supercompensation protocols.

    “A separate study, which found that intravenous delivery of supra-physiological concentrations of glucose and insulin can increase rates of post-exercise glycogen synthesis over 8 h to levels achieved by glycogen supercompensation protocols (37), is largely of theoretical interest only since its use contravenes antidoping rules in sport.”

    From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as [37]

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Authors
Hansen, B. F., Asp, S., Kim, B., & Richter, E. A.
Affiliations
  • Novo Nordisk (Denmark) (DK)
  • University of Copenhagen (DK)
Corresponding author
Hansen, B. F.
ORCID
Richter, E. A.
Venue
Scandinavian Journal of Medicine & Science in Sports
Publisher
Wiley
Published
1999-08
Volume
9
Issue
4
Pages
209-213
ISSN
  • 0905-7188 (ISSN-L)
  • 1600-0838
DOI
10.1111/j.1600-0838.1999.tb00235.x
OpenAlex
W2146121081
Cited by
26
References
24
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2021: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 1 · 2013: 1
FWCI
0.47
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2739 d)
Locations
  • Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Sundhed og Sygdom, Det Frie Forskningsråd
  • Danmarks Grundforskningsfond
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
muscle glycogen, skeletal muscle, hyperglycemic clamp, insulin infusion, glucose infusion, knee extension exercise, high-carbohydrate diet, glycogen resynthesis
MeSH terms
Adult, Blood Glucose, Glucose, Glycogen, Humans, Hypoglycemic Agents, Infusions, Intravenous, Insulin, Male, Exercise, Muscle, Skeletal

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