Cited by 1,384Physical Activity and HealthCardiovascular and exercise physiologyExercise and Physiological Responses

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Evidence for prescribing exercise as therapy in chronic disease

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Pedersen, B. K., Saltin, B.·2006·Scandinavian Journal of Medicine & Science in Sports

DOI 10.1111/j.1600-0838.2006.00520.x

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Abstract

Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including diseases that do not primarily manifest as disorders of the locomotive apparatus. In this review we present the evidence for prescribing exercise therapy in the treatment of metabolic syndrome‐related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases (chronic obstructive pulmonary disease, coronary heart disease, chronic heart failure, intermittent claudication), muscle, bone and joint diseases (osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome) and cancer, depression, asthma and type 1 diabetes. For each disease, we review the effect of exercise therapy on disease pathogenesis, on symptoms specific to the diagnosis, on physical fitness or strength and on quality of life. The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications.

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Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514
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Authors: Pedersen, B. K., & Saltin, B.
Affiliations: University of Copenhagen (DK)
ORCID: Pedersen, B. K.
Venue: Scandinavian Journal of Medicine & Science in Sports
Publisher: Wiley
Published: 2006-02
Volume: 16
Issue: S1
Pages: 3-63
ISSN: 0905-7188 (ISSN-L)
1600-0838
DOI: 10.1111/j.1600-0838.2006.00520.x
OpenAlex: W2133576538
Cited by: 1,384
References: 790
Citations by year: 2026: 21 · 2025: 45 · 2024: 34 · 2023: 48 · 2022: 55 · 2021: 60 · 2020: 71 · 2019: 66 · 2018: 71 · 2017: 73 · 2016: 93 · 2015: 92 · 2014: 96 · 2013: 109 · 2012: 87
FWCI: 7.33
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Foundation
Danmarks Grundforskningsfond (# 02-512-55)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: exercise therapy, exercise prescription, chronic disease, physical activity, metabolic syndrome, insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity, chronic obstructive pulmonary disease, coronary artery disease, chronic heart failure, intermittent claudication, osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome, cancer, depression, asthma, type 1 diabetes, mechanism of action, quality of life, physical fitness, exercise contraindications
MeSH terms: Asthma, Cardiovascular Diseases, Depression, Humans, Metabolic Diseases, Motivation, Musculoskeletal Diseases, Neoplasms, Physical Fitness, Exercise, Exercise Tolerance, Pulmonary Disease, Chronic Obstructive

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Evidence for prescribing exercise as therapy in chronic disease

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