The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Resistance training in the oldest old: consequences for muscle strength, fiber types, fiber size, and MHC isoforms
Abstract
Resistance training‐related changes in muscle strength, muscle size, fiber type, and myosin heavy chain isoform composition in 11 elderly subjects (age range, 85–97 years) after 12 weeks of heavy resistance training (80% of 1 RM) were examined. Twelve subjects constituted a control group. Resistance training increased isometric knee extensor strength 37% (P<0.05) and isokinetic knee strength 41–47% (P<0.05). Lean‐quadriceps cross‐sectional area increased 9.8% (P<0.05). Muscle fiber hypertrophy occurred only in the type 2 fibers (22% (P<0.05)). Type 1 fiber‐type area percentage decreased [4.0 % (P<0.05)] whereas fiber‐type area percentage of type 2a fibers increased [5.9% (P<0.05)]. The relative amount of myosin heavy chain (MHC) I (P<0.05) decreased and the relative amount of MHC IIA increased (P<0.05). No effects in the overall number of capillaries per area was observed, but an increase in the number of capillary contacts in the type 2 fiber pool was observed. Heavy resistance training does have beneficial effects on muscle strength and muscle volume in very old frail humans. Furthermore, an increase in fiber size of the fast muscle fibers and an overall increase in the relative amount of fast MHC IIA can lead not only to a stronger, but maybe more importantly, to a more powerful skeletal muscle.
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In the citing paper
“In frail adults older than 85 years, 3 months of resistance training selectively increased type II fibres, which are preferentially lost with ageing.128”
From Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases (2014) · cites this paper as [128]
In the citing paper
“Another investigation examined the effects of 12 weeks of high intensity (80% 1-RM) resistance exercise in the extremely old (85-97 y). The authors reported significant increases in quadriceps cross-sectional area (10%), Type II muscle fiber hypertrophy (22%), percentage of Type IIa fiber area (6%), and isokinetic knee extensor strength (47%) [32].”
From Protecting muscle mass and function in older adults during bed rest (2010) · cites this paper as [32]
In the citing paper
“Although not specifically evaluated in older adults during bed rest, there is clear evidence that resistance exercise is an effective means of combating the loss of muscle mass and function in a variety of populations [25-34].”
From Protecting muscle mass and function in older adults during bed rest (2010) · cites this paper as [32]
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Cites
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
What is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,142
Aagaard, P., Simonsen, E. B., Andersen, J. L., Magnusson, P., & Dyhre-Poulsen, P. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00283.2002 · Cited by 1,844
Self-citationHigh-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593 · cited 7×
“Most previous studies on resistance training in elderly subjects report a lack of correlation (Fiatarone et al., 1990; Grimby et al., 1992; Sipilä et al., 1996).”
BackgroundResultInfluentialThe numbers of limb motor neurons in the human lumbosacral cord throughout life
Tomlinson, B. E., & Irving, D. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90069-7 · Cited by 602
Larsson, L., & Moss, R. L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019964 · Cited by 513
Skelton, D. A. (2002) · Age and Ageing · doi:10.1093/ageing/31.2.119 · Cited by 505
Muscle hypertrophy response to resistance training in older women
Charette, S. L., McEvoy, L., Pyka, G., Snow-Harter, C., Guido, D., WISWELL, R. A., & Marcus, R. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.5.1912 · Cited by 483
Training-Induced Changes in Neural Function
Aagaard, P. (2003) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200304000-00002 · Cited by 480
Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle
Smerdu, V., Karsch‐Mizrachi, I., Campione, M., Leinwand, L. A., & Schiaffino, S. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.6.c1723 · Cited by 456
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Bergström J., 1962, Muscle electrolytes in man, Scand J Clin Lab Invest, 68, 1
- Fontera WR, 2000, Aging of skeletal muscle, a 12 yr longitudinal study, 88, 1321
- Klitgaard H, 1990, Function, morphology and protein expression of ageing skeletal muscle, a cross-sectional study of elderly men with different training backgrounds, 140, 41
- Lexell J, 1995, Heavy‐resistance training in older Scandinavian men and women, short- and long-term effects on arm and leg muscles, 5, 329
- McCartney N, 1995, Long‐term resistance training in elderly, effects on dynamic strength, exercise capacity, muscle, and bone, 50, B97
- Porter MM, 1995, Aging of human muscle, structure, function and adaptability, 5, 129
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Metadata
- Authors
- Kryger, A. I., & Andersen, J. L.
- Affiliations
- Bispebjerg Hospital (DK)
- Rigshospitalet (DK)
- Corresponding author
- Kryger, A. I.
- ORCID
- Andersen, J. L.
- Venue
- Scandinavian Journal of Medicine & Science in Sports
- Publisher
- Wiley
- Published
- 2007-05-09
- Volume
- 17
- Issue
- 4
- Pages
- 422-430
- ISSN
- 0905-7188 (ISSN-L)
- 1600-0838
- OpenAlex
- W1651443078
- Cited by
- 175
- References
- 38
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 14 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 11
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Danmarks Grundforskningsfond
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- resistance training, oldest old, muscle strength, muscle fiber type, muscle fiber hypertrophy, myosin heavy chain isoforms, MHC IIa, MHC class I, quadriceps cross-sectional area, quadriceps strength, capillary density, muscle power, frail elderly
- MeSH terms
- Aged, 80 and over, Denmark, Female, Humans, Male, Weight Lifting, Muscle Fibers, Skeletal, Myosin Heavy Chains, Protein Isoforms
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