Cited by 175Muscle Physiology and DisordersNutrition and Health in AgingCardiovascular and exercise physiology

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Resistance training in the oldest old: consequences for muscle strength, fiber types, fiber size, and MHC isoforms

Kryger, A. I., Andersen, J. L.·2007·Scandinavian Journal of Medicine & Science in Sports

DOI 10.1111/j.1600-0838.2006.00575.x

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Abstract

Resistance training‐related changes in muscle strength, muscle size, fiber type, and myosin heavy chain isoform composition in 11 elderly subjects (age range, 85–97 years) after 12 weeks of heavy resistance training (80% of 1 RM) were examined. Twelve subjects constituted a control group. Resistance training increased isometric knee extensor strength 37% (P<0.05) and isokinetic knee strength 41–47% (P<0.05). Lean‐quadriceps cross‐sectional area increased 9.8% (P<0.05). Muscle fiber hypertrophy occurred only in the type 2 fibers (22% (P<0.05)). Type 1 fiber‐type area percentage decreased [4.0 % (P<0.05)] whereas fiber‐type area percentage of type 2a fibers increased [5.9% (P<0.05)]. The relative amount of myosin heavy chain (MHC) I (P<0.05) decreased and the relative amount of MHC IIA increased (P<0.05). No effects in the overall number of capillaries per area was observed, but an increase in the number of capillary contacts in the type 2 fiber pool was observed. Heavy resistance training does have beneficial effects on muscle strength and muscle volume in very old frail humans. Furthermore, an increase in fiber size of the fast muscle fibers and an overall increase in the relative amount of fast MHC IIA can lead not only to a stronger, but maybe more importantly, to a more powerful skeletal muscle.

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What is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,142
Increased rate of force development and neural drive of human skeletal muscle following resistance training
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Self-citation
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Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593 · cited 7×
“Most previous studies on resistance training in elderly subjects report a lack of correlation (Fiatarone et al., 1990; Grimby et al., 1992; Sipilä et al., 1996).”
BackgroundResultInfluential
The numbers of limb motor neurons in the human lumbosacral cord throughout life
Tomlinson, B. E., & Irving, D. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90069-7 · Cited by 602
Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.
Larsson, L., & Moss, R. L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019964 · Cited by 513
Explosive power and asymmetry in leg muscle function in frequent fallers and non-fallers aged over 65
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Muscle hypertrophy response to resistance training in older women
Charette, S. L., McEvoy, L., Pyka, G., Snow-Harter, C., Guido, D., WISWELL, R. A., & Marcus, R. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.5.1912 · Cited by 483
Training-Induced Changes in Neural Function
Aagaard, P. (2003) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200304000-00002 · Cited by 480
Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle
Smerdu, V., Karsch‐Mizrachi, I., Campione, M., Leinwand, L. A., & Schiaffino, S. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.6.c1723 · Cited by 456

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Bergström J., 1962, Muscle electrolytes in man, Scand J Clin Lab Invest, 68, 1
Fontera WR, 2000, Aging of skeletal muscle, a 12 yr longitudinal study, 88, 1321
Klitgaard H, 1990, Function, morphology and protein expression of ageing skeletal muscle, a cross-sectional study of elderly men with different training backgrounds, 140, 41
Lexell J, 1995, Heavy‐resistance training in older Scandinavian men and women, short- and long-term effects on arm and leg muscles, 5, 329
McCartney N, 1995, Long‐term resistance training in elderly, effects on dynamic strength, exercise capacity, muscle, and bone, 50, B97
Porter MM, 1995, Aging of human muscle, structure, function and adaptability, 5, 129

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Authors: Kryger, A. I., & Andersen, J. L.
Affiliations: Bispebjerg Hospital (DK)
Rigshospitalet (DK)
Corresponding author: Kryger, A. I.
ORCID: Andersen, J. L.
Venue: Scandinavian Journal of Medicine & Science in Sports
Publisher: Wiley
Published: 2007-05-09
Volume: 17
Issue: 4
Pages: 422-430
ISSN: 0905-7188 (ISSN-L)
1600-0838
DOI: 10.1111/j.1600-0838.2006.00575.x
OpenAlex: W1651443078
Cited by: 175
References: 38
Citations by year: 2026: 4 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 14 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 10 · 2012: 11
FWCI: 3.97
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
PubMed (publishedVersion)
Funders: Danmarks Grundforskningsfond
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: resistance training, oldest old, muscle strength, muscle fiber type, muscle fiber hypertrophy, myosin heavy chain isoforms, MHC IIa, MHC class I, quadriceps cross-sectional area, quadriceps strength, capillary density, muscle power, frail elderly
MeSH terms: Aged, 80 and over, Denmark, Female, Humans, Male, Weight Lifting, Muscle Fibers, Skeletal, Myosin Heavy Chains, Protein Isoforms

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Resistance training in the oldest old: consequences for muscle strength, fiber types, fiber size, and MHC isoforms

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