Nutritional Approaches to Treating Sarcopenia
Abstract
[Extract] The goal of this chapter is to explore the obstacles and opportunities for treating sarcopenia using a nutrition-focused approach. While it is clear that sarcopenia is the result of a complex interplay of various factors, in all cases, an adequate nutritional framework is the fundamental prerequisite for maintaining muscle mass, strength and ultimately functional capacity.
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The per-meal anabolic threshold of dietary protein/amino acid intake is higher in older individuals (25 to 30 g protein per meal, containing about 2.5 to 2.8 g leucine) than in young adults.
“The per-meal anabolic threshold of dietary protein/amino acid intake is higher in older individuals (ie, 25 to 30 g protein per meal, containing about 2.5 to 2.8 g leucine) in comparison with young adults.”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [50]
In the fed state, most researchers agree there is an impairment of the muscle protein anabolic response to meal intake in older adults, although some studies found no difference, especially with high amino acid or protein amounts.
“In the fed state, however, most researchers now agree that there is an impairment of the muscle protein anabolic response to meal intake in older adults, 46,49,50 although some studies found no difference between older and younger adults, especially when high amounts of amino acids or proteins were administered.”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [50]
Paddon-Jones 2012 argue that while a modest increase in dietary protein beyond the recommended dietary allowance may be beneficial for some older adults (perhaps 1.0-1.3 g/kg per day), there is a greater need to specifically examine the quality and quantity of protein consumed with each meal.
“Paddon-Jones 2012 50 1.0e1.3g/kg BW/d .we argue that while a modest increase in dietary protein beyond the RDA may be beneficial for some older adults (perhaps 1.0e1.3g/kg per day), there is a greater need to specifically examine the quality and quantity of protein consumed with each meal.”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as Paddon-Jones 2012 50
Cites
Trumbo, P., Schlicker, S., Yates, A. A., & Poos, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90346-9 · Cited by 5,993 · see citing works
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256 · see citing works
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857 · see citing works
Covinsky, K. E., Palmer, R. M., Fortinsky, R. H., Counsell, S. R., Stewart, A. L., Kresevic, D., Burant, C. J., & Landefeld, C. S. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51152.x · Cited by 1,670 · see citing works
High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593 · see citing works
The underappreciated role of muscle in health and disease
Wolfe, R. R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.475 · Cited by 1,563 · see citing works
The healthcare costs of sarcopenia in the United States
Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52014.x · Cited by 1,546 · see citing works
Slow and fast dietary proteins differently modulate postprandial protein accretion
Boirie, Y., Dangin, M., Gachon, P., Vasson, M.-P., Maubois, J.-L., & Beaufrère, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14930 · Cited by 1,453 · see citing works
Houston, D. K., Nicklas, B. J., Ding, J., Harris, T. B., Tylavsky, F. A., Newman, A. B., Lee, J. S., Sahyoun, N. R., Visser, M., & Kritchevsky, S. B. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.150 · Cited by 1,214 · see citing works
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · see citing works
Mixed muscle protein synthesis and breakdown after resistance exercise in humans
Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132 · see citing works
Sarcopenia with limited mobility: an international consensus
Morley, J. E., Abbatecola, A. M., Argiles, J. M., Baracos, V., Bauer, J., Bhasin, S., Cederholm, T., Stewart Coats, A. J., Cummings, S. R., Evans, W. J., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.04.014 · Cited by 1,125 · see citing works
Effect of 10 Days of Bed Rest on Skeletal Muscle in Healthy Older Adults
Kortebein, P., Ferrando, A., Lombeida, J., Wolfe, R., & Evans, W. J. (2007) · JAMA · doi:10.1001/jama.297.16.1772-b · Cited by 933 · see citing works
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923 · see citing works
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846 · see citing works
Dietary protein recommendations and the prevention of sarcopenia
Paddon-Jones, D., & Rasmussen, B. B. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef8b · Cited by 823 · see citing works
Self-citationPennings, B., Boirie, Y., Senden, J. M., Gijsen, A. P., Kuipers, H., & van Loon, L. J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.008102 · Cited by 656 · see citing works
Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis
Urban, R. J., Bodenburg, Y. H., Gilkison, C., Foxworth, J., Coggan, A. R., Wolfe, R. R., & Ferrando, A. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.5.e820 · Cited by 608 · see citing works
Protein, weight management, and satiety
Paddon-Jones, D., Westman, E., Mattes, R. D., Wolfe, R. R., Astrup, A., & Westerterp-Plantenga, M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1558s · Cited by 549 · see citing works
Effect of Testosterone Treatment on Body Composition and Muscle Strength in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.8.2647 · Cited by 531 · see citing works
Wilkinson, S. B., Tarnopolsky, M. A., MacDonald, M. J., MacDonald, J. R., Armstrong, D., & Phillips, S. M. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1031 · Cited by 530 · see citing works
Ferrando, A. A., Sheffield-Moore, M., Yeckel, C. W., Gilkison, C., Jiang, J., Achacosa, A., Lieberman, S. A., Tipton, K., Wolfe, R. R., & Urban, R. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2001 · Cited by 522 · see citing works
Ello-Martin, J. A., Ledikwe, J. H., & Rolls, B. J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.236s · Cited by 513 · see citing works
Meta-analysis of nitrogen balance studies for estimating protein requirements in healthy adults
Rand, W. M., Pellett, P. L., & Young, V. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.109 · Cited by 506 · see citing works
Katsanos, C. S., Kobayashi, H., Sheffield‐Moore, M., Aarsland, A. A., & Wolfe, R. R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1065 · Cited by 500 · see citing works
Prolonged bed rest decreases skeletal muscle and whole body protein synthesis
Ferrando, A. A., Lane, H. W., Stuart, C. A., Davis-Street, J. E., & Wolfe, R. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e627 · Cited by 498 · see citing works
Hartman, J. W., Tang, J. E., Wilkinson, S. B., Tarnopolsky, M. A., Lawrence, R. L., Fullerton, A. V., & Phillips, S. M. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.373 · Cited by 498 · see citing works
The Natural History of Functional Morbidity in Hospitalized Older Patients
Hirsch, C. H., Sommers, L., Olsen, A., Mullen, L., & Winograd, C. H. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb03451.x · Cited by 485 · see citing works
Amino acid ingestion improves muscle protein synthesis in the young and elderly
Paddon-Jones, D., Sheffield-Moore, M., Zhang, X.-J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00368.2003 · Cited by 467 · see citing works
Self-citationVolpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464 · see citing works
National hospital discharge survey: 2004 annual summary with detailed diagnosis and procedure data.
Kozak, L. J., DeFrances, C. J., & Hall, M. J. (2006) · PubMed · Cited by 459 · see citing works
Influence of Sarcopenia on the Development of Physical Disability: The Cardiovascular Health Study
Janssen, I. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00540.x · Cited by 459 · see citing works
Optimal protein intake in the elderly
Wolfe, R. R., Miller, S. L., & Miller, K. B. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.008 · Cited by 456 · see citing works
Exercise in space: human skeletal muscle after 6 months aboard the International Space Station
Trappe, S., Costill, D., Gallagher, P., Creer, A., Peters, J. R., Evans, H., Riley, D. A., & Fitts, R. H. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91578.2008 · Cited by 454 · see citing works
Dreyer, H. C., Drummond, M. J., Pennings, B., Fujita, S., Glynn, E. L., Chinkes, D. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00582.2007 · Cited by 447 · see citing works
High-Velocity Resistance Training Increases Skeletal Muscle Peak Power in Older Women
Fielding, R. A., LeBrasseur, N. K., Cuoco, A., Bean, J., Mizer, K., & Singh, M. A. F. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50159.x · Cited by 446 · see citing works
Knight, E. L., Stampfer, M. J., Hankinson, S. E., Spiegelman, D., & Curhan, G. C. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-6-200303180-00009 · Cited by 426 · see citing works
Volpi, E., Mittendorfer, B., Wolf, S. E., & Wolfe, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.3.e513 · Cited by 418 · see citing works
Dimeo, F., Fetscher, S., Lange, W., Mertelsmann, R. H., & Keul, J. (1997) · Blood · doi:10.1182/blood.v90.9.3390 · Cited by 417 · see citing works
Guillet, C., Prod'homme, M., Balage, M., Gachon, P., Giraudet, C., Morin, L., Grizard, J., & Boirie, Y. (2004) · The FASEB Journal · doi:10.1096/fj.03-1341fje · Cited by 412 · see citing works
Rieu, I., Balage, M., Sornet, C., Giraudet, C., Pujos, E., Grizard, J., Mosoni, L., & Dardevet, D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110742 · Cited by 410 · see citing works
Role of dietary protein in the sarcopenia of aging.
Paddon-Jones, D., Short, K., Campbell, W., Volpi, E., & Wolfe, R. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1562s · Cited by 403 · see citing works
Self-citationCampbell, W. W., Trappe, T. A., Wolfe, R. R., & Evans, W. J. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.6.m373 · Cited by 397 · see citing works
The Rate of Protein Digestion affects Protein Gain Differently during Aging in Humans
Dangin, M., Guillet, C., Garcia‐Rodenas, C., Gachon, P., Bouteloup‐Demange, C., Reiffers‐Magnani, K., Fauquant, J., Ballèvre, O., & Beaufrère, B. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.036897 · Cited by 395 · see citing works
Resistance exercise as a countermeasure to disuse-induced bone loss
Shackelford, L. C., LeBlanc, A. D., Driscoll, T. B., Evans, H. J., Rianon, N. J., Smith, S. M., Spector, E., Feeback, D. L., & Lai, D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00741.2003 · Cited by 392 · see citing works
Exogenous amino acids stimulate net muscle protein synthesis in the elderly.
Volpi, E., Ferrando, A. A., Yeckel, C. W., Tipton, K. D., & Wolfe, R. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci939 · Cited by 390 · see citing works
Koopman, R., Crombach, N., Gijsen, A. P., Walrand, S., Fauquant, J., Kies, A. K., Lemosquet, S., Saris, W. H. M., Boirie, Y., & van Loon, L. J. C. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27474 · Cited by 383 · see citing works
Millward, D. J., Layman, D. K., Tomé, D., & Schaafsma, G. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1576s · Cited by 359 · see citing works
Meta-Analysis: Protein and Energy Supplementation in Older People
Milne, A. C., Avenell, A., & Potter, J. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-1-200601030-00008 · Cited by 346 · see citing works
Resistance Exercise Reverses Aging in Human Skeletal Muscle
Melov, S., Tarnopolsky, M. A., Beckman, K. B., Felkey, K., & Hubbard, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000465 · Cited by 344 · see citing works
Nutrient signalling in the regulation of human muscle protein synthesis
Fujita, S., Dreyer, H. C., Drummond, M. J., Glynn, E. L., Cadenas, J. G., Yoshizawa, F., Volpi, E., & Rasmussen, B. B. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.134593 · Cited by 339 · see citing works
Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Sanford, A. P., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032159 · Cited by 338 · see citing works
Self-citationPotential Importance of Leucine in Treatment of Obesity and the Metabolic Syndrome
Layman, D. K., & Lasker, D. A. W. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.319s · Cited by 336 · see citing works
Strength training and determinants of VO2max in older men
Frontera, W. R., Meredith, C. N., O’Reilly, K., & Evans, W. J. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.1.329 · Cited by 336 · see citing works
High protein intake sustains weight maintenance after body weight loss in humans
Westerterp-Plantenga, M. S., Lejeune, M. P. G. M., Nijs, I., van Ooijen, M., & Kovacs, E. M. R. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802461 · Cited by 326 · see citing works
Burd, N. A., West, D. W. D., Moore, D. R., Atherton, P. J., Staples, A. W., Prior, T., Tang, J. E., Rennie, M. J., Baker, S. K., & Phillips, S. M. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135038 · Cited by 325 · see citing works
Functional and Metabolic Consequences of Sarcopenia
Vandervoort, A. A., & Symons, T. B. (2001) · Canadian Journal of Applied Physiology · doi:10.1139/h01-007 · Cited by 324 · see citing works
Portion Sizes and the Obesity Epidemic,
Ledikwe, J. H., Ello-Martin, J. A., & Rolls, B. J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.905 · Cited by 320 · see citing works
Koopman, R., Wagenmakers, A. J. M., MANDERS, R. J. F., Zorenc, A. H. G., Senden, J. M., Gorselink, M., KEIZER, H. A., & van Loon, L. J. C. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00413.2004 · Cited by 316 · see citing works
Influence of the Protein Digestion Rate on Protein Turnover in Young and Elderly Subjects
Dangin, M., Boirie, Y., Guillet, C., & Beaufrère, B. (2002) · The Journal of Nutrition · doi:10.1093/jn/131.10.3228s · Cited by 312 · see citing works
Pennings, B., Koopman, R., Beelen, M., Senden, J. M., Saris, W. H., & van Loon, L. J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29649 · Cited by 311 · see citing works
National Hospital Discharge Survey: 2002 annual summary with detailed diagnosis and procedure data.
Kozak, L. J., Owings, M. F., & Hall, M. J. (2005) · PubMed · Cited by 302 · see citing works
Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.
Verhoeven, S., Vanschoonbeek, K., Verdijk, L., Koopman, R., Wodzig, W., Dendale, P., & van Loon, L. V. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26668 · Cited by 286 · see citing works
Higher Protein Intake Preserves Lean Mass and Satiety with Weight Loss in Pre‐obese and Obese Women
Leidy, H. J., Carnell, N. S., Mattes, R. D., & Campbell, W. W. (2007) · Obesity · doi:10.1038/oby.2007.531 · Cited by 277 · see citing works
Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress
Paddon-Jones, D., Sheffield-Moore, M., Cree, M. G., Hewlings, S. J., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0651 · Cited by 254 · see citing works
Self-citationVerdijk, L. B., Jonkers, R. A., Gleeson, B. G., Beelen, M., Meijer, K., Savelberg, H. H., Wodzig, W. K., Dendale, P., & van Loon, L. J. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26626 · Cited by 253 · see citing works
Stimulation of In Vitro Rat Muscle Protein Synthesis by Leucine Decreases with Age
Dardevet, D. P., Sornet, C., Balage, M., & Grizard, J. (2000) · Journal of Nutrition · doi:10.1093/jn/130.11.2630 · Cited by 243 · see citing works
Aging does not impair the anabolic response to a protein-rich meal
Symons, T. B., Schutzler, S. E., Cocke, T. L., Chinkes, D. L., Wolfe, R. R., & Paddon-Jones, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.451 · Cited by 240 · see citing works
Self-citationMilk ingestion stimulates net muscle protein synthesis following resistance exercise
ELLIOT, T. A., CREE, M. G., SANFORD, A. P., WOLFE, R. R., & TIPTON, K. D. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000210190.64458.25 · Cited by 237 · see citing works
Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.03.009 · Cited by 237 · see citing works
Self-citationTipton, K. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00087-4 · Cited by 231 · see citing works
Fujita, S., Rasmussen, B. B., Cadenas, J. G., Drummond, M. J., Glynn, E. L., Sattler, F. R., & Volpi, E. (2007) · Diabetes · doi:10.2337/db06-1566 · Cited by 224 · see citing works
Paddon-Jones, D., Sheffield-Moore, M., Katsanos, C. S., Zhang, X.-J., & Wolfe, R. R. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.006 · Cited by 223 · see citing works
Self-citationFunctional and Metabolic Consequences of Sarcopenia
Evans, W. J. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.998s · Cited by 220 · see citing works
Beckers, P. J., Denollet, J., Possemiers, N. M., Wuyts, F. L., Vrints, C. J., & Conraads, V. M. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn222 · Cited by 206 · see citing works
Koopman, R., Verdijk, L. B., MANDERS, R. J. F., Gijsen, A. P., Gorselink, M., Pijpers, E., Wagenmakers, A. J. M., & van Loon, L. J. C. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.623 · Cited by 202 · see citing works
The satiating power of protein—a key to obesity prevention?
Astrup, A. V. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.1 · Cited by 201 · see citing works
Short-Term Oxandrolone Administration Stimulates Net Muscle Protein Synthesis in Young Men1
Sheffield-Moore, M., Urban, R. J., Wolf, S. E., Jiang, J., Catlin, D. H., Herndon, D. N., Wolfe, R. R., & Ferrando, A. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5923 · Cited by 199 · see citing works
Ambulatory activity of older adults hospitalized with acute medical illness
Fisher, S. R., Goodwin, J. S., Protas, E. J., Kuo, Y., Graham, J. E., Ottenbacher, K. J., & Ostir, G. V. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03202.x · Cited by 192 · see citing works
Suetta, C., Andersen, J. L., Dalgas, U., Berget, J., Koskinen, S., Aagaard, P., Magnusson, S. P., & Kjaer, M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01354.2007 · Cited by 184 · see citing works
Kryger, A. I., & Andersen, J. L. (2007) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00575.x · Cited by 175 · see citing works
Koopman, R., Walrand, S., Beelen, M., Gijsen, A. P., Kies, A. K., Boirie, Y., Saris, W. H. M., & van Loon, L. J. C. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.109173 · Cited by 167 · see citing works
Combaret, L., Dardevet, D. P., Rieu, I., Pouch-Pélissier, M.-N., Béchet, D., Taillandier, D., Grizard, J., & Attaix, D. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098004 · Cited by 165 · see citing works
Leenders, M., Verdijk, L. B., van der Hoeven, L., van Kranenburg, J. M. X., Hartgens, F., Wodzig, W. K. W. H., Saris, W. H. M., & van Loon, L. J. C. (2011) · Journal of Nutrition · doi:10.3945/jn.111.138495 · Cited by 159 · see citing works
Correlation between physical performance and fatigue in cancer patients
Dimeo, F., Stieglitz, R., Novelli‐Fischer, U., Fetscher, S., Mertelsmann, R. H., & Keul, J. (1997) · Annals of Oncology · doi:10.1023/a:1008234310474 · Cited by 158 · see citing works
Henwood, T. R., & Taaffe, D. R. (2006) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2006.00695.x · Cited by 158 · see citing works
Change in Muscle Mass and Muscle Strength After a Hip Fracture: Relationship to Mobility Recovery
Visser, M., Harris, T. B., Fox, K. M., Hawkes, W., Hebel, J. R., YuYahiro, J., Michael, R., Zimmerman, S. I., & Magaziner, J. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.8.m434 · Cited by 157 · see citing works
Urso, M. L., Scrimgeour, A. G., Chen, Y., Thompson, P. D., & Clarkson, P. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00180.2006 · Cited by 155 · see citing works
The significance of protein in food intake and body weight regulation
Westerterp‐Plantenga, M. S. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200311000-00005 · Cited by 142 · see citing works
The effect of oral nutritional supplements on habitual dietary quality and quantity in frail elders.
Singh, M. A. F., Bernstein, M., Ryan, A. D., O'Neill, E. F., Clements, K. M., & Evans, W. J. (2000) · PubMed · Cited by 135 · see citing works
Sarcopenia--exercise as a treatment strategy.
Taaffe, D. R. (2006) · PubMed · Cited by 129 · see citing works
Contribution of Amino Acids and Insulin to Protein Anabolism During Meal Absorption
Volpi, E., Lucidi, P., Cruciani, G., Monacchia, F., Reboldi, G., Brunetti, P., Bolli, G. B., & Feo, P. D. (1996) · Diabetes · doi:10.2337/diab.45.9.1245 · Cited by 129 · see citing works
Functional impact of high protein intake on healthy elderly people
Walrand, S., Short, K. R., Bigelow, M. L., Sweatt, A. J., Hutson, S. M., & Nair, K. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90536.2008 · Cited by 125 · see citing works
Use of an Ambulation Assistive Device Predicts Functional Decline Associated With Hospitalization
Mahoney, J. E., Sager, M. A., & Jalaluddin, M. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.2.m83 · Cited by 122 · see citing works
Børsheim, E., Aarsland, A. A., & Wolfe, R. R. (2004) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.14.3.255 · Cited by 121 · see citing works
Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes
Leenders, M., & van Loon, L. J. C. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00443.x · Cited by 113 · see citing works
Rieu, I., Sornet, C., Bayle, G., Prugnaud, J., Pouyet, C., Balage, M., Papet, I., Grizard, J., & Dardevet, D. P. (2003) · Journal of Nutrition · doi:10.1093/jn/133.4.1198 · Cited by 112 · see citing works
Symons, T. B., Sheffield-Moore, M., Chinkes, D. L., Ferrando, A. A., & Paddon-Jones, D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91137.2008 · Cited by 111 · see citing works
Self-citationResistance training, insulin sensitivity and muscle function in the elderly
Dela, F., & Kjaer, M. (2006) · Essays in Biochemistry · doi:10.1042/bse0420075 · Cited by 108 · see citing works
The Recommended Dietary Allowance of Protein: A Misunderstood Concept
Wolfe, R. R., & Miller, S. L. (2008) · JAMA · doi:10.1001/jama.299.24.2891 · Cited by 107 · see citing works
Role of Leucine in Protein Metabolism During Exercise and Recovery
Layman, D. K. (2002) · Canadian Journal of Applied Physiology · doi:10.1139/h02-038 · Cited by 104 · see citing works
Brooks, N., Cloutier, G. J., Cadena, S. M., Layne, J. E., Nelsen, C. A., Freed, A. M., Roubenoff, R., & Castaneda-Sceppa, C. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01346.2007 · Cited by 102 · see citing works
Dietary Peptides Induce Satiety via Cholecystokinin-A and Peripheral Opioid Receptors in Rats
Pupovac, J., & Anderson, G. H. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2775 · Cited by 101 · see citing works
Novel events in the molecular regulation of muscle mass in critically ill patients
Constantin, D., McCullough, J., Mahajan, R. P., & Greenhaff, P. L. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.206193 · Cited by 100 · see citing works
Fielding, R. A. (1995) · Journal of the American College of Nutrition · doi:10.1080/07315724.1995.10718547 · Cited by 95 · see citing works
Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women
Butterfield, G. E., Thompson, J. L., Rennie, M. J., Marcus, R., Hintz, R. L., & Hoffman, A. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.1.e94 · Cited by 95 · see citing works
Regulation of muscle protein synthesis in humans
Phillips, B. E., Hill, D. S., & Atherton, P. J. (2012) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32834d19bc · Cited by 91 · see citing works
Reversing sarcopenia: how weight training can build strength and vitality.
Evans, W. (1996) · PubMed · Cited by 87 · see citing works
Effects of Exercise on Senescent Muscle
Evans, W. J. (2002) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200210001-00025 · Cited by 85 · see citing works
Paddon-Jones, D., Sheffield-Moore, M., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00291.2004 · Cited by 85 · see citing works
Self-citationDaily protein intakes and eating patterns in young and elderly French
Rousset, S., Mirand, P. P., Brandolini, M., Martin, J., & Boirie, Y. (2003) · British Journal Of Nutrition · doi:10.1079/bjn20031004 · Cited by 83 · see citing works
Inadequate protein intake affects skeletal muscle transcript profiles in older humans
Thalacker‐Mercer, A. E., Fleet, J. C., Craig, B. Α., Carnell, N. S., & Campbell, W. W. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1344 · Cited by 80 · see citing works
Sheffield‐Moore, M., Paddon‐Jones, D., Sanford, A. P., Rosenblatt, J. I., Matlock, A. G., Cree‐Green, M., & Wolfe, R. R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00358.2004 · Cited by 77 · see citing works
Self-citationShort-Term Oxandrolone Administration Stimulates Net Muscle Protein Synthesis in Young Men
Sheffield‐Moore, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.8.2705 · Cited by 74 · see citing works
Caiozzo, V. J., Haddad, F., Lee, S., Baker, M., Paloski, W., & Baldwin, K. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91130.2008 · Cited by 72 · see citing works
Nitrogen balance studies in apparently healthy elderly people and those who are housebound
Bunker, V. W., Lawson, M. S., Stansfield, M. F., & Clayton, B. E. (1987) · British Journal Of Nutrition · doi:10.1079/bjn19870027 · Cited by 69 · see citing works
Campbell, W. W. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00320.x · Cited by 68 · see citing works
Deley, G., Kervio, G., Van Hoecke, J., Verges, B., Grassi, B., & Casillas, J.-M. (2007) · Aging Clinical and Experimental Research · doi:10.1007/bf03324707 · Cited by 66 · see citing works
Morse, C. I., Thom, J. M., Mian, O. S., Birch, K. M., & Narici, M. V. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0246-1 · Cited by 61 · see citing works
Androgen Therapy Induces Muscle Protein Anabolism in Older Women
Sheffield‐Moore, M., Paddon‐Jones, D., Casperson, S. L., Gilkison, C. R., Volpi, E., Wolf, S. E., Jiang, J., Rosenblatt, J. I., & Urban, R. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0588 · Cited by 61 · see citing works
Self-citationEffect of prolonged unweighting of human skeletal muscle on neuromotor force control
Clark, B. C., Pierce, J. R., Manini, T. M., & Ploutz‐Snyder, L. L. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0399-6 · Cited by 59 · see citing works
Beyer, N., Simonsen, L., Bülow, J., Lorenzen, T., Jensen, D. V., Larsen, L., Rasmussen, U., Rennie, M., & Kjær, M. (2007) · Aging Clinical and Experimental Research · doi:10.1007/bf03324706 · Cited by 58 · see citing works
Iglay, H. B., Apolzan, J. W., Gerrard, D. E., Eash, J. K., Anderson, J. C., & Campbell, W. W. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0016-y · Cited by 56 · see citing works
Immobilization effects in young and older adults
Urso, M. L., Clarkson, P. M., & Price, T. B. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0109-1 · Cited by 55 · see citing works
Lee, J. S., Johnson, M. A., Brown, A., & Nord, M. (2011) · Journal of Nutrition · doi:10.3945/jn.111.139378 · Cited by 52 · see citing works
Parise, G., & Yarasheski, K. E. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200011000-00012 · Cited by 51 · see citing works
Zachwieja, J. J., & Yarasheski, K. E. (1999) · Physical Therapy · doi:10.1093/ptj/79.1.76 · Cited by 50 · see citing works
Fielding, R. A. (1995) · Proceedings of the Nutrition Society · doi:10.1079/pns19950066 · Cited by 40 · see citing works
Amino Acid Supplementation for Reversing Bed Rest and Steroid Myopathies
Paddon-Jones, D. J., Wolfe, R. R., & Ferrando, A. A. (2005) · Journal of Nutrition · doi:10.1093/jn/135.7.1809s · Cited by 35 · see citing works
Self-citationInvoluntary weight loss and the nonhealing wound: the role of anabolic agents.
Demling, R. H., & DeSanti, L. (1999) · PubMed · Cited by 32 · see citing works
(2002) · PubMed · Cited by 19 · see citing works
Gender differences in hallway ambulation by older adults hospitalized for medical illness.
Je, M. (1999) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
3 of the 135 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · see citing works
Mori, H., & Tokuda, Y. (2018) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13499 · Cited by 124 · see citing works
Cheng, H., Kong, J., Underwood, C., Petocz, P., Hirani, V., Dawson, B., & O’Leary, F. (2018) · British Journal of Nutrition · doi:10.1017/s0007114517003816 · Cited by 72 · see citing works
Damanti, S., Azzolino, D., Roncaglione, C., Arosio, B., Rossi, P., & Cesari, M. (2019) · Nutrients · doi:10.3390/nu11091991 · Cited by 62 · see citing works
“Spread feeding patterns, in which an equal amount of protein is ingested at each meal, seems to optimize the protein synthetic capacity [74].”
BackgroundChew, S. T. H., Kayambu, G., Lew, C. C. H., Ng, T. P., Ong, F., Tan, J. J., Tan, N. C., & Tham, S.-L. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02240-8 · Cited by 30 · see citing works
Ispoglou, T., Deighton, K., King, R. F., White, H., & Lees, M. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0298-6 · Cited by 21 · see citing works
“A diminished anabolic response to protein [15, 24, 25] and the increased requirements caused by inflammatory and catabolic responses to diseases of ageing may compound this further.”
BackgroundEstrada‐deLeón, D. B., Struijk, E. A., Caballero, F., Rodríguez‐Artalejo, F., & López‐García, E. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02273-6 · Cited by 6 · see citing works
Proteinbedarf älterer Menschen
Diekmann, R., & Bauer, J. M. (2014) · Deutsche Medizinische Wochenschrift · doi:10.1055/s-0033-1359989 · Cited by 6 · see citing works
Li, J., Jiang, L., Saquib, N., Gradidge, P. J.-L., Liu, S., van Horn, L., Richey, P. A., Timberlake, D. S., Beydoun, H. A., Liu, L., et al. (2026) · International Journal of Obesity · doi:10.1038/s41366-025-01978-0 · Cited by 3 · see citing works
“This may suggest that total energy intake also plays a role in in fl uencing both adiposity gain and lean tissue loss.”
Zhang, T., Zhang, C., Du, H., Chang, Y., Zhao, K., Xue, H., Liang, M., & Li, Z. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1657426 · Cited by 1 · see citing works
“The per-meal anabolic threshold of dietary amino acid intake is higher in older individuals (i.e., about 2.5 to 2.8 g leucine) in comparison with young adults (11, 12).”
Influential
- Authors
- Paddon‐Jones, D., & van Loon, L.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Venue
- Sarcopenia
- Publisher
- Wiley
- Published
- 2012-07-27
- Pages
- 275-295
- OpenAlex
- W1901312211
- Cited by
- 10
- References
- 135
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2014: 1 · 2013: 1
- Type
- other
- Language
- en
- Open access
- closed
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, dietary intervention, muscle mass, muscle strength, functional capacity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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