Cited by 240HIV Research and TreatmentT-cell and Retrovirus StudiesVirus-based gene therapy research

Retroviral spread by induction of virological synapses

Open access
Jolly, Clare, Sattentau, Quentin J.·2004·Traffic

Abstract

Cells of the immune system communicate via the formation of receptor‐containing adhesive junctions termed immunological synapses. Recently, retroviruses have been shown to subvert this process in order to pass directly from infected to uninfected immune cells. Such cell–cell viral dissemination appears to function by triggering existing cellular pathways involved in antigen presentation and T‐cell communication. This mode of viral spread has important consequences for both the virus and the host cells in terms of viral pathogenesis and viral resistance to immune and therapeutic intervention. This review summarises the current knowledge concerning virological synapses induced by retroviruses.

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Crossref · 10.1111/j.1600-0854.2004.00209.x

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  • The virological synapse is a cytoskeleton-dependent, stable adhesive junction across which virus is transmitted by direct transfer.

    “The VS is a cytoskeleton-dependent, stable adhesive junction, across which a virus is transmitted by direct transfer [4] (Figure 4a).”

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Research works printed but not linked: 1

  1. Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane recep- tors. Nat Rev Mol Cell Biol 2002;3:639-650.

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Authors
Jolly, C., & Sattentau, Q. J.
Affiliations
University of Oxford (GB)
Corresponding author
Jolly, Clare
Venue
Traffic
Publisher
Wiley
Published
2004-07-06
Volume
5
Issue
9
Pages
643-650
ISSN
  • 1398-9219 (ISSN-L)
  • 1600-0854
OpenAlex
W1619221212
Cited by
240
References
63
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 19 · 2019: 10 · 2018: 10 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 13 · 2013: 13 · 2012: 22
FWCI
1.34
Type
journal article
Language
en
Open access
Locations
  • Traffic (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Medical Research Council (G0100137)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords
retroviruses, virological synapse, immunological synapse, viral dissemination, antigen presentation, immune evasion, viral pathogenesis
MeSH terms
Humans, Intercellular Junctions, T-Lymphocytes, Human T-lymphotropic virus 1, HTLV-I Infections, HIV-1, HIV Infections

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