Retroviral spread by induction of virological synapses
Open accessAbstract
Cells of the immune system communicate via the formation of receptor‐containing adhesive junctions termed immunological synapses. Recently, retroviruses have been shown to subvert this process in order to pass directly from infected to uninfected immune cells. Such cell–cell viral dissemination appears to function by triggering existing cellular pathways involved in antigen presentation and T‐cell communication. This mode of viral spread has important consequences for both the virus and the host cells in terms of viral pathogenesis and viral resistance to immune and therapeutic intervention. This review summarises the current knowledge concerning virological synapses induced by retroviruses.
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The virological synapse is a cytoskeleton-dependent, stable adhesive junction across which virus is transmitted by direct transfer.
“The VS is a cytoskeleton-dependent, stable adhesive junction, across which a virus is transmitted by direct transfer [4] (Figure 4a).”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [4]
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“The VS is a cytoskeleton-dependent, stable adhesive junction, across which a virus is transmitted by direct transfer [4] (Figure 4a).”
BackgroundThe virological synapse facilitates herpes simplex virus entry into T cells
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- Authors
- Jolly, C., & Sattentau, Q. J.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Jolly, Clare
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2004-07-06
- Volume
- 5
- Issue
- 9
- Pages
- 643-650
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1619221212
- Cited by
- 240
- References
- 63
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 19 · 2019: 10 · 2018: 10 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 13 · 2013: 13 · 2012: 22
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Traffic (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council (G0100137)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- retroviruses, virological synapse, immunological synapse, viral dissemination, antigen presentation, immune evasion, viral pathogenesis
- MeSH terms
- Humans, Intercellular Junctions, T-Lymphocytes, Human T-lymphotropic virus 1, HTLV-I Infections, HIV-1, HIV Infections
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