The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Rituximab, an Anti-CD20 Monoclonal Antibody: History and Mechanism of Action
Open accessAbstract
Rituximab, chimeric anti-human CD20, is approved for treatment of B-cell lymphoma in adults. It is being used experimentally in other various immune-related diseases such as immune thrombocytopenic purpura, systemic lupus erythematosus, myasthenia gravis and rheumatoid arthritis. In transplant recipients, it is used for treatment of post-transplant lymphoproliferative disease, to anecdotally reduce pre-formed anti-HLA and anti-ABO antibodies and for the prevention and treatment of acute rejection. This article primarily reviews the science behind rituximab: its history, pharmacokinetics and potential mechanism of action. A need for controlled clinical trials is clearly indicated before the widespread use of this drug in transplant.
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Citations
Cites
Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
Bernasconi, N. L., Traggiai, E., & Lanzavecchia, A. (2002) · Science · doi:10.1126/science.1076071 · Cited by 1,304
Cited by
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
Pescovitz, M. D., Greenbaum, C. J., Krause-Steinrauf, H., Becker, D. J., Gitelman, S. E., Goland, R., Gottlieb, P. A., Marks, J. B., McGee, P. F., Moran, A. M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904452 · Cited by 1,093
Self-citationRejection of the Kidney Allograft
Nankivell, B. J., & Alexander, S. I. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0902927 · Cited by 605
Recent advances in (therapeutic protein) drug development
Lagassé, H. A. D., Alexaki, A., Simhadri, V. L., Katagiri, N. H., Jankowski, W., Sauna, Z. E., & Kimchi-Sarfaty, C. (2017) · F1000Research · doi:10.12688/f1000research.9970.1 · Cited by 481
Mechanism of cellular rejection in transplantation
Ingulli, E. (2010) · Pediatric Nephrology · doi:10.1007/s00467-008-1020-x · Cited by 313
Salvi, M., Vannucchi, G., Campi, I., Currò, N., Dazzi, D., Simonetta, S., Bonara, P., Rossi, S., Sina, C., Guastella, C., et al. (2007) · European Journal of Endocrinology · doi:10.1530/eje.1.02325 · Cited by 264
Metadata
- Authors
- Pescovitz, M. D.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 6
- Issue
- 5
- Pages
- 859-866
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2163100333
- Cited by
- 625
- References
- 1
- FWCI
- 25.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pescovitz, M. D. (2006). Rituximab, an Anti-CD20 Monoclonal Antibody: History and Mechanism of Action. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2006.01288.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
