The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Tacrolimus with Mycophenolate Mofetil (MMF) or Sirolimus vs. Cyclosporine with MMF in Cardiac Transplant Patients: 1-Year Report
Open accessAbstract
The most advantageous combination of immunosuppressive agents for cardiac transplant recipients has not yet been established. Between November 2001 and June 2003, 343 de novo cardiac transplant recipients were randomized to receive steroids and either tacrolimus (TAC) + sirolimus (SRL), TAC + mycophenolate mofetil (MMF) or cyclosporine (CYA) + MMF. Antilymphocyte induction therapy was allowed for up to 5 days. The primary endpoint of >/=3A rejection or hemodynamic compromise rejection requiring treatment showed no significant difference at 6 months (TAC/MMF 22.4%, TAC/SRL 24.3%, CYA/MMF 31.6%, p = 0.271) and 1 year (p = 0.056), but it was significantly lower in the TAC/MMF group when compared only to the CYA/MMF group at 1 year (23.4% vs. 36.8%; p = 0.029). Differences in the incidence of any treated rejection were significant (TAC/SRL = 35%, TAC/MMF = 42%, CYA/MMF = 59%; p < 0.001), as were median levels of serum creatinine (TAC/SRL = 1.5 mg/dL, TAC/MMF = 1.3 mg/dL, CYA/MMF = 1.5 mg/dL; p = 0.032) and triglycerides (TAC/SRL = 162 mg/dL, TAC/MMF = 126 mg/dL, CYA/MMF = 154 mg/dL; p = 0.028). The TAC/SRL group encountered fewer viral infections but more fungal infections and impaired wound healing. These secondary endpoints suggest that the TAC/MMF combination appears to offer more advantages than TAC/SRL or CYA/MMF in cardiac transplant patients, including fewer >/=3A rejections or hemodynamic compromise rejections and an improved side-effect profile.
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Billingham, M. E., Cary, N. R. B., Hammond, M. E. H., Kemnitz, J., Marboe, C. C., Mccallister, H. A., Snovar, D. C., Winters, G. L., & Zerbe, A. (1990) · PubMed · Cited by 1,490
Effect of pravastatin on outcomes after cardiac transplantation
Kobashigawa, J. A., Katznelson, S., Laks, H., Johnson, J. A., Yeatman, L., Wang, X. M., Chia, D., Terasaki, P. I., Sabad, A., Cogert, G. A., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509073331003 · Cited by 1,301
Self-citationEisen, H. J., Tuzcu, E. M., Dorent, R., Kobashigawa, J., Mancini, D., Valantine-von Kaeppler, H. A., Starling, R. C., Sørensen, K., Hummel, M., Lind, J. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022171 · Cited by 1,198
Self-citationFK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION
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A RANDOMIZED ACTIVE-CONTROLLED TRIAL OF MYCOPHENOLATE MOFETIL IN HEART TRANSPLANT RECIPIENTS1
Kobashigawa, J., Miller, L., Renlund, D., Mentzer, R., Alderman, E., Bourge, R., Costanzo, M., Eisen, H., Dureau, G., Ratkovec, R., et al. (1998) · Transplantation · doi:10.1097/00007890-199808270-00016 · Cited by 615
Self-citationKeogh, A., Richardson, M., Ruygrok, P., Spratt, P., Galbraith, A., O’Driscoll, G., Macdonald, P., Esmore, D., Muller, D., & Faddy, S. (2004) · Circulation · doi:10.1161/01.cir.0000136812.90177.94 · Cited by 463
Hertz, M. I., Taylor, D. O., Trulock, E. P., Boucek, M. M., Mohacsi, P. J., Edwards, L. B., & Keck, B. M. (2002) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(02)00498-9 · Cited by 360
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Taylor, D. O., Barr, M. L., Radovancevic, B., Renlund, D. G., Mentzer Jr, R. M., Smart, F. W., Tolman, D. E., Frazier, O. H., Young, J. B., & VanVeldhuisen, P. (1999) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(98)00060-6 · Cited by 318
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Cited by
Cardiac Allograft Vasculopathy: Recent Developments
Schmauss, D., & Weis, M. (2008) · Circulation · doi:10.1161/circulationaha.107.711911 · Cited by 587
The changing face of heart transplantation
Hunt, S. A., & Haddad, F. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.020 · Cited by 225
Thompson, D. M., Meloche, M., Ao, Z., Paty, B., Keown, P., Shapiro, R. J., Ho, S., Worsley, D., Fung, M., Meneilly, G., et al. (2011) · Transplantation · doi:10.1097/tp.0b013e31820437f3 · Cited by 213
Metadata
- Authors
- Kobashigawa, J. A., Miller, L. W., Russell, S. D., Ewald, G. A., Zucker, M. J., Goldberg, L. R., Eisen, H. J., Salm, K., Tolzman, D., Gao, J., Fitzsimmons, W., & First, R.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 6
- Issue
- 6
- Pages
- 1377-1386
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2043851911
- Cited by
- 329
- References
- 18
- FWCI
- 23.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Tacrolimus with Mycophenolate Mofetil (MMF) or Sirolimus vs. Cyclosporine with MMF in Cardiac Transplant Patients: 1-Year Report. https://app.cochat.ai/papers/10.1111/j.1600-6143.2006.01290.x
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- Kobashigawa, J. A., Miller, L. W., Russell, S. D., Ewald, G. A., Zucker, M. J., Goldberg, L. R., Eisen, H. J., Salm, K., Tolzman, D., Gao, J., Fitzsimmons, W., & First, R. (2006). Tacrolimus with Mycophenolate Mofetil (MMF) or Sirolimus vs. Cyclosporine with MMF in Cardiac Transplant Patients: 1-Year Report. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2006.01290.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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