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The Use of Antibody to Complement Protein C5 for Salvage Treatment of Severe Antibody-Mediated Rejection
Open accessAbstract
Desensitized patients are at high risk of developing acute antibody-mediated rejection (AMR). In most cases, the rejection episodes are mild and respond to a short course of plasmapheresis (PP) / low-dose IVIg treatment. However, a subset of patients experience severe AMR associated with sudden onset oliguria. We previously described the utility of emergent splenectomy in rescuing allografts in patients with this type of severe AMR. However, not all patients are good candidates for splenectomy. Here we present a single case in which eculizumab, a complement protein C5 antibody that inhibits the formation of the membrane attack complex (MAC), was used combined with PP/IVIg to salvage a kidney undergoing severe AMR. We show a marked decrease in C5b-C9 (MAC) complex deposition in the kidney after the administration of eculizumab.
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Citations
Cited by
Rejection of the Kidney Allograft
Nankivell, B. J., & Alexander, S. I. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0902927 · Cited by 605
Szczepiorkowski, Z. M., Winters, J. L., Bandarenko, N., Kim, H. C., Linenberger, M. L., Marques, M. B., Sarode, R., Schwartz, J., Weinstein, R., & Shaz, B. H. (2010) · Journal of Clinical Apheresis · doi:10.1002/jca.20240 · Cited by 508
First clinical-grade porcine kidney xenotransplant using a human decedent model
Porrett, P. M., Orandi, B. J., Kumar, V., Houp, J., Anderson, D., Cozette Killian, A., Hauptfeld-Dolejsek, V., Martin, D. E., Macedon, S., Budd, N., et al. (2022) · American Journal of Transplantation · doi:10.1111/ajt.16930 · Cited by 417
Self-citationBaker, R. J., Mark, P. B., Patel, R. K., Stevens, K. K., & Palmer, N. (2017) · BMC Nephrology · doi:10.1186/s12882-017-0553-2 · Cited by 211
Metadata
- Authors
- Locke, J. E., Magro, C. M., Singer, A. L., Segev, D. L., Haas, M., Hillel, A. T., King, K. E., Kraus, E., Lees, L. M., Melacon, J. K., Stewart, Z. A., Warren, D. S., Zachary, A. A., & Montgomery, R. A.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 9
- Issue
- 1
- Pages
- 231-235
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W1512745446
- Cited by
- 319
- References
- 0
- FWCI
- 18.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The Use of Antibody to Complement Protein C5 for Salvage Treatment of Severe Antibody-Mediated Rejection. https://app.cochat.ai/papers/10.1111/j.1600-6143.2008.02451.x
- The paper
- Locke, J. E., Magro, C. M., Singer, A. L., Segev, D. L., Haas, M., Hillel, A. T., King, K. E., Kraus, E., Lees, L. M., Melacon, J. K., Stewart, Z. A., Warren, D. S., Zachary, A. A., & Montgomery, R. A. (2009). The Use of Antibody to Complement Protein C5 for Salvage Treatment of Severe Antibody-Mediated Rejection. American Journal of Transplantation. https://doi.org/10.1111/j.1600-6143.2008.02451.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
