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Cited by 189Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia

Szumlinski, K. K., Lominac, K. D., Kleschen, M. J., Oleson, E. B., Dehoff, M. H., Schwartz, M. K., Seeberg, P. H., Worley, P. F., Kalivas, P. W.·2005·Genes, Brain and Behavior
DOI 10.1111/j.1601-183x.2005.00120.x
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Abstract

Homer proteins are involved in the functional assembly of postsynaptic density proteins at glutamatergic synapses and are implicated in learning, memory and drug addiction. Here, we report that Homer1-knockout (Homer1-KO) mice exhibit behavioral and neurochemical abnormalities that are consistent with the animal models of schizophrenia. Relative to wild-type mice, Homer1-KO mice exhibited deficits in radial arm maze performance, impaired prepulse inhibition, enhanced 'behavioral despair', increased anxiety in a novel objects test, enhanced reactivity to novel environments, decreased instrumental responding for sucrose and enhanced MK-801- and methamphetamine-stimulated motor behavior. No-net-flux in vivo microdialysis revealed a decrease in extracellular glutamate content in the nucleus accumbens and an increase in the prefrontal cortex. Moreover, in Homer1-KO mice, cocaine did not stimulate a rise in frontal cortex extracellular glutamate levels, suggesting hypofrontality. These behavioral and neurochemical data derived from Homer1 mutant mice are consistent with the recent association of schizophrenia with a single-nucleotide polymorphism in the Homer1 gene and suggest that the regulation of extracellular levels of glutamate within limbo-corticostriatal structures by Homer1 gene products may be involved in the pathogenesis of this neuropsychiatric disorder.

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Crossref · 10.1111/j.1601-183x.2005.00120.x

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  1. Smothers C.T., 2003, Effects of Homer2 deletion on the development of ethanol tolerance and NMDA receptor function in mice, Alcohol Clin Exp Res, 27, 13A

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Metadata

Authors
Szumlinski, K. K., Lominac, K. D., Kleschen, M. J., Oleson, E. B., Dehoff, M. H., Schwartz, M. K., Seeberg, P. H., Worley, P. F., & Kalivas, P. W.
Affiliations
  • Medical University of South Carolina (US)
  • Johns Hopkins University (US)
  • Max Planck Institute for Medical Research (DE)
Corresponding author
Szumlinski, K. K.
ORCID
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2005-02-08
Volume
4
Issue
5
Pages
273-288
ISSN
  • 1601-183X (ISSN-L)
  • 1601-1848
DOI
10.1111/j.1601-183x.2005.00120.x
OpenAlex
W2069755036
Cited by
181
References
57
Citations by year
2025: 5 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 16 · 2012: 9
FWCI
8.02
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Genes Brain & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • National Institute of Mental Health (R01MH040817, MH-40817)
  • National Institute on Drug Abuse (DA14185, DA 11742, R21DA014185, R01DA011742)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Homer1, schizophrenia, postsynaptic density, glutamatergic synapses, prepulse inhibition, anxiety, behavioral despair, sucrose preference, glutamate, nucleus accumbens, prefrontal cortex, hypofrontality, single nucleotide polymorphisms, animal models of schizophrenia
MeSH terms
Homer Scaffolding Proteins, Animals, Behavior, Animal, Carrier Proteins, Conditioning, Operant, Exploratory Behavior, Female, Frontal Lobe, Humans, Male, Mice, Inbred C57BL, Neural Inhibition, Nucleus Accumbens, Phenotype, Schizophrenia, Gene Deletion, Mice, Knockout, Glutamic Acid, Maze Learning, Polymorphism, Single Nucleotide, Mice

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