Realistic expectations of prepulse inhibition in translational models for schizophrenia research
Open accessAbstract
Introduction Under specific conditions, a weak lead stimulus, or "prepulse", can inhibit the startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the prepulse, termed "prepulse inhibition" (PPI), is widely used in translational models to understand the biology of brainbased inhibitory mechanisms and their deficiency in neuropsychiatric disorders. In 1981, four published reports with "prepulse inhibition" as an index term were listed on Medline; over the past 5 years, new published Medline reports with "prepulse inhibition" as an index term have appeared at a rate exceeding once every 2.7 days (n=678). Most of these reports focus on the use of PPI in translational models of impaired sensorimotor gating in schizophrenia. This rapid expansion and broad application of PPI as a tool for understanding schizophrenia has, at times, outpaced critical thinking and falsifiable hypotheses about the relative strengths vs. limitations of this measure.Objectives This review enumerates the realistic expectations for PPI in translational models for schizophrenia research, and provides cautionary notes for the future applications of this important research tool.Conclusion In humans, PPI is not "diagnostic"; levels of PPI do not predict clinical course, specific symptoms, or individual medication responses. In preclinical studies, PPI is valuable for evaluating models or model organisms relevant to schizophrenia, "mapping" neural substrates of deficient PPI in schizophrenia, and advancing the discovery and development of novel therapeutics. Across species, PPI is a reliable, robust quantitative phenotype that is useful for probing the neurobiology and genetics of gating deficits in schizophrenia.
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Normalizing PPI deficits in rodent models has enabled drug discovery for potential antipsychotic medications, some of which have proven successful in treating schizophrenia.
“normalizing PPI deficits in rodent models has enabled drug discovery for potential antipsychotic medications [371], some of which have proven successful in treating schizophrenia [368,372].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [368]
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Cites
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892 · see citing works
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407 · see citing works
Dementia Praecox and Paraphrenia.
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-6-1058_8 · Cited by 2,906 · see citing works
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., Erdos, M. R., Stringham, H. M., Chines, P. S., Jackson, A. U., et al. (2007) · Science · doi:10.1126/science.1142382 · Cited by 2,753 · see citing works
BRAFF, D. L., Geyer, M. A., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100810 · Cited by 1,701 · see citing works
Self-citationGeyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484 · see citing works
Self-citationLacro, J. P., Dunn, L. B., Dolder, C. R., Leckband, S. G., & Jeste, D. V. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1007 · Cited by 1,383 · see citing works
Cannon, T. D., Cadenhead, K., Cornblatt, B., Woods, S. W., Addington, J., Walker, E., Seidman, L. J., Perkins, D., Tsuang, M., McGlashan, T., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.3 · Cited by 1,269 · see citing works
Disorders of attention and perception in early schizophrenia
McGhie, A., & Chapman, J. (1961) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1961.tb00936.x · Cited by 1,195 · see citing works
Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics
BRAFF, D. L., Stone, C., Callaway, E., Geyer, M. A., Glick, I. D., & Bali, L. (1978) · Psychophysiology · doi:10.1111/j.1469-8986.1978.tb01390.x · Cited by 1,171 · see citing works
Self-citationLinkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
Freedman, R., Coon, H., Myles-Worsley, M., Orr-Urtreger, A., Olincy, A., Davis, A., Polymeropoulos, M., Holik, J., Hopkins, J., Hoff, M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.587 · Cited by 1,141 · see citing works
The more or less startling effects of weak prestimulation
Graham, F. K. (1975) · Psychophysiology · doi:10.1111/j.1469-8986.1975.tb01284.x · Cited by 1,119 · see citing works
Swerdlow, N. R., Geyer, M. A., & BRAFF, D. L. (2001) · Psychopharmacology · doi:10.1007/s002130100799 · Cited by 1,053 · see citing works
Self-citationGating and Habituation of the Startle Reflex in Schizophrenic Patients
Braff, D. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030038005 · Cited by 1,027 · see citing works
Self-citationMaternal influenza infection causes marked behavioral and pharmacological changes in the offspring
Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025 · see citing works
A primary acoustic startle circuit: lesion and stimulation studies
Davis, M., Gendelman, D. S., Tischler, M., & Gendelman, P. M. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-06-00791.1982 · Cited by 967 · see citing works
Carter, R. J., Lione, L. A., Humby, T., Mangiarini, L., Mahal, A., Bates, G. P., Dunnett, S. B., & Morton, A. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-03248.1999 · Cited by 949 · see citing works
Adler, L. E., Pachtman, E., Franks, R. D., Pecevich, M., Waldo, M. C., & Freedman, R. (1982) · PubMed · Cited by 896 · see citing works
Current Protocols in Neuroscience
(2018) · Current Protocols in Neuroscience · doi:10.1002/(issn)1934-8576 · Cited by 771 · see citing works
Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients
Swerdlow, N. R. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020063007 · Cited by 708 · see citing works
Self-citationSwerdlow, N. R., & Geyer, M. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033326 · Cited by 616 · see citing works
Self-citationDopaminergic stimulation disrupts sensorimotor gating in the rat
Mansbach, R. S., Geyer, M. A., & BRAFF, D. L. (1988) · Psychopharmacology · doi:10.1007/bf00212846 · Cited by 608 · see citing works
Self-citationLIBET, B., WRIGHT, E. W. W., FEINSTEIN, B., & PEARL, D. K. (1979) · Brain · doi:10.1093/brain/102.1.193 · Cited by 589 · cited 2× · see citing works
“While clearly a point for more systematic analysis, such a notion suggests a biological mechanism that is syntonic with psychological models for the intrusion of unedited, preconscious content into conscious awareness in this disorder (Libet et al. 1979; Gray 1995; Swerdlow 1996; Grobstein 2005).”
BackgroundThe Mammalian Startle Response
Davis, M. (1984) · Springer eBooks · doi:10.1007/978-1-4899-2286-1_10 · Cited by 582 · see citing works
Behavioral phenotypes of Disc1 missense mutations in mice
Clapcote, S. J., Lipina, T. V., Millar, J. K., Mackie, S., Christie, S., Ogawa, F., Lerch, J. P., Trimble, K., Uchiyama, M., Sakuraba, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.015 · Cited by 526 · see citing works
The acoustic startle response in rats—circuits mediating evocation, inhibition and potentiation
Koch, M., & Schnitzler, H. U. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)02296-1 · Cited by 521 · see citing works
Psychiatric endophenotypes and the development of valid animal models
Gould, T. D., & Gottesman, I. I. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00186.x · Cited by 507 · see citing works
Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432926100 · Cited by 489 · see citing works
INPUT DYSFUNCTION IN SCHIZOPHRENIA.
Ph, V. (1964) · PubMed · Cited by 473 · see citing works
Ozawa, K., Hashimoto, K., Kishimoto, T., Shimizu, E., Ishikura, H., & Iyo, M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.031 · Cited by 467 · see citing works
BRAFF, D. L., Freedman, R., Schork, N. J., & Gottesman, I. I. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl049 · Cited by 454 · see citing works
Self-citationSwerdlow, N. R., Paulsen, J. S., BRAFF, D. L., Butters, N., Geyer, M. A., & Swenson, M. R. (1995) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.2.192 · Cited by 436 · see citing works
Self-citationSchneider, M., & Koch, M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300225 · Cited by 425 · see citing works
Neural mechanisms of startle behavior
(1987) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(87)90199-4 · Cited by 415 · see citing works
Mismatch Negativity Deficits Are Associated With Poor Functioning in Schizophrenia Patients
Light, G. A., & Braff, D. L. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.127 · Cited by 407 · see citing works
Self-citationSensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results
Castellanos, F. X., Fine, E. J., Kaysen, D. L., Marsh, W., Rapoport, J. L., & Hallett, M. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00101-8 · Cited by 395 · see citing works
Swerdlow, N. R., BRAFF, D. L., & Geyer, M. A. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200006000-00002 · Cited by 392 · see citing works
Self-citationSwerdlow, N. R., Caine, S. B., BRAFF, D. L., & Geyer, M. A. (1992) · Journal of Psychopharmacology · doi:10.1177/026988119200600210 · Cited by 388 · see citing works
Self-citationAntipsychotic Medication Adherence: Is There a Difference Between Typical and Atypical Agents?
Dolder, C. R., Lacro, J. P., Dunn, L. B., & Jeste, D. V. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.103 · Cited by 385 · see citing works
Initial Heritability Analyses of Endophenotypic Measures for Schizophrenia
Greenwood, T. A., BRAFF, D. L., Light, G. A., Cadenhead, K. S., Calkins, M. E., Dobie, D. J., Freedman, R., Green, M. F., Gur, R. E., Gur, R. C., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.11.1242 · Cited by 382 · see citing works
Self-citationPaylor, R. E., Pourcain, B. S., Mupo, A., Ataliotis, P., Spencer, C. M., Sobotka, A., Sparks, C., Choi, C.-H., Oghalai, J. S., Curran, S. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600206103 · Cited by 381 · see citing works
Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat*1
Mansbach, R. S. (1989) · Neuropsychopharmacology · doi:10.1016/0893-133x(89)90035-3 · Cited by 380 · see citing works
Geyer, M. A., Wilkinson, L. S., Humby, T., & Robbins, T. W. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90180-l · Cited by 377 · see citing works
Schizophrenia-Relevant Behavioral Testing in Rodent Models: A Uniquely Human Disorder?
Powell, C. M., & Miyakawa, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.008 · Cited by 368 · see citing works
Lipska, B. K., Weinberger, D. R., Swerdlow, N. R., Geyer, M. A., BRAFF, D. L., & Jaskiw, G. E. (1995) · Psychopharmacology · doi:10.1007/bf02246439 · Cited by 356 · see citing works
Self-citationA preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder
Swerdlow, N. R., Benbow, C. H., Zisook, S., Geyer, M. A., & BRAFF, D. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90300-3 · Cited by 351 · see citing works
Self-citationFragile X mice develop sensory hyperreactivity to auditory stimuli
Chen, L., & Toth, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00036-7 · Cited by 345 · see citing works
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
Kaifu, T., Nakahara, J., Inui, M., Mishima, K., Momiyama, T., Kaji, M., Sugahara, A., Koito, H., Ujike, A., Nakamura, A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16923 · Cited by 342 · see citing works
Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics
Swerdlow, N. R., BRAFF, D. L., Geyer, M. A., & Koob, G. F. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90005-3 · Cited by 341 · see citing works
Self-citationSwerdlow, N. R., Light, G. A., Cadenhead, K. S., Sprock, J., Hsieh, M. H., & Braff, D. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1325 · Cited by 339 · see citing works
Self-citationEvidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia
Mukai, J., Liu, H., Burt, R., Swor, D. E., Lai, W., Karayiorgou, M., & Gogos, J. A. (2004) · Nature Genetics · doi:10.1038/ng1375 · Cited by 315 · see citing works
Raamsdonk, J. M. V., Pearson, J., Slow, E., Hossain, S. M., Leavitt, B. R., & Hayden, M. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0590-05.2005 · Cited by 315 · see citing works
Diverse Psychotomimetics Act Through a Common Signaling Pathway
Svenningsson, P., Tzavara, E. T., Carruthers, R., Rachleff, I., Wattler, S., Nehls, M. C., McKinzie, D. L., Fienberg, A. A., Nomikos, G. G., & Greengard, P. (2003) · Science · doi:10.1126/science.1089681 · Cited by 313 · see citing works
Information-processing deficits and thought disorder in schizophrenia
Perry, W., & BRAFF, D. L. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.3.363 · Cited by 311 · see citing works
Self-citationBorrell, J. I. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00360-8 · Cited by 307 · see citing works
Addington, J., Cadenhead, K. S., Cannon, T. D., Cornblatt, B., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., Woods, S. W., et al. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl075 · Cited by 299 · see citing works
Schneider, T., Turczak, J., & Przewłocki, R. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300767 · Cited by 298 · see citing works
Kinney, G. G., O’Brien, J. A., Lemaire, W., Burno, M., Bickel, D. J., Clements, M. K., Chen, T., Wisnoski, D. D., Lindsley, C. W., Tiller, P. R., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.079244 · Cited by 298 · see citing works
Koenig, J. I., Elmer, G. I., Shepard, P. D., Lee, P. R., Mayo, C. L., Joy, B., Hercher, E., & Brady, D. L. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.030 · Cited by 297 · see citing works
Mouse genetic models for prepulse inhibition: an early review
Geyer, M. A., McIlwain, K. L., & Paylor, R. E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001159 · Cited by 289 · see citing works
Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia
BRAFF, D. L., Geyer, M. A., Light, G. A., Sprock, J., Perry, W., Cadenhead, K. S., & Swerdlow, N. R. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00139-0 · Cited by 288 · see citing works
Self-citationSensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice.
Frankland, P. W., Wang, Y., Rosner, B., Shimizu, T., Balleine, B. W., Dykens, E. M., Ornitz, E. M., & Silva, A. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001432 · Cited by 275 · see citing works
Koch, M., Kungel, M., & Herbert, H. (1993) · Experimental Brain Research · doi:10.1007/bf00228818 · Cited by 272 · see citing works
Grillon, C., Morgan, C. A., Davis, M., & Southwick, S. M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00034-1 · Cited by 263 · see citing works
Fox, G. B., Esbenshade, T. A., Pan, J. B., Radek, R. J., Krueger, K. M., Yao, B. B., Browman, K. E., Buckley, M. J., Ballard, M. E., Komater, V. A., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.078402 · Cited by 260 · see citing works
Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania
Perry, W., Minassian, A., Feifel, D., & Braff, D. L. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01184-2 · Cited by 260 · see citing works
Self-citationTremolizzo, L., Doueiri, M.-S., Dong, E., Grayson, D. R., Davis, J. M., Pinna, G., Tueting, P. A., Rodriguez‐Menendez, V., Costa, E., & Guidotti, A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.046 · Cited by 257 · see citing works
Swerdlow, N. R., Hartman, P. L., & Auerbach, P. P. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00065-0 · Cited by 254 · see citing works
Self-citationLeppert, M., Burt, R. W., Hughes, J. P., Samowitz, W. S., Nakamura, Y., Woodward, S. R., Gardner, E. J., Lalouel, J.-M., & White, R. L. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003293221306 · Cited by 252 · see citing works
The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia
Wolinsky, T., Swanson, C., Smith, K. E., Zhong, H., Borowsky, B., Seeman, P., Branchek, T., & Gerald, C. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00292.x · Cited by 245 · see citing works
Normalization of Information Processing Deficits in Schizophrenia With Clozapine
Kumari, V., Soni, W., & Sharma, T. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1046 · Cited by 245 · see citing works
Deficits in prepulse inhibition and habituation in never-medicated, first-episode schizophrenia
Ludewig, K., Geyer, M. A., & Vollenweider, F. X. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01925-x · Cited by 240 · see citing works
Chiu, C., Brickley, S. G., Jensen, K., Southwell, A. L., McKinney, S. L., Cull-Candy, S. G., Módy, I., & Lester, H. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3364-04.2005 · Cited by 238 · see citing works
Anxiolytic-Like Properties of the Anandamide Transport Inhibitor AM404
Bortolato, M., Campolongo, P., Mangieri, R. A., Scattoni, M. L., Frau, R., Trezza, V., Rana, G. L., Russo, R., Calignano, A., Gessa, G. L., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301061 · Cited by 233 · see citing works
Subjective Referral of the Timing for a Conscious Sensory Experience
Libet, B., Wright, E. W., FEINSTEIN, B., & Pearl, D. K. (1993) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-0355-1_9 · Cited by 232 · see citing works
Fortier, M., Luheshi, G. N., & Boksa, P. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.04.016 · Cited by 229 · see citing works
The contents of consciousness: A neuropsychological conjecture
Gray, J. A. (1995) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00040395 · Cited by 221 · see citing works
Depoortère, R., Dargazanli, G., Estenne‐Bouhtou, G., Coste, A., Lanneau, C., Desvignes, C., Poncelet, M., Héaulme, M., Santucci, V., Decobert, M., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300772 · Cited by 220 · see citing works
Men are more inhibited than women by weak prepulses
Swerdlow, N. R., Auerbach, P. P., Monroe, S. M., Hartston, H. J., Geyer, M. A., & BRAFF, D. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90079-s · Cited by 220 · see citing works
Self-citationMeasurement of Startle Response, Prepulse Inhibition, and Habituation
Geyer, M. A., & Swerdlow, N. R. (1998) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0807s03 · Cited by 219 · see citing works
Self-citationSwerdlow, N. R., & Geyer, M. A. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.1.104 · Cited by 217 · see citing works
Self-citationPreattentional and attentional cognitive deficits as targets for treating schizophrenia
BRAFF, D. L., & Light, G. A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1848-0 · Cited by 213 · see citing works
Self-citationCui, C., Booker, T. K., Allen, R. S., Grady, S. R., Whiteaker, P., Marks, M. J., Salminen, O., Tritto, T., Butt, C. M., Allen, W. R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11045.2003 · Cited by 213 · see citing works
Boyce‐Rustay, J. M., & Holmes, A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301039 · Cited by 209 · see citing works
Effective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients
Weike, A. I., Bauer, U., & Hamm, A. O. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00229-2 · Cited by 206 · see citing works
Vanover, K. E., Weiner, D. M., Makhay, M. M., Veinbergs, I., Gardell, L. R., Lameh, J., Tredici, A. L. D., Piu, F., Schiffer, H. H., Ott, T. R., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.097006 · Cited by 206 · see citing works
Yee, B. K., Keist, R., von Boehmer, L., Studer, R., Benke, D., Hagenbuch, N., Dong, Y., Malenka, R. C., Fritschy, J.-M., Bluethmann, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508752102 · Cited by 201 · see citing works
Prepulse inhibition and latent inhibition: the role of dopamine in the medial prefrontal cortex
Ellenbroek, B. A., Budde, S., & Cools, A. R. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00307-7 · Cited by 197 · see citing works
Duncan, G. E., Moy, S. S., Perez, A., Eddy, D. M., Zinzow-Kramer, W. M., Lieberman, J. A., Snouwaert, J. N., & Koller, B. H. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.01.008 · Cited by 194 · see citing works
Swerdlow, N. R., & Geyer, M. A. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.1.104 · Cited by 192 · see citing works
Self-citationClozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia
Swerdlow, N. R., & Geyer, M. A. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90193-w · Cited by 191 · see citing works
Self-citationGene knockout of glycine transporter 1: Characterization of the behavioral phenotype
Tsai, G. E., Ralph, R. J., Martina, M., Bergeron, R., Berger-Sweeney, J. E., Dunham, K. S., Jiang, Z., Caine, S. B., & Coyle, J. T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402662101 · Cited by 190 · see citing works
Light, G. A., Swerdlow, N. R., & BRAFF, D. L. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.10.1624 · Cited by 188 · see citing works
Self-citationEndogenous kynurenic acid disrupts prepulse inhibition.
Erhardt, S., Schwieler, L., Emanuelsson, C., & Geyer, M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.006 · Cited by 187 · see citing works
Impaired Prepulse Inhibition of Acoustic Startle in Obsessive-Compulsive Disorder
Hoenig, K., Hochrein, A., Quednow, B. B., Maier, W., & Wagner, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.040 · Cited by 185 · see citing works
Szumlinski, K. K., Lominac, K. D., Kleschen, M. J., Oleson, E. B., Dehoff, M. H., Schwartz, M. K., Seeberg, P. H., Worley, P. F., & Kalivas, P. W. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00120.x · Cited by 181 · see citing works
Swerdlow, N. R., Karban, B., Ploum, Y., Sharp, R. F., Geyer, M. A., & Eastvold, A. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01164-7 · Cited by 181 · see citing works
Self-citationWiedholz, L. M., Owens, W. A., Horton, R. E., Feyder, M. J., Karlsson, R.-M., Hefner, K. R., Sprengel, R., Celikel, T., Daws, L. C., & Holmes, A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002056 · Cited by 180 · see citing works
Behavioural characterization of Vitamin D receptor knockout mice
Burne, T. H. J., McGrath, J. J., Eyles, D. W., & Mackay‐Sim, A. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.07.008 · Cited by 179 · see citing works
Erbel-Sieler, C., Dudley, C., Zhou, Y., Wu, X., Estill, S. J., Han, T., Diaz-Arrastia, R., Brunskill, E. W., Potter, S. S., & McKnight, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405310101 · Cited by 178 · see citing works
Galici, R., Echemendia, N. G., Rodriguez, A. L., & Conn, P. J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.091074 · Cited by 175 · see citing works
Ralph, R. J., Varty, G. B., Kelly, M. A., Wang, Y.-M., Caron, M. G., Rubinstein, M., Grandy, D. K., Low, M. J., & Geyer, M. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04627.1999 · Cited by 174 · see citing works
Cannabidiol Reverses MK-801-Induced Disruption of Prepulse Inhibition in Mice
Long, L. E., Malone, D. T., & TAYLOR, D. A. H. B. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300838 · Cited by 173 · see citing works
Pen, G. L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00383-9 · Cited by 173 · see citing works
Kinney, G. G., Sur, C., Burno, M., Mallorga, P. J., Williams, J. B., Figueroa, D. J., Wittmann, M., Lemaire, W., & Conn, P. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07586.2003 · Cited by 172 · see citing works
Lovic, V., & Fleming, A. S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00206-7 · Cited by 170 · see citing works
Boucher, A. A., Arnold, J. C., Duffy, L., Schofield, P. R., Micheau, J., & Karl, T. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0721-3 · Cited by 168 · see citing works
Behavioral characterization of dopamine D-sub-5 receptor null mutant mice.
Holmes, A., Hollon, T. R., Gleason, T., Liu, Z., Dreiling, J. L., Sibley, D. R., & Crawley, J. N. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.5.1129 · Cited by 166 · see citing works
Swerdlow, N. R., Martinez, Z. A., Hanlon, F. M., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04325.2000 · Cited by 163 · see citing works
Self-citationLong‐term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism
Harris, L. W., Sharp, T., Gartlon, J. E., Jones, D. N. C., & Harrison, P. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02902.x · Cited by 162 · see citing works
Calkins, M. E., Dobie, D. J., Cadenhead, K. S., D, A. O. M., Freedman, R., Green, M. F., Greenwood, T. A., Gur, R. E., Gur, R. C., Light, G. A., et al. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl044 · Cited by 160 · see citing works
Self-citationKumari, V., Gray, J. A., Geyer, M. A., Ffytche, D. H., Soni, W., Mitterschiffthaler, M. T., Vythelingum, G. N., Simmons, A., Williams, S., & Sharma, T. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(02)00123-3 · Cited by 159 · see citing works
Lipina, T. V., Labrie, V., Weiner, I., & Roder, J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2210-x · Cited by 159 · see citing works
Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity
Kanes, S., Tokarczyk, J., Siegel, S. J., Bilker, W. B., Abel, T. G., & Kelly, M. P. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.026 · Cited by 158 · see citing works
Afonso, V. M., Sison, M., Lovic, V., & Fleming, A. S. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.3.515 · Cited by 152 · see citing works
Clinical and Sensorimotor Gating Effects of Ketamine in Normals
Duncan, E. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00240-2 · Cited by 150 · see citing works
Menstrual cycle phase effects on prepulse inhibition of acoustic startle
Jovanović, T., Szilagyi, S., Chakravorty, S., Fiallos, A. M., Lewison, B., Parwani, A., Schwartz, M. P., Gonzenbach, S., Rotrosen, J., & Duncan, E. (2004) · Psychophysiology · doi:10.1111/1469-8986.2004.00166.x · Cited by 148 · see citing works
Harte, M., Powell, S. B., Swerdlow, N. R., Geyer, M. A., & Reynolds, G. P. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0627-6 · Cited by 146 · see citing works
Self-citationMarquis, K. L., Sabb, A. L., Logue, S. F., Brennan, J. A., Piesla, M. J., Comery, T. A., Grauer, S. M., Ashby, C. R., Nguyen, H. Q., Dawson, L. A., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.106989 · Cited by 145 · see citing works
Mackeprang, T., Kristiansen, K. T., & Glenthoj, B. Y. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01409-9 · Cited by 144 · see citing works
Nyffeler, M., Meyer, U., Yee, B. K., Feldon, J., & Knuesel, I. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.029 · Cited by 139 · see citing works
Romero, E., Ali, C., Molina‐Holgado, E., Castellano, B., Guaza, C., & Borrell, J. I. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301292 · Cited by 138 · see citing works
Sex differences in prepulse inhibition deficits in chronic schizophrenia
Kumari, V., Aasen, I., & Sharma, T. (2003) · Schizophrenia Research · doi:10.1016/j.schres.2003.09.010 · Cited by 136 · see citing works
“Normal” personality correlates of sensorimotor, cognitive, and visuospatial gating
Swerdlow, N. R., Filion, D. L., Geyer, M. A., & Braff, D. L. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00138-s · Cited by 134 · see citing works
Self-citationCP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity.
Siuciak, J., Chapin, D., McCarthy, S. A., Guanowsky, V., Brown, J. A., Chiang, P., Marala, R., Patterson, T., Seymour, P., Swick, A., et al. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.024 · Cited by 132 · see citing works
The Muscarinic Receptor Agonist Xanomeline Has an Antipsychotic-Like Profile in the Rat
Stanhope, K. J., Mirza, N. R., Bickerdike, M. J., et al. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29291-0 · Cited by 132 · see citing works
Peri-pubertal maturation after developmental disturbance: A model for psychosis onset in the rat
Pen, G. L., Gourévitch, R., Hazane, F., Hoareau, C., Jay, T. M., & Krebs, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.004 · Cited by 131 · see citing works
G protein-coupled receptors in major psychiatric disorders
Catapano, L. A., & Manji, H. K. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.025 · Cited by 131 · see citing works
Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis
Karper, L., Freeman, G., Grillon, C., Morgan, C. A., Charney, D. S., & Krystal, J. H. (1996) · Journal of Neuropsychiatry · doi:10.1176/jnp.8.1.60 · Cited by 130 · see citing works
Day-Wilson, K. M., Jones, D. N. C., Southam, E., Cilia, J., & Totterdell, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.048 · Cited by 129 · see citing works
Kumari, V., Soni, W., & Sharma, T. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.286 · Cited by 126 · see citing works
LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease
Harrison, S. M., Reavill, C., Brown, G., Brown, J. T., Cluderay, J. E., Crook, B., Davies, C. H., Dawson, L. A., Grau, E., Heidbreder, C. A., et al. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.09.001 · Cited by 126 · see citing works
Pillai-Nair, N., Panicker, A. K., Rodriguiz, R. M., Gilmore, K. L., Demyanenko, G. P., Huang, Z. J., Wetsel, W. C., & Maness, P. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0565-05.2005 · Cited by 125 · see citing works
Weil, Z. M., Hotchkiss, A. K., Gatien, M. L., Pieke-Dahl, S., & Nelson, R. J. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.09.016 · Cited by 125 · see citing works
Ouagazzal, A., Jenck, F., & Moreau, J.-L. (2001) · Psychopharmacology · doi:10.1007/s002130100763 · Cited by 124 · see citing works
Early maternal deprivation and prepulse inhibition
Ellenbroek, B. A., & Cools, A. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00794-3 · Cited by 124 · see citing works
Razoux, F., Garcia, R., & Léna, I. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301057 · Cited by 123 · see citing works
Leumann, L., Feldon, J., Vollenweider, F. X., & Ludewig, K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01344-6 · Cited by 123 · see citing works
Risbrough, V. B., Hauger, R. L., Roberts, A. L., Vale, W., & Geyer, M. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5760-03.2004 · Cited by 123 · see citing works
Kumari, V., Antonova, E., Geyer, M. A., Ffytche, D. H., Williams, S., & Sharma, T. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706007139 · Cited by 121 · see citing works
Genomic survey of bipolar illness in the NIMH genetics initiative pedigrees: A preliminary report
Nürnberger, J. I., DePaulo, J. R., Gershon, E. S., Reich, T., Blehar, M. C., Edenberg, H. J., Foroud, T., Miller, M., Bowman, E. S., Mayeda, A. R., et al. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970531)74:3 · Cited by 121 · see citing works
Effects of the 5-HT7 receptor antagonist SB-258741 in animal models for schizophrenia
Pouzet, B., Didriksen, M., & Arnt, J. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00744-4 · Cited by 120 · see citing works
Reduced prepulse inhibition in unaffected siblings of schizophrenia patients
Kumari, V., Das, M., Zachariah, E., Ettinger, U., & Sharma, T. (2005) · Psychophysiology · doi:10.1111/j.1469-8986.2005.00346.x · Cited by 120 · see citing works
Knockout mouse model for Fxr2: a model for mental retardation
Bontekoe, C. J. M. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.5.487 · Cited by 120 · see citing works
Adage, T., Trillat, A., Quattropani, A., Perrin, D., Cavarec, L., Shaw, J., Guerassimenko, O., Giachetti, C., Greco, B. M., Chumakov, I. M., et al. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.06.006 · Cited by 119 · see citing works
Ralph, R. J., Paulus, M. P., Zhuang, X., Hen, R., & Geyer, M. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01489-0 · Cited by 119 · see citing works
Abel, K. M., Waikar, M. V., Pedro, B. M., Hemsley, D., & Geyer, M. A. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200402 · Cited by 119 · see citing works
Park, C., Falls, W. A., Finger, J. H., Longo-Guess, C. M., & Ackerman, S. L. (2002) · Nature Genetics · doi:10.1038/ng908 · Cited by 118 · see citing works
STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating
Fradley, R. L., O’Meara, G. F., Newman, R. J., Andrieux, A., Job, D., & Reynolds, D. S. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.05.012 · Cited by 116 · see citing works
Stability of the acoustic startle reflex, prepulse inhibition, and habituation in schizophrenia
Ludewig, K., Geyer, M. A., Etzensberger, M., & Vollenweider, F. X. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00198-0 · Cited by 115 · see citing works
Spencer, C. M., Serysheva, E., Yuva‐Paylor, L. A., Oostra, B. A., Nelson, D. L., & Paylor, R. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl121 · Cited by 115 · see citing works
Neurobiological Measures of Schizotypal Personality Disorder: Defining an Inhibitory Endophenotype?
Cadenhead, K. S., Light, G. A., Geyer, M. A., McDowell, J. E., & BRAFF, D. L. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.869 · Cited by 114 · see citing works
Self-citationLower Prepulse Inhibition in Children With the 22q11 Deletion Syndrome
Sobin, C. A., Kiley‐Brabeck, K., & Karayiorgou, M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1090 · Cited by 111 · see citing works
Ralph, R. J., Masten, V. L., Otero-Corchón, V., Low, M. J., & Geyer, M. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09604.2002 · Cited by 110 · see citing works
Weiss, I. C., Iorio, L. D., Feldon, J., & Domeney, A. M. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.2.364 · Cited by 109 · see citing works
Hippocampal α5 subunit-containing GABAA receptors modulate the expression of prepulse inhibition
Hauser, J., Rudolph, U., Keist, R., Möhler, H., Feldon, J., & Yee, B. K. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001554 · Cited by 109 · see citing works
Csomor, P., Stadler, R. R., Feldon, J., Yee, B. K., Geyer, M. A., & Vollenweider, F. X. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301421 · Cited by 109 · see citing works
Tenn, C., Fletcher, P., & Kapur, S. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00009-4 · Cited by 109 · see citing works
Pen, G. L., Kew, J. N. C., Alberati, D., Borroni, E., Heitz, M., & Moreau, J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00374-3 · Cited by 108 · see citing works
Ligneau, X., Landais, L., Perrin, D., Piriou, J., Uguen, M., Denis, E., Robert, P., Parmentier, R., Anaclet, C., Lin, J., et al. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.01.023 · Cited by 107 · see citing works
Low dose ketamine increases prepulse inhibition in healthy men
Abel, K. M., Allin, M. P. G., Hemsley, D. R., & Geyer, M. A. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00073-x · Cited by 106 · see citing works
Futamura, T., Kakita, A., Tohmi, M., Sotoyama, H., Takahashi, H., & Nawa, H. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001138 · Cited by 106 · see citing works
Postma, P., Gray, J. A., Sharma, T., Geyer, M. A., Mehrotra, R., Das, M., Zachariah, E., Hines, M., Williams, S., & Kumari, V. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0307-5 · Cited by 105 · see citing works
Paine, T. A., Tomasiewicz, H. C., Zhang, K., & Carlezon, W. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.017 · Cited by 105 · see citing works
Zhang, L., Shirayama, Y., Iyo, M., & Hashimoto, K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301313 · Cited by 105 · see citing works
Temporal order judgement for auditory and visual stimuli
Kanabus, M., Szela̧g, E., Rojek, E., & Pöppel, E. (2002) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2002-1443 · Cited by 105 · see citing works
Dopamine D1 Rather than D2 Receptor Agonists Disrupt Prepulse Inhibition of Startle in Mice
Ralph-Williams, R. J., Lehmann-Masten, V., & Geyer, M. A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300017 · Cited by 105 · see citing works
Quednow, B. B., Wagner, M., Westheide, J., Beckmann, K., Bliesener, N., Maier, W., & Kühn, K.-U. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.012 · Cited by 104 · see citing works
Ferguson, S. A., & Cada, A. M. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.12.014 · Cited by 103 · see citing works
Ouagazzal, A. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00282-2 · Cited by 103 · see citing works
Ralph, R. J., & Caine, S. B. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.074468 · Cited by 103 · see citing works
George, T. P., Termine, A., Sacco, K. A., Allen, T. M., Reutenauer, E. L., Vessicchio, J. C., & Duncan, E. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.022 · Cited by 103 · see citing works
Barr, A. M., Lehmann-Masten, V., Paulus, M., Gainetdinov, R. R., Caron, M. G., & Geyer, M. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300343 · Cited by 103 · see citing works
Oranje, B., van Oel, C. J., Wied, C. C. G., Verbaten, M. N., & Kahn, R. S. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200208000-00005 · Cited by 103 · see citing works
Aasen, I., Kolli, L., & Kumari, V. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105048890 · Cited by 101 · see citing works
Cadenhead, K. S., Carasso, B. S., Swerdlow, N. R., Geyer, M. A., & BRAFF, D. L. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00294-7 · Cited by 98 · see citing works
Self-citationKumari, V., Soni, W., & Sharma, T. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00276-6 · Cited by 98 · see citing works
Wang, C., McInnis, J., West, J. B., Bao, J., Anastasio, N. C., Guidry, J. A., Ye, Y., Salvemini, D., & Johnson, K. M. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041798 · Cited by 98 · see citing works
Sensory Modulation of the Blink Reflex in Patients With Blepharospasm
Gómez-Wong, E. (1998) · Archives of Neurology · doi:10.1001/archneur.55.9.1233 · Cited by 98 · see citing works
The heterozygous reeler mouse: behavioural phenotype
Podhorná, J., & Didriksen, M. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.033 · Cited by 97 · see citing works
Bitsios, P., Giakoumaki, S. G., Theou, K., & Frangou, S. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.04.001 · Cited by 97 · see citing works
Vollenweider, F. X., Remensberger, S., Hell, D., & Geyer, M. A. (1999) · Psychopharmacology · doi:10.1007/s002130050960 · Cited by 97 · see citing works
Sallinen, J., Höglund, I. P. J., Engström, M., Lehtimäki, J., Virtanen, R., Sirviö, J., Wurster, S., Savola, J., & Haapalinna, A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707005 · Cited by 97 · see citing works
Terry, A. V., Gearhart, D. A., Beck, W. D., Truan, J. N., Middlemore, M.-L., Williamson, L. N., Bartlett, M. G., Prendergast, M., Sickles, D. W., & Buccafusco, J. J. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125625 · Cited by 97 · see citing works
Rehn, A., van den Buuse, M., Copolov, D., Briscoe, T. A., Lambert, G. W., & Rees, S. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.047 · Cited by 95 · see citing works
Krebs-Thomson, K., Ruiz, E. M., Masten, V. L., Buell, M. R., & Geyer, M. A. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0566-1 · Cited by 95 · see citing works
Effect of d -amphetamine on prepulse inhibition of the startle reflex in humans
Hutchison, K. E., & Swift, R. M. (1999) · Psychopharmacology · doi:10.1007/s002130050964 · Cited by 95 · see citing works
Valls‐Solé, J., Muñoz, J. E., & Valldeoriola, F. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.02.014 · Cited by 95 · see citing works
Disruption of prepulse inhibition in mice lacking mGluR1
Brody, S. A., Conquet, F., & Geyer, M. A. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03073.x · Cited by 94 · see citing works
Husum, H., Termeer, E. H., Mathé, A. A., Bolwig, T. G., & Ellenbroek, B. A. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00038-2 · Cited by 94 · see citing works
Calkins, M. E. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2003.12.005 · Cited by 94 · see citing works
Abnormalities of the blink reflex in Gilles de la Tourette syndrome.
Smith, S. J., & Lees, A. J. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.7.895 · Cited by 91 · see citing works
Ma, J., & Leung, L.-W. S. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0667-x · Cited by 90 · see citing works
Braff, D. L., Light, G. A., & Swerdlow, N. R. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.015 · Cited by 90 · see citing works
Self-citationBubeníková, V., Votava, M., Horáček, J., Páleníček, T., & Dockery, C. A. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.012 · Cited by 90 · see citing works
Porras‐García, E., Cendelín, J., del Toro, E. D., Vožeh, F., & Delgado-Garcia, J. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03940.x · Cited by 90 · see citing works
Midbrain pathways for prepulse inhibition and startle activation in rat
Yeomans, J. S., Lee, J. C., Yeomans, M. H., Steidl, S., & Li, L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.025 · Cited by 90 · see citing works
Kumari, V., Antonova, E., Zachariah, E., Galea, A., Aasen, I., Ettinger, U., Mitterschiffthaler, M. T., & Sharma, T. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.03.002 · Cited by 89 · see citing works
Swerdlow, N. R. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00110-3 · Cited by 87 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Prepulse inhibition and genetic mouse models of schizophrenia
Powell, S. B., Zhou, X., & Geyer, M. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.021 · Cited by 218 · see citing works
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
Ali, F., Gerhard, D. M., Sweasy, K., Pothula, S., Pittenger, C., Duman, R. S., & Kwan, A. C. (2020) · Nature Communications · doi:10.1038/s41467-019-13809-8 · Cited by 196 · see citing works
Milekic, M. H., Xin, Y., O’Donnell, A., Kumar, K. K., Bradley-Moore, M., Malaspina, D., Moore, H., Brunner, D., Ge, Y., Edwards, J., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.84 · Cited by 190 · see citing works
Hartmann, M. N., Hager, O. M., Reimann, A. V., Chumbley, J. R., Kirschner, M., Seifritz, E., Tobler, P. N., & Kaiser, S. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu102 · Cited by 200 · see citing works
Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes
Cahill, M. E., Xie, Z., Day, M., Photowala, H., Barbolina, M. V., Miller, C. A., Weiss, C., Radulovic, J., Sweatt, J. D., Disterhoft, J. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904636106 · Cited by 170 · see citing works
Kocsis, B. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.002 · Cited by 159 · see citing works
Abnormal sleep spindles, memory consolidation, and schizophrenia
Manoach, D. S., & Stickgold, R. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095754 · Cited by 157 · see citing works
A Review of Oxytocin’s Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia
Feifel, D., Shilling, P. D., & MacDonald, K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.025 · Cited by 110 · see citing works
Sleep deprivation disrupts prepulse inhibition and induces psychosis-like symptoms in healthy humans
Petrovsky, N., Ettinger, U., Hill, A., Frenzel, L., Meyhofer, I., Wagner, M., Backhaus, J., & Kumari, V. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0904-14.2014 · Cited by 102 · see citing works
Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm
Missig, G., Ayers, L. W., Schulkin, J., & Rosen, J. B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.155 · Cited by 79 · see citing works
Preclinical Behavioral Models for Predicting Antipsychotic Activity
Castagné, V., Moser, P. C., & Porsolt, R. D. (2009) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)57010-4 · Cited by 64 · see citing works
Chamera, K., Szuster-Głuszczak, M., Trojan, E., & Basta-Kaim, A. (2020) · Cells · doi:10.3390/cells9071676 · Cited by 31 · see citing works
Leppä, E., Linden, A.-M., Vekovischeva, O. Y., Swinny, J. D., Rantanen, V., Toppila, E., Höger, H., Sieghart, W., Wulff, P., Wisden, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024159 · Cited by 30 · see citing works
Effect of <scp>L</scp>‐theanine on sensorimotor gating in healthy human subjects
Ota, M., Wakabayashi, C., Matsuo, J., Kinoshita, Y., Hori, H., Hattori, K., Sasayama, D., Teraishi, T., Obu, S., Ozawa, H., et al. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12134 · Cited by 16 · see citing works
Acoustic prepulse inhibition: one ear is better than two, but why and when?
Kumari, V., Hamid, A., Brand, A., & Antonova, E. (2015) · Psychophysiology · doi:10.1111/psyp.12391 · Cited by 8 · see citing works
- Authors
- Swerdlow, N. R., Weber, M., Qu, Y., Light, G. A., & Braff, D. L.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Swerdlow, Neal R.
- Venue
- Psychopharmacology
- Published
- 2008-06-21
- Volume
- 199
- Issue
- 3
- Pages
- 331-388
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC2771731
- OpenAlex
- W2062472783
- Cited by
- 529
- References
- 478
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 13 · 2023: 18 · 2022: 19 · 2021: 23 · 2020: 31 · 2019: 21 · 2018: 23 · 2017: 30 · 2016: 38 · 2015: 42 · 2014: 31 · 2013: 51 · 2012: 38
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pfizer
- National Alliance for Research on Schizophrenia and Depression
- ACADIA Pharmaceuticals
- Allergan
- Pfizer Pharmaceuticals
- National Institute of Mental Health (MH 53484, MH68366, R01MH069589, MH65571, MH69589, MH42228, R01MH068366, R37MH042228, R01MH053484, R01MH042228, R01MH059803, MH 79777, MH 58903, R01MH065571, R01MH079777)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- prepulse inhibition, schizophrenia, sensorimotor gating, translational model, animal models of schizophrenia, startle response, inhibition mechanism, preclinical drug screening, quantitative phenotypes, model organisms
- MeSH terms
- Animals, Disease Models, Animal, Humans, Models, Psychological, Schizophrenia, Schizophrenic Psychology, Reflex, Startle, Antipsychotic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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