The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia
Abstract
Homer proteins are involved in the functional assembly of postsynaptic density proteins at glutamatergic synapses and are implicated in learning, memory and drug addiction. Here, we report that Homer1-knockout (Homer1-KO) mice exhibit behavioral and neurochemical abnormalities that are consistent with the animal models of schizophrenia. Relative to wild-type mice, Homer1-KO mice exhibited deficits in radial arm maze performance, impaired prepulse inhibition, enhanced 'behavioral despair', increased anxiety in a novel objects test, enhanced reactivity to novel environments, decreased instrumental responding for sucrose and enhanced MK-801- and methamphetamine-stimulated motor behavior. No-net-flux in vivo microdialysis revealed a decrease in extracellular glutamate content in the nucleus accumbens and an increase in the prefrontal cortex. Moreover, in Homer1-KO mice, cocaine did not stimulate a rise in frontal cortex extracellular glutamate levels, suggesting hypofrontality. These behavioral and neurochemical data derived from Homer1 mutant mice are consistent with the recent association of schizophrenia with a single-nucleotide polymorphism in the Homer1 gene and suggest that the regulation of extracellular levels of glutamate within limbo-corticostriatal structures by Homer1 gene products may be involved in the pathogenesis of this neuropsychiatric disorder.
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“Interestingly, mouse models have shown that a number of proteins associated with glutamate receptors, some of which are directly linked with schizophrenia susceptibility genes, have been suggested to show modifications in patients, which in turn cause schizophrenia-like phenotypes.86,87”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [86]
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Research works printed but not linked: 1
- Smothers C.T., 2003, Effects of Homer2 deletion on the development of ethanol tolerance and NMDA receptor function in mice, Alcohol Clin Exp Res, 27, 13A
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Realistic expectations of prepulse inhibition in translational models for schizophrenia research
Swerdlow, N. R., Weber, M., Qu, Y., Light, G. A., & Braff, D. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1072-4 · Cited by 529
Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457
van den Buuse, M. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp132 · Cited by 352
Overview of Brain Microdialysis
Chefer, V. I., Thompson, A. C., Zapata, A. G., & Shippenberg, T. S. (2009) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0701s47 · Cited by 332
Shiraishi‐Yamaguchi, Y., & Furuichi, T. (2007) · Genome biology · doi:10.1186/gb-2007-8-2-206 · Cited by 343
Metadata
- Authors
- Szumlinski, K. K., Lominac, K. D., Kleschen, M. J., Oleson, E. B., Dehoff, M. H., Schwartz, M. K., Seeberg, P. H., Worley, P. F., & Kalivas, P. W.
- Affiliations
- Medical University of South Carolina (US)
- Johns Hopkins University (US)
- Max Planck Institute for Medical Research (DE)
- Corresponding author
- Szumlinski, K. K.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2005-02-08
- Volume
- 4
- Issue
- 5
- Pages
- 273-288
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2069755036
- Cited by
- 181
- References
- 57
- Citations by year
- 2025: 5 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 16 · 2012: 9
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH040817, MH-40817)
- National Institute on Drug Abuse (DA14185, DA 11742, R21DA014185, R01DA011742)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Homer1, schizophrenia, postsynaptic density, glutamatergic synapses, prepulse inhibition, anxiety, behavioral despair, sucrose preference, glutamate, nucleus accumbens, prefrontal cortex, hypofrontality, single nucleotide polymorphisms, animal models of schizophrenia
- MeSH terms
- Homer Scaffolding Proteins, Animals, Behavior, Animal, Carrier Proteins, Conditioning, Operant, Exploratory Behavior, Female, Frontal Lobe, Humans, Male, Mice, Inbred C57BL, Neural Inhibition, Nucleus Accumbens, Phenotype, Schizophrenia, Gene Deletion, Mice, Knockout, Glutamic Acid, Maze Learning, Polymorphism, Single Nucleotide, Mice
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