Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia
Open accessAbstract
Dysregulated glutamatergic neurotransmission has been strongly implicated in the pathophysiology of schizophrenia (SCZ). Recently, presynaptic modulation of glutamate transmission has been shown to have therapeutic promise. We asked whether genetic knockdown of glutaminase (gene GLS1) to reduce glutamatergic transmission presynaptically by slowing the recycling of glutamine to glutamate, would produce a phenotype relevant to SCZ and its treatment. GLS1 heterozygous (GLS1 het) mice showed about a 50% global reduction in glutaminase activity, and a modest reduction in glutamate levels in brain regions relevant to SCZ pathophysiology, but displayed neither general behavioral abnormalities nor SCZ-associated phenotypes. Functional imaging, measuring regional cerebral blood volume, showed hippocampal hypometabolism mainly in the CA1 subregion and subiculum, the inverse of recent clinical imaging findings in prodromal and SCZ patients. GLS1 het mice were less sensitive to the behavioral stimulating effects of amphetamine, showed a reduction in amphetamine-induced striatal dopamine release and in ketamine-induced frontal cortical activation, suggesting that GLS1 het mice are resistant to the effects of these pro-psychotic challenges. Moreover, GLS1 het mice showed clozapine-like potentiation of latent inhibition, suggesting that reduction in glutaminase has antipsychotic-like properties. These observations provide further support for the pivotal role of altered glutamatergic synaptic transmission in the pathophysiology of SCZ, and suggest that presynaptic modulation of the glutamine-glutamate pathway through glutaminase inhibition may provide a new direction for the pharmacotherapy of SCZ.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The gln/glu ratio increase may reflect a deficiency in glutaminase, the enzyme that converts glutamine into glutamate, which results in reduced glutamate levels and increased glutamine levels in the frontal region.
“This may reflect a deficiency in glutaminase, the enzyme that converts glutamine into glutamate, which results in reduced glutamate levels and increased glutamine levels in the frontal region.61”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971 · see citing works
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,406 · see citing works
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180 · see citing works
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
BRAFF, D. L., Geyer, M. A., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100810 · Cited by 1,701 · see citing works
Recognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,555 · see citing works
An <i>in vivo</i> correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353 · see citing works
Self-citationLaruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning
LeDoux, J., Cicchetti, P., Xagoraris, A., & Romanski, L. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01062.1990 · Cited by 1,167 · see citing works
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
Nakazawa, K., Quirk, M. C., Chitwood, R. A., Watanabe, M., Yeckel, M. F., Sun, L. D., Kato, A., Carr, C. A., Johnston, D., Wilson, M. A., et al. (2002) · Science · doi:10.1126/science.1071795 · Cited by 1,090 · see citing works
Patil, S. T., Zhang, L., Martenyi, F., Lowe, S. L., Jackson, K. A., Andreev, B. V., Avedisova, A. S., Bardenstein, L. M., Gurovich, I. Y., Morozova, M. A., et al. (2007) · Nature Medicine · doi:10.1038/nm1632 · Cited by 1,040 · see citing works
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034 · see citing works
NMDA receptor hypofunction model of schizophrenia
Olney, J. W., Newcomer, J. W., & Farber, N. B. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00029-1 · Cited by 1,020 · see citing works
Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats
Moghaddam, B., & Adams, B. W. (1998) · Science · doi:10.1126/science.281.5381.1349 · Cited by 1,006 · see citing works
Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724 · see citing works
Regulation of Glutaminase Activity and Glutamine Metabolism
Curthoys, N. P., & Watford, M. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.001025 · Cited by 643 · see citing works
Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048520.34839.1a · Cited by 569 · see citing works
Javitt, D. C. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78003-5 · Cited by 563 · see citing works
Kellendonk, C., Simpson, E. H., Polan, H. J., Malleret, G., Vronskaya, S., Winiger, V., Moore, H., & Kandel, E. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.023 · Cited by 520 · see citing works
Self-citationLodge, D., & Grace, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2847-07.2007 · Cited by 475 · see citing works
Astrocytic control of glutamatergic activity: astrocytes as stars of the show
Hertz, L., & Zielke, H. R. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.10.008 · Cited by 470 · see citing works
Neuroimaging studies of the hippocampus in schizophrenia
Heckers, S. (2001) · Hippocampus · doi:10.1002/hipo.1068 · Cited by 420 · see citing works
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.805 · Cited by 392 · see citing works
Weiner, I. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1313-x · Cited by 387 · see citing works
Inbred strain differences in prepulse inhibition of the mouse startle response
Paylor, R. E., & Crawley, J. N. (1997) · Psychopharmacology · doi:10.1007/s002130050333 · Cited by 382 · see citing works
Schobel, S., Lewandowski, N. M., Corcoran, C. M., Moore, H. M., Brown, T. R., Malaspina, D., & Small, S. A. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.115 · Cited by 364 · see citing works
Self-citationMoore, H. M., Jentsch, J. D., Ghajarnia, M., Geyer, M. A., & Grace, A. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.003 · Cited by 359 · see citing works
Self-citationRole for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory
Remondes, M., & Schuman, E. M. (2004) · Nature · doi:10.1038/nature02965 · Cited by 352 · see citing works
Honey, R. C., & Good, M. A. (1993) · Behavioral Neuroscience · doi:10.1037//0735-7044.107.1.23 · Cited by 336 · see citing works
Curthoys, N. P., & Lowry, O. H. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44458-x · Cited by 326 · see citing works
Modeling madness in mice: one piece at a time
Arguello, P. A., & Gogos, J. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.023 · Cited by 309 · see citing works
Mouse genetic models for prepulse inhibition: an early review
Geyer, M. A., McIlwain, K. L., & Paylor, R. E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001159 · Cited by 289 · see citing works
Cognitive Inflexibility and Pre-frontal Dysfunction in Schizophrenia and Mania
Morice, R. D. (1990) · The British Journal of Psychiatry · doi:10.1192/bjp.157.1.50 · Cited by 276 · see citing works
Honey, R. C., & Good, M. A. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.1.23 · Cited by 274 · see citing works
Chen, W., Mahadomrongkul, V., Berger, U. V., Bassan, M., DeSilva, T. M., Tanaka, K., Irwin, N., Aoki, C. J., & Rosenberg, P. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1586-03.2004 · Cited by 267 · see citing works
Paterlini, M., Zakharenko, S. S., Lai, W., Qin, J., Zhang, H., Mukai, J., Westphal, K. G. C., Olivier, B., Sulzer, D. L., Pavlidis, P., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1562 · Cited by 265 · see citing works
Self-citationDo patients with schizophrenia exhibit aberrant salience?
Roiser, J. P., Stephan, K. E., den Ouden, H. E. M., Barnes, T. R. E., Friston, K. J., & Joyce, E. M. (2009) · Psychological Medicine · doi:10.1017/s0033291708003863 · Cited by 262 · see citing works
Daumas, S., Halley, H., Francès, B., & Lassalle, J. (2005) · Learning & Memory · doi:10.1101/lm.81905 · Cited by 259 · see citing works
Probing the human hippocampus using rCBF: Contrasts in schizophrenia
Medoff, D. R., Holcomb, H. H., Lahti, A. C., & Tamminga, C. A. (2001) · Hippocampus · doi:10.1002/hipo.1070 · Cited by 257 · see citing works
What does the hippocampus really do?
Jarrard, L. E. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00034-8 · Cited by 249 · see citing works
The pharmacology of latent inhibition as an animal model of schizophrenia
Moser, P. C., Hitchcock, J. M., Lister, S., & Moran, P. M. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00026-6 · Cited by 244 · see citing works
Paradoxical influence of hippocampal neurogenesis on working memory
Saxe, M., Malleret, G., Vronskaya, S., Mendez‐David, I., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., & Hen, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611718104 · Cited by 244 · see citing works
Self-citationDias, R. S., & Aggleton, J. P. (2000) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01323.x · Cited by 221 · see citing works
Transient Overexpression of Striatal D2 Receptors Impairs Operant Motivation and Interval Timing
Drew, M. R., Simpson, E., Kellendonk, C., Herzberg, W., Lipatova, O., Fairhurst, S. P., Kandel, E., Malapani, C., & Balsam, P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1736-07.2007 · Cited by 220 · see citing works
Self-citationChaudhry, F. A., Reimer, R. J., & Edwards, R. H. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201070 · Cited by 206 · see citing works
Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial
Tiihonen, J., Hallikainen, T., Ryynänen, O., Repo‐Tiihonen, E., Kotilainen, I., Eronen, M., Toivonen, P., Wahlbeck, K., & Putkonen, A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00524-9 · Cited by 191 · see citing works
Dunn, L. A., Atwater, G. E., & Kilts, C. D. (1993) · Psychopharmacology · doi:10.1007/bf02244927 · Cited by 171 · see citing works
Tordera, R. M., Totterdell, S., Wojcik, S. M., Brose, N., Elizalde, N., Lasheras, B., & del Rı́o, J. A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05259.x · Cited by 169 · see citing works
Anxiogenic effects of methyl-β-carboline-3-carboxylate in a light/dark choice situation
Belzung, C., Misslin, R., Vogel, E., Dodd, R. H., & Chapouthier, G. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90006-2 · Cited by 169 · see citing works
Boyer, P., Phillips, J. L., Rousseau, F. L., & Ilivitsky, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.12.008 · Cited by 168 · see citing works
Resting neural activity distinguishes subgroups of schizophrenia patients
Malaspina, D., Harkavy‐Friedman, J., Corcoran, C. M., Mujica-Parodi, L. R., PRINTZ, D. J., Gorman, J. M., & Heertum, R. V. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.013 · Cited by 166 · see citing works
Karlsson, R.-M., Tanaka, K., Saksida, L. M., Bussey, T. J., Heilig, M., & Holmes, A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.215 · Cited by 165 · see citing works
Jentsch, D. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00004-9 · Cited by 164 · see citing works
Lipina, T. V., Labrie, V., Weiner, I., & Roder, J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2210-x · Cited by 159 · see citing works
Rorick‐Kehn, L. M., Johnson, B. G., Knitowski, K. M., Salhoff, C. R., Witkin, J. M., Perry, K. W., Griffey, K. I., Tizzano, J. P., Monn, J. A., McKinzie, D. L., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0758-3 · Cited by 155 · see citing works
Impaired Motor Learning in Mice Expressing TorsinA with the DYT1 Dystonia Mutation
Sharma, N., Baxter, M. G., Petravicz, J., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0855-05.2005 · Cited by 145 · see citing works
The development of a cognitive model of schizophrenia: Placing it in context
Hemsley, D. R. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.12.008 · Cited by 141 · see citing works
Increased neural response related to neutral faces in individuals at risk for psychosis
Romanczuk‐Seiferth, N., Pauly, K. D., Habel, U., Kellermann, T., Shah, N. J., Ruhrmann, S., Klosterkötter, J., Schneider, F. W., & Kircher, T. T. J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.020 · Cited by 141 · see citing works
Takahata, R., & Moghaddam, B. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300127 · Cited by 140 · see citing works
Yee, B. K., Balic, E., Singer, P., Schwerdel, C., Grampp, T., Gabernet, L., Knuesel, I., Benke, D., Feldon, J., Möhler, H., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5120-05.2006 · Cited by 137 · see citing works
BDNF-mediated neurotransmission relies upon a myosin VI motor complex
Yano, H., Ninan, I., Zhang, H., Milner, T. A., Arancio, O., & Chao, M. V. (2006) · Nature Neuroscience · doi:10.1038/nn1730 · Cited by 134 · see citing works
Self-citationDuration judgements in patients with schizophrenia
Elvevåg, B., McCormack, T., Gilbert, A. L., Brown, G. D. A., Weinberger, D. R., & Goldberg, T. E. (2003) · Psychological Medicine · doi:10.1017/s0033291703008122 · Cited by 133 · see citing works
Masson, J., Darmon, M. C., Conjard‐Duplany, A., Chuhma, N., Ropert, N., Thoby‐Brisson, M., Foutz, A. S., Parrot, S., Miller, G. M., Jorisch, R., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4241-05.2006 · Cited by 131 · see citing works
Self-citationIntercellular metabolic compartmentation in the brain: past, present and future
Hertz, L. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.08.016 · Cited by 129 · see citing works
Steffek, A. E., McCullumsmith, R. E., Haroutunian, V. H., & Meador‐Woodruff, J. H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.032 · Cited by 124 · see citing works
Excitatory Synaptic Transmission Persists Independently of the Glutamate–Glutamine Cycle
Kam, K., & Nicoll, R. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1198-07.2007 · Cited by 124 · see citing works
Razoux, F., Garcia, R., & Léna, I. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301057 · Cited by 123 · see citing works
Contextual insensitivity in schizophrenic language processing: Evidence from lexical ambiguity.
Titone, D. A., Levy, D. L., & Holzman, P. S. (2000) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.109.4.761 · Cited by 115 · see citing works
Gozzi, A., Large, C. H., Schwarz, A. J., Bertani, S., Crestan, V., & Bifone, A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301547 · Cited by 114 · see citing works
Duncan, G. E., Miyamoto, S., Leipzig, J. N., & Lieberman, J. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01776-x · Cited by 110 · see citing works
Holcomb, H. H., Lahti, A. C., Medoff, D. R., Cullen, T. J., & Tamminga, C. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300824 · Cited by 108 · see citing works
Madl, J. E., Larson, A. A., & Beitz, A. J. (1986) · Journal of Histochemistry & Cytochemistry · doi:10.1177/34.3.2419390 · Cited by 107 · see citing works
Miyamoto, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00127-x · Cited by 105 · see citing works
Karlsson, R., Tanaka, K., Heilig, M. A., & Holmes, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.001 · Cited by 100 · see citing works
Gluck, M. R., Thomas, R. G., Davis, K. L., & Haroutunian, V. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1165 · Cited by 98 · see citing works
Mapping the central effects of ketamine in the rat using pharmacological MRI
Littlewood, C. L., Jones, N., O’Neill, M. J., Mitchell, S. N., Tricklebank, M. D., & Williams, S. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0344-0 · Cited by 97 · see citing works
Najlerahim, A., Harrison, P. J., BARTON, A. J. L., et al. (1990) · Molecular Brain Research · doi:10.1016/0169-328x(90)90082-o · Cited by 95 · see citing works
Moghaddam, B., & Bolinao, M. L. (1994) · Synapse · doi:10.1002/syn.890180409 · Cited by 95 · see citing works
Contextual insensitivity in schizophrenic language processing: Evidence from lexical ambiguity.
Titone, D. A., Levy, D. L., & Holzman, P. S. (2000) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.109.4.761 · Cited by 91 · see citing works
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania
Arban, R., Maraia, G., Brackenborough, K. T., Winyard, L. A., Wilson, A. W., Gerrard, P. A., & Large, C. H. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.08.015 · Cited by 91 · see citing works
Use of a modified prepulse inhibition paradigm to assess complex auditory discrimination in rodents
FITCH, R. H., Threlkeld, S. W., McClure, M. M., & Peiffer, A. M. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.07.013 · Cited by 91 · see citing works
Black, M. D., Varty, G. B., Arad, M., Barak, S., Levie, A. D., Boulay, D., Pichat, P., Griebel, G., & Weiner, I. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1289-2 · Cited by 83 · see citing works
Imaging the Aβ-Related Neurotoxicity of Alzheimer Disease
Moreno, H., Wu, W. E., Lee, T., Brickman, A. M., Mayeux, R. P., Brown, T. R., & Small, S. A. (2007) · Archives of Neurology · doi:10.1001/archneur.64.10.1467 · Cited by 82 · see citing works
Self-citationThe misattribution of salience in delusional patients with schizophrenia
Holt, D. J., Titone, D. A., Long, L. S., GOFF, D. C., Cather, C., Rauch, S. L., Judge, A. M., & Kuperberg, G. R. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.12.858 · Cited by 81 · see citing works
Gaisler‐Salomon, I., & Weiner, I. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1311-z · Cited by 72 · see citing works
Self-citationIncreased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia
Bruneau, E., McCullumsmith, R. E., Haroutunian, V. H., et al. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.12.012 · Cited by 70 · see citing works
The potential role of lamotrigine in schizophrenia
Large, C. H., Webster, E. L., & Goff, D. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0020-9 · Cited by 69 · see citing works
Elvevåg, B., Brown, G. D. A., McCormack, T., Vousden, J. I., & Goldberg, T. E. (2004) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.113.4.509 · Cited by 65 · see citing works
Soyka, M., Koch, W., Möller, H. ‐., Rüther, T., & Tatsch, K. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0563-0 · Cited by 62 · see citing works
Inhibition of glutamine synthetase activity prevents memory consolidation
Gibbs, M. E., O'Dowd, B. S., Hertz, L., et al. (1996) · Cognitive Brain Research · doi:10.1016/0926-6410(96)00020-1 · Cited by 61 · see citing works
Weiner, I. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00145-5 · Cited by 60 · see citing works
Nilsson, M., Waters, N., Waters, N., Carlsson, A., & Carlsson, M. L. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170008 · Cited by 59 · see citing works
Calas, A.-G., Richard, O. A., Même, S., et al. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.04.020 · Cited by 57 · see citing works
Handbook of medical psychiatry
Moore, D. P., & Jefferson, J. W. (1996) · Medical Entomology and Zoology · Cited by 52 · see citing works
Evaluating Glutamatergic Transmission in Schizophrenia
Tamminga, C. A., Lahti, A. C., Medoff, D. R., et al. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.062 · Cited by 48 · see citing works
David, H., Sissaoui, K., & Abraini, J. H. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.08.009 · Cited by 45 · see citing works
Proposed cycles for functional glutamate trafficking in synaptic neurotransmission
Maciejewski, P. K., & Rothman, D. L. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.09.015 · Cited by 45 · see citing works
Ichikawa, J., & Meltzer, H. Y. (1992) · Brain Research · doi:10.1016/0006-8993(92)90805-j · Cited by 35 · see citing works
Salience and psychosis: moving from theory to practise
Jensen, J., & Kapur, S. (2008) · Psychological Medicine · doi:10.1017/s0033291708003899 · Cited by 35 · see citing works
Molecular mechanism of schizophrenia with reference to disrupted-in-schizophrenia 1 (DISC1)
Matsuzaki, S., & Tohyama, M. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.018 · Cited by 34 · see citing works
Conjard‐Duplany, A., Brun, V., Martin, M., Baverel, G., & Ferrier, B. (2002) · Biochemical Journal · doi:10.1042/bj20020331 · Cited by 31 · see citing works
Self-citationMaeshima, H., Ohnuma, T., Sakai, Y., Shibata, N., Baba, H., Ihara, H., Higashi, M., Ohkubo, T., Nozawa, E., Abe, S., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.06.009 · Cited by 30 · see citing works
O’Leary‐Moore, S. K., Galloway, M. P., McMechan, A. P., et al. (2007) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.03.062 · Cited by 26 · see citing works
Self-citationZhang, B., Yuan, Y., Jia, Y., et al. (2004) · European Psychiatry · doi:10.1016/j.eurpsy.2004.09.028 · Cited by 25 · see citing works
Hunt, M. J., Garcia, R., Large, C. H., & Kasicki, S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.04.009 · Cited by 20 · see citing works
Deutsch, S. I., Long, K. D., Rosse, R. B., Tizabi, Y., Weizman, R., Eller, J., & Mastropaolo, J. P. (2006) · Contemporary clinical neuroscience · doi:10.1007/978-1-59745-058-4_10 · Cited by 13 · see citing works
Early spatial memory deficit induced by 2,5-hexanedione in the rat
Carney, R., Dardis, C., Cullen, W. K., et al. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(01)00538-0 · Cited by 10 · see citing works
Effects of neuroleptics on glutaminase from rat synaptosomes
Sherman, A. D., Hamrah, M., & Mott, J. (1988) · Neurochemical Research · doi:10.1007/bf00973293 · Cited by 9 · see citing works
Serotonergic Dysfunctions in Schizophrenia: Possible Therapeutic Implications
Verhoeff, J. T. A. N. P. L. G. (2003) · CRC Press eBooks · doi:10.3109/9780203912485-23 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Moghaddam, B., & Javitt, D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.181 · Cited by 1,035 · see citing works
Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457 · see citing works
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Xiang, Y., Stine, Z. E., Xia, J., Lu, Y., O’Connor, R. S., Altman, B. J., Hsieh, A. L., Gouw, A. M., Thomas, A. G., Gao, P., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci75836 · Cited by 409 · see citing works
Self-citationGDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution
Karaca, M., Frigerio, F., Migrenne, S., Martin-Levilain, J., Skytt, D. M., Pajecka, K., Martin-del-Rio, R., Gruetter, R., Tamarit-Rodriguez, J., Waagepetersen, H. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.003 · Cited by 60 · see citing works
Ji, C., Tang, Y., Zhang, Y., Huang, X., Li, C., Yang, Y., Wu, Q., Xia, X., Cai, Q., Qi, X.-R., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112712 · Cited by 16 · see citing works
- Authors
- Gaisler-Salomon, I., Miller, G. M., Chuhma, N., Lee, S., Zhang, H., Ghoddoussi, F., Lewandowski, N., Fairhurst, S., Wang, Y., Conjard-Duplany, A., Masson, J., Balsam, P., Hen, R., Arancio, O., Galloway, M. P., Moore, H. M., Small, S. A., & Rayport, S.
- Affiliations
- New York State Psychiatric Institute (US)
- Columbia University (US)
- Wayne State University (US)
- Inserm (FR)
- Corresponding author
- Small, Scott A
- Rayport, Stephen
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2009-06-10
- Volume
- 34
- Issue
- 10
- Pages
- 2305-2322
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC2811085
- OpenAlex
- W1978403015
- Cited by
- 86
- References
- 116
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 11 · 2014: 3 · 2013: 7 · 2012: 9
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Max-Planck-Gesellschaft
- National Institutes of Health (5p50mh066171-05)
- National Institute on Aging (R01AG025161, P50AG008702)
- National Institute of Mental Health (P50-MH066171, MH068073, R01MH068073)
- National Institute on Drug Abuse (R21DA014055, K02DA000356, T32DA016224, R01DA016736, R01DA016373)
- National Institute of Neurological Disorders and Stroke (R01NS049442, MH068073)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- glutaminase, GLS1, schizophrenia, glutamatergic neurotransmission, presynaptic glutamate release, amphetamine sensitivity, striatal dopamine release, latent inhibition, clozapine, regional cerebral blood volume, mouse model
- MeSH terms
- Acoustic Stimulation, Amphetamine, Central Nervous System Stimulants, Analysis of Variance, Animals, Behavior, Animal, Clozapine, Exploratory Behavior, Glutaminase, Hippocampus, Image Processing, Computer-Assisted, Inhibition, Psychological, Ketamine, Magnetic Resonance Imaging, Memory, Short-Term, Mice, Inbred C57BL, Motor Activity, Synaptic Transmission, Magnetic Resonance Spectroscopy, Oxygen, Protons, Reflex, Startle, Antipsychotic Agents, Microdialysis, Mice, Knockout, Excitatory Amino Acid Antagonists, Glutamic Acid, Maze Learning, Excitatory Postsynaptic Potentials, Freezing Reaction, Cataleptic, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
