Increased Plasma and Erythrocyte Selenium Concentrations but Decreased Erythrocyte Glutathione Peroxidase Activity after Selenium Supplementation in Children with Down Syndrome
Abstract
ABSTRACT. An investigation was made of the activity of glutathione peroxidase (GSH‐Px) in erythrocytes and the levels of selenium in plasma and erythrocytes before, during and after selenium supplementation in children with Down syndrome (DS). This subject is of interest since it has been suggested that selenium supplementation could enhance the GSH‐Px activity in erythrocytes, probably leading to unproved protection against oxygen radicals, which might cause damage by lipid peroxidation, especially in the brain. Forty‐eight children with DS were treated with selenium‐rich yeast tablets (10 μg/kg body weight/day) for 6 months. The supplementation was well tolerated and no side effects were observed. Selenium supplementation resulted in increased concentrations of selenium both in plasma and erythrocytes, but decreased GSH‐Px‐activity in erythrocytes. Plasma and erythrocyte selenium levels had almost regained the initial values 12 months after termination of the supplementation. Erythrocyte GSH‐Px activity, on the other hand, remained reduced and did not return to the presupplementation levels. Until we gain more knowledge about the biological functions of selenium in man and the role of oxygen metabolism in the development of presenile dementia in DS, universal selenium supplementation in DS patients cannot be recommended.
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Supplementation of children (6 months to 16 years) with selenium over 6 months caused reduced effect of GPx in erythrocytes.
“Unexpectedly, supplementation of children (from 6 months to 16 years of age) with selenium over a period of 6 months caused the reduced effect of GPx in erythrocytes (Anneren et al. 1989).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Anneren et al. 1989
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
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- Authors
- ANNEREN, G., GEBRE‐MEDHIN, M., & GUSTAVSON, K. ‐.
- Affiliations
- Uppsala University Hospital (SE)
- Uppsala University (SE)
- ORCID
- GEBRE‐MEDHIN, M.
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 1989-11
- Volume
- 78
- Issue
- 6
- Pages
- 879-884
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2110251149
- Cited by
- 15
- References
- 19
- Citations by year
- 2023: 1 · 2020: 1 · 2017: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- Down syndrome, selenium supplementation, erythrocyte glutathione peroxidase, plasma selenium, erythrocyte selenium, antioxidant enzymes, lipid peroxidation, oxygen free radicals, children, early-onset dementia
- MeSH terms
- Adolescent, Brain, Child, Child, Preschool, Down Syndrome, Erythrocytes, Female, Glutathione Peroxidase, Humans, Infant, Male, Selenium
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