Antioxidants in Down Syndrome: From Preclinical Studies to Clinical Trials

Melatonin as a natural ally against oxidative stress: a physicochemical examination

Galano, A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00916.x · Cited by 1,154 · see citing works

Down syndrome

Antonarakis, S. E., Skotko, B. G., Rafii, M. S., Strydom, A., Pape, S. E., Bianchi, D. W., Sherman, S. L., & Reeves, R. H. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0143-7 · Cited by 964 · see citing works

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

Manchester, L. C., Coto‐Montes, A. M., Boga, J. A., Andersen, L. P. H., Zhou, Z., Galano, A., Vriend, J. P., Tan, D. X., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12267 · Cited by 946 · see citing works

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

Busciglio, J., & Yankner, B. A. (1995) · Nature · doi:10.1038/378776a0 · Cited by 741 · see citing works

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L. J., Fisher, E. M. C., & Strydom, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3983 · Cited by 562 · see citing works

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

Tan, D.-X., Manchester, L., Qin, L., & Reiter, R. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122124 · Cited by 402 · see citing works

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., & Yankner, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00604-9 · Cited by 387 · see citing works

Curry Consumption and Cognitive Function in the Elderly

Ng, T. P., Chiam, P., Lee, T. M., Chua, H.-C., Lim, L. E. C., & Kua, E. H. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj267 · Cited by 353 · see citing works

Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome

Nunomura, A., Perry, G. L., Pappolla, M. A., Friedland, R. P., Hirai, K., Chiba, S., & Smith, M. A. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.11.1011 · Cited by 322 · see citing works

Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant

Wang, N., Tan, H., Li, S., Xu, Y., Guo, W., & Feng, Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7478523 · Cited by 293 · see citing works

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

de la Torre, R., de Sola, S., Hernández, G., Farré, M., Pujol, J., Rodríguez, J. C., Espadaler, J. M., Langohr, K., Cuenca‐Royo, A., Príncipe, A., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30034-5 · Cited by 291 · see citing works

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

Head, E., T. Lott, I., M. Wilcock, D., & A. Lemere, C. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666151020114607 · Cited by 289 · see citing works

Cellular Senescence in Neurodegenerative Diseases

Martínez‐Cué, C., & Rueda, N. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00016 · Cited by 285 · see citing works

Epigallocatechin‐3‐gallate, a DYRK1A inhibitor, rescues cognitive deficits in D own syndrome mouse models and in humans

de la Torre, R., Sola, S. D., Pons‐Espinal, M., Duchon, A., de Lagrán, M. M., Farré, M., Fitó, M., Benejam, B., Langohr, K., Rodríguez, J. C., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300325 · Cited by 283 · see citing works

Dementia in Down's syndrome

Ballard, C. G., Mobley, W. C., Hardy, J., Williams, G. H., & Corbett, A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00063-6 · Cited by 274 · see citing works

Prevalence of Down Syndrome Among Children and Adolescents in 10 Regions of the United States

Shin, M., Besser, L. M., Kucik, J. E., Lu, C., Siffel, C., Correa, A., & Collaborative, T. C. A. M. P. A. S. (. (2009) · PEDIATRICS · doi:10.1542/peds.2009-0745 · Cited by 259 · see citing works

Elevation in the Ratio of Cu/Zn-Superoxide Dismutase to Glutathione Peroxidase Activity Induces Features of Cellular Senescence and This Effect Is Mediated by Hydrogen Peroxide

de Haan, J. B., Cristiano, F., Iannello, R. C., Bladier, C., Kelner, M. J., & Kola, I. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.2.283 · Cited by 233 · see citing works

Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions

Dey, A., Bhattacharya, R., Mukherjee, A., & Pandey, D. K. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.005 · Cited by 232 · see citing works

Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis

Wilcock, D. M., & Griffin, W. S. T. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-84 · Cited by 230 · see citing works

Botanical Phenolics and Brain Health

Sun, A. Y., Wang, Q., Simonyi, Á., & Sun, G. Y. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8052-z · Cited by 225 · see citing works

Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial

Sanmukhani, J., Satodiya, V., Trivedi, J. S., Patel, T. K., Tiwari, D., Panchal, B. N., Goel, A., & Tripathi, C. B. (2013) · Phytotherapy Research · doi:10.1002/ptr.5025 · Cited by 208 · see citing works

Abnormalities of the nucleus basalis in Down's syndrome

Casanova, M. F., Walker, L. C., Whitehouse, P. J., & Price, D. L. (1985) · Annals of Neurology · doi:10.1002/ana.410180306 · Cited by 202 · see citing works

Trisomy 21 and early brain development

Haydar, T. F., & Reeves, R. H. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.001 · Cited by 200 · see citing works

Rodent models in Down syndrome research: impact and future opportunities

Hérault, Y., Delabar, J. M., Fisher, E., Tybulewicz, V. L. J., Yu, E. Y., & Brault, V. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.029728 · Cited by 191 · see citing works

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for down syndrome

Bianchi, P., Ciani, E., Guidi, S., Trazzi, S., Felice, D., Grossi, G., Fernandez, M., Giuliani, A., Calza, L., & Bartesaghi, R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0534-10.2010 · Cited by 188 · see citing works

Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia

Marzia Perluigi, A., & Butterfield, D. A. (2011) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/724904 · Cited by 180 · see citing works

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

Helguera, P. R., Seiglie, J., Rodríguez, J. A., Hanna, M., Helguera, G. F., & Busciglio, J. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.005 · Cited by 179 · see citing works

Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities

Rueda, N., Flórez, J., & Martínez-Cué, C. (2012) · Neural Plasticity · doi:10.1155/2012/584071 · Cited by 171 · see citing works

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

Butterfield, D. A., Marzia Perluigi, A., Reed, T. T., Muharib, T., Hughes, C. P., Robinson, R. A. S., & Rukhsana Sultana, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4109 · Cited by 167 · see citing works

Mouse models of Down syndrome: gene content and consequences

Gupta, M., Dhanasekaran, A. R., & Gardiner, K. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9661-8 · Cited by 167 · see citing works

Evaluation of Senescence in Mesenchymal Stem Cells Isolated from Equine Bone Marrow, Adipose Tissue, and Umbilical Cord Tissue

Vidal, M. A., Walker, N. J., Napoli, E., & Borjesson, D. L. (2011) · Stem Cells and Development · doi:10.1089/scd.2010.0589 · Cited by 165 · see citing works

The heme oxygenase system and its functions in the brain.

Maines, M. D. (2000) · PubMed · Cited by 158 · see citing works

Melatonin reverses H ₂ O ₂ ‐induced premature senescence in mesenchymal stem cells via the <scp>SIRT</scp> 1‐dependent pathway

Zhou, L., Chen, X., Liu, T., Gong, Y., Chen, S., Pan, G., Cui, W., Luo, Z., Pei, M., Yang, H., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12250 · Cited by 158 · see citing works

Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity

Chen, J., Chua, K., Chua, C. C., Yu, H., Pei, A., Chua, B. H. L., Hamdy, R. C., Xu, X., & Liu, C.-F. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.054 · Cited by 153 · see citing works

Cu/Zn-superoxide dismutase and glutathione peroxidase during aging.

de Haan, J. B., Cristiano, F., Iannello, R. C., & Kola, I. (1995) · PubMed · Cited by 139 · see citing works

Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

Lott, I. T., Doran, E., Nguyen, V. Q., Tournay, A., Head, E., & Gillen, D. L. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34114 · Cited by 136 · see citing works

Usp16 contributes to somatic stem-cell defects in Down’s syndrome

Adorno, M., Sikandar, S. S., Mitra, S. S., Kuo, A. H., di Robilant, B. N., Acosta, V. H., Ouadah, Y., Quarta, M., Rodriguez, J., Qian, D., et al. (2013) · Nature · doi:10.1038/nature12530 · Cited by 134 · see citing works

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain

Domenico, F. D., Coccia, R., Cocciolo, A., Murphy, M. P., Cenini, G., Head, E., Butterfield, D. A., Giorgi, A., Schininà, M. E., Mancuso, C., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.013 · Cited by 133 · see citing works

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

Valenti, D., Manente, G. A., Moro, L., Marra, E., & Vacca, R. A. (2011) · Biochemical Journal · doi:10.1042/bj20101908 · Cited by 133 · see citing works

The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model

Valenti, D., Lidia de, B. A. R. I., Rasmo, D. D., Signorile, A., Henrion‐Caude, A., Contestabile, A., & Vacca, R. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.03.003 · Cited by 128 · see citing works

Fetal Down Syndrome Brains Exhibit Aberrant Levels of Neurotransmitters Critical for Normal Brain Development

Whittle, N., Sartori, S. B., Dierssen, M., Lubec, G., & Singewald, N. (2007) · Pediatrics · doi:10.1542/peds.2006-3448 · Cited by 127 · see citing works

Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome

Bayen, É., Possin, K. L., Chen, Y., de Langavant, L. C., & Yaffe, K. S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.2210 · Cited by 125 · see citing works

Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome

Kim, S. H., Vlkolinský, R., Cairns, N. J., & Lübec, G. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000661 · Cited by 124 · see citing works

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

Bordi, M., Darji, S., Sato, Y., Mellén, M., Berg, M. J., Kumar, A., Jiang, Y., & Nixon, R. A. (2019) · Cell Death &amp; Disease · doi:10.1038/s41419-019-1752-5 · Cited by 124 · see citing works

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

Lockrow, J. P., Prakasam, A., Huang, P., Bimonte‐Nelson, H. A., Sambamurti, K., & Granholm, A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.021 · Cited by 123 · see citing works

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

Cenini, G., Dowling, A. L. S., Beckett, T. L., Barone, E., Mancuso, C., Murphy, M. P., LeVine, H., Lott, I. T., Schmitt, F. A., Butterfield, D. A., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.001 · Cited by 122 · see citing works

Neurogenesis impairment: An early developmental defect in Down syndrome

Stagni, F., Giacomini, A., Emili, M., Guidi, S., & Bartesaghi, R. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.07.026 · Cited by 120 · see citing works

Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome

Ebrahim, A. S., Shimohata, A., Akagi, T., Yu, W., Yamaguchi, M., Murayama, M., Chui, D., Takeuchi, T., Amano, K., Subramhanya, K. H., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl211 · Cited by 118 · see citing works

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

Lockrow, J. P., Boger, H. A., Bimonte‐Nelson, H. A., & Granholm, A. C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.036 · Cited by 116 · see citing works

Early Glycoxidation Damage in Brains from Down's Syndrome

Odetti, P. R., Angelini, G., Dapino, D., Zaccheo, D., Garibaldi, S., Dagna-Bricarelli, F., Piombo, G., Perry, G. L., Smith, M. A., Traverso, N., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8186 · Cited by 116 · see citing works

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

Shichiri, M., Yoshida, Y., Ishida, N., Hagihara, Y., Iwahashi, H., Tamai, H., & Niki, E. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.023 · Cited by 115 · see citing works

Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury

Esposito, G., Imitola, J., Lu, J., De Filippis, D., Scuderi, C., Ganesh, V. S., Folkerth, R., Hecht, J., Shin, S., Iuvone, T., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddm322 · Cited by 115 · see citing works

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

Trazzi, S., Mitrugno, V. M., Valli, E., Fuchs, C., Rizzi, S., Guidi, S., Perini, G., Bartesaghi, R., & Ciani, E. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr033 · Cited by 112 · see citing works

Beta-Amyloid, Oxidative Stress and Down Syndrome

Lott, I. T., Head, E., Doran, E. W., & Busciglio, J. A. (2006) · Current Alzheimer Research · doi:10.2174/156720506779025305 · Cited by 110 · see citing works

The neurobiology of acetyl-L-carnitine

Traina, G. (2016) · Frontiers in bioscience · doi:10.2741/4459 · Cited by 109 · see citing works

Are oxidative stress and mitochondrial dysfunction the key players in the neurodegenerative diseases?

Carlo, M. D., Giacomazza, D., Picone, P., Nuzzo, D., & Biagio, P. L. S. (2012) · Free Radical Research · doi:10.3109/10715762.2012.714466 · Cited by 106 · see citing works

Redox proteomics and amyloid β-peptide: Insights into Alzheimer disease

Butterfield, D. A., & Boyd‐Kimball, D. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14589 · Cited by 105 · see citing works

Supplementation with antioxidants and folinic acid for children with Down’s syndrome: randomised controlled trial

Ellis, J., Tan, H. K., Gilbert, R. E., Muller, D. P. R., Henley, W., Moy, R. J., Pumphrey, R., Ani, C. C., Davies, S., Edwards, V., et al. (2008) · BMJ · doi:10.1136/bmj.39465.544028.ae · Cited by 101 · see citing works

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

Tramutola, A., Lanzillotta, C., Barone, E., Arena, A., Zuliani, I., Mosca, L., Blarzino, C., Butterfield, D. A., Marzia Perluigi, A., & Domenico, F. D. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0133-9 · Cited by 101 · see citing works

Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cells

Izzo, A., Nitti, M. P., Mollo, N., Paladino, S., Procaccini, C., Faicchia, D., Calı̀, G., Genesio, R., Bonfiglio, F., Cicatiello, R., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx016 · Cited by 100 · see citing works

Normalizing the gene dosage of Dyrk1A in a mouse model of down syndrome rescues several Alzheimer’s disease phenotypes

García-Cerro, S., Rueda, N., Vidal, V., Lantigua, S., & Martínez-Cué, C. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.06.010 · Cited by 100 · see citing works

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

Perluigi, M., di Domenico, F., Fiorini, A., Cocciolo, A., Giorgi, A., Foppoli, C., Butterfield, D. A., Giorlandino, M., Giorlandino, C., Eugenia Schininà, M., et al. (2011) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.201000121 · Cited by 97 · see citing works

Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects

Piccoli, C., Izzo, A., Scrima, R., Bonfiglio, F., Manco, R., Negri, R., Quarato, G., Cela, O., Ripoli, M. C., Prisco, M., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds529 · Cited by 96 · see citing works

Mitochondria as pharmacological targets in Down syndrome

Valenti, D., Braidy, N., Rasmo, D. D., Signorile, A., Rossi, L., Atanasov, A. G., Volpicella, M., Henrion‐Caude, A., Nabavi, S. M., & Vacca, R. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.014 · Cited by 96 · see citing works

NORADRENALINE IN ALZHEIMER-TYPE DEMENTIA AND DOWN SYNDROME

Yates, C. M., Ritchie, I. M., Simpson, J., Maloney, A. F. J., & Gordon, A. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90269-5 · Cited by 94 · see citing works

Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

Valenti, D., Tullo, A., Caratozzolo, M. F., Merafina, R. S., Scartezzini, P., Marra, E., & Vacca, R. A. (2010) · Biochemical Journal · doi:10.1042/bj20100581 · Cited by 93 · see citing works

Possible Compensatory Events in Adult Down Syndrome Brain Prior to the Development of Alzheimer Disease Neuropathology: Targets for Nonpharmacological Intervention

Head, E., Lott, I. T., Patterson, D. W., Doran, E. W., & Haier, R. J. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11110 · Cited by 89 · see citing works

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

Di Domenico, F., Tramutola, A., Foppoli, C., Head, E., Perluigi, M., & Butterfield, D. A. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.009 · Cited by 89 · see citing works

Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down Syndrome and Alzheimer’s disease

Balcz, B., Kirchner, L., Cairns, N. J., Fountoulakis, M., & Lübec, G. (2001) · Springer eBooks · doi:10.1007/978-3-7091-6262-0_15 · Cited by 88 · see citing works

ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons

Helguera, P., Pelsman, A., Pigino, G., Wolvetang, E., Head, E., & Busciglio, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5107-04.2005 · Cited by 88 · see citing works

Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein

Gómez, W., Morales, R., Maracaja‐Coutinho, V., Parra, V., & Nassif, M. (2020) · Aging · doi:10.18632/aging.102677 · Cited by 87 · see citing works

Antioxidants in Down syndrome

Lott, I. T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.010 · Cited by 82 · see citing works

Lithium Restores Neurogenesis in the Subventricular Zone of the Ts65Dn Mouse, a Model for Down Syndrome

Bianchi, P., Ciani, E., Contestabile, A., Guidi, S., & Bartesaghi, R. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00246.x · Cited by 80 · see citing works

Exosomal biomarkers in Down syndrome and Alzheimer's disease

Hamlett, E. D., Ledreux, A., Potter, H., Chial, H. J., Patterson, D., Espinosa, J. M., Bettcher, B. M., & Granholm, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.028 · Cited by 78 · see citing works

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome

Stagni, F., Giacomini, A., Emili, M., Trazzi, S., Guidi, S., Sassi, M., Ciani, E., Rimondini, R., & Bartesaghi, R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.07.031 · Cited by 76 · see citing works

Vitamin E: Mechanism of transport and regulation in the CNS

Lee, P., & Ulatowski, L. M. (2018) · IUBMB Life · doi:10.1002/iub.1993 · Cited by 76 · see citing works

Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer's Disease

Di Domenico, F., Pupo, G., Mancuso, C., Barone, E., Paolini, F., Arena, A., Blarzino, C., Schmitt, F. A., Head, E., Butterfield, D. A., et al. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-141254 · Cited by 75 · see citing works

Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and Dementia

Coskun, P. E., & Busciglio, J. A. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/383170 · Cited by 73 · see citing works

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

Tramutola, A., Lanzillotta, C., Di Domenico, F., Head, E., Butterfield, D. A., Perluigi, M., & Barone, E. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104772 · Cited by 73 · see citing works

Long‐term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle‐aged T s65 D n mice, a model of D own syndrome

Corrales, A., Martinez, P. M., García-Cerro, S., Vidal, V., García, E., Flórez, J., Sánchez‐Barceló, E. J., Martínez‐Cué, C., & Rueda, N. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12037 · Cited by 69 · see citing works

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

Domenico, F. D., Tramutola, A., Barone, E., Lanzillotta, C., Defever, O., Arena, A., Zuliani, I., Foppoli, C., Iavarone, F., Vincenzoni, F., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101162 · Cited by 69 · see citing works

Plant polyphenols as natural drugs for the management of Down syndrome and related disorders

Vacca, R. A., Valenti, D., Caccamese, S., Daglia, M., Braidy, N., & Nabavi, S. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.023 · Cited by 68 · see citing works

Increased lipid peroxidation in Down’s syndrome mouse models

Ishihara, K., Amano, K., Takaki, E., Ebrahim, A. S., Shimohata, A., Shibazaki, N., Inoue, I., Takaki, M., Ueda, Y., Sago, H., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06294.x · Cited by 67 · see citing works

GVS‐111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons

Pelsman, A., Hoyo‐Vadillo, C., Гудашева, Т. А., Середенин, С. Б., Ostrovskaya, R. U., & Busciglio, J. A. (2003) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(03)00031-5 · Cited by 65 · see citing works

Pharmacotherapy of Down syndrome

Palumbo, M. L., & McDougle, C. J. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1529167 · Cited by 64 · see citing works

Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down Syndrome

Contestabile, A., Fila, T., Bartesaghi, R., & Ciani, E. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00168.x · Cited by 63 · see citing works

A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS

Stagni, F., Giacomini, A., Guidi, S., Emili, M., Uguagliati, B., Salvalai, M. E., Bortolotto, V., Grilli, M., Rimondini, R., & Bartesaghi, R. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.018 · Cited by 63 · see citing works

Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome

Gulesserian, T., Engidawork, E., Fountoulakis, M., & Lübec, G. (2001) · Springer eBooks · doi:10.1007/978-3-7091-6262-0_6 · Cited by 62 · see citing works

Systemic oxidative stress in children and teenagers with Down syndrome

Garlet, T. R., Parisotto, E. B., de Medeiros, G. D. S., Pereira, L. C. R., Moreira, E. A. D. M., Dalmarco, E. M., Dalmarco, J. B., & Filho, D. W. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.08.017 · Cited by 62 · see citing works

Prenatal treatment of Down syndrome

Guedj, F., Bianchi, D. W., & Delabar, J. M. (2014) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000056 · Cited by 62 · see citing works

The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

Aivazidis, S., Coughlan, C. M., Rauniyar, A. K., Jiang, H. L., Liggett, L. A., Maclean, K. N., & Roede, J. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176307 · Cited by 62 · see citing works

Vitamin E in aging persons with Down syndrome

Sano, M. C., Aisen, P. S. S., Andrews, H., Tsai, W., Lai, F., Dalton, A. J., McCallion, P., Zendell, A. L., Mintz, M., Young, J. M., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002714 · Cited by 61 · see citing works

Oxidative Stress and Down Syndrome. Do Antioxidants Play a Role in Therapy?

Muchová, J., Žitňanová, I., & Ďuračková, Z. (2014) · Physiological Research · doi:10.33549/physiolres.932722 · Cited by 60 · see citing works

Overexpression of S100β in Down’s syndrome: correlation with patient age and with β‐amyloid deposition

Royston, McKenzie, Gentleman, Sheng, Mann, Griffin, & Mrak (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00196.x · Cited by 59 · see citing works

Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms

Ulatowski, L. M., Dreussi, C., Noy, N., Barnholtz‐Sloan, J. S., Klein, E. A., & Manor, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.528 · Cited by 59 · see citing works

Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study

Gimeno, A., García‐Giménez, J. L., Audı́, L., Torán, N., Andaluz, P., Dası́, F., Viña, J., & Pallardó, F. V. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.014 · Cited by 59 · see citing works

Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of Down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes

Stringer, M., Abeysekera, I., Thomas, J. R., LaCombe, J., Stancombe, K., Stewart, R. B., Dria, K. J., Wallace, J. M., Goodlett, C. R., & Roper, R. J. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.05.003 · Cited by 59 · see citing works

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

Zamponi, E., Zamponi, N., Coskun, P., Quassollo, G., Lorenzo, A., Cannas, S., Pigino, G., Chialvo, D., Gardiner, K., Busciglio, J., et al. (2018) · Aging Cell · doi:10.1111/acel.12812 · Cited by 59 · see citing works

Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: Insights from proteomics

Marzia Perluigi, A., Domenico, F. D., & Butterfield, D. A. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300066 · Cited by 58 · see citing works

The astroglial-derived S100β protein stimulates the expression of nitric oxide synthase in rodent macrophages through p38 MAP kinase activation

Esposito, G., Filippis, D. D., Cirillo, C., Sarnelli, G., Cuomo, R., & Iuvone, T. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.023 · Cited by 57 · see citing works

Systematic review and meta-analysis shows a specific micronutrient profile in people with Down Syndrome: Lower blood calcium, selenium and zinc, higher red blood cell copper and zinc, and higher salivary calcium and sodium

Saghazadeh, A., Mahmoudi, M., Ashkezari, A. D., Rezaie, N., & Rezaei, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175437 · Cited by 57 · see citing works

DNA damage and repair in children with Down's syndrome

Morawiec, Z., Janik-Papis, K., Kowalski, M., Stetkiewicz, T., Szaflik, J., Morawiec-Bajda, A., Sobczuk, A., & Błasiak, J. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.07.010 · Cited by 55 · see citing works

Peroxiredoxin 2 ( PRDX2 ), an antioxidant enzyme, is underexpressed in Down syndrome fetal brains

Sánchez-Font, M. F., Sebasti�, J., Sanfeliu, C., Crist�fol, R., Marfany, G., & Gonz�les-Duarte, R. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3048-1 · Cited by 55 · see citing works

Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21

Rodríguez‐Sureda, V., García, Á. V., Sánchez, O., Audı́, L., & Domı́nguez, C. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/509241 · Cited by 54 · see citing works

Positron Emission Tomography and Neuropathologic Estimates of Fibrillar Amyloid-β in a Patient With Down Syndrome and Alzheimer Disease

Sabbagh, M. N. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.535 · Cited by 52 · see citing works

Effect of Leucovorin (Folinic Acid) on the Developmental Quotient of Children with Down's Syndrome (Trisomy 21) and Influence of Thyroid Status

Bléhaut, H., Mircher, C., Ravel, A., Conte, M., de Portzamparc, V., Poret, G., de Kermadec, F. H., Rethoré, M. O., & Sturtz, F. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008394 · Cited by 51 · see citing works

Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of D own syndrome

Corrales, A., Vidal, R., García-Cerro, S., Vidal, V., Martinez, P. M., García, E., Flórez, J., Sánchez‐Barceló, E. J., Martínez‐Cué, C., & Rueda, N. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12097 · Cited by 51 · see citing works

Amyloid-β impairs development of neuronal progenitor cells by oxidative mechanisms

Mazur‐Kolecka, B., Golabek, A. A., Nowicki, K., Flory, M. J., & Frackowiak, J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.006 · Cited by 48 · see citing works

Mitochondrial dysfunction in mouse trisomy 16 brain

Bambrick, L. L., & Fiskum, G. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.045 · Cited by 48 · see citing works

Nutritional supplementation in Down syndrome: theoretical considerations and current status

Ani, C. C., Grantham‐McGregor, S., & Muller, D. P. R. (2000) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162200000359 · Cited by 48 · see citing works

Vitamin and Mineral Supplementation in Down's Syndrome

Bennett, F. C., McClelland, S., Kriegsmann, E., Andrus, L. B., & Sells, C. J. (1983) · PEDIATRICS · doi:10.1542/peds.72.5.707 · Cited by 47 · see citing works

Age-dependent oxidative stress-induced DNA damage in Down’s lymphocytes

Zana, M., Szécsényi, A., Czibula, Á., Bjelik, A., Juhász, A., Rimanóczy, Á., Szabó, K., Vetró, Á., Szűcs, P., Várkonyi, Á., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.04.167 · Cited by 45 · see citing works

Use of megadoses of vitamins with minerals in Down syndrome

Smith, G. F., Spiker, D., Peterson, C., Cicchetti, D., & Justine, P. (1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)80118-3 · Cited by 44 · see citing works

Prolonged coenzyme Q10 treatment in Down syndrome patients, effect on DNA oxidation

Tiano, L., Padella, L., Santoro, L., Carnevali, P., Principi, F., Brugè, F., Gabrielli, O., & Littarru, G. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.025 · Cited by 43 · see citing works

Activation of p53 in Down Syndrome and in the Ts65Dn mouse brain is associated with a pro-apoptotic phenotype

Tramutola, A., Pupo, G., Di Domenico, F., Barone, E., Arena, A., Lanzillotta, C., Broekaart, D., Blarzino, C., Head, E., Butterfield, D. A., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151105 · Cited by 40 · see citing works

Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome

Rueda, N., Flórez, J., & Martínez‐Cué, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.11.020 · Cited by 39 · see citing works

Targeting Mitochondrial Network Architecture in Down Syndrome and Aging

Mollo, N., Cicatiello, R., Aurilia, M., Scognamiglio, R., Genesio, R., Charalambous, M., Paladino, S., Conti, A. M. F., Nitsch, L., & Izzo, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093134 · Cited by 39 · see citing works

Acetylcholine and aromatic amine systems in postmortem brain of an infant with Down's syndrome

McGeer, E. G., Norman, M. G., Boyes, B. E., OʼKusky, J. R., Suzuki, J., & McGeer, P. L. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90184-0 · Cited by 37 · see citing works

Chronic Melatonin Administration Reduced Oxidative Damage and Cellular Senescence in the Hippocampus of a Mouse Model of Down Syndrome

Parisotto, E. B., Vidal, V., García-Cerro, S., Lantigua, S., Wilhelm Filho, D., Sanchez-Barceló, E. J., Martínez-Cué, C., & Rueda, N. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2008-8 · Cited by 37 · see citing works

Vitamin E and Alzheimer's disease in subjects with Down's syndrome

JACKSON, C. V. E., Holland, A. J., Williams, C. A., & Dickerson, J. W. T. (1988) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1988.tb01439.x · Cited by 36 · see citing works

Effects of nutritional supplementation on IQ and certain other variables associated with Down syndrome.

Weathers, C. (1983) · PubMed · Cited by 34 · see citing works

Green tea EGCG plus fish oil omega-3 dietary supplements rescue mitochondrial dysfunctions and are safe in a Down's syndrome child

Vacca, R. A., & Valenti, D. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.04.012 · Cited by 34 · see citing works

Antioxidant intervention attenuates oxidative stress in children and teenagers with Down syndrome

Parisotto, E. B., Garlet, T. R., Cavalli, V. L. D. L. O., Zamoner, A., da Rosa, J. S., Bastos, J., Micke, G. A., Fröde, T. S., Pedrosa, R. C., & Wilhelm Filho, D. (2014) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.03.013 · Cited by 34 · see citing works

Homocysteine and oxidative stress in Egyptian children with Down syndrome

Meguid, N. A., Dardir, A. A., El-Sayed, E. M., Ahmed, H. H., Hashish, A. F., & Ezzat, A. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.04.058 · Cited by 33 · see citing works

Effects of acetyl-l-carnitine in diabetic neuropathy and other geriatric disorders

Sergi, G., Pizzato, S., Piovesan, F., Trevisan, C., Veronese, N., & Manzato, E. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0770-3 · Cited by 32 · see citing works

Defective DNA repair and increased chromatin binding of DNA repair factors in Down syndrome fibroblasts

Necchi, D., Pinto, A., Tillhon, M., Dutto, I., Serafini, M. M., Lanni, C., Govoni, S. M., Racchi, M., & Prosperi, E. (2015) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2015.07.009 · Cited by 30 · see citing works

Anti-IL17 treatment ameliorates Down syndrome phenotypes in mice

Rueda, N., Vidal, V., García-Cerro, S., Narcís, J. O., Llorens-Martı́n, M., Corrales, A., Lantigua, S., Iglesias, M., Merino, J., Merino, R., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.008 · Cited by 30 · see citing works

α-Tocopherol supplementation reduces biomarkers of oxidative stress in children with Down syndrome: a randomized controlled trial

Nachvak, S. M., Neyestani, T. R., Mahboob, S., Sabour, S., Keshavarz, S.-A., & Speakman, J. R. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.97 · Cited by 29 · see citing works

Dysfunction of the ubiquitin–proteasome system in the cerebellum of aging Ts65Dn mice

Necchi, D., Lomoio, S., & Scherini, E. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.009 · Cited by 29 · see citing works

Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells

Mollo, N., Nitti, M. P., Zerillo, L., Faicchia, D., Micillo, T., Accarino, R., Secondo, A., Petrozziello, T., Calı̀, G., Cicatiello, R., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00606 · Cited by 29 · see citing works

THE EFFECTSOF MULTIVITAMINS AND MINERALS ON CHILDREN WITH DOWN SYNDROME

Bidder, R. T., Gray, P., Newcombe, R. G., Evans, B. K., & Hughes, M. (1989) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1989.tb04032.x · Cited by 27 · see citing works

The effect of acetyl-l-carnitine administration on persons with Down syndrome

Pueschel, S. M. (2006) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2004.07.009 · Cited by 24 · see citing works

Persistence of the benefit of an antioxidant therapy in children and teenagers with Down syndrome

Parisotto, E. B., Giaretta, A. G., Zamoner, A., Moreira, E. A. M., Fröde, T. S., Pedrosa, R. C., & Filho, D. W. (2015) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2015.07.010 · Cited by 23 · see citing works

Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome

Lee, S. E., Duran-Martinez, M., Khantsis, S., Bianchi, D., & Guedj, F. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.10.001 · Cited by 23 · see citing works

Senescence in amniocytes and placentas from trisomy 21 pregnancies

Amiel, A., Fejgin, M. D., Liberman, M., Sharon, Y., Kidron, D., & Biron‐Shental, T. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.768982 · Cited by 22 · see citing works

Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome

Day, S. M., Yang, W., Wang, X., Stern, J. E., Zhou, X., Macauley, S. L., & Ma, T. (2019) · eNeuro · doi:10.1523/eneuro.0031-19.2019 · Cited by 21 · see citing works

The Shape of Mitochondrial Dysfunction in Down Syndrome

Zamponi, E., & Helguera, P. R. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22673 · Cited by 20 · see citing works

The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome

Larsen, E. L., Padella, L., Bergholdt, H. K. M., Henriksen, T., Santoro, L., Gabrielli, O., Poulsen, H. E., Littarru, G. P., Orlando, P., & Tiano, L. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.001 · Cited by 19 · see citing works

Purification and biochemical characterization of glutathione S-transferase from Down syndrome and normal children erythrocytes: A comparative study

Hamed, R. R., Maharem, T. M., Meguid, N. A., Sabry, G. M., Abdalla, A.-M., & Guneidy, R. A. (2011) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2011.01.013 · Cited by 18 · see citing works

Pre- and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse model of Down syndrome

Corrales, A., Parisotto, E. B., Vidal, V., García-Cerro, S., Lantigua, S., Diego, M., Filho, D. W., Sánchez‐Barceló, E. J., Martínez‐Cué, C., & Rueda, N. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.022 · Cited by 18 · see citing works

Timing of Treatment with the Flavonoid 7,8-DHF Critically Impacts on Its Effects on Learning and Memory in the Ts65Dn Mouse

Giacomini, A., Stagni, F., Emili, M., Uguagliati, B., Rimondini, R., Bartesaghi, R., & Guidi, S. (2019) · Antioxidants · doi:10.3390/antiox8060163 · Cited by 18 · see citing works

Muscle stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome

Pawlikowski, B. T., Betta, N. D., Elston, T. L., Williams, D. A., & Olwin, B. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-22342-5 · Cited by 17 · see citing works

Copper accumulation in the brain causes the elevation of oxidative stress and less anxious behavior in Ts1Cje mice, a model of Down syndrome

Ishihara, K., Kawashita, E., Shimizu, R., Nagasawa, K., Yasui, H., Sago, H., Yamakawa, K., & Akiba, S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.015 · Cited by 17 · see citing works

Prenatal, but not Postnatal, Curcumin Administration Rescues Neuromorphological and Cognitive Alterations in Ts65Dn Down Syndrome Mice

Rueda, N., Vidal, V., García-Cerro, S., Puente, A., Campa, V. M., Lantigua, S., Narcís, J. O., Bartesaghi, R., & Martínez‐Cué, C. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa207 · Cited by 17 · see citing works

Increased Plasma and Erythrocyte Selenium Concentrations but Decreased Erythrocyte Glutathione Peroxidase Activity after Selenium Supplementation in Children with Down Syndrome

ANNEREN, G., GEBRE‐MEDHIN, M., & GUSTAVSON, K. ‐. (1989) · Acta Paediatrica · doi:10.1111/j.1651-2227.1989.tb11167.x · Cited by 15 · see citing works

Antioxidants and Prevention of Cognitive Decline Does Duration of Use Matter?

Yaffe, K. S. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.20.2167 · Cited by 14 · see citing works

Redox balance in patients with Down's syndrome before and after dietary supplementation with alpha-lipoic acid and L-cysteine.

Gualandri, W., Gualandri, L., Demartini, G., Esposti, R. D., Marthyn, P., Volontè, S., Stangoni, L., Borgonovo, M., & FRASCHINI, F. (2003) · PubMed · Cited by 14 · see citing works

The Role of Iron Toxicity in Oxidative Stress-induced Cellular Degeneration in Down Syndrome: Protective Effects of Phenolic Antioxidants

Manna, C., Tagliafierro, L., Scala, I., Granese, B., Andria, G., & Zappia, V. (2012) · Current Nutrition & Food Science · doi:10.2174/157340112802651176 · Cited by 13 · see citing works

Hematopoietic Stem Cells from Ts65Dn Mice Are Deficient in the Repair of DNA Double-Strand Breaks

Wang, Y., Chang, J., Shao, L., Feng, W., Luo, Y., Chow, M., Du, W., Meng, A., & Zhou, D. (2016) · Radiation Research · doi:10.1667/rr14407.1 · Cited by 13 · see citing works

Nutritional supplementation in Down syndrome: theoretical considerations and current status

Ani, C. C., Grantham‐McGregor, S., & Muller, D. P. R. (2000) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2000.tb00072.x · Cited by 9 · see citing works

In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome

Naert, G., Ferré, V. M., Keller, E., Slender, A., Gibbins, D., Fisher, E., Tybulewicz, V. L. J., & Maurice, T. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117743484 · Cited by 6 · see citing works

Serum cholinesterases in Down syndrome children before and after nutritional supplementation.

Lakshmi, K. T., Surekha, R. H., Srikanth, B., & Jyothy, A. (2008) · PubMed · Cited by 5 · see citing works

Mouse Models of Down Syndrome and Alzheimer’s Disease: Similarities and Differences

(2015) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681081380115010013 · Cited by 2 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

Marzia Perluigi, A., Domenico, F. D., & Butterfield, D. A. (2023) · Physiological Reviews · doi:10.1152/physrev.00030.2022 · Cited by 306 · see citing works

Superoxide Dismutase Administration: A Review of Proposed Human Uses

Rosa, A. C., Corsi, D., Cavi, N., Bruni, N., & Dosio, F. (2021) · Molecules · doi:10.3390/molecules26071844 · Cited by 286 · see citing works

Sleep and circadian disturbances in children with neurodevelopmental disorders

Bruni, O., Breda, M., Mammarella, V., Mogavero, M. P., & Ferri, R. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-024-01052-9 · Cited by 74 · see citing works

Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2

Buttari, B., Tramutola, A., Rojo, A. I., Chondrogianni, N., Saha, S., Berry, A., Giona, L., Miranda, J. P., Profumo, E., Davinelli, S., et al. (2025) · Biomolecules · doi:10.3390/biom15010113 · Cited by 47 · see citing works

Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules

Lanzillotta, C., & Domenico, F. D. (2021) · Biomolecules · doi:10.3390/biom11020266 · Cited by 35 · see citing works

Rebalancing the unbalanced aged immune system – A special focus on zinc

Baarz, B. R., & Rink, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101541 · Cited by 35 · see citing works

Cellular senescence and premature aging in Down Syndrome

Peng, L., Baradar, A. A., Aguado, J., & Wolvetang, E. J. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111824 · Cited by 34 · see citing works

Signalling Pathways Implicated in Alzheimer′s Disease Neurodegeneration in Individuals with and without Down Syndrome

Martínez‐Cué, C., & Rueda, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186906 · Cited by 26 · see citing works

CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome

Pagnotta, S. E., Tramutola, A., Barone, E., Domenico, F. D., Pittalà, V., Salerno, L., Folgiero, V., Caforio, M., Locatelli, F., Petrini, S., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.006 · Cited by 24 · see citing works

Implications of Down’s syndrome on oral health status in patients

Goud, E. S. S., Gulati, S., Agrawal, A., Pani, P., Nishant, K., Pattnaik, S. J., & Gupta, S. (2021) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_885_21 · Cited by 25 · see citing works

Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model

Lanzillotta, C., Rataj-Baniowska, M., Prestia, F., Sette, C., Nalesso, V., Marzia Perluigi, A., Barone, E., Duchon, A., Tramutola, A., Hérault, Y., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106523 · Cited by 18 · see citing works

Dietary Antioxidants and Brain Health: Focus on Cognitive and Affective Disorders

Godos, J., & Grosso, G. (2021) · Antioxidants · doi:10.3390/antiox10111659 · Cited by 18 · see citing works

Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?

Buczyńska, A., Sidorkiewicz, I., Ławicki, S., Kretowski, A. J., & Zbucka-Krętowska, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112382 · Cited by 16 · see citing works

Therapeutics for mitochondrial dysfunction-linked diseases in Down syndrome

Ganguly, B. B., & Kadam, N. N. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.11.003 · Cited by 18 · see citing works

The Role of Oxidative Stress in Trisomy 21 Phenotype

Buczyńska, A., Sidorkiewicz, I., Kretowski, A. J., & Zbucka-Krętowska, M. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01417-6 · Cited by 18 · see citing works

Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome

Puente-Bedia, A., Berciano, M. T., Martínez‐Cué, C., Lafarga, M., & Rueda, N. (2022) · Antioxidants · doi:10.3390/antiox11122438 · Cited by 13 · see citing works

General Dietary Recommendations for People with Down Syndrome

Gruszka, J., & Włodarek, D. (2024) · Nutrients · doi:10.3390/nu16162656 · Cited by 13 · see citing works

Identification of metabolomics-based biomarker discovery in individuals with down syndrome utilizing kernel-tree model-enhanced explainable artificial intelligence methodology

Çolak, C., Yağın, F. H., Yagin, B., Alkhateeb, A., Al-Rawi, M. B. A., Akhloufi, M. A., & Aghaei, M. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1567199 · Cited by 13 · see citing works

Metformin modulates oxidative stress via activation of AMPK/NF-κB signaling in Trisomy 21 fibroblasts: an in vitro study

Buczyńska, A., Malinowski, P., Żbikowski, A., Kretowski, A. J., & Zbucka-Krętowska, M. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1577044 · Cited by 9 · see citing works

DOWN SENDROMLU BİREYLERDE BESLENME DURUMU

Yoldaş, K., & Yılmazer, Y. (2021) · European Journal of Science and Technology · doi:10.31590/ejosat.831542 · Cited by 7 · see citing works

Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?

Zuo, X. (2025) · Aging and Disease · doi:10.14336/ad.2025.0189 · Cited by 9 · see citing works

Oxidative Stress and Down Syndrome: A Systematic Review

Slivšek, G., Mijač, S., Dolanc, I., Fabijanec, M., Petković, S., Mautner, R., Lončarek, K., Kranjčić, J., Blagaić, A. B., Marinović, M., et al. (2025) · Antioxidants · doi:10.3390/antiox14070816 · Cited by 8 · see citing works

New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome

Conan, P., Léon, A., Caroff, N., Rollet, C., Chaïr, L., Martin, J., Bihel, F. J. ‐., Mignen, O., Voisset, C., & Friocourt, G. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1110163 · Cited by 5 · see citing works

Lifestyle Intervention Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in Children with Down Syndrome

Scoppola, V., Crudele, A., Mosca, A., Panera, N., Camillo, C. D., Bock, C., Raponi, M., Villani, A., Alisi, A., & Valentini, D. (2025) · Nutrients · doi:10.3390/nu17142331 · Cited by 4 · see citing works

Future Perspectives in Oxidative Stress in Trisomy 13 and 18 Evaluation

Buczyńska, A., Sidorkiewicz, I., Hameed, A., Kretowski, A. J., & Zbucka-Krętowska, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11071787 · Cited by 5 · see citing works

Network Pharmacology Identifies Intersection Genes of Apigenin and Naringenin in Down Syndrome as Potential Therapeutic Targets

Amir, M., Shafi, S., Parveen, S., Reshi, A. A., & Ahmad, A. (2024) · Pharmaceuticals · doi:10.3390/ph17081090 · Cited by 3 · see citing works

Down syndrome: a model for chromosome abnormalities

Overk, C., & Mobley, W. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85654-6.00007-1 · Cited by 2 · see citing works

Dietary supplements for children with Down syndrome: exploration of current use and scientific evidence : Fieldwork and literature study

van der Haar, S., & Zeinstra, G. G. (2021) · doi:10.18174/554328 · Cited by 2 · see citing works

Physical Activity Among Down Syndrome Children in Amman, Jordan

Amawi, A. T., Soub, R. I. A., & Ghazzawi, H. (2023) · Palestinian medical and pharmaceutical journal/Palestinian medical & pharmaceutical journal · doi:10.59049/2790-0231.1243 · Cited by 1 · see citing works

Cognitive and molecular characterization of the Ts66Yah murine model of Down syndrome: deepening on hippocampal changes associated with genotype and agingPreprint

Lanzillotta, C., Rataj-Baniowska, M., Prestia, F., Sette, C., Nalesso, V., Marzia Perluigi, A., Barone, E., Duchon, A., Tramutola, A., Hérault, Y., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.02.573811

Oxidative stress in Down syndrome: unraveling the intertwined pathways for novel target identification

Lim, C.-W., Hamid, H. A., Ling, K., & Cheah, P.-S. (2025) · Current Opinion in Physiology · doi:10.1016/j.cophys.2025.100864

Down Syndrome

Rouhani, M. H., Navab, F. S., Shahdadian, F., & Keyhanpour, S. (2026) · SpringerBriefs in modern perspectives on disability research. · doi:10.1007/978-981-95-8150-4_3

Neonatal Treatment with Astaxanthin-Loaded Stealth Solid Lipid Nanoparticles Activates the Impaired NRF2 Pathway and Reduces Hippocampal Oxidative Stress in a Mouse Model of Trisomy 21

Angelozzi, L., Santonocito, D., Flotta, F., Uguagliati, B., Emili, M., Rueda, N., Martínez‐Cué, C., Puglia, C., Stagni, F., & Guidi, S. (2026) · Cells · doi:10.3390/cells15161495

From Feeding Difficulties to Nutritional Risk in Children with Down Syndrome

Ravančić, M. E., Obradović, V., & Škrabal, S. (2026) · Nutrients · doi:10.3390/nu18193295

Antioxidants in Down syndrome

Lott, I. T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.010 · Cited by 82 · see citing works

Oxidative Stress and Down Syndrome. Do Antioxidants Play a Role in Therapy?

Muchová, J., Žitňanová, I., & Ďuračková, Z. (2014) · Physiological Research · doi:10.33549/physiolres.932722 · Cited by 60 · see citing works

Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules

Lanzillotta, C., & Domenico, F. D. (2021) · Biomolecules · doi:10.3390/biom11020266 · Cited by 35 · see citing works

Brain oxidative stress and pathophysiological significance in Down syndrome

Ishihara, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817986-4.00008-0

Therapeutics for mitochondrial dysfunction-linked diseases in Down syndrome

Ganguly, B. B., & Kadam, N. N. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.11.003 · Cited by 18 · see citing works