Narcotic and nicotine effects on the neonatal auditory system
Abstract
To evaluate narcotic and nicotine effects on the neonatal auditory system, brain stem auditory evoked responses were recorded in 15 infants prenatally exposed to both narcotics and nicotine (median gestational age 38.4 weeks, median birth weight 2820 g), in 15 nicotine exposed infants (gestational age 40.0 weeks, birth weight 3000 g) and in 24 healthy term infants (gestational age 40.1 weeks, birth weight 3310 g) who served as controls. Whereas nicotine-exposed and control infants were similar in all brain stem auditory evoked response measurements, narcotic/nicotine infants had bilaterally increased wave V latencies (left: p = 0.005; right: p = 0.04) and I-V intervals (left: p = 0.02; right: p = 0.01) when compared to controls. Our findings suggest that prenatal narcotic but not nicotine exposure negatively affects maturation or integrity of the neonatal auditory brain stem tract and that neither narcotic nor nicotine exposure is associated with hearing loss in the neonate.
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At least one human study of auditory brainstem responses provided evidence for the absence of altered signal detection based on a lack of difference in auditory brainstem responses.
“At least one human study of auditory brainstem responses provided evidence for the absence of altered signal detection based on a lack of difference in auditory brainstem responses [65]”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [65]
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- Authors
- Trammer, R. M., Aust, G., Köster, K., & Obladen, M.
- Affiliations
- Freie Universität Berlin (DE)
- Corresponding author
- Obladen, Michael
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 1992-12
- Volume
- 81
- Issue
- 12
- Pages
- 962-965
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2172221447
- Cited by
- 21
- References
- 13
- Citations by year
- 2024: 2 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Keywords
- prenatal opioid exposure, prenatal nicotine exposure, brain stem auditory evoked response, wave V latency, hearing loss, drug-exposed infants
- MeSH terms
- Brain Stem, Female, Heroin Dependence, Humans, Infant, Newborn, Maternal-Fetal Exchange, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Smoking, Evoked Potentials, Auditory, Brain Stem
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