Prenatal iv nicotine exposure produces a sex difference in sensorimotor gating of the auditory startle reflex in adult rats

Lacy, Ryan T.; Mactutus, Charles F.; Harrod, Steven B.

doi:10.1016/j.ijdevneu.2010.12.001

Cited by 17Prenatal Substance Exposure EffectsNicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Prenatal iv nicotine exposure produces a sex difference in sensorimotor gating of the auditory startle reflex in adult rats

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Lacy, Ryan T., Mactutus, Charles F., Harrod, Steven B.·2011·International Journal of Developmental Neuroscience

DOI 10.1016/j.ijdevneu.2010.12.001PMC PMC3312379

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Abstract

Maternal smoking during pregnancy is associated with auditory processing deficits in children; these effects have been confirmed with animal models of continuous high-dose prenatal nicotine exposure. The present experiments utilized a novel, low-dose, intermittent, intravenous (IV) gestational nicotine exposure model to investigate potential deficits on the preattentive process of sensorimotor gating, as indexed by prepulse inhibition (PPI), in preweanling and adult rat offspring. Pregnant dams received bolus IV injections of nicotine (0.05 mg/kg/injection) 3×/day on gestational days 8-21. Auditory and tactile stimulus modalities were probed with tone and air puff prepulse stimuli, respectively. These prepulse stimuli preceded a 100 dB(A) startle tone by six different interstimulus intervals (ISIs; 0, 8, 40, 80, 120, 4000 ms) to define a curve of response inhibition. The magnitude of PPI increased with age, from 59 to 81% inhibition. Preweanlings (PNDs 14 and 18) and adults (PND 75) gestationally exposed to nicotine exhibited altered startle responding relative to controls, but the nature of the deficit became more localized at later ages. The entire curve of response inhibition in preweanlings exposed to prenatal nicotine (PND 14) was shifted up relative to controls, and notably, did not interact with prepulse stimulus modality, suggesting a generalized increased sensorimotor responsiveness as a function of prenatal nicotine. At PND 18, a shift in the response curve across all ISIs was again noted, but varied as a function of prepulse stimulus modality; the increased sensorimotor responsiveness was specific to the auditory, but not tactile, sensory modality. In adulthood, male and female animals prenatally exposed to nicotine were differentially sensitive to modulation by the ISIs, relative to control male and female animals. Specifically, despite robust PPI, adult females exposed to gestational nicotine were relatively insensitive to changes in ISI from 8 to 120 ms; in contrast, the robust PPI of nicotine-exposed males demonstrated a clear focal point of inhibition at 40 ms. These findings indicate that a low, daily dosing of IV prenatal nicotine produces long-lasting alterations in auditory PPI. An important implication of this research is that "chipping" with smoked-tobacco products during pregnancy may produce enduring changes in sensorimotor processing.

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Animal research supports that nicotine harms auditory processing.
“Animal research supports that nicotine adversely affects auditory processing.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [146]
Rodent studies suggest prenatal nicotine exposure delays reflex maturation, including negative geotaxis and surface righting, and causes long-lasting changes in filtering auditory information.
“rodent studies suggest that prenatal nicotine exposure delays maturation of reflexes, including negative geotaxis and surface righting (measures of limb coordination and locomotor development), as well as causing long-lasting alterations in filtering auditory information.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [146]

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Hord LL Moran LM Booze RM Harrod SB Mactutus CF submitted Ontogeny of prepulse inhibition: the role of prepulse sensory modality Int J Dev Neurosci PMC4937996 26415825

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Authors: Lacy, R. T., Mactutus, C. F., & Harrod, S. B.
Affiliations: University of South Carolina (US)
Corresponding author: Harrod, Steven B.
ORCID: Lacy, Ryan T.
Mactutus, Charles F.
Harrod, Steven B.
Venue: International Journal of Developmental Neuroscience
Publisher: Wiley
Published: 2010-12-08
Volume: 29
Issue: 2
Pages: 153-161
ISSN: 0736-5748 (ISSN-L)
1873-474X
DOI: 10.1016/j.ijdevneu.2010.12.001
PMC: PMC3312379
OpenAlex: W2018019588
Cited by: 17
References: 97
Citations by year: 2026: 1 · 2022: 1 · 2019: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
FWCI: 2.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Developmental Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: University of South Carolina (K‐21)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: prenatal nicotine exposure, smoking during pregnancy, prepulse inhibition, sensorimotor gating, acoustic startle response, sex differences, auditory processing deficits, interstimulus interval, chipping, rats, startle response
MeSH terms: Acoustic Stimulation, Animals, Female, Ganglionic Stimulants, Humans, Injections, Intravenous, Male, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Reflex, Sex Characteristics, Reflex, Startle, Rats, Sprague-Dawley, Rats, Sensory Gating

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Prenatal iv nicotine exposure produces a sex difference in sensorimotor gating of the auditory startle reflex in adult rats

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