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Cited by 55Growth Hormone and Insulin-like Growth FactorsPancreatic function and diabetesHypothalamic control of reproductive hormones

Insulin: the other anabolic hormone of puberty

Caprio, S·1999·Acta Paediatrica
DOI 10.1111/j.1651-2227.1999.tb14410.x
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Abstract

To determine the effect of puberty on insulin action, we used the euglycaemic-hyperinsulinaemic clamp technique in combination with stable isotopes and indirect calorimetry in lean pre-adolescents, adolescents and adults. These studies indicated that the insulin resistance induced by normal puberty alters glucose metabolism but is insufficient to adversely affect insulin-stimulated protein metabolism or to inhibit lipolysis. Using the hyperglycaemic clamp technique, we evaluated the impact of the insulin resistance on insulin secretion in pre-adolescents, adolescents and young adults. These studies revealed that the insulin and C-peptide responses to a standardized intravenous hyperglycaemic stimulus were two- to threefold greater in adolescents than in pre-adolescent children and adults. As growth hormone (GH), insulin-like growth factor I (IGF-I) and insulin levels normally peak during puberty, we examined the influence of insulin on IGF-I regulation by measuring basal GH, total and free IGF-I, and IGF binding protein (IGFBP) levels in lean adolescents and young adults. During the clamp studies, the adolescents exhibited low levels of IGFBP-1 and -2 as well as a reduced insulin-induced suppression of IGFBP-1, compared with lean adults. Thus, we postulate that the insulin resistance of puberty induces compensatory hyperinsulinaemia, which in turn suppresses circulating levels of IGFBP-1, which in turn leads to increased levels of free IGF-1.

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Authors
Caprio, S.
Affiliations
Yale University (US)
Corresponding author
Caprio, S
ORCID
Caprio, S
Venue
Acta Paediatrica
Publisher
Wiley
Published
1999-12
Volume
88
Issue
s433
Pages
84-87
ISSN
  • 0365-1436 (ISSN-L)
  • 0803-5253
  • 1651-2227
DOI
10.1111/j.1651-2227.1999.tb14410.x
OpenAlex
W2033010604
Cited by
55
References
21
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
1.82
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3064 d)
Locations
  • Acta Paediatrica (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hd030671-05)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK20495)
  • National Center for Research Resources (RR06022)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD30671)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
insulin resistance, puberty, hyperinsulinemia, insulin secretion, insulin-like growth factor I, IGF-binding protein-1, growth hormone, glucose metabolism, protein metabolism, lipolysis, adolescents, anabolic hormones
MeSH terms
Adolescent, Adult, Calorimetry, Indirect, Child, Glucose, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Puberty

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