The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Preoperative cranial ultrasound findings in infants with major congenital heart disease
Abstract
Background: Advances in diagnostic testing and surgical techniques have resulted in reduced mortality in neonates with congenital heart disease (CHD) and a major concern for neurological morbidity in the presence of preoperative neurological injury. Objectives: To determine the incidence and nature of preoperative cerebral ultrasound abnormalities in neonates with major CHD and to examine the relationship between cerebral abnormalities and the type of CHD. Methods: Retrospective study; inclusion criteria: (1) neonates with major CHD admitted to the NICU over a 3‐y period, (2) gestational age > 35 wk, (3) documented preoperative cranial ultrasound available; exclusion criteria: (1) small for gestational age, (2) other congenital anomalies and/or chromosomal abnormalities, (3) a 5‐min Apgar score < 7, (4) congenital infection. Cranial ultrasounds (CUS) were reviewed without knowledge of the cardiac defect. CHDs were categorized. Results: Fifty of 108 neonates with CHD met the inclusion criteria. Twenty‐one patients (42%) had abnormalities on CUS. Thirteen of these (26%) had widened ventricular and/or subarachnoid spaces, three (6%) lenticulostriate vasculopathy, one (2%) calcification in the basal nuclei, and four (8%) had acute ischaemic changes. Cerebral abnormalities occurred more frequendy in patients with coarctation or hypoplastic left heart syndrome (HLHS) than transposition of the great arteries (TGA) (63% vs 14%; n.s.). Conclusion: There is a high incidence of preoperative cerebral ultrasound abnormalities in this group of neonates with major CHD.
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“Reports from a number of investigators have documented a high prevalence of anatomic and functional neurologic abnormalities prior to surgery in newborns with CHD [9-17], and an association of such abnormalities with childhood developmental status [11,13,18,19].”
From Brain Volume and Metabolism in Fetuses With Congenital Heart Disease: Evaluation With Quantitative Magnetic Resonance Imaging and Spectroscopy (2010) · cites this paper as [13]
In the citing paper
“However, there is increasing evidence that adverse neurodevelopmental outcomes in children with complex CHD are due not only perioperative insult, but to inborn factors as well.”
From Brain Volume and Metabolism in Fetuses With Congenital Heart Disease: Evaluation With Quantitative Magnetic Resonance Imaging and Spectroscopy (2010) · cites this paper as [13]
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Metadata
- Authors
- TE PAS, A. B., VAN WEZEL‐MEIJLER, G., BÖKENKAMP‐GRAMANN, R., & WALTHER, F. J.
- Affiliations
- Leiden University Medical Center (NL)
- ORCID
- WALTHER, FRANS J.
- Venue
- Acta Paediatrica
- Publisher
- Wiley
- Published
- 2005-11
- Volume
- 94
- Issue
- 11
- Pages
- 1597-1603
- ISSN
- 0365-1436 (ISSN-L)
- 0803-5253
- 1651-2227
- OpenAlex
- W2006160374
- Cited by
- 61
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Paediatrica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- congenital heart disease, neonates, cranial ultrasound, neurological injury, hypoplastic left heart syndrome, coarctation of the aorta, transposition of the great arteries, lenticulostriate vasculopathy, basal ganglia calcification, cerebral ischemia
- MeSH terms
- Abnormalities, Multiple, Brain, Brain Diseases, Echoencephalography, Female, Heart Defects, Congenital, Humans, Infant, Newborn, Male, Preoperative Care, Retrospective Studies, Sweden, Incidence, Single-Blind Method
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