RADIOGRAPHIC AND ANGIOGRAPHIC EVALUATIONS OF FERRETS EXPERIMENTALLY INFECTED WITH DIROFILARIA IMMITIS
Abstract
Five ferrets of each sex were each inoculated with 15 third‐stage infective larvae of Dirofilaria immitis to study radiographic and angiographic changes in the cardiopulmonary system following heartworm infection; 5 additional ferrets of each sex served as noninfected controls. Prior to inoculation and every 8 weeks thereafter until 40 weeks, the infected and noninfected ferrets were radiographed; angiographic examinations were done prior to necropsy. At necropsy, the worms in the heart, lungs, and associated vessels were counted, and lung histosections were prepared and examined for changes. Radiographic changes were seen in the right side of the heart and associated vessels of infected ferrets as compared with the noninfected ferrets, but changes were less prominent than those seen in heartworm‐infected dogs and cats. The changes were primarily an increase in the size of the right side of the heart, especially the right atrium. Radiographically, no changes could be visualized in the pulmonary vascular system. Worms in the enlarged cranial vena cava, azygous vein, and left caudal lobar pulmonary artery of infected animals were delineated by angiography. Histologically, no changes were seen in the pulmonary vascular tissues.
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Radiographic changes in ferrets typically consist of cardiomegaly and severe pleural effusion.
“Radiographic changes in ferrets typically consist of cardiomegaly and severe pleural effusion (198,406).”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [406]
Cites
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Human and animal dirofilariasis: The emergence of a zoonotic mosaic
Simón, F., Siles-Lucas, M., Morchón, R., González-Miguel, J., Mellado, I., Carretón, E., & Montoya-Alonso, J. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-12 · Cited by 834 · see citing works
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Self-citation
- Authors
- Supakorndej, P., Lewis, R. E., McCall, J. W., Dzimianski, M. T., & Holmes, R. A.
- Affiliations
- University of Georgia (US)
- Louisiana State University (US)
- Corresponding author
- Supakorndej, Prasit
- ORCID
- Lewis, Robert E.
- Venue
- Veterinary Radiology & Ultrasound
- Publisher
- Wiley
- Published
- 1995-01
- Volume
- 36
- Issue
- 1
- Pages
- 23-29
- ISSN
- 1058-8183 (ISSN-L)
- 1740-8261
- OpenAlex
- W1988237974
- Cited by
- 16
- References
- 18
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Radiology & Ultrasound (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- Dirofilaria immitis, heartworm infection, ferrets, radiographic changes, right atrial enlargement, right heart enlargement, cranial vena cava, azygos vein, pulmonary artery, lung histopathology, experimental infection
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