Dirofilaria immitis: Experimental Infections in the Ferret (Mustela putorius furo)
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The ferret, Mustela putorius furo, was found to be susceptible to Dirofilaria immitis infection when exposed to low (14) or high (280-420) numbers of infective larvae harvested from Aedes aegypti. Eight ferrets (half of them cortisonized) were inoculated subcutaneously with 14 larvae each. All of them were subsequently found to harbor D. immitis in the heart, and all but one of them had worms of both sexes. Six of these ferrets were examined for microfilaremia at 31 to 35 weeks after inoculation; 3 were positive (one observed only at postmortem examination) and there was evidence that fertilization of female worms had occurred in one other. Females up to 25.5 cm and males up to 16.0 cm were recovered. There was no evidence that the cortisonization of some ferrets had affected the infections. Both male and female ferrets became infected. Four cortisonized ferrets were inoculated with 280 or 420 larvae of D. immitis (divided equally between subcutaneous and intraperitoneal routes). All of them died 16 to 18 weeks after inoculation, yielding 102 to 125 immature D. immitis. In these lethal infections, worms were recovered from the heart and adjoining vessels, and also from vascular and extravascular sites throughout the body.
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Other carnivores such as cats or ferrets should not be considered involved in the transmission of Dirofilaria spp. because microfilaraemia is absent or short-lasting in these hosts.
“The likelihood of other carnivores such as cats or ferrets being involved in the transmission of Dirofilaria spp. should not be considered because microfilaraemia is absent or short-lasting in these hosts (Campbell and Blair 1978; McCall et al. 2008; Bajer et al. 2016).”
From The current situation of canine dirofilariosis in Hungary (2020) · cites this paper as Campbell and Blair 1978
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Self-citation
- Authors
- Campbell, W. C., & Blair, L. S.
- Venue
- The Journal of Parasitology
- Publisher
- JSTOR
- Published
- 1978-02
- Volume
- 64
- Issue
- 1
- Pages
- 119
- ISSN
- 0022-3395 (ISSN-L)
- OpenAlex
- W2331778219
- Cited by
- 27
- References
- 1
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 3 · 2014: 1 · 2013: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Parasitology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Keywords
- Dirofilaria immitis, ferrets, canine heartworm disease, experimental infection, infective larvae, Aedes aegypti, microfilaremia, heartworm infection, fatal infection, host susceptibility
- MeSH terms
- Animals, Carnivora, Cortisone, Dirofilaria immitis, Dirofilariasis, Female, Ferrets, Heart, Male
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