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Melatonin: Nature’s most versatile biological signal?
Open accessAbstract
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light/dark cycle via the suprachiasmatic nucleus. Pinealocytes function as 'neuroendocrine transducers' to secrete melatonin during the dark phase of the light/dark cycle and, consequently, melatonin is often called the 'hormone of darkness'. Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities. Melatonin is exclusively involved in signaling the 'time of day' and 'time of year' (hence considered to help both clock and calendar functions) to all tissues and is thus considered to be the body's chronological pacemaker or 'Zeitgeber'. Synthesis of melatonin also occurs in other areas of the body, including the retina, the gastrointestinal tract, skin, bone marrow and in lymphocytes, from which it may influence other physiological functions through paracrine signaling. Melatonin has also been extracted from the seeds and leaves of a number of plants and its concentration in some of this material is several orders of magnitude higher than its night-time plasma value in humans. Melatonin participates in diverse physiological functions. In addition to its timekeeping functions, melatonin is an effective antioxidant which scavenges free radicals and up-regulates several antioxidant enzymes. It also has a strong antiapoptotic signaling function, an effect which it exerts even during ischemia. Melatonin's cytoprotective properties have practical implications in the treatment of neurodegenerative diseases. Melatonin also has immune-enhancing and oncostatic properties. Its 'chronobiotic' properties have been shown to have value in treating various circadian rhythm sleep disorders, such as jet lag or shift-work sleep disorder. Melatonin acting as an 'internal sleep facilitator' promotes sleep, and melatonin's sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients. A recently introduced melatonin analog, agomelatine, is also efficient for the treatment of major depressive disorder and bipolar affective disorder. Melatonin's role as a 'photoperiodic molecule' in seasonal reproduction has been established in photoperiodic species, although its regulatory influence in humans remains under investigation. Taken together, this evidence implicates melatonin in a broad range of effects with a significant regulatory influence over many of the body's physiological functions.
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“Children typically produce more melatonin than adults, which may infer that their need for dietary supplementation may require further scrutiny and be limited to specific disease states [4,11].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [4]
In the citing paper
“Production gradually declines as people age, starting in the late twenties to the fifties, with production leveling at approximately 30 pg/mL [4,11] (see Figure 1).”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [4]
In the citing paper
“Aside from aging, production of melatonin can be influenced by illness [12], diet [4], environmental factors like bright light at night [13], medication use [14], and lifestyle [15].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [4]
In the citing paper
“Melatonin is colloquially referred to as the “hormone of darkness” since it is produced in response to darkness, as perceived by the eye’s retina [4].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [4]
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Citations
Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Regulation of antioxidant enzymes: a significant role for melatonin
Rodrı́guez, C., Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,990
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
Brainard, G. C., Hanifin, J. P., Greeson, J. M., Byrne, B., Glickman, G., Gerner, E., & Rollag, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06405.2001 · Cited by 1,930
Mortality Associated With Sleep Duration and Insomnia
Kripke, D. F., Garfinkel, L., Wingard, D. L., Klauber, M. R., & Marler, M. R. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.131 · Cited by 1,614
The Pineal and Its Hormones in the Control of Reproduction in Mammals*
Reiter, R. J. (1980) · Endocrine Reviews · doi:10.1210/edrv-1-2-109 · Cited by 1,254
Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096
Tan, D., Reiter, R. J., Manchester, L. C., Yan, M.-T., El-Sawi, M. R., Sainz, R. M., Mayo, J. C., Kohen, R., Allegra, M., & Hardelan, R. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394443 · Cited by 1,065
The melatonin rhythm: both a clock and a calendar
Reiter, R. J. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923947 · Cited by 997
The basic physiology and pathophysiology of melatonin
Claustrat, B., Brun, J., & Chazot, G. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.08.001 · Cited by 951
Research works printed but not linked: 8
- Hardeland R, 1996, Metabolism and Cellular Dynamics of Indoles, 6
- Dubocovich ML, 2000, The IUPHAR Compendium of Receptor Characterization and Classification, 271
- 10.1007/BF03033887 · DOI
- 10.1016/j.exger.2005.08.009 · DOI
- Olie P, 2005, Confirmed clinical efficacy of agomelatine (25–50 mg) in major depression; two randomized, double‐blind controlled studies, Eur Neuropsychopharmacol, 15, S416
- 10.1097/00007632-200303150-00008 · DOI
- 10.1034/j.1600-079X.2001.300105.x · DOI
- 10.1210/jc.86.1.129 · DOI · Paper page
Cited by
Sorted by citations
Items 601–700 of 883
Lee, J., & Lee, D. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.03.010 · Cited by 7
Morning melatonin levels in Prader–Willi syndrome
Butler, M. G., Brandau, D. T., Theodoro, M. F., & Garg, U. C. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33001 · Cited by 7
Evolution from Mammals: Heterosexual Reproductive Behavior to Human Erotic Bisexuality
Wunsch, S. (2010) · Journal of Bisexuality · doi:10.1080/15299716.2010.500960 · Cited by 7
Effects of pinealectomy and exogenous melatonin on the brains, testes, duodena and stomachs of rats.
Tasdemir, S., Şamdancı, E., Parlakpınar, H., Polat, A., Taşdemir, C., Cengiz, N., Sapmaz, H. İ., & Acet, A. (2012) · PubMed · Cited by 7
Gobbo, M. G., Tamarindo, G. H., Ribeiro, D. L., Campos, S. G. P., Taboga, S. R., & Góes, R. M. (2017) · Cell Biology International · doi:10.1002/cbin.10920 · Cited by 7
Yarmolinskaya, M. I., Tkhazaplizheva, S. S., Молотков, А. С., Tkachenko, N. N., Borodina, V. L., Andreeva, N. Y., Kleimenova, T. S., & Lysenko, V. V. (2019) · Journal of obstetrics and women s diseases · doi:10.17816/jowd68351-60 · Cited by 7
Waterhouse, J. M., & Atkinson, G. (2008) · Biological Rhythm Research · doi:10.1080/09291010802067106 · Cited by 6
Induction of hepatocellular carcinoma in mice and the role of melatonin
Abdel-Mawla, A. A., Fadali, G. A., Youssef, E. A., & Eliwa, H. (2013) · The Journal of Basic and Applied Zoology · doi:10.1016/j.jobaz.2012.12.004 · Cited by 7
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Singh, A. P., & Kaur, R. (2014) · doi:10.21746/ijbio.2014.04.009 · Cited by 7
Avancées dans la génétique de la glycémie à jeun
Bouatia‐Naji, N., Bonnefond, A., & Froguel, P. (2009) · médecine/sciences · doi:10.1051/medsci/20092511897 · Cited by 7
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Carrera-González, M. P., Ramı́rez-Expósito, M. J., & Martı́nez-Martos, J. M. (2009) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152009788451824 · Cited by 7
Grigg-Damberger, M. M. (2007) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000275605.46668.86 · Cited by 7
Ramasubramanya, A. H., Singh, P., Lin, K.-C., Prasad, S., & Muthukumar, S. (2025) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2025.100656 · Cited by 5
Torrado, J. J., Anaya, B. J., Kara, A., Öngoren, B., Esteban-Ruiz, S., Laguna, A., Guillén, A., Saro, M. G., & Serrano, D. R. (2024) · Gels · doi:10.3390/gels10090595 · Cited by 6
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Holst, M. M., Wirth, M. D., Allison, P., Burch, J. B., Andrew, M. E., Fekedulegn, D. B., Hussey, J. R., Charles, L. E., & Violanti, J. M. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1895197 · Cited by 6
Mondal, G., Khan, Z. A., Devi, S. D., Labala, R. K., & Chattoraj, A. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.676332 · Cited by 7
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Mets, M. A. J., van Deventer, K. R., Olivier, B., Volkerts, E. R., & Verster, J. C. (2009) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-9923-8_16 · Cited by 6
Zhou, J., Yang, F., Zhou, L., Wang, J.-G., Wen, P., Luo, H., Li, W., Song, Z. J., Sharman, E. H., & Bondy, S. C. (2013) · Brain Research · doi:10.1016/j.brainres.2013.12.013 · Cited by 6
Wei, Y.-M., Xu, Y., Yu, C., & Han, J. (2009) · PubMed · Cited by 6
Rosenkranz, E., Thissen, A. K., Siegel, S., Piroth, M. D., Clusmann, H., Gebauer, J., Brabant, G. E., & Kreitschmann‐Andermahr, I. (2018) · Clinical Endocrinology · doi:10.1111/cen.13814 · Cited by 6
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Rastogi, S., Gupta, S., Haldar, C., & Chandra, D. (2020) · Egyptian Journal of Basic and Applied Sciences · doi:10.1080/2314808x.2019.1707626 · Cited by 6
Huffeldt, N. P., Tigano, A., Erikstad, K. E., Goymann, W., Jenni‐Eiermann, S., Moum, T. B., & Reiertsen, T. K. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.104930 · Cited by 6
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Johnsson, A., Helfrich‐Förster, C., & Engelmann, W. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1468-5_18 · Cited by 5
Wunsch, S. (2007) · HAL · Cited by 6
Liao, C., Wei, C., Chen, M., Hsieh, W., Lin, C., & Chen, P. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1006332 · Cited by 8
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Yoshida, M., Araki, A., & Adachi, H. (2023) · Early Human Development · doi:10.1016/j.earlhumdev.2023.105923 · Cited by 5
Bizzoca, M. E., Caponio, V. C. A., Muzio, L. L., Claudio, P. P., & Cortese, A. (2024) · Cancers · doi:10.3390/cancers16173004 · Cited by 5
Labunets, І. F. (2013) · Advances in Gerontology · doi:10.1134/s207905701304005x · Cited by 5
Schobersberger, W., Gufler, V., Griesmacher, A., Bartenbach, C., Canazei, M., Staggl, S., & HOFFMANN, G. E. (2007) · Pteridines · doi:10.1515/pteridines.2007.18.1.69 · Cited by 5
Essentials of Sleep Neuropharmacology
Bianchi, M. T. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1703-7.10005-2 · Cited by 5
RENSIS, F. D., Morini, G., Garcia-Ispierto, I., & López-Gatius, F. (2020) · Annals of Animal Science · doi:10.2478/aoas-2020-0012 · Cited by 5
Prospective Role of Melatonin in Signaling and Alleviation of Stress in Plants
Mathur, P., & Pramanik, S. (2020) · Signaling and communication in plants · doi:10.1007/978-3-030-54478-2_11 · Cited by 5
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Breljak, D., Micek, V., Gerić, M., Gajski, G., Oguić, S. K., Rašić, D., Karaica, D., Vrhovac, I., Ljubojević, M., Orct, T., et al. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2022.503443 · Cited by 5
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Chao, Y., Wu, K., Yeh, C., Su, S., Reiter, R. J., & Yang, S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28566 · Cited by 5
Melatonin-induced phase and dose responses in a diurnal mammal, Funambulus pennantii
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Gul, M., Khan, F. A., Wani, S. A., Bhat, S. A., Mir, S. A., Malik, A. A., Kumar, A., Narayan, S., Moinuddin, Fayaz, F., et al. (2021) · Journal of Applied and Natural Science · doi:10.31018/jans.v13i2.2673 · Cited by 5
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Norman, T. R. (2009) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2009.00411.x · Cited by 5
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Fitzpatrick, A. J. (2006) · Alternative and Complementary Therapies · doi:10.1089/act.2006.12.282 · Cited by 4
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Williams, B., Clarke, R., Aspe, R., Cole, M., & Hughes, J. D. (2017) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000317 · Cited by 5
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Self-citationShabajee, P., Bonnaud, A., Malpaux, B., Delagrange, P., Audinot, V., Yous, S., Boutin, J. A., Stéphan, J.-P., Leprince, J., & Legros, C. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.000785 · Cited by 4
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Khoshdel, R. E. A. R. (2013) · Journal of Metabolic Syndrome · doi:10.4172/2167-0943.1000128 · Cited by 4
Santano, C., de Lara, M. P., & Pintor, J. J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-956-7_10 · Cited by 4
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Moritani, C., Kawakami, K., Fujita, A., Kawakami, K., Shimoda, H., Hatanaka, T., & Tsuboi, S. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.051 · Cited by 4
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Zeng, Q., Liu, X., Liu, J., Wu, Y., Zhang, Y., He, Z., Wei, Y., Zeng, G., Zou, D., & Guo, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-02248-9 · Cited by 3
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Silva, C. F. (2010) · Cited by 3
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Metadata
- Authors
- Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R.
- Affiliations
- Universiti Sains Malaysia (MY)
- Istituto Cantonale di Patologia (CH)
- Universidad de Buenos Aires (AR)
- University of Göttingen (DE)
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2006-06-15
- Volume
- 273
- Issue
- 13
- Pages
- 2813-2838
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2049985521
- Cited by
- 875
- References
- 293
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 33 · 2023: 33 · 2022: 42 · 2021: 56 · 2020: 47 · 2019: 49 · 2018: 42 · 2017: 45 · 2016: 34 · 2015: 38 · 2014: 53 · 2013: 53 · 2012: 51
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Keywords
- melatonin, pineal gland, suprachiasmatic nucleus, circadian rhythm, sleep regulation, antioxidant activity, anti-apoptotic signaling, neuroprotection, neurodegenerative diseases, immunomodulation, circadian rhythm sleep disorders, jet lag, shift work disorder, insomnia, agomelatine, photoperiodism, seasonal reproduction, melatonin analogues
- MeSH terms
- Animals, Antioxidants, Chronobiology Phenomena, Depression, Humans, Melatonin, Models, Chemical, Plant Proteins, Sleep, Signal Transduction, Free Radical Scavengers, Apoptosis, Receptors, Melatonin
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