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Cited by 218Circadian rhythm and melatoninSleep and related disordersSleep and Work-Related Fatigue

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Diminished Melatonin Secretion in the Elderly Caused by Insufficient Environmental Illumination1

Mishima, K., Okawa, M., Shimizu, T., Hishikawa, Y.·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.1.7097
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Abstract

The pineal hormone melatonin has some circadian regulatory effects and is assumed to have a close relation with sleep initiation and maintenance. Many previous reports have described age-related decreases in melatonin levels, especially in elderly insomniacs (EIs), which may act as causal or exacerbating factors in sleep disturbances in the elderly. Ten elderly residents with psychophysiological insomnia (mean age, 74.2 yr), 10 healthy residents of the same home [elderly control (EC) group; mean age, 72.7 yr], and 10 healthy young control subjects (mean age, 20.9 yr) living at home participated in this study. The elderly persons, especially the EIs, were exposed to significantly less environmental light and simultaneously suffered from significantly diminished nocturnal melatonin secretion. Supplementary exposure to 4 h (1000 to 1200 h, 1400 to 1600 h) of midday bright light in the EI group significantly increased melatonin secretion to levels similar to those in the young control group without circadian phase-shifting. There was a tendency for the magnitude of the increase in nocturnal melatonin secretion stimulated by bright light to parallel amelioration of sleep disturbances in these subjects. The present findings suggest that we need to pay attention to elderly individuals who suffer under conditions of poor environmental light resulting in disorganized circadian rhythms, including the sleep-wake cycle.

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Metadata

Authors
Mishima, K., Okawa, M., Shimizu, T., & Hishikawa, Y.
Affiliations
  • Akita University (JP)
  • National Center of Neurology and Psychiatry (JP)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-01-01
Volume
86
Issue
1
Pages
129-134
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.1.7097
OpenAlex
W2061740819
Cited by
218
References
8
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 12 · 2020: 9 · 2019: 15 · 2018: 11 · 2017: 8 · 2016: 14 · 2015: 12 · 2014: 14 · 2013: 12 · 2012: 7
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
melatonin secretion, older adults, psychophysiological insomnia, bright light exposure, circadian rhythm, sleep disorders, age-related decline, circadian phase shift, sleep-wake cycle
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Female, Humans, Sleep Initiation and Maintenance Disorders, Lighting, Male, Melatonin, Periodicity, Reference Values, Sleep

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