The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mechanisms of obesity and related pathologies: The macro‐ and microcirculation of adipose tissue
Open accessAbstract
Adipose tissue is an endocrine organ made up of adipocytes, various stromal cells, resident and infiltrating immune cells, and an extensive endothelial network. Adipose secretory products, collectively referred to as adipokines, have been identified as contributors to the negative consequences of adipose tissue expansion that include cardiovascular disease, diabetes and cancer. Systemic blood circulation provides transport capabilities for adipokines and fuels for proper adipose tissue function. Adipose tissue microcirculation is heavily impacted by adipose tissue expansion, some adipokines can induce endothelial dysfunction, and angiogenesis is necessary to counter hypoxia arising as a result of tissue expansion. Tumors, such as invasive lesions in the mammary gland, co‐opt the adipose tissue microvasculature for local growth and metastatic spread. Lymphatic circulation, an area that has received little metabolic attention, provides an important route for dietary and peripheral lipid transport. We review adipose circulation as a whole and focus on the established and potential interplay between adipose tissue and the microvascular endothelium.
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Cites
Unexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
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Self-citationHyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice
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Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
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Self-citationWhite Fat Progenitor Cells Reside in the Adipose Vasculature
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Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
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Self-citationFunctionally specialized junctions between endothelial cells of lymphatic vessels
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Identification of White Adipocyte Progenitor Cells In Vivo
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Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
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Cited by
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941
Self-citationOverview of Epidemiology and Contribution of Obesity to Cardiovascular Disease
Bastien, M., Poirier, P., Lemieux, I., & Després, J.-P. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.10.016 · Cited by 1,125
Fibrosis and adipose tissue dysfunction.
Sun, K., Tordjman, J., Clément, K., & Scherer, P. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.016 · Cited by 960
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Metadata
- Authors
- Rutkowski, J. M., Davis, K. E., & Scherer, P. E.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2009-09-25
- Volume
- 276
- Issue
- 20
- Pages
- 5738-5746
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1567156395
- Cited by
- 253
- References
- 49
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rutkowski, J. M., Davis, K. E., & Scherer, P. E. (2009). Mechanisms of obesity and related pathologies: The macro‐ and microcirculation of adipose tissue. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2009.07303.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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