Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
Open accessAbstract
The ATP‐binding cassette (ABC) transporters are a superfamily of membrane proteins that are best known for their ability to transport a wide variety of exogenous and endogenous substances across membranes against a concentration gradient via ATP hydrolysis. There are seven subfamilies of human ABC transporters, one of the largest being the ‘C’ subfamily (gene symbol ABCC ). Nine ABCC subfamily members, the so‐called multidrug resistance proteins (MRPs) 1–9, have been implicated in mediating multidrug resistance in tumor cells to varying degrees as the efflux extrude chemotherapeutic compounds (or their metabolites) from malignant cells. Some of the MRPs are also known to either influence drug disposition in normal tissues or modulate the elimination of drugs (or their metabolites) via hepatobiliary or renal excretory pathways. In addition, the cellular efflux of physiologically important organic anions such as leukotriene C 4 and cAMP is mediated by one or more of the MRPs. Finally, mutations in several MRPs are associated with human genetic disorders. In this minireview, the current biochemical and physiological knowledge of MRP1–MRP9 in cancer chemotherapy and human genetic disease is summarized. The mutations in MRP2/ABCC2 leading to conjugated hyperbilirubinemia (Dubin–Johnson syndrome) and in MRP6/ABCC6 leading to the connective tissue disorder Pseudoxanthoma elasticum are also discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Another disadvantage of targeting the active site of kinases is that those inhibitors are highly susceptible to resistance arising from mutations in the catalytic domain, such as drug resistance to imatinib in chronic myeloid leukemia patients.
“Another disadvantage of targeting the active site of kinases is that those inhibitors are highly susceptible to resistance arising from mutations in the catalytic domain, such as drug resistance to imatinib in the case of chronic myeloid leukemia patients [4, 105].”
From The design and development of covalent protein-protein interaction inhibitors for cancer treatment (2020) · cites this paper as [105]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037 · see citing works
Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects
Samuelsson, B. O., Dahlén, S., LINDGREN, J. Å., Rouzer, C. A., & Serhan, C. N. (1987) · Science · doi:10.1126/science.2820055 · Cited by 2,233 · see citing works
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
Luo, G., Ducy, P. F., McKee, M. D., Pinero, G. J., Loyer, E. M., Behringer, R. R., & Karsenty, G. (1997) · Nature · doi:10.1038/386078a0 · Cited by 2,118 · see citing works
A family of drug transporters: the multidrug resistance-associated proteins
Borst, P., Evers, R., Kool, M., & Wijnholds, J. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.16.1295 · Cited by 1,751 · see citing works
Leslie, E. M., Deeley, R. G., & Cole, S. P. C. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.10.012 · Cited by 1,407 · see citing works
ABC transporters in cancer: more than just drug efflux pumps
Fletcher, J. I., Haber, M., Henderson, M. J., & Norris, M. D. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2789 · Cited by 1,022 · see citing works
Kool, M., de Haas, M., Scheffer, G. L., Scheper, R. J., van Eijk, M. J., Juijn, J. A., Baas, F., & Borst, P. (1997) · PubMed · Cited by 882 · see citing works
Leier, I., Jedlitschky, G., Buchholz, U., Cole, S. P. C., Deeley, R. G., & KEPPLER, D. O. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46856-1 · Cited by 854 · see citing works
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene
Paulusma, C. C., Bosma, P. J., Zaman, G. J. R., Bakker, C., Otter, M. Y., Scheffer, G. L., Scheper, R. J., Borst, P., & Elferink, R. P. J. O. (1996) · Science · doi:10.1126/science.271.5252.1126 · Cited by 817 · see citing works
König, J., Nies, A. T., Cui, Y., Leier, I., & KEPPLER, D. O. R. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00169-8 · Cited by 786 · see citing works
Deeley, R. G., Westlake, C., & Cole, S. P. C. (2006) · Physiological Reviews · doi:10.1152/physrev.00035.2005 · Cited by 761 · see citing works
Cui, Y., König, J., Buchholz, U., Spring, H., Leier, I., & KEPPLER, D. O. R. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23190-4 · Cited by 674 · see citing works
Structure and mechanism of ABC transporter proteins
Hollenstein, K., Dawson, R. J. P., & Locher, K. P. (2007) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2007.07.003 · Cited by 672 · see citing works
Altered wound healing in mice lacking a functional osteopontin gene (spp1).
Liaw, L., Birk, D. E., Ballas, C. B., Whitsitt, J. S., Davidson, J. M., & Hogan, B. L. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2131 · Cited by 664 · see citing works
The ATP-dependent glutathione S-conjugate export pump
Ishikawa, T. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90489-v · Cited by 658 · see citing works
MRP3, an organic anion transporter able to transport anti-cancer drugs
Kool, M., van der Linden, M., de Haas, M., Scheffer, G. L., de Vree, J. M. L., Smith, A. J., Jansen, G., Peters, G. J., Ponne, N. J., Scheper, R. J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6914 · Cited by 645 · see citing works
Büchler, M. W., König, J., Brom, M., Kartenbeck, J., Spring, H., Horie, T., & KEPPLER, D. O. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15091 · Cited by 639 · see citing works
Mutations in ABCC6 cause pseudoxanthoma elasticum
Bergen, A. A. B., Plomp, A. S., Schuurman, E. J. M., Terry, S. F., Breuning, M. H., Dauwerse, H. G., Swart, J., Kool, M., Soest, S. V., Baas, F., et al. (2000) · Nature Genetics · doi:10.1038/76109 · Cited by 590 · see citing works
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
Schuetz, J. D., Connelly, M., Sun, D., Paibir, S. G., Flynn, P. M., Srinivas, R. V., Kumar, A., & Fridland, A. (1999) · Nature Medicine · doi:10.1038/12487 · Cited by 575 · see citing works
Paulusma, C., Kool, M., Bosma, P., Scheffer, G., Borg, F. T., Scheper, R., Tytgat, G., Borst, P., Baas, F., & Elferink, R. O. O. (1997) · Hepatology · doi:10.1002/hep.510250635 · Cited by 561 · see citing works
Loe, D. W., Almquist, K. C., Deeley, R. G., & Cole, S. P. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9675 · Cited by 560 · see citing works
Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum
Saux, O. L., Urbán, Z., Tschuch, C., Csiszár, K., Bacchelli, B., Quaglino, D., Pasquali‐Ronchetti, I., Pope, F. M., Richards, A. J., Terry, S. F., et al. (2000) · Nature Genetics · doi:10.1038/76102 · Cited by 538 · see citing works
Reid, G., Wielinga, P. R., Zelcer, N., van der Heijden, I., Kuil, A., de Haas, M., Wijnholds, J., & Borst, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1033060100 · Cited by 531 · see citing works
König, J., Rost, D., Cui, Y., & KEPPLER, D. O. R. (1999) · Hepatology · doi:10.1002/hep.510290404 · Cited by 503 · see citing works
van Aubel, R. A. M. H., Smeets, P. H. E., Peters, J. G. P., Bindels, R. J. M., & Rüssel, F. G. M. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v133595 · Cited by 501 · see citing works
Wijnholds, J., Mol, C. A. A. M., van Deemter, L., de Haas, M., Scheffer, G. L., Baas, F., Beijnen, J. H., Scheper, R. J., Hatse, S., Clercq, E. D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120159197 · Cited by 478 · see citing works
Taniguchi, K., WADA, M., Kohno, K., Nakamura, T., Kawabe, T., Kawakami, M., Kagotani, K., Okumura, K., Akiyama, S.-I., & Kuwano, M. (1996) · PubMed · Cited by 470 · see citing works
CHRONIC IDIOPATHIC JAUNDICE WITH UNIDENTIFIED PIGMENT IN LIVER CELLS
Dubin, I. N., & Johnson, F. B. (1954) · Medicine · doi:10.1097/00005792-195409000-00001 · Cited by 454 · see citing works
The Multidrug Resistance Protein 5 Functions as an ATP-dependent Export Pump for Cyclic Nucleotides
Jedlitschky, G., Burchell, B., & KEPPLER, D. O. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005463200 · Cited by 442 · see citing works
Wijnholds, J., Evers, R., van Leusden, M. R., Mol, C. A. A. M., Zaman, G. J. R., Mayer, U., Beijnen, J. H., van der Valk, M., Krimpenfort, P., & Borst, P. (1997) · Nature Medicine · doi:10.1038/nm1197-1275 · Cited by 432 · see citing works
Rüssel, F. G. M., Koenderink, J. J., & Masereeuw, R. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.01.006 · Cited by 418 · see citing works
Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy
Leggas, M. L., Adachi, M., Scheffer, G. L., Sun, D., Wielinga, P. R., Du, G., Mercer, K. E., Zhuang, Y., Panetta, J. C., Johnston, B., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7612-7621.2004 · Cited by 415 · see citing works
Kartenbeck, J., Leuschner, U., Mayer, R., & KEPPLER, D. O. R. (1996) · Hepatology · doi:10.1053/jhep.1996.v23.pm0008621134 · Cited by 398 · see citing works
Loe, D. W., Deeley, R. G., & Cole, S. P. C. (1998) · PubMed · Cited by 395 · see citing works
The apical conjugate efflux pump ABCC2 (MRP2)
Nies, A. T., & KEPPLER, D. O. R. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0109-y · Cited by 394 · see citing works
Ringpfeil, F., Lebwohl, M., Christiano, A. M., & Uitto, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100041297 · Cited by 388 · see citing works
Nies, A. T., Jedlitschky, G., König, J., Herold‐Mende, C. C., Steiner, H. H., Schmitt, H.-P., & KEPPLER, D. O. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.051 · Cited by 381 · see citing works
Transport of glutathione and glutathione conjugates by MRP1
Cole, S. P. C., & Deeley, R. G. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.06.008 · Cited by 369 · see citing works
Reid, G., Wielinga, P. R., Zelcer, N., de Haas, M., van Deemter, L., Wijnholds, J., Balzarini, J. M., & Borst, P. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.5.1094 · Cited by 368 · see citing works
Kool, M., van der Linden, M., de Haas, M., Baas, F., & Borst, P. (1999) · PubMed · Cited by 361 · see citing works
Hirohashi, T., Suzuki, H. I., & Sugiyama, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15181 · Cited by 351 · see citing works
Jansen, P. L. M., Peters, W. H. M., & Lamers, W. H. (1985) · Hepatology · doi:10.1002/hep.1840050408 · Cited by 347 · see citing works
Expression of members of the multidrug resistance protein family in human term placenta
St–Pierre, M. V., Serrano, M. A., Macı́as, R. I. R., Dubs, U., Hoechli, M., Lauper, U., Meier, P. J., & Marı́n, J. J. G. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1495 · Cited by 325 · see citing works
Chen, Z., Lee, K., WALTHER, S. E., Raftogianis, R. B., Kuwano, M., Zeng, H., & Kruh, G. D. (2002) · PubMed · Cited by 316 · see citing works
Self-citationKikuchi, S., Hata, M., Fukumoto, K., Yamane, Y., Matsui, T., Tamura, A., Yonemura, S., Yamagishi, H., KEPPLER, D. O. R., Tsukita, S., et al. (2002) · Nature Genetics · doi:10.1038/ng905 · Cited by 308 · see citing works
A SNP in the ABCC11 gene is the determinant of human earwax type
Yoshiura, K.-I., Kinoshita, A., Ishida, T., Ninokata, A., Ishikawa, T., Kaname, T., Bannai, M., Tokunaga, K., Sonoda, S., Komaki, R., et al. (2006) · Nature Genetics · doi:10.1038/ng1733 · Cited by 297 · see citing works
Multidrug resistance-associated proteins 3, 4, and 5
Borst, P., de Wolf, C., & van de Wetering, K. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0054-9 · Cited by 296 · see citing works
Schaub, T. P., Kartenbeck, J., König, J., Vogel, O., Witzgall, R., Kriz, W., & KEPPLER, D. O. R. (1997) · Journal of the American Society of Nephrology · doi:10.1681/asn.v881213 · Cited by 294 · see citing works
Burger, H., Foekens, J. A., Look, M. P., Gelder, M. E. M., Klijn, J. G. M., Wiemer, E. A. C., Stoter, G., & Nooter, K. (2003) · PubMed · Cited by 292 · see citing works
LEIER, I., JEDLITSCHKY, G., BUCHHOLZ, U., CENTER, M., COLE, S. P. C., DEELEY, R. G., & KEPPLER, D. (1996) · Biochemical Journal · doi:10.1042/bj3140433 · Cited by 291 · see citing works
Complete Characterization of the Human ABC Gene Family
Dean, M. C., & Allikmets, R. L. (2001) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1012823120935 · Cited by 290 · see citing works
Soroka, C. J., Lee, J. M., Azzaroli, F., & Boyer, J. L. (2001) · Hepatology · doi:10.1053/jhep.2001.23501 · Cited by 288 · see citing works
Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
Deeley, R. G., & Cole, S. P. C. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.12.036 · Cited by 285 · see citing works
Tissue Distribution and Induction of Human Multidrug Resistant Protein 3
Scheffer, G. L., Kool, M., de Haas, M., de Vree, J. M. L., Pijnenborg, A. C. L. M., Bosman, D. K., Elferink, R. P. J. O., van der Valk, P., Borst, P., & Scheper, R. J. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780411 · Cited by 266 · see citing works
Hirohashi, T., Suzuki, H., Ito, K., Ogawa, K., Kume, K., Shimizu, T., & Sugiyama, Y. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13278-6 · Cited by 265 · see citing works
Belinsky, M. G., Chen, Z., Shchaveleva, I., Zeng, H., & Kruh, G. D. (2002) · PubMed · Cited by 262 · see citing works
Self-citationCharacterization of Drug Transport by the Human Multidrug Resistance Protein 3 (ABCC3)
Zelcer, N., SAEKI, T., Reid, G., Beijnen, J. H., & Borst, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107041200 · Cited by 258 · see citing works
Wada, M. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.2.203 · Cited by 256 · see citing works
Guo, Y., Kotova, E., Chen, Z., Lee, K., Hopper-Borge, E. A., Belinsky, M. G., & Kruh, G. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304059200 · Cited by 251 · see citing works
Self-citationPratt, S. E., Shepard, R. L., Kandasamy, R. A., Johnston, P. A., Perry, W., & Dantzig, A. H. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0291 · Cited by 245 · see citing works
Cloning and Targeted Deletion of the Mouse Fetuin Gene
Jahnen‐Dechent, W., Schinke, T., Trindl, A., Müller‐Esterl, W., Sablitzky, F., Kaiser, S., & Blessing, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31496 · Cited by 244 · see citing works
Lorico, A., Rappa, G., Finch, R. A., Yang, D. D., Flavell, R. A., & Sartorelli, A. C. (1997) · PubMed · Cited by 241 · see citing works
Iliás, A., Urbán, Z., Seidl, T. L., Saux, O. L., Sinkó, E., Boyd, C. D., Sarkadi, B., & Váradi, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110918200 · Cited by 240 · see citing works
Toh, S., Wada, M., Uchiumi, T., Inokuchi, A., Makino, Y., Horie, Y., Adachi, Y., Sakisaka, S., & Kuwano, M. (1999) · The American Journal of Human Genetics · doi:10.1086/302292 · Cited by 230 · see citing works
Evers, R., de Haas, M., Sparidans, R. W., Beijnen, J. H., Wielinga, P. R., Lankelma, J., & Borst, P. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1262 · Cited by 223 · see citing works
Structure and function of ABC transporters: the ATP switch provides flexible control
Linton, K. J., & Higgins, C. F. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0126-x · Cited by 221 · see citing works
Mammalian multidrug-resistance proteins (MRPs)
Slot, A. J., Molinski, S. V., & Cole, S. P. C. (2011) · Essays in Biochemistry · doi:10.1042/bse0500179 · Cited by 219 · see citing works
Zelcer, N., van de Wetering, K., Hillebrand, M. J. X., Sarton, E. Y., Kuil, A., Wielinga, P. R., Tephly, T. R., Dahan, A., Beijnen, J. H., & Borst, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502530102 · Cited by 215 · see citing works
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)1
Kiuchi, Y., Suzuki, H., Hirohashi, T., Tyson, C. A., & Sugiyama, Y. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00899-0 · Cited by 213 · see citing works
Huisman, M. T., Chhatta, A. A., van Tellingen, O., Beijnen, J. H., & Schinkel, A. H. (2005) · International Journal of Cancer · doi:10.1002/ijc.21013 · Cited by 212 · see citing works
Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy
Tiwari, A. K., Sodani, K. S., Dai, C., Ashby, C. R., & Chen, Z. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111795164048 · Cited by 211 · see citing works
Self-citationHegedűs, T., Őrfi, L., Seprődi, A., Váradi, A., Sarkadi, B., & Kéri, G. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00095-9 · Cited by 207 · see citing works
Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia
Li, C., Krishnamurthy, P. C., Penmatsa, H., Marrs, K. L., Wang, X. Q., Zaccolo, M., Jalink, K., Li, M., Nelson, D. J., Schuetz, J. D., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.037 · Cited by 206 · see citing works
Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum
Gorgels, T. G. M. F., Hu, X., Scheffer, G. L., van der Wal, A. C., Toonstra, J., de Jong, P. T. V. M., Kuppevelt, T. H. V., Levelt, C. N., de Wolf, A., Loves, W. J. P., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi183 · Cited by 206 · see citing works
Targeted Ablation of the Abcc6 Gene Results in Ectopic Mineralization of Connective Tissues
Klement, J. F., Matsuzaki, Y., Jiang, Q.-J., Terlizzi, J. P., Choi, H. Y., Fujimoto, N., Li, K., Pulkkinen, L., Birk, D. E., Sundberg, J. P., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8299-8310.2005 · Cited by 205 · see citing works
MRP6 (ABCC6) Detection in Normal Human Tissues and Tumors
Scheffer, G. L., Hu, X., Pijnenborg, A. C. L. M., Wijnholds, J., Bergen, A. A. B., & Scheper, R. J. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780444 · Cited by 202 · see citing works
Wijnholds, J., Scheffer, G. L., van der Valk, M., van der Valk, P., Beijnen, J. H., Scheper, R. J., & Borst, P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.5.797 · Cited by 202 · see citing works
Zelcer, N., Huisman, M. T., Reid, G., Wielinga, P. R., Breedveld, P., Kuil, A., Knipscheer, P., Schellens, J. H. M., Schinkel, A. H., & Borst, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303504200 · Cited by 201 · see citing works
A Spectrum of ABCC6 Mutations Is Responsible for Pseudoxanthoma Elasticum
Saux, O. L., Beck, K., Sachsinger, C., Silvestri, C., Treiber, C., Göring, H. H. H., Johnson, E. W., Paepe, A. D., Pope, F. M., Pasquali‐Ronchetti, I., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/323704 · Cited by 200 · see citing works
Analysis of the Drug Resistance Profile of Multidrug Resistance Protein 7 (ABCC10)
Hopper-Borge, E. A., Chen, Z., Shchaveleva, I., Belinsky, M. G., & Kruh, G. D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3111 · Cited by 198 · see citing works
Self-citationMcAleer, M. A., Breen, M. A., White, N. L., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23541 · Cited by 198 · see citing works
Expression of Drug Resistance Proteins Pgp, MRP1, MRP3, MRP5 AND GST-π in Human Glioma
Calatozzolo, C., Gelati, M., Ciusani, E., et al. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-004-6152-7 · Cited by 197 · see citing works
Maher, J. M., Slitt, A. L., Cherrington, N. J., Cheng, X., & Klaassen, C. D. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.003780 · Cited by 195 · see citing works
Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
Nies, A. T., König, J., Pfannschmidt, M., Klar, E., Hofmann, W. J., & KEPPLER, D. O. R. (2001) · International Journal of Cancer · doi:10.1002/ijc.1498 · Cited by 189 · see citing works
Zelcer, N., van de Wetering, K., de Waart, R. D., Scheffer, G. L., Marschall, H., Wielinga, P. R., Kuil, A., Kunne, C., Smith, A. J., van der Valk, M., et al. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.07.022 · Cited by 179 · see citing works
Wielinga, P. R., Reid, G., Challa, E. E., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.6.1321 · Cited by 179 · see citing works
Chen, Z., Kawabe, T., Ono, M., Aoki, S., Sumizawa, T., Furukawa, T., Uchiumi, T., Wada, M., Kuwano, M., & Akiyama, S.-I. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.6.1219 · Cited by 178 · see citing works
Self-citationAnalysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily
Hopper-Borge, E. A., Belinsky, M. G., Zeng, H., Tosolini, A., Testa, J. R., & Kruh, G. D. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00646-7 · Cited by 178 · see citing works
Expression of the multidrug resistance-associated protein (MRP) gene in human cancers.
Nooter, K., Westerman, A. M., Flens, M. J., Zaman, G. J., Scheper, R. J., van Wingerden, K. E., Burger, H., Oostrum, R. G., Boersma, T., & Sonneveld, P. (1995) · PubMed · Cited by 174 · see citing works
Bera, T. K., Lee, S. H., Salvatore, G., et al. (2001) · Molecular Medicine · doi:10.1007/bf03401856 · Cited by 174 · see citing works
Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms
Li, Q., Jiang, Q., Pfendner, E. G., Váradi, A., & Uitto, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00795.x · Cited by 174 · see citing works
Belinsky, M. G., Bain, L. J., Balsara, B., Testa, J. R., & Kruh, G. D. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.22.1735 · Cited by 170 · see citing works
Analysis of the In Vivo Functions of Mrp3
Belinsky, M. G., Dawson, P. A., Shchaveleva, I., Bain, L. J., Wang, R., Ling, V. W. T., Chen, Z., Grinberg, A., Westphal, H., Klein–Szanto, A. J., et al. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.010587 · Cited by 167 · see citing works
Self-citationLeslie, E. M., Ito, K.-I., Upadhyaya, P., Hecht, S. S., Deeley, R. G., & Cole, S. P. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102453200 · Cited by 167 · see citing works
Ito, K., Olsen, S. L., Qiu, W., Deeley, R. G., & Cole, S. P. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011246200 · Cited by 166 · see citing works
Rost, D., Mahner, S., Sugiyama, Y., et al. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00318.2001 · Cited by 166 · see citing works
Glutathione Stimulates Sulfated Estrogen Transport by Multidrug Resistance Protein 1
Qian, Y., Song, W., Cui, H.-R., Cole, S. P. C., & Deeley, R. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008251200 · Cited by 164 · see citing works
Characterization of the Transport Properties of Human Multidrug Resistance Protein 7 (MRP7, ABCC10)
Chen, Z., Hopper-Borge, E. A., Belinsky, M. G., Shchaveleva, I., Kotova, E., & Kruh, G. D. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.351 · Cited by 160 · see citing works
Self-citationVerapamil Stimulates Glutathione Transport by the 190-kDa Multidrug Resistance Protein 1 (MRP1)
Loe, D. W., Deeley, R. G., & Cole, S. P. C. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39265-1 · Cited by 159 · see citing works
Kawabe, T., Chen, Z., Wada, M., et al. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00979-5 · Cited by 159 · see citing works
Self-citationChu, X., Kato, Y., Niinuma, K., Sudo, K.-I., Hakusui, H., & Sugiyama, Y. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36601-7 · Cited by 158 · see citing works
MRP3, BCRP, and P-Glycoprotein Activities are Prognostic Factors in Adult Acute Myeloid Leukemia
Benderra, Z., Faussat, A. M., Sayada, L., Perrot, J., Tang, R., Chaoui, D., Morjani, H., Marzac, C., Marie, J., & Legrand, O. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1895 · Cited by 154 · see citing works
Tammur, J., Prades, C., Reguigne-Arnould, I., Rzhetsky, A., Hutchinson, A. A., Adachi, M., Schuetz, J. D., Swoboda, K. J., Ptáček, L. J., Rosier, M., et al. (2001) · Gene · doi:10.1016/s0378-1119(01)00572-8 · Cited by 145 · see citing works
Characterization of Mice Lacking the Multidrug Resistance Protein Mrp2 (Abcc2)
Chu, X., Strauss, J. R., Mariano, M. A., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.098665 · Cited by 143 · see citing works
Kruh, G. D., Guo, Y., Hopper-Borge, E. A., Belinsky, M. G., & Chen, Z. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0114-1 · Cited by 142 · see citing works
Self-citationTransporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity
Krishnamurthy, P. C., Schwab, M. G., Takenaka, K., Nachagari, D., Morgan, J., Leslie, M., Du, W., Boyd, K. L., Cheok, M. H.-C., Nakauchi, H., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6790 · Cited by 141 · see citing works
Struk, B., Cai, L., Zäch, S., Ji, W., Chung, J., Lumsden, A. L., Stümm, M., Huber, M., Schaen, L., Kim, C.-A., et al. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000114 · Cited by 141 · see citing works
Wielinga, P. R., Hooijberg, J. H., Gunnarsdottir, S., Kathmann, I., Reid, G., Zelcer, N., van der Born, K., de Haas, M., van der Heijden, I., Kaspers, G. J. L., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2810 · Cited by 139 · see citing works
Hopper-Borge, E. A., Xu, X., Shen, T., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1420 · Cited by 136 · see citing works
Chen, Z., Guo, Y., Belinsky, M. G., Kotova, E., & Kruh, G. D. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.007138 · Cited by 135 · see citing works
Self-citationIto, K., Oleschuk, C. J., Westlake, C., Vasa, M. Z., Deeley, R. G., & Cole, S. P. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105160200 · Cited by 132 · see citing works
Nagano, J., Kono, S., Preston, D. L., Moriwaki, H., Sharp, G. B., Koyama, K., & Mabuchi, K. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000401)86:1 · Cited by 131 · see citing works
ATP-Dependent Transport of Leukotrienes B4 and C4 by the Multidrug Resistance Protein ABCC4 (MRP4)
Rius, M., Hummel-Eisenbeiss, J., & KEPPLER, D. O. R. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.131342 · Cited by 130 · see citing works
Leslie, E. M., Deeley, R. G., & Cole, S. P. C. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.1.11 · Cited by 124 · see citing works
Uitto, J., Pulkkinen, L., & Ringpfeil, F. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(00)01869-4 · Cited by 122 · see citing works
Bera, T. K., Iavarone, C., Vasantha Kumar, M. V., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102187299 · Cited by 121 · see citing works
Hasegawa, M., Kusuhara, H., Adachi, M., Schuetz, J. D., Takeuchi, K., & Sugiyama, Y. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005090966 · Cited by 120 · see citing works
Sandusky, G. E., Mintze, K., Pratt, S. E., & Dantzig, A. H. (2002) · Histopathology · doi:10.1046/j.1365-2559.2002.01403.x · Cited by 118 · see citing works
Xiong, H., Turner, K. C., Ward, E. S., et al. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38933-5 · Cited by 118 · see citing works
Mechanisms of renal anionic drug transport
El‐Sheikh, A. A. K., Masereeuw, R., & Rüssel, F. G. M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.085 · Cited by 117 · see citing works
zu Schwabedissen, H. E. M., Grube, M., Heydrich, B., Linnemann, K., Fusch, C., Kroemer, H. K., & Jedlitschky, G. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62230-4 · Cited by 114 · see citing works
Wang, W., Soroka, C. J., Mennone, A., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.06.013 · Cited by 109 · see citing works
Plasschaert, S. L. A., de Bont, E. S. J. M., Boezen, M., van der Kolk, D. M., Daenen, S. M. G. J., Faber, K. N., Kamps, W. A., de Vries, E. G. E., & Vellenga, E. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1096 · Cited by 108 · see citing works
MRP2 and 3 in health and disease
Borst, P., Zelcer, N., & van de Wetering, K. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.05.051 · Cited by 107 · see citing works
Hanaka, H., Pawelzik, S., Johnsen, J. I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910218106 · Cited by 105 · see citing works
Multiple Splicing Variants of Two New Human ATP-Binding Cassette Transporters, ABCC11 and ABCC12
Yabuuchi, H., Shimizu, H., Takayanagi, S., & Ishikawa, T. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5865 · Cited by 104 · see citing works
XENOBIOTIC AND ENDOBIOTIC TRANSPORTER MRNA EXPRESSION IN THE BLOOD-TESTIS BARRIER
Augustine, L. M., Markelewicz, R. J., Boekelheide, K., & Cherrington, N. J. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.001024 · Cited by 102 · see citing works
Rost, D., König, J., Weiß, G., Klar, E., Stremmel, W., & KEPPLER, D. O. R. (2001) · Gastroenterology · doi:10.1053/gast.2001.28648 · Cited by 101 · see citing works
Wakai (2010) · Oncology Reports · doi:10.3892/or_00000721 · Cited by 99 · see citing works
Rius, M., Thon, W., KEPPLER, D. O. R., & Nies, A. T. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000180411.03808.cb · Cited by 99 · see citing works
Dazert, P., Meissner, K., Vogelgesang, S., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63513-4 · Cited by 97 · see citing works
Mao, Q., Deeley, R. G., & Cole, S. P. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004584200 · Cited by 97 · see citing works
P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 Determine the Pharmacokinetics of Etoposide
Lagas, J. S., Fan, L., Wagenaar, E., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1321 · Cited by 97 · see citing works
Extracutaneous Ultrastructural Alterations in Pseudoxanthoma Elasticum
Gheduzzi, D., Sammarco, R., Quaglino, D., et al. (2003) · Ultrastructural Pathology · doi:10.1080/01913120390248584 · Cited by 92 · see citing works
ATP-Binding Cassette C Transporters in Human Pancreatic Carcinoma Cell Lines
Hagmann, W., Jesnowski, R., Faissner, R., Guo, C., & Löhr, M. J. (2008) · Pancreatology · doi:10.1159/000178884 · Cited by 90 · see citing works
van der Kolk, D. M., de Vries, E. G. E., Koning, J., et al. (1998) · PubMed · Cited by 88 · see citing works
Zhang, D., Cole, S. P. C., & Deeley, R. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010008200 · Cited by 87 · see citing works
Toyoda, Y., Sakurai, A., Mitani, Y., Nakashima, M., Yoshiura, K.-I., Nakagawa, H., Sakai, Y., Ota, I., Lezhava, A., Hayashizaki, Y., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-129098 · Cited by 86 · see citing works
Kruh, G. D., Belinsky, M. G., Gallo, J. M., et al. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9039-1 · Cited by 84 · see citing works
Bortfeld, M., Rius, M., König, J., Herold‐Mende, C. C., Nies, A. T., & KEPPLER, D. O. R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.025 · Cited by 82 · see citing works
Ryu, S., Kawabe, T., Nada, S., & Yamaguchi, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005149200 · Cited by 82 · see citing works
Zamek‐Gliszczynski, M. J., Hoffmaster, K. A., Humphreys, J. E., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101840 · Cited by 82 · see citing works
Guo, Y., Köck, K., Ritter, C. A., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0442 · Cited by 82 · see citing works
Involvement of MRP4 (ABCC4) in the Luminal Efflux of Ceftizoxime and Cefazolin in the Kidney
Ci, L., Kusuhara, H., Adachi, M., et al. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.031823 · Cited by 82 · see citing works
Ishizuka, H., Konno, K., Shiina, T., Naganuma, H., Nishimura, K., Ito, K., Suzuki, H., & Sugiyama, Y. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35038-4 · Cited by 80 · see citing works
ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinoma.
Ohishi, Y., Oda, Y., Uchiumi, T., Kobayashi, H., Hirakawa, T., Miyamoto, S., Kinukawa, N., Nakano, H., Kuwano, M., & Tsuneyoshi, M. (2002) · PubMed · Cited by 80 · see citing works
Androgen regulation of multidrug resistance‐associated protein 4 (MRP4/ABCC4) in prostate cancer
Ho, L. L., Kench, J. G., Handelsman, D. J., et al. (2008) · The Prostate · doi:10.1002/pros.20809 · Cited by 77 · see citing works
Mottino, A. D., Hoffman, T., Jennes, L., et al. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.6.g1261 · Cited by 77 · see citing works
A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions.
Hosokawa, S., Tagaya, O., Mikami, T., Nozaki, Y., Kawaguchi, A., Yamatsu, K., & Shamoto, M. (1992) · PubMed · Cited by 77 · see citing works
Oguri, T., Ozasa, H., Uemura, T., Bessho, Y., Miyazaki, M., Maeno, K., 前田, 浩., Sato, S., & Ueda, R. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2088 · Cited by 76 · see citing works
Borst, P., van de Wetering, K., & Schlingemann, R. O. (2008) · Cell Cycle · doi:10.4161/cc.7.11.6005 · Cited by 76 · see citing works
Haimeur, A., Conseil, G., Deeley, R. G., & Cole, S. P. C. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1375 · Cited by 75 · see citing works
Krause, M. D. S., de Oliveira, L. P., da Silveira, E. M. S., et al. (2006) · Cell Biochemistry and Function · doi:10.1002/cbf.1343 · Cited by 69 · see citing works
Payen, L. F., Courtois, A., Campion, J. P., Guillouzo, A., & Fardel, O. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00496-2 · Cited by 68 · see citing works
ABCC10/MRP7 is associated with vinorelbine resistance in non-small cell lung cancer
Oguri (1994) · Oncology Reports · doi:10.3892/or_00000217 · Cited by 65 · see citing works
MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte
Ortiz, D. F., Li, S., Iyer, R., Zhang, X., Novikoff, P. M., & Arias, I. M. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.6.g1493 · Cited by 64 · see citing works
Longhurst, T., O’Neill, G. M., Harvie, R. M., & Davey, R. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.545 · Cited by 62 · see citing works
Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1
Conrad, S., Viertelhaus, A., Orzechowski, A., Hoogstraate, J. A., Gjellan, K., Schrenk, D., & Kauffmann, H.-M. (2001) · Toxicology · doi:10.1016/s0300-483x(00)00354-1 · Cited by 62 · see citing works
ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum
Hu, X., Plomp, A. S., Wijnholds, J., ten Brink, J. B., Soest, S. V., van den Born, L. I., LEYS, A. M., Peek, R., de Jong, P. T. V. M., & Bergen, A. A. B. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200953 · Cited by 61 · see citing works
Neonatal Dubin-Johnson Syndrome: Long-Term Follow-up and MRP2 Mutations Study
Lee, J., Chen, H., Chen, H., Ni, Y., Hsu, H., & Chang, M. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000203093.10908.bb · Cited by 61 · see citing works
Steinbach, D., Lengemann, J., Voigt, A., et al. (2003) · PubMed · Cited by 59 · see citing works
Bandler, P. E., Westlake, C. J., Grant, C. E., et al. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.045674 · Cited by 59 · see citing works
Cerumen Genetics and Human Breast Cancer
Petrakis, N. L. (1971) · Science · doi:10.1126/science.173.3994.347 · Cited by 58 · see citing works
Leslie, E. M., Bowers, R. J., Deeley, R. G., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.044073 · Cited by 57 · see citing works
Immunolocalization of Multidrug Resistance Protein 5 in the Human Genitourinary System
Nies, A. T., Spring, H., Thon, W., et al. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)65141-5 · Cited by 57 · see citing works
Ninomiya, M., Ito, K., & Horie, T. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.002196 · Cited by 50 · see citing works
Involvement of NHERF1 in apical membrane localization of MRP4 in polarized kidney cells
Hoque, M. T., Conseil, G., & Cole, S. P. C. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.014 · Cited by 49 · see citing works
Hoque, M. T., & Cole, S. P. C. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6778 · Cited by 49 · see citing works
Role of MRP4 (ABCC4) in Platelet Adenine Nucleotide-Storage
Jedlitschky, G., Cattaneo, M., Lubenow, L. E., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090425 · Cited by 48 · see citing works
楢崎, 史., Oka, M., Nakano, R., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7703 · Cited by 48 · see citing works
Expression of Multidrug Resistance Associated Protein 5 (MRP5) on Cornea and Its Role in Drug Efflux
Karla, P. K., Quinn, T., Herndon, B., Thomas, P., Pal, D., & Mitra, A. K. (2009) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2008.0084 · Cited by 47 · see citing works
Andrić, S. A., Kostic, T. S., & Stojilković, S. S. (2006) · Endocrinology · doi:10.1210/en.2006-0091 · Cited by 47 · see citing works
Miura, K., Yoshiura, K.-I., Miura, S., et al. (2007) · Human Genetics · doi:10.1007/s00439-007-0356-9 · Cited by 42 · see citing works
Naramoto, H., Uematsu, T., Uchihashi, T., Doto, R., Matsuura, T., Usui, Y., Uematsu, S., Li, X., Takahashi, M., Yamaoka, M., et al. (2007) · International Journal of Oncology · doi:10.3892/ijo.30.2.393 · Cited by 41 · see citing works
Shimizu, H., Taniguchi, H., Hippo, Y., et al. (2003) · Gene · doi:10.1016/s0378-1119(03)00504-3 · Cited by 40 · see citing works
Pseudoxanthoma Elasticum: a Metabolic Disease?
Jiang, Q., & Uitto, J. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700267 · Cited by 40 · see citing works
Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm
Ono, N., van der Heijden, I., Scheffer, G. L., et al. (2007) · Biochemical Journal · doi:10.1042/bj20070292 · Cited by 39 · see citing works
Asakura, E., Nakayama, H., Sugie, M., et al. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.11.035 · Cited by 38 · see citing works
Interaction of gatifloxacin with efflux transporters: A possible mechanism for drug resistance
Kwatra, D., Vadlapatla, R. K., Vadlapudi, A. D., et al. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.05.027 · Cited by 37 · see citing works
Yoo, W., Pae, N. S., Lee, S. J., et al. (2006) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2005.12.046 · Cited by 36 · see citing works
Boraldi, F., Quaglino, D., Croce, M. A., et al. (2003) · Matrix Biology · doi:10.1016/j.matbio.2003.09.001 · Cited by 34 · see citing works
Kim, H.-S., Min, Y.-D., & Choi, C.-H. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4746 · Cited by 33 · see citing works
Yoshida, M., Suzuki, T., Komiya, T., et al. (2001) · International Journal of Cancer · doi:10.1002/ijc.1490 · Cited by 32 · see citing works
Iram, S. H., & Cole, S. P. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.166959 · Cited by 32 · see citing works
Phenobarbital Alters Hepatic Mrp2 Function by Direct and Indirect Interactions
Patel, N. J., Zamek‐Gliszczynski, M. J., Zhang, P., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.1.154 · Cited by 31 · see citing works
Roy, U. B., Chakravarty, G., zu Bentrup, K. H., & Mondal, D. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.2002 · Cited by 28 · see citing works
Qin, L., Zheng, J., Grant, C. E., et al. (2008) · Biochemistry · doi:10.1021/bi801532g · Cited by 24 · see citing works
cGMP (guanosine 3′,5′-cyclic monophosphate) transport across human erythrocyte membranes
Wu, C., Woodcock, H., Hladky, S. B., et al. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.02.005 · Cited by 22 · see citing works
Molecular cloning of the murine cMOAT ATPase
Fritz, F., Chen, J., Hayes, P., et al. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00132-9 · Cited by 21 · see citing works
Kao, H.-H., Chang, M., Cheng, J., et al. (2003) · Journal of Biomedical Science · doi:10.1007/bf02256002 · Cited by 18 · see citing works
Boadu, E., & Sager, G. (2004) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510410003895 · Cited by 16 · see citing works
Biliary Excretion of Phenolphthalein Sulfate in Rats
Tanaka, H., Sano, N., & Takikawa, H. (2003) · Pharmacology · doi:10.1159/000070456 · Cited by 13 · see citing works
Xu, H.-L., Gavrilyuk, V., Wolde, H. M., et al. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01105.2003 · Cited by 13 · see citing works
Kanda, D., Takagi, H., Kawahara, Y., et al. (2009) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.24.464 · Cited by 11 · see citing works
Compensatory Expression of MRP3 in the Livers of MRP2-Deficient EHBRs Is Promoted by DHA Intake
Kazuhiro, K. U. B. O., Sekine, S., & Saito, M. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90387 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins
Yang, N. J., & Hinner, M. J. (2015) · Methods in Molecular Biology · doi:10.1007/978-1-4939-2272-7_3 · Cited by 826 · see citing works
Combination therapy based on nano codelivery for overcoming cancer drug resistance
Wang, H., & Huang, Y. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100024 · Cited by 115 · see citing works
The design and development of covalent protein-protein interaction inhibitors for cancer treatment
Cheng, S.-S., Yang, G.-J., Wang, W., Leung, C.-H., & Ma, D.-L. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00850-0 · Cited by 98 · see citing works
Tateno, S., Iida, M., Fujii, S., Suwa, T., Katayama, M., Tokuyama, H., Yamamoto, J., Ito, T., Sakamoto, S., Handa, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61027-w · Cited by 36 · see citing works
Zhang, H., Wang, Y.-J., Zhang, Y.-K., Wang, D.-S., Kathawala, R. J., Patel, A., Talele, T. T., Chen, Z.-S., & Fu, L.-W. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.04.008 · Cited by 34 · see citing works
Self-citation
- Authors
- Chen, Z., & Tiwari, A. K.
- Affiliations
- St. John's University (US)
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2011-08
- Volume
- 278
- Issue
- 18
- Pages
- 3226-3245
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- PMC
- PMC3168698
- OpenAlex
- W1754555893
- Cited by
- 274
- References
- 195
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 7 · 2023: 10 · 2022: 11 · 2021: 16 · 2020: 19 · 2019: 25 · 2018: 15 · 2017: 18 · 2016: 17 · 2015: 23 · 2014: 30 · 2013: 32 · 2012: 23
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- FEBS Journal (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R15CA143701)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- multidrug resistance protein, ABCC transporters, ABC transporters, multidrug resistance, cancer chemotherapy, drug efflux, drug disposition, organic anion transport, leukotriene C4, cyclic AMP, Dubin-Johnson syndrome, pseudoxanthoma elasticum, genetic disorders
- MeSH terms
- Multidrug Resistance-Associated Protein 2, Animals, Humans, Mutation, Neoplasms, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Protein Isoforms, ATP-Binding Cassette, Sub-Family C Proteins, Genetic Diseases, Inborn
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
