Combination therapy based on nano codelivery for overcoming cancer drug resistance

Cancer immunoediting: from immunosurveillance to tumor escape

Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002) · Nature Immunology · doi:10.1038/ni1102-991 · Cited by 5,393 · see citing works

Analysis of nanoparticle delivery to tumours

Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218 · see citing works

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

Chou, T.-C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.10 · Cited by 5,163 · see citing works

Cancer drug resistance: an evolving paradigm

Holohan, C., Van Schaeybroeck, S., Longley, D. B., & Johnston, P. G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3599 · Cited by 4,681 · see citing works

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Galon, J., & Bruni, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0007-y · Cited by 3,414 · see citing works

The Tumor Microenvironment Innately Modulates Cancer Progression

Hinshaw, D. C., & Shevde, L. A. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3962 · Cited by 3,270 · see citing works

Drug resistance in cancer: An overview

Housman, G., Byler, S., Heerboth, S., Lapinska, K., Longacre, M., Snyder, N., & Sarkar, S. (2014) · Cancers · doi:10.3390/cancers6031769 · Cited by 2,463 · see citing works

Drug Resistance and the Solid Tumor Microenvironment

Tredan, O., Galmarini, C. M., Patel, K., & Tannock, I. F. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm135 · Cited by 2,116 · see citing works

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

Kelly, B., & O'Neill, L. A. (2015) · Cell Research · doi:10.1038/cr.2015.68 · Cited by 1,876 · see citing works

Tumor microenvironment and therapeutic response

Wu, T., & Dai, Y. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.01.043 · Cited by 1,802 · see citing works

Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

O’Brien, M. E. R., Wigler, N., Inbar, M., Rosso, R., Grischke, E., Santoro, A., Catane, R., Kieback, D., Tomczak, P., Ackland, S. P., et al. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh097 · Cited by 1,739 · see citing works

Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?

Feng, R., Zong, Y., Cao, S., & Xu, R. (2019) · 癌症：英文版 · doi:10.1186/s40880-019-0368-6 · Cited by 1,630 · see citing works

Targeting metastasis

Steeg, P. S. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.25 · Cited by 1,363 · see citing works

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

Danhier, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.015 · Cited by 1,288 · see citing works

Mechanisms of drug combinations: interaction and network perspectives

Jia, J., Zhu, F., Ma, X., Cao, Z., Li, Y. X., & Chen, Y. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2683 · Cited by 975 · see citing works

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

Mitchem, J. B., Brennan, D. J., Knolhoff, B. L., Belt, B. A., Zhu, Y., Sanford, D. E., Belaygorod, L., Carpenter, D. H., Collins, L. I., Piwnica-Worms, D. R., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2731 · Cited by 943 · see citing works

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

Ashkenazi, A., Fairbrother, W. J., Leverson, J. D., & Souers, A. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.253 · Cited by 903 · see citing works

Mechanisms of chemoresistance in cancer stem cells

Abdullah, L. N., & Chow, E. K. (2013) · Clinical and Translational Medicine · doi:10.1186/2001-1326-2-3 · Cited by 721 · see citing works

Nanoparticle-based combination therapy toward overcoming drug resistance in cancer

Hu, C. J., & Zhang, L. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.01.008 · Cited by 688 · see citing works

Autophagy and multidrug resistance in cancer

Li, Y., Lei, Y., Yao, N., Wang, C., Hu, N., Ye, W., Zhang, D., & Chen, Z. (2017) · 癌症：英文版 · doi:10.1186/s40880-017-0219-2 · Cited by 667 · see citing works

Recent advances of cocktail chemotherapy by combination drug delivery systems

Hu, Q., Sun, W., Wang, C., & Gu, Z. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.022 · Cited by 625 · see citing works

Adaptive Immune Resistance: How Cancer Protects from Immune Attack

Ribas, A. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0563 · Cited by 620 · see citing works

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

Wojtkowiak, J. W., Verduzco, D., Schramm, K. J., & Gillies, R. J. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200292c · Cited by 568 · see citing works

Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review

Riaz, M. K., Riaz, M., Zhang, X., Lin, C., Wong, K. H., Chen, X., Zhang, G., Lü, A., & Yang, Z. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010195 · Cited by 510 · see citing works

Tumor microenvironment and cancer therapy resistance

Sun, Y. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.044 · Cited by 384 · see citing works

Nanomedicine of synergistic drug combinations for cancer therapy – Strategies and perspectives

Zhang, R. X., Wong, H. L., Xue, H. Y., Eoh, J. Y., & Wu, X. Y. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.012 · Cited by 380 · see citing works

Nanoparticles for combination drug therapy

Ma, L., Kohli, M., & Smith, A. (2013) · ACS Nano · doi:10.1021/nn405674m · Cited by 367 · see citing works

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

Gurunathan, S., Kang, M.-H., Qasim, M., & Kim, J.-H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103264 · Cited by 367 · see citing works

In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy

Tardi, P. G., Johnstone, S. A., Harasym, N. L., Xie, S., Harasym, T. O., Zisman, N., Harvie, P., Bermudes, D. G., & Mayer, L. D. (2008) · Leukemia Research · doi:10.1016/j.leukres.2008.06.028 · Cited by 357 · see citing works

Molecular mechanisms of drug resistance and its reversal in cancer

Yandım, M. K., Adan, A., & Baran, Y. (2015) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2015.1015957 · Cited by 347 · see citing works

From mice to humans: developments in cancer immunoediting

Teng, M. W. L., Galon, J., Fridman, W.-H., & Smyth, M. J. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80004 · Cited by 337 · see citing works

Targeted nanomedicine for cancer therapeutics: Towards precision medicine overcoming drug resistance

Bar-Zeev, M., Livney, Y. D., & Assaraf, Y. G. (2017) · Drug Resistance Updates · doi:10.1016/j.drup.2017.05.002 · Cited by 316 · see citing works

The role of tumor microenvironment in therapeutic resistance

Son, B., Lee, S., Youn, H., Kim, E., Kim, W., & Youn, B. (2016) · Oncotarget · doi:10.18632/oncotarget.13907 · Cited by 305 · see citing works

Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes

Hansen, A. E., Petersen, A. L., Henriksen, J. R., Børresen, B., Rasmussen, P., Elema, D. R., af Rosenschöld, P. M., Kristensen, A. T., Kjær, A., & Andresen, T. L. (2015) · ACS Nano · doi:10.1021/acsnano.5b01324 · Cited by 277 · see citing works

Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases

Chen, Z., & Tiwari, A. K. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08235.x · Cited by 274 · see citing works

Exploiting nanotechnology to overcome tumor drug resistance: Challenges and opportunities

Kirtane, A. R., Kalscheuer, S., & Panyam, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.001 · Cited by 262 · see citing works

Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach

Taylor, S., Spugnini, E. P., Assaraf, Y. G., Azzarito, T., Rauch, C., & Fais, S. (2015) · Drug Resistance Updates · doi:10.1016/j.drup.2015.08.004 · Cited by 259 · see citing works

Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications

Wu, W., Luo, L., Wang, Y., Wu, Q., Dai, H.-B., Li, J., Durkan, C., Wang, N., & Wang, G. (2018) · Theranostics · doi:10.7150/thno.23459 · Cited by 247 · see citing works

EGFR T790M Mutation: A Double Role in Lung Cancer Cell Survival?

Suda, K., Onozato, R., Yatabe, Y., & Mitsudomi, T. (2009) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181913c9f · Cited by 227 · see citing works

Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin β3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery

Jin, H., He, Y., Zhao, P., Hu, Y., Tao, J., Chen, J., & Huang, Y. (2018) · Theranostics · doi:10.7150/thno.27246 · Cited by 220 · see citing works

Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer

Raoof, S., Mulford, I. J., Frisco-Cabanos, H., Nangia, V., Timonina, D., Labrot, E., Hafeez, N., Bilton, S. J., Drier, Y., Ji, F., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0887-2 · Cited by 216 · see citing works

Mechanisms of Multidrug Resistance in Cancer Treatment

Harris, A. L., & Hochhauser, D. (1992) · Acta Oncologica · doi:10.3109/02841869209088904 · Cited by 208 · see citing works

Rationally designed nanovehicles to overcome cancer chemoresistance

Livney, Y. D., & Assaraf, Y. G. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.006 · Cited by 205 · see citing works

Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1

Wang, H., Tang, Y., Fang, Y., Zhang, M., Wang, H., He, Z., Wang, B., Xu, Q., & Huang, Y. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00021 · Cited by 195 · see citing works

Resistance Is Futile: Targeting Mitochondrial Energetics and Metabolism to Overcome Drug Resistance in Cancer Treatment

Bosc, C., Selak, M. A., & Sarry, J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.013 · Cited by 193 · see citing works

Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer

Christie, E. L., Pattnaik, S., Beach, J. A., Copeland, A., Rashoo, N., Fereday, S., Hendley, J., Alsop, K., Brady, S. W., Lamb, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09312-9 · Cited by 193 · see citing works

The roles of glucose metabolic reprogramming in chemo- and radio-resistance

Lin, J., Xia, L., Liang, J., Han, Y., Wang, H., Oyang, L., Tan, S., Tian, Y., Rao, S., Chen, X., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1214-z · Cited by 191 · see citing works

Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology

Sabnis, A. J., & Bivona, T. G. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.12.009 · Cited by 183 · see citing works

Mechanisms of acquired tumor drug resistance

Алексахина, С. Н., Kashyap, A., & Имянитов, Е. Н. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.188310 · Cited by 178 · see citing works

Mitochondria-Targeting Polydopamine Nanoparticles To Deliver Doxorubicin for Overcoming Drug Resistance

Li, W.-Q., Wang, Z., Hao, S., He, H., Wan, Y., Zhu, C., Sun, L.-P., Cheng, G., & Zheng, S. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b01540 · Cited by 172 · see citing works

Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response

Mellor, H. R., & Callaghan, R. (2008) · Pharmacology · doi:10.1159/000115967 · Cited by 169 · see citing works

Immune Effects of Chemotherapy, Radiation, and Targeted Therapy and Opportunities for Combination With Immunotherapy

Wargo, J. A., Reuben, A., Cooper, Z. A., Oh, K. S., & Sullivan, R. J. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.05.007 · Cited by 167 · see citing works

Dual‐Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug‐Resistant Cancer Therapy

Zhao, P., Yin, W., Wu, A., Tang, Y., Wang, J., Pan, Z., Lin, T., Zhang, M., Chen, B., Duan, Y., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700403 · Cited by 160 · see citing works

The beginning of the end of the nanomedicine hype

Park, K. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.05.044 · Cited by 158 · see citing works

Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms

Yamaoka, T., Ohba, M., & Ohmori, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112420 · Cited by 152 · see citing works

Autophagy in Cancer Stem Cells: A Potential Link Between Chemoresistance, Recurrence, and Metastasis

Ojha, R., Bhattacharyya, S., & Singh, S. K. (2015) · BioResearch open access · doi:10.1089/biores.2014.0035 · Cited by 150 · see citing works

Designer combination therapy for cancer

Lane, D. P. (2006) · Nature Biotechnology · doi:10.1038/nbt0206-163 · Cited by 145 · see citing works

The therapeutic potential of targeting ABC transporters to combat multi-drug resistance

Bugde, P., Biswas, R., Mérien, F., Lu, J., Liu, D., Chen, M., Zhou, S., & Li, Y. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1310841 · Cited by 137 · see citing works

Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer

Zhang, M., Liu, E., Cui, Y., & Huang, Y. (2017) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2017.0054 · Cited by 134 · see citing works

Drug delivery micelles with efficient near-infrared photosensitizer for combined image-guided photodynamic therapy and chemotherapy of drug-resistant cancer

Zhen, S., Yi, X., Zhao, Z., Lou, X., Xia, F., & Tang, B. Z. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119330 · Cited by 134 · see citing works

Stimuli sensitive polymers and self regulated drug delivery systems: A very partial review

Siegel, R. A. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.035 · Cited by 128 · see citing works

Nanodrug delivery systems for targeting the endogenous tumor microenvironment and simultaneously overcoming multidrug resistance properties

Li, R., & Xie, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.020 · Cited by 127 · see citing works

Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance

Chen, S., Yang, K., Tuguntaev, R. G., Mozhi, A., Zhang, J., Wang, P. C., & Liang, X. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.020 · Cited by 126 · see citing works

Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning

Milane, L. S., Duan, Z., & Amiji, M. M. (2011) · Cancer Cell International · doi:10.1186/1475-2867-11-3 · Cited by 118 · see citing works

Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy

Kang, X., Wang, H., Peng, H., Chen, B., Zhang, W., Wu, A., Xu, Q., & Huang, Y. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.10 · Cited by 117 · see citing works

Autophagy and Hallmarks of Cancer

Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N. G., Feng, H., Hu, B., & Cheng, S. (2018) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2018027913 · Cited by 116 · see citing works

Reprogramming Tumor-Associated Macrophages To Reverse EGFRT790M Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat

Peng, H., Chen, B., Huang, W., Tang, Y., Jiang, Y., Zhang, W., & Huang, Y. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03756 · Cited by 113 · see citing works

pH/Redox Dual-Responsive Polyplex with Effective Endosomal Escape for Codelivery of siRNA and Doxorubicin against Drug-Resistant Cancer Cells

Gao, Y., Li, J., Wang, Q., Hu, H., Zhao, X., Chen, D., & Qiao, M. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b02016 · Cited by 109 · see citing works

MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer

Lu, X. J., Liu, R., Wang, M., Kumar, A. K., Pan, F., He, L., Hu, Z., & Guo, Z. (2019) · Oncogene · doi:10.1038/s41388-019-0986-0 · Cited by 105 · see citing works

Role of the tumor microenvironment in the pathogenesis of gastric carcinoma

Chung, H. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i7.1667 · Cited by 104 · see citing works

Co-Delivery of Trichosanthin and Albendazole by Nano-Self-Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis

Tang, Y., Liang, J., Wu, A., Chen, Y., Zhao, P., Lin, T., Zhang, M., Xu, Q., Wang, J., & Huang, Y. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b05292 · Cited by 104 · see citing works

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

Qie, S., Yoshida, A., Parnham, S. R., Oleinik, N. V., Beeson, G. C., Beeson, C. C., Öğretmen, B., Bass, A. J., Wong, K., Rustgi, A. K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09179-w · Cited by 101 · see citing works

Reversing of multidrug resistance breast cancer by co-delivery of P-gp siRNA and doxorubicin via folic acid-modified core-shell nanomicelles

Wu, Y., Zhang, Y., Zhang, W., Sun, C., Wu, J., & Tang, J. (2016) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2015.11.041 · Cited by 100 · see citing works

Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting

Zhou, M., Li, L., Li, L., Lin, X., Wang, F., Li, Q., & Huang, Y. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.11.005 · Cited by 99 · see citing works

Eugenol potentiates cisplatin anti‐cancer activity through inhibition of ALDH‐positive breast cancer stem cells and the NF‐κB signaling pathway

Islam, S. S., Al-Sharif, I. S., Sultan, A. M., Al‐Mazrou, A., Remmal, A., & Aboussekhra, A. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22758 · Cited by 90 · see citing works

Temporally Controlled Photothermal/Photodynamic and Combined Therapy for Overcoming Multidrug Resistance of Cancer by Polydopamine Nanoclustered Micelles

Xing, Y., Ding, T., Wang, Z., Wang, L., Guan, H., Tang, J., Mo, D., & Zhang, J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b00472 · Cited by 90 · see citing works

A dual pH-sensitive liposomal system with charge-reversal and NO generation for overcoming multidrug resistance in cancer

Chen, M., Song, F., Liu, Y., Tian, J. H., Liu, C., Li, R., & Zhang, Q. (2018) · Nanoscale · doi:10.1039/c8nr06218h · Cited by 86 · see citing works

Enhancing tumor chemotherapy and overcoming drug resistance through autophagy-mediated intracellular dissolution of zinc oxide nanoparticles

Hu, Y. B., Zhang, H., Dong, L., Xu, M., Zhang, L., Ding, W., Zhang, J., Lin, J., Zhang, Y., Qiu, B., et al. (2019) · Nanoscale · doi:10.1039/c8nr08442d · Cited by 83 · see citing works

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis

Tang, Z., Takahashi, Y., Chen, C., Liu, Y., He, H., Tsotakos, N., Serfass, J. M., Gebru, M. T., Chen, H., Young, M. M., et al. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.133 · Cited by 82 · see citing works

Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy

Wang, Z., He, Q., Zhao, W., Luo, J., & Gao, W. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.017 · Cited by 80 · see citing works

Remodeling Tumor‐Associated Macrophages and Neovascularization Overcomes EGFRT790M‐Associated Drug Resistance by PD‐L1 Nanobody‐Mediated Codelivery

Yin, W., Yu, X., Kang, X., Zhao, Y., Zhao, P., Jin, H., Fu, X., Wan, Y., Peng, C., & Huang, Y. (2018) · Small · doi:10.1002/smll.201802372 · Cited by 80 · see citing works

Synergistic Cytotoxicity of Irinotecan and Cisplatin in Dual-Drug Targeted Polymeric Nanoparticles

Valencia, P. M., Pridgen, E. M., Perea, B., Gadde, S., Sweeney, C. J., Kantoff, P. W., Bander, N. H., Lippard, S. J., Langer, R., Karnik, R., et al. (2012) · Nanomedicine · doi:10.2217/nnm.12.134 · Cited by 75 · see citing works

Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuli-responsive self-assembling nanocomposites

Xu, F., Zhong, H., Chang, Y., Li, D., Jin, H., Zhang, M., Wang, H., Jiang, C., Shen, Y., & Huang, Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.12.018 · Cited by 74 · see citing works

Therapeutically targeting tumor microenvironment–mediated drug resistance in estrogen receptor–positive breast cancer

Shee, K., Yang, W., Hinds, J. W., Hampsch, R. A., Varn, F. S., Traphagen, N. A., Patel, K., Cheng, C., Jenkins, N. P., Kettenbach, A. N., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20171818 · Cited by 74 · see citing works

Four distinct immune microenvironment subtypes in gastric adenocarcinoma with special reference to microsatellite instability

Cho, J., Chang, Y. H., Heo, Y. J., Kim, S., Kim, N. K. D., Park, J. O., Kang, W. K., Lee, J., & Kim, K. (2018) · ESMO Open · doi:10.1136/esmoopen-2018-000326 · Cited by 74 · see citing works

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

Fianco, G., Mongiardi, M. P., Levi, A., Luca, T. D., Desideri, M., Trisciuoglio, D., Bufalo, D. D., Cinà, I., Benedetto, A. D., Mottolese, M., et al. (2017) · eLife · doi:10.7554/elife.22593 · Cited by 73 · see citing works

Paraptosis‐Inducing Nanomedicine Overcomes Cancer Drug Resistance for a Potent Cancer Therapy

Zhou, Y., Huang, F., Yang, Y., Wang, P., Zhang, Z., Tang, Y., Shen, Y., & Wang, K. (2018) · Small · doi:10.1002/smll.201702446 · Cited by 71 · see citing works

Mitochondrial Surface Engineering for Multidrug Resistance Reversal

Chen, W., Shi, K., Chu, B., Wei, X., & Qian, Z. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b05188 · Cited by 68 · see citing works

Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma

Fianco, G., Contadini, C., Ferri, A., Cirotti, C., Stagni, V., & Barilà, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123798 · Cited by 62 · see citing works

Enhancing solid tumor therapy with sequential delivery of dexamethasone and docetaxel engineered in a single carrier to overcome stromal resistance to drug delivery

Zhang, L., Su, H., Liu, Y., Pang, N., Li, J., & Qi, X. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.004 · Cited by 60 · see citing works

Programmable Codelivery of Doxorubicin and Apatinib Using an Implantable Hierarchical‐Structured Fiber Device for Overcoming Cancer Multidrug Resistance

He, Y., Li, X., Ma, J., Ni, G., Yang, G., & Zhou, S. (2019) · Small · doi:10.1002/smll.201804397 · Cited by 59 · see citing works

Construction of Dual Stimuli-Responsive Platinum(IV) Hybrids with NQO1 Targeting Ability and Overcoming Cisplatin Resistance

Fang, L., Qin, X., Zhao, J., & Gou, S. (2019) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.8b03386 · Cited by 55 · see citing works

Acquired resistance to cancer immunotherapy

Draghi, A., Chamberlain, C. A., Furness, A. J. S., & Donia, M. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0692-y · Cited by 51 · see citing works

Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy

Wang, S., Xu, Y., Chan, H. F., Kim, H., Wang, Y., Leong, K. W., & Chen, M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.04.018 · Cited by 50 · see citing works

Dual‐Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug‐Resistant Cancer Therapy

Zhao, P., Yin, W., Wu, A., Tang, Y., Wang, J., Pan, Z., Lin, T., Zhang, M., Chen, B., Duan, Y., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910144 · Cited by 50 · see citing works

pH- and photothermal-driven multistage delivery nanoplatform for overcoming cancer drug resistance

Huang, W., Zhao, H., Wan, J., Zhou, Y., Xu, Q., Zhao, Y., Yang, X., & Gan, L. (2019) · Theranostics · doi:10.7150/thno.33958 · Cited by 47 · see citing works

Combination of drugs and carriers in drug delivery technology and its development

Du, Y., & Chen, B. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s198056 · Cited by 45 · see citing works

Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment

Li, Y., Luo, J., Lin, M., Zhi, P., Guo, W.-W., Han, M. Y., You, J., & Gao, J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00199 · Cited by 45 · see citing works

EPR or no EPR? The billion-dollar question

Wang, A. Z. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac8108 · Cited by 44 · see citing works

Development and Assessment of Conventional and Targeted Drug Combinations for Use in the Treatment of Aggressive Breast Cancers

Waterhouse, D., Gelmon, K. A., Klasa, R. J., Chi, K., Huntsman, D. D., Ramsay, E., Wasan, E. K., Edwards, L., Tucker, C., Zastre, J. A., et al. (2006) · Current Cancer Drug Targets · doi:10.2174/156800906778194586 · Cited by 42 · see citing works

Chemotherapy and immunotherapy combination in advanced prostate cancer.

Slovin, S. F. (2012) · PubMed · Cited by 39 · see citing works

Cancer Targeting: Responsive Polymers for Stimuli-Sensitive Drug Delivery

Bhatnagar, S., & Venuganti, V. V. K. (2014) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2015.10325 · Cited by 36 · see citing works

SHR ‐A1403, a novel c‐mesenchymal‐epithelial transition factor (c‐Met) antibody‐drug conjugate, overcomes AZD 9291 resistance in non‐small cell lung cancer cells overexpressing c‐Met

Tong, M., Gao, M., Xu, Y., Li, F., Li, Y., Bao, X., Fu, H., Quan, H., & Lou, L. (2019) · Cancer Science · doi:10.1111/cas.14180 · Cited by 27 · see citing works

Role of tumor hypoxia in acquisition of resistance to microtubule-stabilizing drugs

Das, V., Štěpánková, J., Hajdúch, M., & Miller, J. H. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.02.001 · Cited by 26 · see citing works

Folate-Targeted Redox-Responsive Polymersomes Loaded with Chemotherapeutic Drugs and Tariquidar to Overcome Drug Resistance

Qin, Y., Zhang, Z., Huang, C., Fan, F., Liu, L., Li, L., Wang, H., Liu, Z., Yang, J., Wang, C., et al. (2018) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2018.2623 · Cited by 26 · see citing works

Nanoparticle–Peptide–Drug Bioconjugates for Unassisted Defeat of Multidrug Resistance in a Model Cancer Cell Line

Sangtani, A., Petryayeva, E., Susumu, K., Oh, E., Huston, A. L., Lasarte‐Aragonés, G., Medintz, I. L., Algar, W. R., & Delehanty, J. B. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00755 · Cited by 24 · see citing works

Overcoming Resistance to AC0010, a Third Generation of EGFR Inhibitor, by Targeting c-MET and BCL-2

Xu, W., Tang, W., Li, T., Zhang, X., & Sun, Y. (2019) · Neoplasia · doi:10.1016/j.neo.2018.11.004 · Cited by 23 · see citing works

Codelivery of paclitaxel and small interfering RNA by octadecyl quaternized carboxymethyl chitosan-modified cationic liposome for combined cancer therapy

Zhang, R., Wang, S., Chen, A., Chen, W., Liu, Y., Wu, W., Kang, Y., & Ye, S.-F. (2015) · Journal of Biomaterials Applications · doi:10.1177/0885328215579297 · Cited by 19 · see citing works

Molecular mechanisms of drug resistance

Mader, R. M., Schmidt, W. M., Steger, G. G., & Krupitza, G. (2009) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp47049 · Cited by 15 · see citing works

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Bahri, M., Fleurence, J., Faraj, S., Daho, M. B. M., Fougeray, S., & Birklé, S. (2019) · Journal of Visualized Experiments · doi:10.3791/58291 · Cited by 5 · see citing works

Comparative effectiveness of nab-paclitaxel vs. paclitaxel monotherapy as first-line (1L) treatment of metastatic triple-negative breast cancer (mTNBC) in US clinical practice

Luhn, T., Chui, S., Hsieh, A., Yi, J.-H., Mecke, A., Bajaj, P., Hasnain, W., Falgas, A., Ton, T. G. N., & Kurian, A. W. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy272.306 · Cited by 2 · see citing works

Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works

Advances in drug delivery systems, challenges and future directions

Ezike, T. C., Okpala, U. S., Onoja, U. L., Nwike, C. P., Ezeako, E. C., Okpara, O. J., Okoroafor, C. C., Eze, S. C., Kalu, O. L., Odoh, E. C., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17488 · Cited by 1,023 · see citing works

Multifunctional nanoparticle-mediated combining therapy for human diseases

Li, X., Peng, X., Zoulikha, M., Boafo, G. F., Magar, K. T., Ju, Y., & He, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01668-1 · Cited by 546 · see citing works

Lactate and lactylation in cancer

Chen, J., Huang, Z., Chen, Y., Tian, H., Chai, P., Shen, Y., Yao, Y., Xu, S., Ge, S., & Jia, R. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02082-x · Cited by 524 · see citing works

Liposomes for Tumor Targeted Therapy: A Review

Wang, S., Chen, Y., Guo, J., & Huang, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032643 · Cited by 329 · see citing works

Battling Chemoresistance in Cancer: Root Causes and Strategies to Uproot Them

Ramos, A., Sadeghi, S., & Tabatabaeian, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179451 · Cited by 298 · see citing works

Nanoliposomes in Cancer Therapy: Marketed Products and Current Clinical Trials

Taléns‐Visconti, R., Dı́ez-Sales, O., de Julián‐Ortiz, J. V., & Nácher, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084249 · Cited by 127 · see citing works

Codelivery of Phytochemicals with Conventional Anticancer Drugs in Form of Nanocarriers

Kumar, G., Virmani, T., Sharma, A., & Pathak, K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030889 · Cited by 90 · see citing works

Pharmaceutical liposomal delivery—specific considerations of innovation and challenges

Peng, T., Xu, W., Li, Q., Ding, Y., & Huang, Y. (2022) · Biomaterials Science · doi:10.1039/d2bm01252a · Cited by 80 · see citing works

Multifunctional Lipid Bilayer Nanocarriers for Cancer Immunotherapy in Heterogeneous Tumor Microenvironments, Combining Immunogenic Cell Death Stimuli with Immune Modulatory Drugs

Nel, A. E., Mei, K., Liao, Y., & Liu, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c01252 · Cited by 77 · see citing works

Nanotechnology-empowered strategies in treatment of skin cancer

Chandra, J., Hasan, N., Nasir, N., Wahab, S., Veeraveedu, P. T., Sahebkar, A., Ahmad, F. J., & Kesharwani, P. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116649 · Cited by 78 · see citing works

Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

Fonseca, M., Jarak, I., Victor, F., Domingues, C., Veiga, F., & Figueiras, A. (2024) · Materials · doi:10.3390/ma17020319 · Cited by 76 · see citing works

Targeting lactate metabolism and immune interaction in breast tumor via protease-triggered delivery

Zhao, P., Wang, S., Jiang, J., Gao, Y., Wang, Y., Zhao, Y., Zhang, J., Zhang, M., & Huang, Y. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.024 · Cited by 62 · see citing works

Fabrication of anionic dextran-coated micelles for aptamer targeted delivery of camptothecin and survivin-shRNA to colon adenocarcinoma

Sanati, S., Taghavi, S., Abnous, K., Taghdisi, S. M., Babaei, M., Ramezani, M., & Alibolandi, M. (2021) · Gene Therapy · doi:10.1038/s41434-021-00234-0 · Cited by 60 · see citing works

Cervical cancer: Novel treatment strategies offer renewed optimism

yadav, G., Srinivasan, G., & jain, A. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155136 · Cited by 55 · see citing works

Craft of Co-encapsulation in Nanomedicine: A Struggle To Achieve Synergy through Reciprocity

Bhattacharjee, S. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.2c00033 · Cited by 50 · see citing works

Co‐Delivery of Precisely Prescribed Multi‐Prodrug Combination by an Engineered Nanocarrier enables Efficient Individualized Cancer Chemotherapy

Li, Y., Jiang, Y., Zheng, Z., Du, N., Guan, S., Guo, W., Tang, X., Cui, J., Zhang, L., Liu, K., et al. (2022) · Advanced Materials · doi:10.1002/adma.202110490 · Cited by 49 · see citing works

Targeting glycolysis for cancer therapy using drug delivery systems

Huang, Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.003 · Cited by 51 · see citing works

Nanomedicine-driven molecular targeting, drug delivery, and therapeutic approaches to cancer chemoresistance

Khot, V. M., Salunkhe, A. B., Pricl, S., Bauer, J., Thorat, N. D., & Townley, H. E. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.016 · Cited by 47 · see citing works

Nanomedicines for combating multidrug resistance of cancer

Zhu, Y., Jia, H., Duan, Q., & Wu, F. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1715 · Cited by 46 · see citing works

Recent advances in the development of biocompatible nanocarriers and their cancer cell targeting efficiency in photodynamic therapy

Kumar, S. S. D., & Abrahamse, H. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.969809 · Cited by 39 · see citing works

Bio-nanomaterials: Promising anticancer properties and treatment strategies

Elemike, E. E., Onunkwo, I. C., Ughumiakpor, O., Alawuru, F., Mukoro, A., Ishom, P., Obarakpor, F., Hossain, I., & Aziza, A. E. (2025) · Nano TransMed · doi:10.1016/j.ntm.2025.100076 · Cited by 41 · see citing works

Surfactant-Enabled Nanocarriers in Breast Cancer Therapy: Targeted Delivery and Multidrug Resistance Reversal

Jadhav, A., & Nagaraj, K. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17060779 · Cited by 35 · see citing works

Understanding the implications of co-delivering therapeutic agents in a nanocarrier to combat multidrug resistance (MDR) in breast cancer

Fulfager, A., & Yadav, K. S. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102405 · Cited by 32 · see citing works

A review on tumor-targeting liposomes: Fabrication, mechanism and applications

Basak, S., Das, T. K., & Ganguly, S. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117460 · Cited by 30 · see citing works

Emerging concepts in designing next-generation multifunctional nanomedicine for cancer treatment

Chakraborty, K., Tripathi, A., Mishra, S., Mallick, A. M., & Roy, R. S. (2022) · Bioscience Reports · doi:10.1042/bsr20212051 · Cited by 29 · see citing works

Combining β-Carotene with 5-FU via Polymeric Nanoparticles as a Novel Therapeutic Strategy to Overcome uL3-Mediated Chemoresistance in p53-Deleted Colorectal Cancer Cells

Carotenuto, P., Pecoraro, A., Brignola, C., Barbato, A., Franco, B., Longobardi, G., Conte, C., Quaglia, F., Russo, G., & Russo, A. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00876 · Cited by 26 · see citing works

Strategy for Traceless Codrug Delivery with Platinum(IV) Prodrug Complexes Using Self-Immolative Linkers

Lee, V. E. Y., Lim, Z. C., Chew, S. L., & Ang, W. H. (2021) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.0c03299 · Cited by 26 · see citing works

Regulation of the PI3K/AKT/mTOR signaling pathway with synthesized bismuth oxide nanoparticles from Ginger (Zingiber officinale) extract: Mitigating the proliferation of colorectal cancer cells

Zhou, Y., Zhang, H., Cheng, Z., & Wang, H. (2021) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103607 · Cited by 23 · see citing works

Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer

El‐Tanani, M., Nsairat, H., Aljabali, A. A. A., Matalka, I. I., Alkilany, A. M., & Tambuwala, M. M. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2311812 · Cited by 23 · see citing works

Recent Progress of Novel Nanotechnology Challenging the Multidrug Resistance of Cancer

Zhang, C., Zhou, X., Zhang, H., Han, X., Li, B., Yang, R., & Zhou, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.776895 · Cited by 23 · see citing works

Teaching new tricks to old dogs: A review of drug repositioning of disulfiram for cancer nanomedicine

Zhao, P., Tang, X., & Huang, Y. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200127 · Cited by 22 · see citing works

Lipid-based nanoparticle-mediated combination therapy for breast cancer management: a comprehensive review

Gupta, P., Neupane, Y. R., Aqil, M., Kohli, K., & Sultana, Y. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01366-z · Cited by 21 · see citing works

Recent Trends in Nanomedicine-Based Strategies to Overcome Multidrug Resistance in Tumors

Khan, M. M., & Torchilin, V. P. (2022) · Cancers · doi:10.3390/cancers14174123 · Cited by 20 · see citing works

Promoted cellular uptake and intracellular cargo release of ICG/DOX-carrying hybrid polymeric nanoassemblies upon acidity-activated PEG detachment to enhance cancer photothermal/chemo combination therapy

Hung, Y.-N., Liu, Y., Chou, Y.-H., Hu, S., Cheng, B., & Chiang, W. (2021) · European Polymer Journal · doi:10.1016/j.eurpolymj.2021.110944 · Cited by 19 · see citing works

Nanoparticle technologies in precision oncology and personalized vaccine development: Challenges and advances

İmani, S., Moradi, S., Faraj, T. A., Hassanpoor, P., Musapour, N., Najmaldin, S. K., Abdulhamd, A. H., Mohammadi, A. T., Taha, C. H., & Aminnezhad, S. (2025) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2025.100353 · Cited by 18 · see citing works

Silibinin-Loaded Nanostructured Lipid Carriers for Growth Inhibition of Cisplatin-Resistant Ovarian Cancer Cells

Jafari, S., Bakhshaei, A., Eskandani, M., & Molavi, O. (2022) · Assay and Drug Development Technologies · doi:10.1089/adt.2022.060 · Cited by 18 · see citing works

Drug delivery systems for tissue engineering: exploring novel strategies for enhanced regeneration

de Oliveira, J. L., da Silva, M. E. X., Hotza, D., Sayer, C., & Immich, A. P. S. (2024) · Journal of Nanoparticle Research · doi:10.1007/s11051-024-06074-4 · Cited by 18 · see citing works

Development and validation of HPLC method for simultaneous estimation of erlotinib and niclosamide from liposomes optimized by screening design

Padakanti, A. P., Pawar, S. D., Kumar, P., & Chella, N. (2023) · Journal of Liposome Research · doi:10.1080/08982104.2022.2162540 · Cited by 17 · see citing works

The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update

Torki, Z., Ghavi, D., Hashemi, S., Rahmati, Y., Rahmanpour, D., Pornour, M., & Alivand, M. R. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-021-04337-8 · Cited by 17 · see citing works

Permanently Charged Cationic Lipids—Evolution from Excipients to Therapeutic Lipids

Pushpa Ragini, S., Banerjee‬‬‬‬‬‬‬‬‬, R., Drummond, C. J., & Conn, C. E. (2024) · Small Science · doi:10.1002/smsc.202300270 · Cited by 16 · see citing works

Nanotechnology-mediated combinational drug delivery approach for cancer therapy

Handa, M., Khairnar, P., Kesharwani, P., & Shukla, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85873-1.00008-3 · Cited by 15 · see citing works

GSH/pH dual responsive chitosan nanoparticles for reprogramming M2 macrophages and overcoming cancer chemoresistance

Zhao, X., Zheng, C., Wang, Y., Hao, J., & Liu, Y. (2023) · Biomaterials Science · doi:10.1039/d3bm01741a · Cited by 15 · see citing works

Quercetin-polysaccharides based hydrogels: A review of applications, molecular associations, chemical and biological modifications, toxicological implications and future perspectives

Ashfaq, M., Ali, S., & Summer, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144845 · Cited by 14 · see citing works

Enhanced Codelivery of Gefitinib and Azacitidine for Treatment of Metastatic-Resistant Lung Cancer Using Biodegradable Lipid Nanoparticles

Elzayat, E. M., Sherif, A. Y., Nasr, F. A., Attwa, M. W., Alshora, D. H., Ahmad, S. F., & Alqahtani, A. S. (2023) · Materials · doi:10.3390/ma16155364 · Cited by 14 · see citing works

Polyethylenimine-based iron oxide nanoparticles enhance cisplatin toxicity in ovarian cancer cells in the presence of a static magnetic field

Ashoori, F., Verdom, B. H., Satari, M., & Abdolmaleki, P. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1217800 · Cited by 15 · see citing works

Preparation, Optimization, and In-Vitro Evaluation of Brusatol- and Docetaxel-Loaded Nanoparticles for the Treatment of Prostate Cancer

Adekiya, T. A., Moore, M., Thomas, M. A., Lake, G., Hudson, T., & Adesina, S. K. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16010114 · Cited by 14 · see citing works

Overcoming drug resistance with specific nano scales to targeted therapy: Focused on metastatic cancers

Kadhum, W. R., Majeed, A. A., Saleh, R. O., Ali, E., Alhajlah, S. H., Alwaily, E. R., Mustafa, Y. F., Ghildiyal, P., Alawadi, A. H., & Alsalamy, A. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155137 · Cited by 14 · see citing works

Nanomedicine-based drug delivery strategies for the treatment of atherosclerosis

Lin, Y., Lin, R., Lin, H.-B., & Shen, S. (2024) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2024.100189 · Cited by 14 · see citing works

Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

Gomes, E. R., & Franco, M. S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010105 · Cited by 11 · see citing works

Advances in Nanomedicine Design: Multidisciplinary Strategies for Unmet Medical Needs

Ahmed, T., Liu, F.-C. F., Lu, B., Lip, H., Park, E., Alradwan, I. A., Liu, J. F., He, C., Zetrini, A., Zhang, T., et al. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00038 · Cited by 14 · see citing works

Self-Assembled Micelles of Amphiphilic PEGylated Drugs for Cancer Treatment

Amili, M. A., Zhu, J., Wang, Z., & Guo, S. (2021) · Current Drug Targets · doi:10.2174/1389450122666201231130702 · Cited by 14 · see citing works

Targeted Codelivery of Prodigiosin and Simvastatin Using Smart BioMOF: Functionalization by Recombinant Anti-VEGFR1 scFv

Mirzaeinia, S., Zeinali, S., Budiša, N., & Karbalaei‐Heidari, H. R. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.866275 · Cited by 13 · see citing works

Rational design of oral delivery nanosystems for hypoglycemic peptides

Peng, T., Shao, X., Li, L., Liu, H., Song, W., Hou, J., Zhong, H., Ding, Y., & Huang, Y. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102031 · Cited by 13 · see citing works

Nanoengineering Solutions for Cancer Therapy: Bridging the Gap between Clinical Practice and Translational Research

Garg, P. K., Pareek, S., Kulkarni, P., Salgia, R., & Singhal, S. S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13123466 · Cited by 13 · see citing works

Functionalized Lipid Nanocarriers for Simultaneous Delivery of Docetaxel and Tariquidar to Chemoresistant Cancer Cells

Kim, C. H., Lee, S. K., Choi, J. Y., Lyu, M. J., Jung, H. M., Goo, Y. T., Kang, M. J., & Choi, Y. W. (2023) · Pharmaceuticals · doi:10.3390/ph16030349 · Cited by 12 · see citing works

Complex formulation strategies to overcome the delivery hurdles of lapatinib in metastatic breast cancer

Singh, N., Reddy, K. P., Das, P., Kishor, B. K., & Datta, P. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104315 · Cited by 12 · see citing works

Artificial Intelligence (AI): It?s Role in Drug Discovery and Novel Drug Delivery System

Hujuri, C. D. L. (2024) · International Journal of Science and Research (IJSR) · doi:10.21275/sr24219203948 · Cited by 12 · see citing works

Functional combination of resveratrol and tamoxifen to overcome tamoxifen‐resistance in breast cancer cells

Radwan, A. M., Abosharaf, H. A., Sharaky, M. M., Abdelmonem, R., & Effat, H. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400261 · Cited by 11 · see citing works

Enhancing Chemosensitivity in Drug-Resistant Breast Cancer Cells Using β-Cyclodextrin-Loaded Quercetin and Doxorubicin Inclusion Complex via Modulating SRC/PI3K/Akt Pathway

Pawar, C. S., Balamurugan, K., Baskar, S., Prasad, N. R., & Khan, H. A. (2025) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-025-05219-y · Cited by 11 · see citing works

In Situ Nanoparticle Self-Assembly for Combination Delivery of Therapeutics to Non-Small Cell Lung Cancer

Hatami, E., Nagesh, P. K. B., Chauhan, N., Jaggi, M., Chauhan, S., & Yallapu, M. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c01158 · Cited by 10 · see citing works

A technical note on emerging combination approach involved in the onconanotherapeutics

Iqubal, M. K., Kaur, H., Md, S., Alhakamy, N. A., Iqubal, A., Ali, J., & Baboota, S. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2132018 · Cited by 11 · see citing works

Phytochemical analysis and evaluation of acute toxicity and antioxidant, antibacterial, and anti-inflammatory activities of ethanolic extracts from branches and leaves of Jacaranda rugosa

Rocha-Filho, C. A. A., de Araújo, L. C. C., Silva, P. M., Machado, J. C. B., Ferreira, M. R. A., Soares, L. A. L., Silva, M. V., Silva, T. G., Napoleão, T. H., & Paiva, P. M. G. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.08.026 · Cited by 9 · see citing works

Polydopamine-Coated Copper-Substituted Mesoporous Silica Nanoparticles for Dual Cancer Therapy

Busa, P., Koutavarapu, R., & Kuthati, Y. (2022) · Coatings · doi:10.3390/coatings12010060 · Cited by 8 · see citing works

Dual-crosslinked injectable in situ forming Alginate/CaCl2/Pluronic F127/α-Cyclodextrin hydrogels incorporating Doxorubicin and graphene-based nanomaterials for cancer chemo-photothermal therapy

Gonçalves, J. J., Melo, B. L., Pouso, M. R., Correia, I. J., & de Melo‐Diogo, D. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107520 · Cited by 7 · see citing works

Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach

Sherif, A. Y., Harisa, G. I., Shahba, A. A.-W., Nasr, F. A., Taha, E. I., & Alqahtani, A. S. (2023) · Drug Development Research · doi:10.1002/ddr.22097 · Cited by 6 · see citing works

Effect of the Combination of Synthetic Anthelmintics with Carvacryl Acetate in Emulsions with and without a Sodium Alginate Matrix on Haemonchus contortus

Ximenes, L. F., Pinheiro, H. N., Filho, J. V. D. A., André, W. P. P., Abreu, F. O. M. D. S., Cardial, M. R. L., Castelo‐Branco, D. D. S. C. M., Melo, A. C. F. L., Lopes, F. F. D. S., de Morais, S. M., et al. (2024) · Animals · doi:10.3390/ani14071007 · Cited by 6 · see citing works

Exosome-immobilized porous microspheres for efficiently combined and prolonged cancer treatment

Lee, A., Lee, J. H., So, C., Kim, I. G., & Mok, H. (2024) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-024-00139-w · Cited by 6 · see citing works

“Actual” peptide properties required for nanoparticle development in precision cancer therapeutic delivery

Zaiki, Y., Yap, P., Gan, C., Rani, M. F. A., Traini, D., & Wong, T. W. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113866 · Cited by 6 · see citing works

Nanoparticle-based combination of LMWH and doxorubicin for the efficient treatment of hepatocellular carcinoma with portal vein tumor thrombus

Zhang, X., Li, B., Lu, Z., Lu, Z., Zhao, G., Xu, S., Wu, Z., Chu, T., Qi, F., Wu, S., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101787 · Cited by 6 · see citing works

Advancing healthcare: Exploring recent innovations in drug delivery systems

Hoque, M., Hossain, M. S., Akram, T., & Das, S. (2023) · International Journal of Multidisciplinary Research and Growth Evaluation · doi:10.54660/.ijmrge.2023.4.5.50-55 · Cited by 6 · see citing works

Liposomal Nanocarriers Containing siRNA as Small Molecule-Based Drugs to Overcome Cancer Drug Resistance

Safaei, M., Khalighi, F., Behabadi, F. A., Abpeikar, Z., Goodarzi, A., Kouhpayeh, S. A., Najafipour, S., & Ramezani, V. (2023) · Nanomedicine · doi:10.2217/nnm-2023-0176 · Cited by 6 · see citing works

Liposomal Drug Delivery: Progress, Clinical Outlook, and Ongoing Challenges

Tiwari, C., Tomer, J., & Kumar, D. (2024) · Recent Advances in Drug Delivery and Formulation · doi:10.2174/0126673878300031240703070511 · Cited by 6 · see citing works

Collaboration of Hprt/K-RAS/c-Myc mutation in the oncogenesis of T-lymphocytic leukemia: a comparative study

Kadry, M. O., Abdel‐Hamid, A. Z., & Megeed, R. M. A. (2024) · Future Science OA · doi:10.2144/fsoa-2023-0111 · Cited by 5 · see citing works

Nanotherapeutics against malaria: A decade of advancements in experimental models

Avalos‐Padilla, Y., & Fernàndez‐Busquets, X. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1943 · Cited by 5 · see citing works

Titanium dioxide nanostructure-loaded Adriamycin surmounts resistance in breast cancer therapy: ABCA/P53/C-myc crosstalk

Megeed, R. M. A., Abdel‐Hamid, A. Z., & Kadry, M. O. (2024) · Future Science OA · doi:10.2144/fsoa-2023-0107 · Cited by 5 · see citing works

Monitoring the efficacy of chemotherapeutic drugs using dark field imaging

Khoubafarin, S., Kharel, A., Malla, S., Nath, P., Kaur, D., Tiwari, A. K., & Ray, A. (2022) · Label-free Biomedical Imaging and Sensing (LBIS) · doi:10.1117/12.2609874 · Cited by 5 · see citing works

Combination Therapy for Overcoming Multidrug Resistance in Breast Cancer Through Hedgehog Signaling Pathway Regulation

Liu, Y., Yang, Y., & Qi, X. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17050572 · Cited by 4 · see citing works

Artificial Intelligence in Drug Discovery and Delivery: Advancements and Applications

Mahjoub, M. A., & Sheikholislam, Z. (2023) · Journal of Biomedical Research & Environmental Sciences · doi:10.37871/jbres1778 · Cited by 3 · see citing works

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Wang, C., Pan, J., Chen, S., Qiu, L., Hu, H., Ji, L., Wang, J., Liu, W., & Ni, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s459428 · Cited by 4 · see citing works

Phenylboronic acid-functionalized co-delivery micelles with synergistic effect and down-regulation of HIF-1alpha to overcome multidrug resistance

Huang, Y., He, Y., Xia, X., Quan, H., & Yu, J. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102346 · Cited by 4 · see citing works

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Watkins, C. M., Hallam, S., Austin, M. J., & Rosales, A. M. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202504277 · Cited by 3 · see citing works

Chitosan capped-NLCs enhanced codelivery of gefitinib and simvastatin into MDR HCC: impact of compositions on cell death, JNK3, and Telomerase

Alzhrani, R. F., Alluhaidan, A. A., ALAMRI, S. M., Harisa, G. I., Bakheit, A. H. H., Asiri, H. H., & Attia, S. M. (2024) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2024.053337 · Cited by 3 · see citing works

Titanium nanostructure mitigating doxorubicin–induced testicular toxicity in rats via regulating major autophagy signaling pathways

Megeed, R. M. A., Abdel‐Hamid, A. Z., & Kadry, M. O. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101869 · Cited by 3 · see citing works

Liposome-assisted combination chemotherapy improves the anti-proliferation and anti-angiogenesis response of cisplatin in breast cancer; experimental and computational study

Valinezhadi, N., Dehghan, G., Yaghoubzad-Maleki, M., Mohammadi, M., Alizadeh, A. A., & Hamishehkar, H. (2025) · Journal of Chemotherapy · doi:10.1080/1120009x.2025.2484078 · Cited by 3 · see citing works

Overcoming the challenges of drug resistance through combination drug delivery approach

Tonbul, H., Şahin, A., & Çapan, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85873-1.00003-4 · Cited by 3 · see citing works

Current Status of Natural Products/siRNA Co‐Delivery for Cancer Therapy

Jacob, M. M., Santhosh, A., Rajeev, A., Joy, R., John, P. M., John, F., & George, J. (2022) · ChemistrySelect · doi:10.1002/slct.202203476 · Cited by 3 · see citing works

Introduction to chemotherapy

Acharya, P. C., & Kurosu, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90575-6.00014-4 · Cited by 3 · see citing works

Novel Strategies Using Sagacious Targeting for Site-Specific Drug Delivery in Breast Cancer Treatment: Clinical Potential and Applications

Ebrahimnejad, P., Mohammadi, Z., Babaei, A., Ahmadi, M., Amirkhanloo, S., Asare‐Addo, K., & Nokhodchid, A. (2023) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v41.i1.20 · Cited by 3 · see citing works

Rational design of a poly-L-glutamic acid-based combination conjugate for hormone-responsive breast cancer treatment

Boix-Montesinos, P., Medel, M., Malfanti, A., Đorđević, S., Masiá, E., Charbonnier, D., Carrascosa-Marco, P., Armiñán, A., & Vicent, M. J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.09.002 · Cited by 3 · see citing works

Recent Advances in Nanocarrier-mediated Combination Drug Therapy for Tackling Solid-resistant Tumors

Rafiya, K., Awasthi, S., Qureshi, S. A., Hasan, N., & Ahmad, F. J. (2025) · Current Drug Delivery · doi:10.2174/0115672018341670241124150932 · Cited by 5 · see citing works

Comprehensive Review on the Development of Phytonanomedicines for Cancer Treatment

Fernandes, D. A. (2025) · Biomedical Materials & Devices · doi:10.1007/s44174-025-00280-x · Cited by 3 · see citing works

Spontaneously Self-Assembled Microgel Film as Co-Delivery System for Skincare Applications

Aguirre, G., Taboada, P., & Billon, L. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091422 · Cited by 3 · see citing works

High-efficiency engineering of cell membrane nanovesicles with intrinsic homotypic targeting for precision cancer drug delivery

Ho, T.-L., Phan, T., Tsai, I.-L., Huynh, Q.-D. T., Shen, Y., & Fan, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148793 · Cited by 2 · see citing works

Immunopathology to Nanotherapeutics: Redefining Psoriasis Management in Autoimmune Disease

Kamble, A. S., Sutar, A. D., Behera, B., Gupta, P. K., & Shukla, R. (2025) · ACS Nano Medicine · doi:10.1021/acsnanomed.5c00077 · Cited by 2 · see citing works

The deformation of cancer cells through narrow micropores holds the potential to regulate genes that impact cancer malignancy

Choi, J. S., Lee, S. H., Park, H. B., Chun, C., Kim, Y., Kim, K. H., Weon, B. M., Kim, D., Kim, H. J., & Lee, J. H. (2023) · Lab on a Chip · doi:10.1039/d3lc00069a · Cited by 2 · see citing works

Enhanced Antitumor Efficacy of Cytarabine and Idarubicin in Acute Myeloid Leukemia Using Liposomal Formulation: In Vitro and In Vivo Studies

Zhu, C., Liu, Y., Ji, X., Si, Y., Tao, X., Zhang, X., & Yin, L. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16091220 · Cited by 2 · see citing works

Codelivery of Bortezomib and Modified DR5-Selective TRAIL via Amphiphilic Poly( N -vinylpyrrolidone) Bionanocomposites to Overcome Glioblastoma Resistance

Kukovyakina, E. V., Kulikov, P. P., Bagrov, D. V., Moiseenko, A. V., Trifonova, T. S., Isakova, A. A., Shuvalova, M. L., Svirshchevskaya, E. V., Khan, I. I., Pokrovsky, V. S., et al. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01651 · Cited by 1 · see citing works

Harnessing TPGS-based Nanoparticles to Overcome Multidrug Resistance in Cancer

Mangu, K., Nadimpalli, A. V., Chenna, S. R., & Rizwanullah, M. (2026) · Biomedical Materials & Devices · doi:10.1007/s44174-026-00719-9 · Cited by 1 · see citing works

Dopamine-Loaded Polymer-Drug Conjugates for Potential Synergistic Anti-Cancer Treatment

Naki, T., Matshe, W. M. R., Ubanako, P. N., Adeyemi, S. A., Balogun, M. O., Ray, S. S., Choonara, Y. E., & Aderibigbe, B. A. (2022) · Polymer-Plastics Technology and Materials · doi:10.1080/25740881.2022.2029895 · Cited by 1 · see citing works

Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer

Zhang, M., Liu, E., Cui, Y., & Huang, Y. (2017) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2017.0054 · Cited by 134 · see citing works

Dual-drug codelivery nanosystems: An emerging approach for overcoming cancer multidrug resistance

Gong, J., Shi, T., Liu, J., Pei, Z., Liu, J., Ren, X., Li, F., & Qiu, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114505 · Cited by 82 · see citing works

Co-delivery of dual-drugs with nanoparticle to overcome multidrug resistance

Sun, Y., Chen, K., Zhang, A., Liu, F., Hu, J., Zhong, X. Y., & Xie, J. (2016) · European Journal of BioMedical Research · doi:10.18088/ejbmr.2.2.2016.pp12-18 · Cited by 53 · see citing works

Multifunctional nanoplatforms co-delivering combinatorial dual-drug for eliminating cancer multidrug resistance

Xiao, W., Song, M., Li, W., Huang, J., Yang, G. Y., & Wang, Y. (2021) · Theranostics · doi:10.7150/thno.59342 · Cited by 108 · see citing works

Integrating Nanotechnology in Cancer Treatment: Drug Targeting, Multidrug Resistance (MDR) Mechanisms, Therapeutic Strategies and Future Perspectives

S.*, R. V. K. A. (2026) · Journal of Pharmaceutical Sciences · doi:10.5281/zenodo.20844658