The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Glycosaminoglycans: key players in cancer cell biology and treatment
Abstract
Glycosaminoglycans are natural heteropolysaccharides that are present in every mammalian tissue. They are composed of repeating disaccharide units that consist of either sulfated or non‐sulfated monosaccharides. Their molecular size and the sulfation type vary depending on the tissue, and their state either as part of proteoglycan or as free chains. In this regard, glycosami‐noglycans play important roles in physiological and pathological conditions. During recent years, cell biology studies have revealed that glycosaminoglycans are among the key macromolecules that affect cell properties and functions, acting directly on cell receptors or via interactions with growth factors. The accumulated knowledge regarding the altered structure of glycosaminoglycans in several diseases indicates their importance as biomarkers for disease diagnosis and progression, as well as pharmacological targets. This review summarizes how the fine structural characteristics of glycosaminoglycans, and enzymes involved in their biosynthesis and degradation, are involved in cell signaling, cell function and cancer progression. Prospects for glycosaminoglycan‐based therapeutic targeting in cancer are also discussed.
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Self-citationAMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
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Cited by
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Self-citationProteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics
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Self-citationGlycosaminoglycans from marine sources as therapeutic agents
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Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation
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Metadata
- Authors
- Afratis, N., Gialeli, C., Nikitovic, D., Tsegenidis, T., Karousou, E., Theocharis, A. D., Pavão, M. S., Tzanakakis, G. N., & Karamanos, N. K.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2012-03-12
- Volume
- 279
- Issue
- 7
- Pages
- 1177-1197
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W1771887010
- Cited by
- 554
- References
- 155
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Afratis, N., Gialeli, C., Nikitovic, D., Tsegenidis, T., Karousou, E., Theocharis, A. D., Pavão, M. S., Tzanakakis, G. N., & Karamanos, N. K. (2012). Glycosaminoglycans: key players in cancer cell biology and treatment. The FEBS Journal. https://doi.org/10.1111/j.1742-4658.2012.08529.x
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