Cited by 253Immunotoxicology and immune responsesToxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

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Prenatal Exposures to Persistent and Non‐Persistent Organic Compounds and Effects on Immune System Development

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Hertz‐Picciotto, Irva, Park, Hye‐Youn, Dostal, Miroslav, Kocan, Anton, Trnovec, Tomas, Sram, Radim·2008·Basic & Clinical Pharmacology & Toxicology

DOI 10.1111/j.1742-7843.2007.00190.x

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Abstract

Abstract: Immune system development, particularly in the prenatal period, has far‐reaching consequences for health during early childhood, as well as throughout life. Environmental disturbance of the complex balances of Th1 and Th2 response mechanisms can alter that normal development. Dysregulation of this process or an aberrant trajectory or timing of events can result in atopy, asthma, a compromised ability to ward off infection, or other auto‐immune disease. A wide range of chemical, physical and biological agents appear to be capable of disrupting immune development. This MiniReview briefly reviews developmental milestones of the immune system in the prenatal period and early life, and then presents examples of environmentally induced alterations in immune markers. The first example involves a birth cohort study linked to an extensive programme of air pollution monitoring; the analysis shows prenatal ambient polycyclic aromatic hydrocarbons (PAH) and fine particle (PM2.5) exposures to be associated with altered lymphocyte immunophenotypic distributions in cord blood and possible changes in cord serum immunoglobulin E levels. The second example is a study of prenatal‐polychlorinated biphenyl (PCB) exposures and the foetal development of the thymus, the organ responsible for lymphocyte maturation. Mothers with higher serum concentrations of PCBs gave birth to neonates having smaller indices of thymus size. Finally, this report underscores the tight connection between development of the immune system and that of the central nervous system, and the plausibility that disruption of critical events in immune development may play a role in neurobehavioural disorders.

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Authors: Hertz‐Picciotto, I., Park, H., Dostal, M., Kocan, A., Trnovec, T., & Sram, R.
Affiliations: University of California, Davis (US)
Slovak Medical University (SK)
Corresponding author: Hertz‐Picciotto, Irva
ORCID: Hertz‐Picciotto, Irva
Trnovec, Tomas
Venue: Basic & Clinical Pharmacology & Toxicology
Publisher: Wiley
Published: 2008-01-22
Volume: 102
Issue: 2
Pages: 146-154
ISSN: 1742-7835 (ISSN-L)
1742-7843
DOI: 10.1111/j.1742-7843.2007.00190.x
OpenAlex: W2146912985
Cited by: 253
References: 88
Citations by year: 2026: 9 · 2025: 8 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 17 · 2020: 9 · 2019: 11 · 2018: 17 · 2017: 16 · 2016: 9 · 2015: 16 · 2014: 10 · 2013: 21 · 2012: 18
FWCI: 1.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Basic & Clinical Pharmacology & Toxicology (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Environmental Protection Agency (R-829388)
United States Agency for International Development
Health Effects Institute
Ministry of Environment
National Institutes of Health (ES11269, R01-CA96525)
National Cancer Institute (R01 CA96525, R01CA096525)
National Institute of Environmental Health Sciences (1 P01-ES11269, P01ES011269, R829388, ES11269)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: prenatal exposure, persistent organic pollutants, immune system development, Th1/Th2 balance, polycyclic aromatic hydrocarbons, PM2.5, air pollution, polychlorinated biphenyls, thymus development, cord blood lymphocytes, immunoglobulin E, atopy, asthma, neurobehavioral disorders
MeSH terms: Air Pollution, Animals, Autistic Disorder, Environmental Pollutants, Female, Humans, Hypersensitivity, Immune System, Maternal-Fetal Exchange, Polychlorinated Biphenyls, Polycyclic Aromatic Hydrocarbons, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Exposure

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Prenatal Exposures to Persistent and Non‐Persistent Organic Compounds and Effects on Immune System Development

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