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Cited by 64Air Quality and Health ImpactsAsthma and respiratory diseasesIndoor Air Quality and Microbial Exposure

Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life

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de Barros Mendes Lopes, Thais, Groth, Espen E., Veras, Mariana, Furuya, Tatiane K., de Souza Xavier Costa, Natalia, Ribeiro Júnior, Gabriel, Lopes, Fernanda Degobbi, de Almeida, Francine M. +4 more·2018·Environmental Pollution
DOI 10.1016/j.envpol.2018.05.055PMC PMC6407120
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Abstract

Gestational exposure to air pollution is associated with negative outcomes in newborns and children. In a previous study, we demonstrated a synergistic negative effect of pre- and postnatal exposure to PM 2.5 on lung development in mice. However, the means by which air pollution affects development of the lung have not yet been identified. In this study, we exposed pregnant BALB/c mice and their offspring to concentrated urban PM 2.5 (from São Paulo, Brazil; target dose 600 μg/m 3 for 1 h daily). Exposure was started on embryonic day 5.5 (E5.5, time of placental implantation). Lung tissue of fetuses and offspring was submitted to stereological and transcriptomic analyses at E14.5 (pseudoglandular stage of lung development), E18.5 (saccular stage) and P40 (postnatal day 40, alveolarized lung). Additionally, lung function and cellularity of bronchoalveolar lavage (BAL) fluid were studied in offspring animals at P40. Compared to control animals that were exposed to filtered air throughout gestation and postnatal life, PM-exposed mice exhibited higher lung elastance and a lower alveolar number at P40 whilst the total lung volume and cellularity of BAL fluid were not affected. Glandular and saccular structures of fetal lungs were not altered upon gestational exposure; transcriptomic signatures, however, showed changes related to DNA damage and its regulation, inflammation and regulation of cell proliferation. A differential expression was validated at E14.5 for the candidates Sox8, Angptl4 and Gas1. Our data substantiate the in utero biomolecular effect of gestational exposure to air pollution and provide first-time stereological evidence that pre- and early life-postnatal exposure compromise lung development, leading to a reduced number of alveoli and an impairment of lung function in the adult mouse.

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  • Gestational exposure to concentrated urban PM2.5 and PM0.1 from São Paulo did not substantially alter glandular and saccular structures of fetal lungs, but offspring showed significantly lower alveolar number and higher lung elastance at postnatal day 40.

    “While glandular and saccular structures of fetal lungs were not substantially altered following gestational exposure to concentrated urban PM2.5 and PM0.1 from São Paulo, offspring showed significantly lower alveolar number and higher lung elastance at postnatal day 40.”

    From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [107]

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  • Genes related to DNA damage, cell proliferation, and inflammation were differentially expressed in fetal lung after gestational exposure to concentrated urban PM2.5 and PM0.1.

    “Genes related to DNA damage, cell proliferation, and inflammation were differentially expressed in the fetal lung suggesting a complex interplay of pathways influencing long-term lung alterations.”

    From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [107]

    The Discussion reports differential expression of fetal-lung genes linked to DNA damage, inflammation, and cell proliferation after gestational PM2.5 exposure. It also suggests that multiple pathways may contribute to later lung effects. The source does not establish the claim’s additional PM0.1 exposure. (LLM, conf=0.86)

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Research works printed but not linked: 69

  1. Andrade MD, de Miranda RM, Fornaro A, Kerr A, Oyama B, de Andre PA, Saldiva P, 2012 Vehicle emissions and PM(2.5) mass concentrations in six Brazilian cities. Air Qual. Atmos. Health 5, 79– 88. 10.1007/s11869-010-0104-5. 22408695 PMC3286514 · DOI
  2. Ardini-Poleske ME, Clark RF, Ansong C, Carson JP, Corley RA, Deutsch GH, Hagood JS, Kaminski N, Mariani TJ, Potter SS, Pryhuber GS, Warburton D, Whitsett JA, Palmer SM, Ambalavanan N, Lung MAPCT, 2017 LungMAP: the molecular atlas of lung development program. Am. J. Physiol. Lung Cell Mol. Physiol ajplung.00139.02017 10.1152/ajplung.00139.2017. PMC5792185 28798251 · DOI
  3. Bates JHT, 2009 Lung Mechanics An Inverse Modeling Approach. Cambridge University Press, Cambridge, NY, USA.
  4. Burnett RT, Pope CA 3rd, Ezzati M, Olives C, Lim SS, Mehta S, Shin HH, Singh G, Hubbell B, Brauer M, Anderson HR, Smith KR, Balmes JR, Bruce NG, Kan H, Laden F, Pruss-Ustun A, Turner MC, Gapstur SM, Diver WR, Cohen A, 2014 An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure. Environ. Health Perspect 122, 397– 403. 10.1289/ehp.1307049. 24518036 PMC3984213 · DOI · Paper page
  5. Calderon-Garciduenas L, Leray E, Heydarpour P, Torres-Jardon R, Reis J, 2016 Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: the clinical impact on children and beyond. Rev. Neurol. (Paris) 172, 69– 80. 10.1016/j.neurol.2015.10.008. 26718591 · DOI
  6. Caprioli A, Villasenor A, Wylie LA, Braitsch C, Marty-Santos L, Barry D, Karner CM, Fu S, Meadows SM, Carroll TJ, Cleaver O, 2015 Wnt4 is essential to normal mammalian lung development. Dev. Biol 406, 222– 234. 10.1016/j.ydbio.2015.08.017. 26321050 PMC7050435 · DOI
  7. Chang DR, Martinez Alanis D, Miller RK, Ji H, Akiyama H, McCrea PD, Chen J, 2013 Lung epithelial branching program antagonizes alveolar differentiation. Proc. Natl. Acad. Sci. U. S. A 110, 18042– 18051. 10.1073/pnas.1311760110. 24058167 PMC3831485 · DOI
  8. Choe SE, Boutros M, Michelson AM, Church GM, Halfon MS, 2005 Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset. Genome Biol. 6, R16 10.1186/gb-2005-6-2-r16. 15693945 PMC551536 · DOI
  9. Cross JC, Werb Z, Fisher SJ, 1994 Implantation and the placenta: key pieces of the development puzzle. Science 266, 1508– 1518. 7985020
  10. Dallas PB, Gottardo NG, Firth MJ, Beesley AH, Hoffmann K, Terry PA, Freitas JR, Boag JM, Cummings AJ, Kees UR, 2005 Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RTPCR – how well do they correlate? BMC Genom. 6, 59 10.1186/1471-2164-6-59. PMC1142514 15854232 · DOI
  11. de Miranda RM, de Fatima Andrade M, Fornaro A, Astolfo R, de Andre PA, Saldiva P, 2012 Urban air pollution: a representative survey of PM(2.5) mass concentrations in six Brazilian cities. Air Qual. Atmos. Health 5, 63– 77. 10.1007/s11869-010-0124-1. 22408694 PMC3286513 · DOI
  12. Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dolle P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A, 2011 A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 9, e1000582 10.1371/journal.pbio.1000582. 21267068 PMC3022534 · DOI · Paper page
  13. Dijk W, Kersten S, 2014 Regulation of lipoprotein lipase by Angptl4. Trends Endocrinol. Metabol 25, 146– 155. 10.1016/j.tem.2013.12.005. 24397894 · DOI
  14. Drummond D, Baravalle-Einaudi M, Lezmi G, Vibhushan S, Franco-Montoya ML, Hadchouel A, Boczkowski J, Delacourt C, 2017 Combined effects of in utero and adolescent tobacco smoke exposure on lung function in C57Bl/6J mice. Environ. Health Perspect 125, 392– 399. 10.1289/ehp54. 27814244 PMC5332197 · DOI
  15. Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y, 2017 Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development. Thorax 72, 481– 484. 10.1136/thoraxjnl-2016-209598. 28070014 PMC5520249 · DOI
  16. Eden E, Navon R, Steinfeld I, Lipson D, Yakhini Z, 2009 GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinf. 10, 48 10.1186/1471-2105-10-48. PMC2644678 19192299 · DOI · Paper page
  17. Fabregat A, Sidiropoulos K, Garapati P, Gillespie M, Hausmann K, Haw R, Jassal B, Jupe S, Korninger F, McKay S, Matthews L, May B, Milacic M, Rothfels K, Shamovsky V, Webber M, Weiser J, Williams M, Wu G, Stein L, Hermjakob H, D’Eustachio P, 2016 The reactome pathway knowledgebase. Nucleic Acids Res. 44, D481– D487. 10.1093/nar/gkv1351. 26656494 PMC4702931 · DOI · Paper page
  18. Fanucchi MV, Plopper CG, Evans MJ, Hyde DM, Van Winkle LS, Gershwin LJ, Schelegle ES, 2006 Cyclic exposure to ozone alters distal airway development in infant rhesus monkeys. Am. J. Physiol. Lung Cell Mol. Physiol 291, L644– L650. 10.1152/ajplung.00027.2006. 16648242 · DOI
  19. Feng S, Gao D, Liao F, Zhou F, Wang X, 2016 The health effects of ambient PM2.5 and potential mechanisms. Ecotoxicol. Environ. Saf 128, 67– 74. 10.1016/j.ecoenv.2016.01.030. 26896893 · DOI
  20. Gomes RF, Shen X, Ramchandani R, Tepper RS, Bates JH, 2000 Comparative respiratory system mechanics in rodents. J. Appl. Physiol 89, 908– 916. 10956333
  21. Guo L, Li SY, Ji FY, Zhao YF, Zhong Y, Lv XJ, Wu XL, Qian GS, 2014 Role of Angptl4 in vascular permeability and inflammation. Inflamm. Res 63, 13– 22. 10.1007/s00011-013-0678-0. 24173241 · DOI
  22. Hantos Z, Daroczy B, Suki B, Nagy S, Fredberg JJ, 1992 Input impedance and peripheral inhomogeneity of dog lungs. J. Appl. Physiol 72, 168– 178. 1537711
  23. Hsia CC, Hyde DM, Ochs M, Weibel ER, 2010 An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am. J. Respir. Crit. Care Med. 181, 394– 418. 10.1164/rccm.200809-1522ST. 20130146 PMC5455840 · DOI
  24. Huang da W, Sherman BT, Lempicki RA, 2009 Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc 4, 44– 57. 10.1038/nprot.2008.211. 19131956 · DOI · Paper page
  25. Hyde DM, Tyler NK, Putney LF, Singh P, Gundersen HJ, 2004 Total number and mean size of alveoli in mammalian lung estimated using fractionator sampling and unbiased estimates of the Euler characteristic of alveolar openings. Anat. Rec. Part A Discov. Mol. Cell. Evol. Biol 277, 216– 226. 10.1002/ar.a.20012. 14983516 · DOI
  26. Jedrychowski WA, Perera FP, Maugeri U, Mroz E, Klimaszewska-Rembiasz M, Flak E, Edwards S, Spengler JD, 2010 Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers. Paediatr. Perinat. Epidemiol 24, 492– 501. 10.1111/j.1365-3016.2010.01136.x. 20670230 PMC3761386 · DOI
  27. Jedrychowski WA, Perera FP, Spengler JD, Mroz E, Stigter L, Flak E, Majewska R, Klimaszewska-Rembiasz M, Jacek R, 2013 Intrauterine exposure to fine particulate matter as a risk factor for increased susceptibility to acute broncho-pulmonary infections in early childhood. Int. J. Hyg Environ. Health 216, 395– 401. 10.1016/j.ijheh.2012.12.014. 23333083 PMC3657308 · DOI
  28. Kannan S, Misra DP, Dvonch JT, Krishnakumar A, 2006 Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential effect modification by nutrition. Environ. Health Perspect 114, 1636– 1642. 17107846 PMC1665414
  29. Kelly FJ, Fussell JC, 2012 Size, source and chemical composition as determinants of toxicity attributable to ambient particulate matter. Atmos. Environ 60, 504– 526. 10.1016/j.atmosenv.2012.06.039. · DOI
  30. Knust J, Ochs M, Gundersen HJ, Nyengaard JR, 2009 Stereological estimates of alveolar number and size and capillary length and surface area in mice lungs. Anat. Rec 292, 113– 122. 10.1002/ar.20747. 19115381 · DOI
  31. Korten I, Ramsey K, Latzin P, 2016 Air pollution during pregnancy and lung development in the child. Paediatr. Respir. Rev 10.1016/j.prrv.2016.08.008. 27665510 · DOI · Paper page
  32. Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A, McDermott MG, Monteiro CD, Gundersen GW, Ma’ayan A, 2016 Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 44, W90– W97. 10.1093/nar/gkw377. 27141961 PMC4987924 · DOI · Paper page
  33. La Paglia L, Listi A, Caruso S, Amodeo V, Passiglia F, Bazan V, Fanale D, 2017 Potential role of ANGPTL4 in the cross talk between metabolism and cancer through PPAR signaling pathway. PPAR Res. 2017, 8187235. 10.1155/2017/8187235. PMC5274667 28182091 · DOI
  34. Lee KK, Leung AK, Tang MK, Cai DQ, Schneider C, Brancolini C, Chow PH, 2001 Functions of the growth arrest specific 1 gene in the development of the mouse embryo. Dev. Biol 234, 188– 203. 10.1006/dbio.2001.0249. 11356029 · DOI
  35. Li X, Huang S, Jiao A, Yang X, Yun J, Wang Y, Xue X, Chu Y, Liu F, Liu Y, Ren M, Chen X, Li N, Lu Y, Mao Z, Tian L, Xiang H, 2017 Association between ambient fine particulate matter and preterm birth or term low birth weight: an updated systematic review and meta-analysis. Environ. Pollut 227, 596– 605. 10.1016/j.envpol.2017.03.055. 28457735 · DOI
  36. Mauad T, Rivero DH, de Oliveira RC, Lichtenfels AJ, Guimaraes ET, de Andre PA, Kasahara DI, Bueno HM, Saldiva PH, 2008 Chronic exposure to ambient levels of urban particles affects mouse lung development. Am. J. Respir. Crit. Care Med 178, 721– 728. 10.1164/rccm.200803-436OC. 18596224 PMC2556454 · DOI · Paper page
  37. Mazzoli-Rocha F, Oliveira VR, Barcellos BC, Moreira DK, Saldiva PH, Faffe DS, Zin WA, 2016 Time-dependency of mice lung recovery after a 4-week exposure to traffic or biomass air pollutants. Respir. Physiol. Neurobiol 230, 16– 21. 10.1016/j.resp.2016.05.003. 27179431 · DOI
  38. Mi H, Huang X, Muruganujan A, Tang H, Mills C, Kang D, Thomas PD, 2017 PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements. Nucleic Acids Res. 45, D183– D189. 10.1093/nar/gkw1138. 27899595 PMC5210595 · DOI
  39. Morales E, Garcia-Esteban R, de la Cruz OA, Basterrechea M, Lertxundi A, de Dicastillo MD, Zabaleta C, Sunyer J, 2015 Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age. Thorax 70, 64– 73. 10.1136/thoraxjnl-2014-205413. 25331281 · DOI
  40. Noel A, Xiao R, Perveen Z, Zaman H, Le Donne V, Penn A, 2017 Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero. Respir. Res 18, 104 10.1186/s12931-017-0591-0. 28651580 PMC5485620 · DOI
  41. Petryszak R, Keays M, Tang YA, Fonseca NA, Barrera E, Burdett T, Fullgrabe A, Fuentes AM, Jupp S, Koskinen S, Mannion O, Huerta L, Megy K, Snow C, Williams E, Barzine M, Hastings E, Weisser H, Wright J, Jaiswal P, Huber W, Choudhary J, Parkinson HE, Brazma A, 2016 Expression Atlas update–an integrated database of gene and protein expression in humans, animals and plants. Nucleic Acids Res. 44, D746– D752. 10.1093/nar/gkv1045. 26481351 PMC4702781 · DOI
  42. Pozarska A, Rodriguez-Castillo JA, Surate Solaligue DE, Ntokou A, Rath P, Mizikova I, Madurga A, Mayer K, Vadasz I, Herold S, Ahlbrecht K, Seeger W, Morty RE, 2017 Stereological monitoring of mouse lung alveolarization from the early postnatal period to adulthood. Am. J. Physiol. Lung Cell Mol. Physiol 312, L882– L895. 10.1152/ajplung.00492.2016. 28314804 · DOI
  43. Rockich BE, Hrycaj SM, Shih HP, Nagy MS, Ferguson MA, Kopp JL, Sander M, Wellik DM, Spence JR, 2013 Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc. Natl. Acad. Sci. U. S. A 110, E4456– E4464. 10.1073/pnas.1311847110. 24191021 PMC3839746 · DOI
  44. Rosti K, Goldman A, Kajander T, 2015 Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1. BMC Biochem. 16, 8 10.1186/s12858-015-0037-6. 25888394 PMC4349606 · DOI
  45. Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, Braisted J, Klapa M, Currier T, Thiagarajan M, Sturn A, Snuffin M, Rezantsev A, Popov D, Ryltsov A, Kostukovich E, Borisovsky I, Liu Z, Vinsavich A, Trush V, Quackenbush J, 2003 TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34, 374– 378. 12613259
  46. Schittny JC, 2017 Development of the lung. Cell Tissue Res. 367, 427– 444. 10.1007/s00441-016-2545-0. 28144783 PMC5320013 · DOI
  47. Segovia J, Zarco N, 2014 Gas1 is a pleiotropic regulator of cellular functions: from embryonic development to molecular actions in cancer gene therapy. Mini Rev. Med. Chem 14, 1139– 1147. 25429664
  48. She ZY, Yang WX, 2015 SOX family transcription factors involved in diverse cellular events during development. Eur. J. Cell Biol 94, 547– 563. 10.1016/j.ejcb.2015.08.002. 26340821 · DOI
  49. Siddika N, Balogun HA, Amegah AK, Jaakkola JJ, 2016 Prenatal ambient air pollution exposure and the risk of stillbirth: systematic review and meta-analysis of the empirical evidence. Occup. Environ. Med 73, 573– 581. 10.1136/oemed-2015-103086. 27221104 · DOI · Paper page
  50. Sioutas C, Koutrakis P, Burton RM, 1995 A technique to expose animals to concentrated fine ambient aerosols. Environ. Health Perspect 103, 172– 177. 7737066 PMC1519008
  51. Sock E, Schmidt K, Hermanns-Borgmeyer I, Bosl MR, Wegner M, 2001 Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. Mol. Cell Biol 21, 6951– 6959. 10.1128/mcb.21.20.6951-6959.2001. 11564878 PMC99871 · DOI
  52. Soto SF, Melo JO, Marchesi GD, Lopes KL, Veras MM, Oliveira IB, Souza RM, de Castro I, Furukawa LNS, Saldiva PHN, Heimann JC, 2017 Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. PLoS One 12, e0183314 10.1371/journal.pone.0183314. 28820906 PMC5562329 · DOI
  53. Stapleton CM, Joo JH, Kim YS, Liao G, Panettieri RA Jr., Jetten AM, 2010 Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways. Exp. Cell Res 316, 507– 516. 10.1016/j.yexcr.2009.12.004. 20025870 PMC2815125 · DOI
  54. Teng C, Wang Z, Yan B, 2016 Fine particle-induced birth defects: impacts of size, payload, and beyond. Birth Defects Res. Part C Embryo Today 108, 196– 206. 10.1002/bdrc.21136. 27581067 · DOI
  55. Thevenot P, Saravia J, Giaimo J, Happel KI, Dugas TR, Cormier SA, 2013 Chronic alcohol induces M2 polarization enhancing pulmonary disease caused by exposure to particulate air pollution. Alcohol Clin. Exp. Res 37, 1910– 1919. 10.1111/acer.12184. 23763452 PMC3775861 · DOI
  56. To T, Zhu J, Larsen K, Simatovic J, Feldman L, Ryckman K, Gershon A, Lougheed MD, Licskai C, Chen H, Villeneuve PJ, Crighton E, Su Y, Sadatsafavi M, Williams D, Carlsten C, 2016 Progression from Asthma to chronic obstructive pulmonary disease. Is air pollution a risk factor? Am. J. Respir. Crit. Care Med 194, 429– 438. 10.1164/rccm.201510-1932OC. 26950751 · DOI
  57. Traboulsi H, Guerrina N, Iu M, Maysinger D, Ariya P, Baglole CJ, 2017 Inhaled pollutants: the molecular scene behind respiratory and systemic diseases associated with ultrafine particulate matter. Int. J. Mol. Sci 18 10.3390/ijms18020243. PMC5343780 28125025 · DOI
  58. Unachukwu U, Trischler J, Goldklang M, Xiao R, D’Armiento J, 2017 Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal lungs. Faseb. J 31, 2340– 2351. 10.1096/fj.201601063R. 28209772 PMC6191095 · DOI
  59. Ustiyan V, Zhang Y, Perl AK, Whitsett JA, Kalin TV, Kalinichenko VV, 2016 beta-catenin and Kras/Foxm1 signaling pathway are critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis. Dev. Dynam 245, 590– 604. 10.1002/dvdy.24393. PMC4844868 26869074 · DOI
  60. Veras MM, Damaceno-Rodrigues NR, Caldini EG, Maciel Ribeiro AA, Mayhew TM, Saldiva PH, Dolhnikoff M, 2008 Particulate urban air pollution affects the functional morphology of mouse placenta. Biol. Reprod 79, 578– 584. 10.1095/biolreprod.108.069591. 18509159 · DOI · Paper page
  61. Veras MM, de Oliveira Alves N, Fajersztajn L, Saldiva P, 2016 Before the first breath: prenatal exposures to air pollution and lung development. Cell Tissue Res. 10.1007/s00441-016-2509-4. 27726025 · DOI
  62. Vieira SE, 2015 The health burden of pollution: the impact of prenatal exposure to air pollutants. Int. J. Chronic Obstr. Pulm. Dis 10, 1111– 1121. 10.2147/copd.s40214. PMC4468952 26089661 · DOI
  63. Weider M, Wegner M, 2017 SoxE factors: transcriptional regulators of neural differentiation and nervous system development. Semin. Cell Dev. Biol 63, 35– 42. 10.1016/j.semcdb.2016.08.013. 27552919 · DOI
  64. Winckelmans E, Vrijens K, Tsamou M, Janssen BG, Saenen ND, Roels HA, Kleinjans J, Lefebvre W, Vanpoucke C, de Kok TM, Nawrot TS, 2017 Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort. Environ. Health 16 (52). 10.1186/s12940-017-0264-y. PMC5458481 28583124 · DOI
  65. Wright RJ, Brunst KJ, 2013 Programming of respiratory health in childhood: influence of outdoor air pollution. Curr. Opin. Pediatr 25, 232e239 10.1097/MOP.0b013e32835e78cc. 23422354 · DOI
  66. Xie C, Han Y, Liu Y, Han L, Liu J, 2014 miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer. Int. J. Clin. Exp. Pathol 7, 7518– 7526. 25550787 PMC4270566
  67. Yoshizaki K, Fuziwara CS, Brito JM, Santos TM, Kimura ET, Correia AT, Amato-Lourenco LF, Vasconcellos P, Silva LF, Brentani MM, Mauad T, Saldiva PH, Macchione M, 2016 The effects of urban particulate matter on the nasal epithelium by gender: an experimental study in mice. Environ. Pollut 213, 359– 369. 10.1016/j.envpol.2016.02.044. 26942683 · DOI
  68. Zhu P, Goh YY, Chin HF, Kersten S, Tan NS, 2012 Angiopoietin-like 4: a decade of research. Biosci. Rep 32, 211– 219. 10.1042/bsr20110102. 22458843 · DOI
  69. Zhu X, Guo X, Wu S, Wei L, 2016 ANGPTL4 correlates with NSCLC progression and regulates epithelial-mesenchymal transition via ERK pathway. Lung 194, 637– 646. 10.1007/s00408-016-9895-y. 27166634 · DOI

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Authors
de Barros Mendes Lopes, T., Groth, E. E., Veras, M., Furuya, T. K., de Souza Xavier Costa, N., Ribeiro Júnior, G., Lopes, F. D., de Almeida, F. M., Cardoso, W. V., Saldiva, P. H. N., Chammas, R., & Mauad, T.
Affiliations
  • Universidade de São Paulo (BR)
  • Columbia University Irving Medical Center (US)
ORCID
Venue
Environmental Pollution
Publisher
Elsevier BV
Published
2018-10
Volume
241
Pages
511-520
ISSN
0269-7491 (ISSN-L)
DOI
10.1016/j.envpol.2018.05.055
PMC
PMC6407120
OpenAlex
W2805674956
Cited by
64
References
1
Citations by year
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FWCI
3.46
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Environmental Pollution (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Brazilian National Institute of Science and Technology – National Institute of Integrated Analysis of Environmental Risk (INCT-INAIRA)
  • Brazilian National Council for Scientific and Technological Development (573813/2006-6)
  • São Paulo Research Foundation (08/577717-6)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords
PM2.5, urban air pollution, prenatal exposure, postnatal exposure, lung development, alveolar number, lung function, lung elastance, bronchoalveolar lavage, DNA damage, inflammation, cell proliferation, Sox8, ANGPTL4, GAS1, fetal lung, mouse model
MeSH terms
Angiopoietin-Like Protein 4, Air Pollution, Animals, Brazil, DNA Damage, Elasticity, Female, Gene Expression Regulation, Lung, Male, Pregnancy, Prenatal Exposure Delayed Effects, Pulmonary Alveoli, Time Factors, Cell Cycle Proteins, Mice, Particulate Matter, SOXE Transcription Factors, GPI-Linked Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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