Effect of Withania somnifera on Insulin Sensitivity in Non‐Insulin‐Dependent Diabetes Mellitus Rats
Open accessAbstract
We investigated the effect of an aqueous extract of Withania somnifera (WS) on insulin sensitivity in non-insulin-dependent diabetes mellitus (NIDDM) rats. NIDDM was induced by single intraperitoneal injection of streptozotocin (100 mg/kg) to 2 days old rat pups. WS (200 and 400 mg/kg) was administered orally once a day for 5 weeks after the animals were confirmed diabetic (i.e. 75 days after streptozotocin injection). A group of citrate control rats (group I) were also maintained that has received citrate buffer on the second day of their birth. A significant increase in blood glucose, glycosylated haemoglobin (HbA(1)c) and serum insulin levels were observed in NIDDM control rats. Treatment with WS reduced the elevated levels of blood glucose, HbA(1)c and insulin in the NIDDM rats. An oral glucose tolerance test was also performed in the same groups, in which we found a significant improvement in glucose tolerance in the rats treated with WS. The insulin sensitivity was assessed for both peripheral insulin resistance and hepatic insulin resistance. WS treatment significantly improved insulin sensitivity index (K(ITT)) that was significantly decreased in NIDDM control rats. There was significant rise in homeostasis model assessment of insulin resistance (HOMA-R) in NIDDM control rats whereas WS treatment significantly prevented the rise in HOMA-R in NIDDM-treated rats. Our data suggest that aqueous extract of WS normalizes hyperglycemia in NIDDM rats by improving insulin sensitivity.
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Withania somnifera treatment significantly improves insulin sensitivity index in non-insulin-dependent diabetes mellitus rats.
“In addition to that, WS treatment could significantly improve the insulin sensitivity index in non-insulin-dependent diabetes mellitus (NIDDM) rats [27].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [27]
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- Authors
- Anwer, T., Sharma, M., Pillai, K. K., & Iqbal, M.
- Affiliations
- Jamia Hamdard (IN)
- Corresponding author
- Sharma, Manju
- Venue
- Basic & Clinical Pharmacology & Toxicology
- Publisher
- Wiley
- Published
- 2008-03-16
- Volume
- 102
- Issue
- 6
- Pages
- 498-503
- ISSN
- 1742-7835 (ISSN-L)
- 1742-7843
- OpenAlex
- W2079458858
- Cited by
- 75
- References
- 49
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 10 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Basic & Clinical Pharmacology & Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- Withania somnifera, insulin sensitivity, type 2 diabetes, streptozotocin-induced diabetes, aqueous plant extract, hyperglycemia, insulin resistance, glucose tolerance, glycosylated haemoglobin, HOMA-IR, hepatic insulin resistance, peripheral insulin resistance
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Glucose Tolerance Test, Glycated Hemoglobin, Hypoglycemic Agents, Insulin, Insulin Resistance, Plant Extracts, Rats, Wistar, Withania, Rats
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