Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works

Biological effects of the superoxide radical

Fridovich, I. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90526-6 · Cited by 1,422 · see citing works

New Substances of Plant Origin Which Increase Nonspecific Resistance

Brekhman, I. I., & Dardymov, I. V. (1969) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.09.040169.002223 · Cited by 595 · see citing works

Antioxidant activity of glycowithanolides from Withania somnifera.

Bhattacharya, S. K., Satyan, K. S., & Ghosal, S. (1997) · PubMed · Cited by 287 · see citing works

(−) deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats

Carrillo, M.-C., Kanai, S., Nokubo, M., & Kitani, K. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90466-o · Cited by 258 · see citing works

Free radicals in biological systems—a review orientated to inflammatory processes

Blake, D. R., Allen, R. E., & Lunec, J. (1987) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072188 · Cited by 234 · see citing works

Effect of stress on the antioxidant enzymes and gastric ulceration

Das, D. K., & Banerjee, R. K. (1993) · Molecular and Cellular Biochemistry · doi:10.1007/bf00936440 · Cited by 221 · see citing works

Anti‐stress activity of sitoindosides VII and VIII, new acylsterylglucosides from Withania somnifera

Bhattacharya, S. K., Goel, R., Kaur, R., & Ghosal, S. (1987) · Phytotherapy Research · doi:10.1002/ptr.2650010108 · Cited by 164 · see citing works

Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization.

Devi, P. U. (1996) · PubMed · Cited by 158 · see citing works

Effect of ashwagandha on lipid peroxidation in stress-induced animals

Dhuley, J. N. (1998) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(97)00151-7 · Cited by 157 · see citing works

Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycowithanolides from Withania somnifera

Ghosal, S., Lal, J., Srivastava, R. S., Bhattacharya, S. K., Upadhyay, S. N., Jaiswal, A. K., & Chattopadhyay, U. (1989) · Phytotherapy Research · doi:10.1002/ptr.2650030510 · Cited by 147 · see citing works

Effect of Trasina, an Ayurvedic herbal formulation, on pancreatic islet superoxide dismutase activity in hyperglycaemic rats.

Bhattacharya, S. K., Satyan, K. S., & Chakrabarti, A. (1997) · PubMed · Cited by 134 · see citing works

Effects of glycowithanolides from <i>Withania somnifera</i> on an animal model of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats

Bhattacharya, S. K., Kumar, A., & Ghosal, S. (1995) · Phytotherapy Research · doi:10.1002/ptr.2650090206 · Cited by 112 · see citing works

Free radicals in health and disease

Singal, P. K., Petkau, A., Gerrard, J. M., Hrushovetz, S. B., & Foerster, J. (1988) · Molecular and Cellular Biochemistry · doi:10.1007/bf00421045 · Cited by 108 · see citing works

Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice

Davis, L., & Kuttan, G. (1998) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00039-7 · Cited by 101 · see citing works

Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas.

Bhattacharya, S. K., Bhattacharya, A., & Chakrabarti, A. (2000) · PubMed · Cited by 86 · see citing works

Anti-granuloma activity of Iraqi Withania somnifera

Al-Hindawi, M. K., Al-Khafaji, S. H., & Abdul-Nabi, M. H. (1992) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(92)90069-4 · Cited by 75 · see citing works

Footshock-induced freezing behavior in rats as a model for assessing anxiolytics

Conti, L. H., Maciver, C. R., Ferkany, J. W., & Abreu, M. E. (1990) · Psychopharmacology · doi:10.1007/bf02247130 · Cited by 74 · see citing works

Effect of Withania somnifera on glycosaminoglycan synthesis in carrageenin-induced air pouch granuloma

Begum, V. H., & Sadique, J. (1987) · Biochemical Medicine and Metabolic Biology · doi:10.1016/0885-4505(87)90091-0 · Cited by 42 · see citing works

Free Radicals in Health and Disease

Kendler, B. S. (1995) · The Nurse Practitioner · doi:10.1097/00006205-199507000-00003 · Cited by 41 · see citing works

Mechanisms of Biologic Aging

Balin, A. K., & Allen, R. G. (1986) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30798-8 · Cited by 36 · see citing works

Effects of neuroleptics on electrodermal activity in schizophrenic patients: a review

Schnur, D. B. (1990) · Psychopharmacology · doi:10.1007/bf02247121 · Cited by 26 · see citing works

Age-related increases in superoxide dismutase activity and thiobarbituric acid-reactive substances: Effect of bio-catalyzer in aged rat brain

Santiago, L. A., Osato, J. A., Liu, J., & Mori, A. (1993) · Neurochemical Research · doi:10.1007/bf00966786 · Cited by 26 · see citing works

Herbs That Heal

Weiner, J. A. (1994) · Cited by 10 · see citing works

In vivo hypotensive activity of Pistacia lentiscus L

Sanz, M., Terencio, M. C., & Payá, M. (1988) · Phytotherapy Research · doi:10.1002/ptr.2650020412 · Cited by 7 · see citing works

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Howes, M. R., Perry, N. S. L., & Houghton, P. J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1280 · Cited by 418 · see citing works

Withania somnifera: an Indian ginseng

Kulkarni, S. K., & Dhir, A. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.011 · Cited by 416 · see citing works

Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda

Govindarajan, R., Vijayakumar, M., & Pushpangadan, P. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.02.035 · Cited by 406 · see citing works

Pharmacologic overview of Withania somnifera, the Indian Ginseng

Dar, N. J., Hamid, A., & Ahmad, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2012-1 · Cited by 391 · see citing works

Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress

Bhattacharya, S. K., & Muruganandam, A. V. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00110-2 · Cited by 344 · see citing works

Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds

Rai, S., Wahile, A., Mukherjee, K., Saha, B. P., & Mukherjee, P. K. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.09.025 · Cited by 310 · see citing works

Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects

Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306 · see citing works

Traditional medicinal plant knowledge and use by local healers in Sekoru District, Jimma Zone, Southwestern Ethiopia

Yineger, H., & Yewhalaw, D. (2007) · Journal of Ethnobiology and Ethnomedicine · doi:10.1186/1746-4269-3-24 · Cited by 303 · see citing works

Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats

Ahmad, M., Saleem, S., Ahmad, A. S., Ansari, M. A., Yousuf, S., Hoda, M. N., & Islam, F. (2005) · Human &amp; Experimental Toxicology · doi:10.1191/0960327105ht509oa · Cited by 227 · see citing works

PASS-assisted exploration of new therapeutic potential of natural products

Goel, R. K., Singh, D., Lagunin, A. A., & Poroikov, V. (2010) · Medicinal Chemistry Research · doi:10.1007/s00044-010-9398-y · Cited by 214 · see citing works

Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease

Thenmozhi, A. J., Raja, T. R. W., Manivasagam, T., Janakiraman, U., & Essa, M. M. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1144846 · Cited by 173 · see citing works

Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse

Rajasankar, S., Manivasagam, T., Venkatachalam, S., Prakash, S., Muthusamy, R., Krishnamurti, A., & Surendran, S. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.003 · Cited by 161 · see citing works

Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects

Mandlik, D. S., & Namdeo, A. G. (2020) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1741484 · Cited by 149 · see citing works

A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process

Haider, S., Liaquat, L., Shahzad, S., Sadir, S., Madiha, S., Batool, Z., Tabassum, S., Saleem, S., Naqvi, F. F., & Perveen, T. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.01.016 · Cited by 145 · see citing works

Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

Kurapati, K. R. V., Atluri, V., Samikkannu, T., & Nair, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077624 · Cited by 117 · see citing works

Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism

Prakash, J., Yadav, S. K., Chouhan, S., & Singh, S. P. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1005-4 · Cited by 128 · see citing works

Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress

Haider, S., Liaquat, L., Ahmad, S., Batool, Z., Siddiqui, R. A., Tabassum, S., Shahzad, S., Rafiq, S., & Naz, N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227631 · Cited by 127 · see citing works

Neurodegenerative diseases and Withania somnifera (L.): An update

Dar, N. J., & Ahmad, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112769 · Cited by 123 · see citing works

Possible Neuroprotective Effect of <i>Withania somnifera</i> Root Extract Against 3-Nitropropionic Acid-Induced Behavioral, Biochemical, and Mitochondrial Dysfunction in an Animal Model of Huntington's Disease

Kumar, P., & Kumar, A. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0028 · Cited by 120 · see citing works

Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats

Gupta, A., & Singh, S. B. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2013.835325 · Cited by 120 · see citing works

Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats

Bhatnagar, M., Sisodia, S. S., & Bhatnagar, R. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1352.027 · Cited by 120 · see citing works

Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): an experimental study in rat model

Satyanarayana, S., Nammi, S., Kolanukonda, R., Koppula, S., & Boini, K. M. (2005) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-5-1 · Cited by 119 · see citing works

Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress

Nataraj, J., Manivasagam, T., Thenmozhi, A. J., & Essa, M. M. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000010 · Cited by 116 · see citing works

Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology.

Winters, M. (2006) · PubMed · Cited by 115 · see citing works

Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain

Suresh Ramnath, N. A. I. K., Pilgaonkar, V. W., & Panda, V. S. (2006) · Phytotherapy Research · doi:10.1002/ptr.1976 · Cited by 113 · see citing works

Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A

Grover, A., Shandilya, A., Punetha, A., Bisaria, V. S., & Sundar, D. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-s4-s25 · Cited by 113 · see citing works

Withanolide A Prevents Neurodegeneration by Modulating Hippocampal Glutathione Biosynthesis during Hypoxia

Baitharu, I., Jain, V., Deep, S. N., Shroff, S., Sahu, J. K., Naik, P. K., & Ilavazhagan, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105311 · Cited by 111 · see citing works

W ithania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta-analysis

Durg, S., Dhadde, S. B., Vandal, R., Shivakumar, B. S., & Charan, C. S. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12398 · Cited by 110 · see citing works

Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology

Uddin, M. S., Mamun, A. A., Kabir, M. T., Jakaria, M., Mathew, B., Barreto, G. E., & Ashraf, G. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1420-2 · Cited by 110 · see citing works

Antioxidant property of α-asarone against noise-stress-induced changes in different regions of rat brain

Manikandan, S., & Seema Devi, R. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.07.007 · Cited by 107 · see citing works

Acute and Sub‐Acute Oral Toxicity Assessment of the Hydroalcoholic Extract of Withania somnifera Roots in Wistar Rats

Prabu, P. C., Panchapakesan, S., & Raj, C. D. (2012) · Phytotherapy Research · doi:10.1002/ptr.4854 · Cited by 104 · see citing works

Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice

Birla, H., Keswani, C., Nand, S., Singh, S. S., Zahra, W., Dilnashin, H., Rathore, A. S., & Singh, S. P. (2019) · Behavioral and Brain Functions · doi:10.1186/s12993-019-0160-4 · Cited by 101 · see citing works

A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide

Liao, L.-Y., He, Y.-F., Li, L., Meng, H., Dong, Y.-M., Yi, F., & Xiao, P. (2018) · Chinese Medicine · doi:10.1186/s13020-018-0214-9 · Cited by 100 · see citing works

Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review

Gaurav, H., Yadav, D., Maurya, A., Yadav, H., Yadav, R., Shukla, A. C., Sharma, M., Gupta, V. K., & Palazón, J. (2023) · Molecules · doi:10.3390/molecules28031208 · Cited by 99 · see citing works

Withanolides and Related Steroids

Misico, R. I., Nicotra, V. E., Oberti, J. C., Barboza, G. E., Gil, R. R., & Burton, G. (2011) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-7091-0748-5_3 · Cited by 99 · see citing works

Neuroprotective Effects of Withania somnifera Dunal.: A Possible Mechanism

Bhatnagar, M., Sharma, D., & Salvi, M. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9987-7 · Cited by 95 · see citing works

Neuroprotective Herbs for Stroke Therapy In Traditional Eastern Medicine

Kim, H. (2005) · Neurological Research · doi:10.1179/016164105x25234 · Cited by 93 · see citing works

Ashwagandha (Withania somnifera): Role in Safeguarding Health, Immunomodulatory Effects, Combating Infections and Therapeutic Applications: A Review

Tiwari, R., Chakrabort, S., Saminathan, M., Dhama, K., & Singh, S. V. (2014) · Journal of Biological Sciences · doi:10.3923/jbs.2014.77.94 · Cited by 93 · see citing works

Protective Effect of Acorus calamus LINN on Free Radical Scavengers and Lipid Peroxidation in Discrete Regions of Brain against Noise Stress Exposed Rat

Manikandan, S., SRIKUMAR, R., Parthasarathy, N. J., & Devi, R. S. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.2327 · Cited by 92 · see citing works

Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson’s disease mice

Kavitha, M., Nataraj, J., Essa, M. M., Memon, M. A., & Manivasagam, T. (2013) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2013.09.016 · Cited by 91 · see citing works

Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer’s Disease1

Prema, A., Justin Thenmozhi, A., Manivasagam, T., Mohamed Essa, M., & Guillemin, G. J. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161103 · Cited by 90 · see citing works

Rectal gel application of Withania somnifera root extract expounds anti-inflammatory and muco-restorative activity in TNBS-induced Inflammatory Bowel Disease

Pawar, P. K., Gilda, S., Sharma, S., Jagtap, S., Paradkar, A. R., Mahadik, K. R., Ranjekar, P. K., & Harsulkar, A. (2011) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-11-34 · Cited by 89 · see citing works

Protective effect of black tea extract against aluminium chloride-induced Alzheimer's disease in rats: A behavioural, biochemical and molecular approach

Bharathi, M. D., Thenmozhi, A. J., & Manivasagam, T. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.001 · Cited by 88 · see citing works

Total Antioxidant Levels are Low During Active TB and Rise with Anti‐tuberculosis Therapy

Wiid, I. J. F., Seaman, T., Hoal, E. G., Benadé, A., & van Helden, P. D. (2004) · IUBMB Life · doi:10.1080/15216540410001671259 · Cited by 87 · see citing works

Free radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root

Lee, S. E., Ju, E. M., & Kim, J. H. (2001) · Experimental & Molecular Medicine · doi:10.1038/emm.2001.43 · Cited by 86 · see citing works

Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats

Chaudhary, G., Sharma, U., Jagannathan, N. R., & Gupta, Y. K. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03849.x · Cited by 85 · see citing works

Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A

Grover, A., Shandilya, A., Agrawal, V., Pratik, P., Bhasme, D., Bisaria, V. S., & Sundar, D. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-s1-s30 · Cited by 85 · see citing works

Withaferin-A attenuates multiple low doses of Streptozotocin (MLD-STZ) induced type 1 diabetes

Tekula, S., Khurana, A., Anchi, P., & Godugu, C. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.090 · Cited by 84 · see citing works

In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β‐amyloid(1–42)‐induced cytotoxicity in differentiated PC12 cells

Kumar, S., Seal, C. J., Howes, M. R., Kite, G. C., & Okello, E. J. (2010) · Phytotherapy Research · doi:10.1002/ptr.3261 · Cited by 84 · see citing works

Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor‐kappa‐B, cyclooxygenase and tumor cell proliferation

Mulabagal, V., Subbaraju, G. V., Rao, C. V., Sivaramakrishna, C., DeWitt, D. L., Holmes, D., Sung, B., Aggarwal, B. B., Tsay, H., & Nair, M. G. (2009) · Phytotherapy Research · doi:10.1002/ptr.2736 · Cited by 79 · see citing works

Review on anticancerous therapeutic potential of Withania somnifera (L.) Dunal

Singh, N., Yadav, S. S., Rao, A. S., Nandal, A., Kumar, S., Ganaie, S. A., & Narasihman, B. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113704 · Cited by 77 · see citing works

Effect of Withania somnifera root extract on reserpine‐induced orofacial dyskinesia and cognitive dysfunction

Naidu, P. S., Singh, A., & Kulkarni, S. K. (2006) · Phytotherapy Research · doi:10.1002/ptr.1823 · Cited by 77 · see citing works

Withania somnifera (ASHWAGANDHA) ATTENUATES ANTIOXIDANT DEFENSE IN AGED SPINAL CORD AND INHIBITS COPPER INDUCED LIPID PEROXIDATION AND PROTEIN OXIDATIVE MODIFICATIONS

Gupta, S. K., Dua, A., & Vohra, B. P. S. (2003) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2003.19.3.211 · Cited by 77 · see citing works

Effect of <i>Withania somnifera</i> on Insulin Sensitivity in Non‐Insulin‐Dependent Diabetes Mellitus Rats

Anwer, T., Sharma, M., Pillai, K. K., & Iqbal, M. (2008) · Basic &amp; Clinical Pharmacology &amp; Toxicology · doi:10.1111/j.1742-7843.2008.00223.x · Cited by 75 · see citing works

Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia

Bhattacharya, S. K., Bhattacharya, D., Sairam, K., & Ghosal, S. (2002) · Phytomedicine · doi:10.1078/0944-7113-00089 · Cited by 75 · see citing works

Stress and ageing interactions: A paradox in the context of shared etiological and physiopathological processes

Pardon, M. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.007 · Cited by 72 · see citing works

Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

Grover, A., Agrawal, V., Shandilya, A., Bisaria, V. S., & Sundar, D. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-s13-s22 · Cited by 67 · see citing works

Effect of Withania somnifera Root Extract on Haloperidol-Induced Orofacial Dyskinesia: Possible Mechanisms of Action

Naidu, P. S., Singh, A., & Kulkarni, S. K. (2003) · Journal of Medicinal Food · doi:10.1089/109662003322233503 · Cited by 66 · see citing works

Unusual withanolides from aeroponically grown Withania somnifera

Xu, Y.-M., Gao, S., Bunting, D. P., & Gunatilaka, A. A. L. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2010.12.020 · Cited by 65 · see citing works

An Aqueous Extract of <i>Withania somnifera</i> Root Inhibits Amyloid β Fibril Formation <i>In Vitro</i>

Kumar, S., Harris, R. J., Seal, C. J., & Okello, E. J. (2012) · Phytotherapy Research · doi:10.1002/ptr.3512 · Cited by 62 · see citing works

Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2

Sarveswaran, S. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i7.1018 · Cited by 62 · see citing works

Unique Medicinal Properties of Withania somnifera: Phytochemical Constituents and Protein Component

Dar, P. A., Singh, L. R., Kamal, M. A., & Dar, T. A. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151125001751 · Cited by 61 · see citing works

Computational Evidence to Inhibition of Human Acetyl Cholinesterase by Withanolide A for Alzheimer Treatment

Grover, A., Shandilya, A., Agrawal, V., Bisaria, V. S., & Sundar, D. (2012) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2012.10507408 · Cited by 60 · see citing works

Withania somnifera as a potential anxiolytic and immunomodulatory agent in acute sleep deprived female Wistar rats

Kaur, T., Singh, H., Mishra, R., Manchanda, S., Gupta, M., Saini, V., Sharma, A., & Kaur, G. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2900-1 · Cited by 57 · see citing works

Lipid Peroxidation was Involved in the Memory Impairment of Carbon Monoxide-induced Delayed Neuron Damage

Wang, P., Zeng, T., Zhang, C., Gao, X.-C., Liu, Z., Xie, K., & Zhao-fu, C. (2009) · Neurochemical Research · doi:10.1007/s11064-008-9908-1 · Cited by 59 · see citing works

Chronic stress-induced oxidative damage and hyperlipidemia are accompanied by atherosclerotic development in rats

Devaki, M., Ramadas, N., & Yajurvedi, H. N. (2012) · Stress · doi:10.3109/10253890.2012.719052 · Cited by 59 · see citing works

Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications

Sharifi‐Rad, J., Quispe, C., Ayatollahi, S. A., Kobarfard, F., Staniak, M., Stępień-Warda, A., Czopek, K., Sen, S., Acharya, K., Matthews, K. R., et al. (2021) · Journal of Food Quality · doi:10.1155/2021/8985179 · Cited by 58 · see citing works

Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes

Grover, A., Shandilya, A., Bisaria, V. S., & Sundar, D. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-s4-s15 · Cited by 56 · see citing works

Recent advances in elucidating the biological properties of Withania somnifera and its potential role in health benefits

Alam, N., Hossain, M., Khalil, M. I., Moniruzzaman, M., Sulaiman, S. A., & Gan, S. H. (2011) · Phytochemistry Reviews · doi:10.1007/s11101-011-9221-5 · Cited by 55 · see citing works

Enhanced withanolide production by overexpression of squalene synthase in Withania somnifera

Grover, A., Samuel, G., Bisaria, V. S., & Sundar, D. (2013) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2012.12.011 · Cited by 54 · see citing works

Plants traditionally used in age-related brain disorders (dementia): an ethanopharmacological survey

Suganthy, N., Pandian, S. K., & Kasi, P. D. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2012.738423 · Cited by 53 · see citing works

Ashwagandha

Bharti, V. K., Malik, J. K., & Gupta, R. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802147-7.00052-8 · Cited by 53 · see citing works

Cuminum cyminumextract attenuates scopolamine-induced memory loss and stress-induced urinary biochemical changes in rats: A noninvasive biochemical approach

Koppula, S., & Choi, D. (2011) · Pharmaceutical Biology · doi:10.3109/13880209.2010.541923 · Cited by 52 · see citing works

Anti-ulcer activity of Ipomoea batatas tubers (sweet potato)

Panda, V. S., & Sonkamble, M. (2012) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v2i3.99 · Cited by 49 · see citing works

Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats

Koppula, S., & Kumar, H. (2013) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v12i4.17 · Cited by 47 · see citing works

Nephroprotective Effect ofWithania somnifera:A Dose-Dependent Study

Jeyanthi, T., & Subramanian, P. (2009) · Renal Failure · doi:10.3109/08860220903150320 · Cited by 47 · see citing works

Genetically Modified Hairy Roots of Withania somnifera Dunal: A Potent Source of Rejuvenating Principles

Kumar, V., Murthy, K. N. C., Bhamid, S., Sudha, C. G., & Ravishankar, G. A. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.37 · Cited by 46 · see citing works

Withania somnifera Root Extract Has Potent Cytotoxic Effect against Human Malignant Melanoma Cells

Halder, B., Singh, S., & Thakur, S. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137498 · Cited by 46 · see citing works

A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies

Esmaealzadeh, N., Iranpanah, A., Sarris, J. J., & Rahimi, R. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154354 · Cited by 45 · see citing works

Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats.

Kumar, A. J., Kumar, R., Rahman, M. S., Iqubal, M. A., Anand, G., Niraj, P. K., & Ali, M. D. (2015) · Europe PMC (PubMed Central) · Cited by 45 · see citing works

Effect of Withania somnifera Supplementation on Rotenone-Induced Oxidative Damage in Cerebellum and Striatum of the Male Mice Brain

Manjunath, M. J., & ., M. (2013) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524911313010007 · Cited by 45 · see citing works

‘Ashvagandharishta’ prepared using yeast consortium from Woodfordia fruticosa flowers exhibit hepatoprotective effect on CCl4 induced liver damage in Wistar rats

Bhondave, P., Devarshi, P. P., Mahadik, K. R., & Harsulkar, A. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.10.025 · Cited by 43 · see citing works

Effects of syringic acid on chronic MPTP/probenecid induced motor dysfunction, dopaminergic markers expression and neuroinflammation in C57BL/6 mice

Rekha, K. R., Selvakumar, G. P., & Sivakamasundari, R. I. (2014) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2014.02.004 · Cited by 42 · see citing works

Functional characterization and differential expression studies of squalene synthase from Withania somnifera

Gupta, N., Sharma, P., Kumar, R. J. S., Vishwakarma, R. K., & Khan, B. M. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1743-4 · Cited by 41 · see citing works

Overexpression of squalene synthase in Withania somnifera leads to enhanced withanolide biosynthesis

Patel, N., Patel, P., Kendurkar, S. V., Thulasiram, H. V., & Khan, B. M. (2015) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-015-0778-3 · Cited by 40 · see citing works

Effect of gallic acid on chronic restraint stress-induced anxiety and memory loss in male BALB/c mice.

Salehi, A., Rabiei, Z., & Setorki, M. (2018) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2018.31230.7523 · Cited by 40 · see citing works

The ethanol extract of Aquilariae Lignum ameliorates hippocampal oxidative stress in a repeated restraint stress mouse model

Lee, H.-Y., Lee, J., Kim, H.-G., Kim, W., Lee, S.-B., Choi, Y. H., & Son, C. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1902-1 · Cited by 40 · see citing works

Interactions Between Chronic Stress and Chronic Consumption of Caffeine on the Enzymatic Antioxidant System

Noschang, C. G., Krolow, R., Pettenuzzo, L. F., Ávila, M. C., Fachin, A., Arcego, D. M., Toigo, E. V. P., Crema, L. M., Diehl, L. A., Vendite, D., et al. (2009) · Neurochemical Research · doi:10.1007/s11064-009-9945-4 · Cited by 39 · see citing works

Amelioration of bromobenzene hepatotoxicity by Withania somnifera pretreatment: Role of mitochondrial oxidative stress

Vedi, M., Rasool, M., & Prince, S. E. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.08.009 · Cited by 39 · see citing works

Investigation of CYP3A4 and CYP2D6 Interactions ofWithania somniferaandCentella asiaticain Human Liver Microsomes

Savai, J., Varghese, A., Pandita, N. S., & Chintamaneni, M. (2015) · Phytotherapy Research · doi:10.1002/ptr.5308 · Cited by 39 · see citing works

Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry

Dcruz, M. M., & Andrade, C. (2022) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2121699 · Cited by 38 · see citing works

Evaluation and Selection of Candidate Reference Genes for Normalization of Quantitative RT-PCR in Withania somnifera (L.) Dunal

Singh, V., Kaul, S. C., Wadhwa, R., & Pati, P. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118860 · Cited by 38 · see citing works

Antioxidant and anti-inflammatory potential of hesperidin against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced experimental Parkinson′s disease in mice

Manivasagam, T., Nataraj, J., Tamilselvam, K., Essa, M., & Janakiraman, U. (2013) · International journal of Nutrition Pharmacology Neurological Diseases · doi:10.4103/2231-0738.114875 · Cited by 38 · see citing works

A Review on Pharmacological Profile of Withania somnifera (Ashwagandha).

Kaur, N., Niazi, J., & Raman, B. (2013) · HAL · Cited by 38 · see citing works

Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment

Ahmed, M. E., Javed, H., Khan, M. M., Vaibhav, K., Ahmad, A., Khan, A., Tabassum, R., Islam, F., Safhi, M. M., & Islam, F. (2013) · PROTOPLASMA · doi:10.1007/s00709-013-0482-2 · Cited by 37 · see citing works

Phytochemical Identification, Acute, and Sub-Acute Oral Toxicity Studies of the Foliar Extract of Withania frutescens

Moussaoui, A. E., Bourhia, M., Jawhari, F. Z., Mechchate, H., Slighoua, M., Bari, A., Ullah, R., Mahmood, H. M., Ali, S. S., Ibenmoussa, S., et al. (2020) · Molecules · doi:10.3390/molecules25194528 · Cited by 37 · see citing works

Inhibition of Morphine- and Ethanol-Mediated Stimulation of Mesolimbic Dopamine Neurons by Withania somnifera

Bassareo, V., Talani, G., Frau, R., Porru, S., Rosas, M., Kasture, S. B., Peana, A. T., Loi, E., Sanna, E., & Acquas, E. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00545 · Cited by 36 · see citing works

Effect of Ilex extracts and isolated compounds on peroxidase secretion of rat submandibulary glands

Filip, R., Sebastian, T., Ferraro, G., & Anesini, C. A. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2006.10.014 · Cited by 36 · see citing works

Remedial antioxidant action of Withania somnifera on restraint stress‐induced oxidative damage

Al‐Qirim, T. M., Zafir, A., & Banu, N. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.611.12 · Cited by 3 · see citing works

Antioxidant activity of glycowithanolides from Withania somnifera.

Bhattacharya, S. K., Satyan, K. S., & Ghosal, S. (1997) · PubMed · Cited by 287 · see citing works

Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress

Bhattacharya, S. K., & Muruganandam, A. V. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00110-2 · Cited by 344 · see citing works

Protective Role Of Withania Somnifera On Cerebellar Oxidative Stress And Sensorimotor Coordination In Chronic Unpredictable Stress Induced Depression Model Wistar Rats

Vats, A. (2024) · African Journal of Biomedical Research · doi:10.53555/ajbr.v27i3.4530 · Cited by 1 · see citing works

In vitro andin vivo activity of eugenol on human herpesvirus

Benencia, F., & Courr�ges, M. C. (2000) · Phytotherapy Research · doi:10.1002/1099-1573(200011)14:7 · Cited by 181 · see citing works