Opioids in gastroenterology: treating adverse effects and creating therapeutic benefits
Open accessAbstract
The use of opioid medications on both an acute and chronic basis is ubiquitous in the United States. As opioid receptors densely populate the gastrointestinal tract, symptoms and side effects can be expected in these patients. In the esophagus, dysmotility may result, manifesting with dysphagia and a syndrome indistinguishable from primary achalasia. In the stomach, a marked delay in gastric emptying may occur with postprandial nausea and early satiety. Postoperatively, particularly with abdominal surgery, opioid-induced ileus may ensue. In the colon, opioid-induced constipation is common. A unique syndrome termed narcotic bowel syndrome is characterized by chronic abdominal pain often accompanied by nausea and vomiting in the absence of other identifiable causes. With the recognition of the important role of opioids on gastrointestinal function, novel drugs have been developed that use this physiology. These medications include peripheral acting opioid agonists to treat opioid-induced constipation and combination agonist and antagonists used for diarrhea-predominant irritable bowel syndrome. This review summarizes the most recent data in these areas.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several papers have addressed opioid-related GI concerns, yet no authors make any specific nutrition recommendations.
“Several papers have addressed opioid-related GI concerns, yet no authors make any specific nutrition recommendations (174, 175).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [174]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
The Fifth Vital Sign—What Does It Mean?
Walid, M. S., Donahue, S., Darmohray, D. M., Hyer, L. A., & Robinson, J. S. (2008) · Pain Practice · doi:10.1111/j.1533-2500.2008.00222.x · Cited by 86 · see citing works
RetractedLacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866 · see citing works
Opioid Complications and Side Effects
Benyamin, R. M. (2008) · Pain Physician · doi:10.36076/ppj.2008/11/s105 · Cited by 2,271 · see citing works
Postoperative Nausea and Vomiting: Its Etiology, Treatment, and Prevention
Watcha, M. F., & White, P. F. (1992) · Anesthesiology · doi:10.1097/00000542-199207000-00023 · Cited by 1,728 · see citing works
Caraceni, A. T., Hanks, G. W., Kaasa, S., Bennett, M., Brunelli, C., Cherny, N. I., Dale, O., Conno, F. D., Fallon, M., Hanna, M., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70040-2 · Cited by 1,247 · see citing works
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216 · see citing works
A Flood of Opioids, a Rising Tide of Deaths
Okie, S. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1011512 · Cited by 832 · see citing works
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
Williams, J. T., Ingram, S. L., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J., & Christie, M. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.005942 · Cited by 802 · see citing works
Prevalence of chronic benign pain disorder among adults: a review of the literature
Verhaak, P. F. M., Kerssens, J. J., Dekker, J., Sorbi, M. J., & Bensing, J. M. (1998) · Pain · doi:10.1016/s0304-3959(98)00117-1 · Cited by 743 · see citing works
Opioid-Induced Bowel Dysfunction
Kurz, A. M., & Sessler, D. I. (2003) · Drugs · doi:10.2165/00003495-200363070-00003 · Cited by 587 · see citing works
Pharmacological Mechanisms of Opioid Analgesics
Pasternak, G. W. (1993) · Clinical Neuropharmacology · doi:10.1097/00002826-199302000-00001 · Cited by 554 · see citing works
Incidence, Prevalence, and Management of Opioid Bowel Dysfunction
Pappagallo, M. (2001) · The American Journal of Surgery · doi:10.1016/s0002-9610(01)00782-6 · Cited by 531 · see citing works
Claing, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00023-5 · Cited by 519 · see citing works
BELL, T. J., Panchal, S. J., Miaskowski, C. A., Bolge, S. C., Milanova, T. F., & Williamson, R. (2008) · Pain Medicine · doi:10.1111/j.1526-4637.2008.00495.x · Cited by 500 · see citing works
Mechanisms and Treatment of Postoperative Ileus
Luckey, A. E. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.2.206 · Cited by 481 · see citing works
The WHO Analgesic Ladder for Cancer Pain Management
Jadad, A. R. (1995) · JAMA · doi:10.1001/jama.1995.03530230056031 · Cited by 454 · see citing works
Mansfield, K. E., Sim, J., Jordan, J. L., & Jordan, K. P. (2016) · Pain · doi:10.1097/j.pain.0000000000000314 · Cited by 402 · see citing works
Function of opioids in the enteric nervous system
Wood, J. D., & Galligan, J. J. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1743-3150.2004.00554.x · Cited by 372 · see citing works
Parkman, H. P., Yates, K. P., Hasler, W. L., Nguyen, L. A. B., Pasricha, P. J., Snape, W. J., Farrugia, G., Koch, K. L., Abell, T. L., McCallum, R. W., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.015 · Cited by 348 · see citing works
Eluxadoline for Irritable Bowel Syndrome with Diarrhea
Lembo, A. J., Lacy, B. E., Zuckerman, M. J., Schey, R., Dove, L. S., Andrae, D. A., Davenport, J. M., McIntyre, G., Lopez, R., Turner, L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1505180 · Cited by 334 · cited 1× · see citing works
“5%) of patients without a gallbladder.(58) This was confirmed in a more recent study of nearly 2000 patients with diarrheapredominant IBS, with 10 patients developing sphincter of Oddi spasm, most at the higher eluxadoline dose of 100 mg.”
Self-citationNaloxegol for Opioid-Induced Constipation in Patients with Noncancer Pain
Chey, W. D., Webster, L. R., Sostek, M. B., Lappalainen, J., Barker, P. N., & Tack, J. F. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1310246 · Cited by 328 · see citing works
Ending the Opioid Epidemic — A Call to Action
Murthy, V. H. (2016) · New England Journal of Medicine · doi:10.1056/nejmp1612578 · Cited by 294 · see citing works
Role of loperamide and placebo in management of irritable bowel syndrome (IBS)
Cann, P. A., Read, N. W., Holdsworth, C. D., & Barends, D. (1984) · Digestive Diseases and Sciences · doi:10.1007/bf01296258 · Cited by 257 · see citing works
Meißner, W., Leyendecker, P., Mueller‐Lissner, S., Nadstawek, J., Hopp, M., Ruckes, C., Wirz, S., Fleischer, W., & Reimer, K. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.06.012 · Cited by 257 · see citing works
Camilleri, M., Bharucha, A. E., Ueno, R., Burton, D., Thomforde, G. M., Baxter, K., McKinzie, S., & Zinsmeister, A. R. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00264.2005 · Cited by 253 · see citing works
Self-citationBuynak, R. J., Shapiro, D. Y., Okamoto, A., Hove, I. V., Rauschkolb, C., Steup, A., Lange, B., Lange, C., & Etropolski, M. S. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2010.497720 · Cited by 252 · see citing works
The use of quaternary narcotic antagonists in opiate research
Brown, D. R., & Goldberg, L. I. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90072-3 · Cited by 247 · see citing works
The Narcotic Bowel Syndrome: Clinical Features, Pathophysiology, and Management
Grunkemeier, D., Cassara, J. E., Dalton, C. B., & Drossman, D. A. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.06.013 · Cited by 241 · see citing works
Thompson, D. R. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03536.x · Cited by 238 · see citing works
Afilalo, M., Etropolski, M. S., Kuperwasser, B., Kelly, K., Okamoto, A., Hove, I. V., Steup, A., Lange, B., Rauschkolb, C., & Häeussler, J. (2010) · Clinical Drug Investigation · doi:10.2165/11533440-000000000-00000 · Cited by 228 · see citing works
Incomplete cross tolerance and multiple mu opioid peptide receptors
Pasternak, G. W. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01616-3 · Cited by 214 · see citing works
Low-Dose Oral Naloxone Reverses Opioid-Induced Constipation and Analgesia
Liu, M., & Wittbrodt, E. T. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(01)00369-4 · Cited by 204 · see citing works
Oral naloxone reverses opioid-associated constipation
Meißner, W., Schmidt, U., Hartmann, M., Kath, R., & Reinhart, K. (2000) · Pain · doi:10.1016/s0304-3959(99)00185-2 · Cited by 203 · see citing works
Opioid-Induced Esophageal Dysfunction (OIED) in Patients on Chronic Opioids
Ratuapli, S. K., Crowell, M. D., DiBaise, J. K., Vela, M. F., Ramirez, F. C., Burdick, G. E., Lacy, B. E., & Murray, J. A. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.154 · Cited by 198 · see citing works
Rentz, A. M., Yu, R., Müller-Lissner, S. A., & Leyendecker, P. (2009) · Journal of Medical Economics · doi:10.3111/13696990903430481 · Cited by 191 · see citing works
Bagnol, D., Mansour, A., Akil, H., & Watson, S. J. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00227-3 · Cited by 188 · see citing works
Holzer, P. D. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.004 · Cited by 180 · see citing works
Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain
Tuteja, A. K., BISKUPIAK, J. E., Stoddard, G. J., & Lipman, A. G. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01458.x · Cited by 177 · see citing works
Loperamide in Treatment of Irritable Bowel Syndrome—A Double-Blind Placebo Controlled Study
Lavö, B., Stenstam, M., & Nielsen, A.-L. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528709091003 · Cited by 175 · see citing works
Treatment of irritable bowel syndrome: a review of randomised controlled trials
Akehurst, R. L., & KALTENTHALER, E. (2001) · Gut · doi:10.1136/gut.48.2.272 · Cited by 165 · see citing works
Effects of morphine on the human sphincter of Oddi.
Helm, J. F., Venu, R. P., Geenen, J. E., Hogan, W. J., Dodds, W. J., Toouli, J., & Arndorfer, R. C. (1988) · Gut · doi:10.1136/gut.29.10.1402 · Cited by 163 · see citing works
Pattern of use and subjective effects of Salvia divinorum among recreational users
González, D., Riba, J., Bouso, J. C., Gómez-Jarabo, G., & Barbanoj, M. J. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.04.001 · Cited by 163 · see citing works
Löwenstein, O., Leyendecker, P., Hopp, M., Schutter, U., Rogers, P., Uhl, R., Bond, S. J., Kremers, W. K., Nichols, T., Krain, B., et al. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560902796798 · Cited by 158 · see citing works
Opiate‐induced oesophageal dysmotility
Kraichely, R. E., Arora, A. S., & Murray, J. A. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04212.x · Cited by 156 · see citing works
Opioid receptor desensitization: mechanisms and its link to tolerance
Allouche, S., Noble, F., & Marie, N. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00280 · Cited by 155 · see citing works
SUN, W. M., Read, N. W., & Verlinden, M. H. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709025060 · Cited by 154 · see citing works
Michna, E., Blonsky, E. R., Schulman, S. L., Tzanis, E. L., Manley, A. L., Zhang, H., Iyer, S. S., & Randazzo, B. P. (2011) · Journal of Pain · doi:10.1016/j.jpain.2010.11.008 · Cited by 153 · see citing works
Loperamide Treatment of the Irritable Bowel Syndrome
Hovdenak, N. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528709091004 · Cited by 149 · see citing works
Eluxadoline Benefits Patients With Irritable Bowel Syndrome With Diarrhea in a Phase 2 Study
Dove, L. S., Lembo, A. J., Randall, C. W., Fogel, R., Andrae, D. A., Davenport, J. M., McIntyre, G., Almenoff, J. S., & Covington, P. S. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.006 · Cited by 148 · see citing works
Naloxone antagonizes narcotic self blockade of emesis in the cat.
Costello, D., & Borison, H. L. (1977) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31039-6 · Cited by 146 · see citing works
Peptide opioid antagonist separates peripheral and central opioid antitransit effects.
Shook, J. E., Pelton, J. T., Hruby, V. J., & Burks, T. F. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11008-2 · Cited by 145 · see citing works
Molecular Physiology of Enteric Opioid Receptors
Galligan, J. J., & Akbarali, H. I. (2014) · The American Journal of Gastroenterology Supplements · doi:10.1038/ajgsup.2014.5 · Cited by 144 · see citing works
Choi, Y. S., & Billings, J. A. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00424-4 · Cited by 142 · see citing works
Effect of morphine on gastroesophageal reflux and transient lower esophageal sphincter relaxation
Penagini, R., & Bianchi, P. A. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9247457 · Cited by 138 · see citing works
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs
Faassen, F. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(03)00372-7 · Cited by 130 · see citing works
Kress, H. G. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.06.017 · Cited by 130 · see citing works
Ling, G. S. F., Paúl, D., Simantov, R., & Pasternak, G. W. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90272-5 · Cited by 125 · see citing works
Hasler, W. L., Wilson, L., Parkman, H. P., Koch, K. L., Abell, T. L., Nguyen, L. A. B., Pasricha, P. J., Snape, W. J., McCallum, R. W., Sarosiek, I., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12091 · Cited by 124 · see citing works
Kappa opioids and the modulation of pain
Kivell, B. M., & Prisinzano, T. E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1819-6 · Cited by 123 · see citing works
Stefano, G. B., Goumon, Y., Casares, F. M., Cadet, P., Fricchione, G. L., Rialas, C. M., Peter, D., Sonetti, D., Guarna, M., Welters, I. D., et al. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01611-8 · Cited by 123 · see citing works
Diversity and Complexity of the Mu Opioid Receptor Gene: Alternative Pre-mRNA Splicing and Promoters
Pan, Y. (2005) · DNA and Cell Biology · doi:10.1089/dna.2005.24.736 · Cited by 121 · see citing works
Effects of morphine and naloxone on esophageal motility and gastric emptying in man
Mittal, R. K., Frank, E. B., Lange, R., & McCallum, R. W. (1986) · Digestive Diseases and Sciences · doi:10.1007/bf01303214 · Cited by 118 · see citing works
Webster, L. R., Dhar, S., Eldon, M. A., Masuoka, L. K., Lappalainen, J., & Sostek, M. B. (2013) · Pain · doi:10.1016/j.pain.2013.04.024 · Cited by 117 · see citing works
Webster, L. R., Chey, W. D., Tack, J. F., Lappalainen, J., Diva, U., & Sostek, M. B. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12899 · Cited by 117 · see citing works
Yuan, C., Wei, G., Foss, J. F., O’Connor, M. F., Karrison, T., & Osinski, J. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.1.118 · Cited by 116 · see citing works
Consensus Recommendations on Initiating Prescription Therapies for Opioid-Induced Constipation
Argoff, C. E., Brennan, M. J., Camilleri, M., Davies, A. N., Fudin, J., Galluzzi, K. E., Gudin, J. A., Lembo, A. J., Stanos, S. P., & Webster, L. R. (2015) · Pain Medicine · doi:10.1111/pme.12937 · Cited by 112 · see citing works
Ueberall, M., Müller-Lissner, S. A., Buschmann-Kramm, C., & Bosse, B. (2011) · Journal of International Medical Research · doi:10.1177/147323001103900106 · Cited by 105 · see citing works
Jamal, M. M., Adams, A., Jansen, J.-P., & Webster, L. R. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.106 · Cited by 102 · see citing works
Cryer, B., Katz, S., Vallejo, R., Popescu, A., & Ueno, R. (2014) · Pain Medicine · doi:10.1111/pme.12437 · Cited by 99 · see citing works
Sandner‐Kiesling, A., Leyendecker, P., Hopp, M., Tarau, L., Lejčko, J., Meißner, W., Ševčík, P., Hakl, M., Hřib, R., Uhl, R., et al. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2010.02360.x · Cited by 99 · see citing works
Chronic opioid induced constipation in patients with nonmalignant pain: challenges and opportunities
Nelson, A. D., & Camilleri, M. (2015) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15578608 · Cited by 96 · see citing works
Coyne, K. S., Margolis, M. K., Yeomans, K., King, F. R., Chavoshi, S., Payne, K. A., & LoCasale, R. J. (2015) · Pain Medicine · doi:10.1111/pme.12724 · Cited by 90 · see citing works
Williams, P. I. (1999) · European Journal of Anaesthesiology · doi:10.1046/j.1365-2346.1999.00561.x · Cited by 89 · see citing works
Safety of Eluxadoline in Patients with Irritable Bowel Syndrome with Diarrhea
Cash, B. D., Lacy, B. E., Schoenfeld, P. S., Dove, L. S., & Covington, P. S. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.542 · Cited by 88 · see citing works
Molecular recognition of opioid receptor ligands
Kane, B. E., Svensson, B. G., & Ferguson, D. M. (2006) · The AAPS Journal · doi:10.1208/aapsj080115 · Cited by 83 · see citing works
Bee, L., Bannister, K., Rahman, W., & Dickenson, A. H. (2010) · Pain · doi:10.1016/j.pain.2010.10.004 · Cited by 81 · see citing works
On the role of extracellular loops of opioid receptors in conferring ligand selectivity
Metzger, T. G., & Ferguson, D. M. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01185-h · Cited by 80 · see citing works
The Narcotic Bowel Syndrome: A Recent Update
Drossman, D. A., & Szigethy, E. (2014) · The American Journal of Gastroenterology Supplements · doi:10.1038/ajgsup.2014.6 · Cited by 78 · see citing works
Long-Acting Opioids and Short-Acting Opioids: Appropriate Use in Chronic Pain Management
Fine, P. G., Mahajan, G., & McPherson, M. L. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00666.x · Cited by 77 · see citing works
Definitions and Outcome Measures of Clinical Trials Regarding Opioid-induced Constipation
Gaertner, J., Siemens, W., Camilleri, M., Davies, A. N., Drossman, D. A., Webster, L. R., & Becker, G. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000246 · Cited by 76 · see citing works
Jeong, I. D., Camilleri, M., Shin, A., Iturrino, J., Boldingh, A., Busciglio, I. A., Burton, D. D., Ryks, M. D., Rhoten, D. L., & Zinsmeister, A. R. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05040.x · Cited by 65 · see citing works
Drossman, D. A., Morris, C. B., Edwards, H., Wrennall, C. E. D., Weinland, S. R., Aderoju, A. O., Kelapure, R., Hu, Y., Dalton, C. B., Bouma, M. H., et al. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.142 · Cited by 65 · see citing works
Methylnaltrexone and Gastrointestinal Perforation
Mackey, A. C., Green, L., Greene, P., & Avigan, M. (2010) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2010.01.011 · Cited by 63 · see citing works
Effects of meperidine on the pancreatic and biliary sphincter
Sherman, S., Gottlieb, K. T., Uzer, M. F., Smith, M. T., Khusro, Q. E., Earle, D. T., Brunelle, R. L., Hawes, R. H., & Lehman, G. A. (1996) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(96)70158-x · Cited by 63 · see citing works
Burness, C. B., & Keating, G. M. (2014) · Drugs · doi:10.1007/s40265-014-0177-9 · Cited by 62 · see citing works
The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesis
Ariumi, H., Saito, R., Nago, S., Hyakusoku, M., Takano, Y., & Kamiya, H. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01113-7 · Cited by 57 · see citing works
Dose-related effects of synthetic human beta-endorphin and naloxone on fed gastrointestinal motility
Camilleri, M., Malagelada, J., Stanghellini, V., Zinsmeister, A. R., Kao, P.-C., & Li, C. H. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.251.1.g147 · Cited by 57 · see citing works
Smith, K. J., Hopp, M., Mundin, G., Bond, S. J., Bailey, P., Woodward, J., Palaniappan, K., Church, A., Limb, M. C., & Connor, A. L. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.563236 · Cited by 56 · see citing works
Opioid Bowel Dysfunction and Narcotic Bowel Syndrome: A Population-Based Study
Choung, R. S., Locke, G. R., Zinsmeister, A. R., Schleck, C. D., & Talley, N. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.71 · Cited by 55 · see citing works
The Effect of Loperamide on Anorectal Function in Normal Healthy Men
Musial, F., Enck, P., Kalveram, K. T., & Erckenbrecht, J. F. (1992) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199212000-00011 · Cited by 54 · see citing works
Achalasia and chronic opiate use: innocent bystanders or associated conditions?
Ravi, K., Murray, J. A., Geno, D. M., & Katzka, D. A. (2015) · Diseases of the Esophagus · doi:10.1111/dote.12291 · Cited by 52 · see citing works
Diagnosis and treatment of narcotic bowel syndrome
Kurlander, J. E., & Drossman, D. A. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.53 · Cited by 49 · see citing works
Xu, L., Zhou, X., Yi, P., Zhang, M., Li, J., & Xu, M. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.01.027 · Cited by 49 · see citing works
Cuppoletti, J., Chakrabarti, J. L., Tewari, K. P., & Malinowska, D. H. (2012) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-012-9406-6 · Cited by 46 · see citing works
Wirz, S., Nadstawek, J., van Elsen, C., JUNKER, U., & Wartenberg, H. C. (2011) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2011.01286.x · Cited by 44 · see citing works
Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms
Iyer, S. S., Randazzo, B. P., Tzanis, E. L., Schulman, S. L., Zhang, H., Wang, W., & Manley, A. L. (2011) · Value in Health · doi:10.1016/j.jval.2010.11.003 · Cited by 44 · see citing works
WALSH, S. L., Heilig, M. A., Nuzzo, P. A., Henderson, P., & Lofwall, M. R. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00419.x · Cited by 44 · see citing works
Opioid and opioid-like drug effects on whole-gut transit measured by scintigraphy.
Maurer, A. H., Krevsky, B., Knight, L. C., & Brown, K. (1996) · PubMed · Cited by 43 · see citing works
Hirayama, T. T., Ishii, F., Yago, K., & Ogata, H. (2001) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.121.179 · Cited by 42 · see citing works
Intravenous ondansetron for the control of opioid-induced nausea and vomiting
Sussman, G., Shurman, J., Creed, M. R., Larsen, L. S., Ferrer-Brechner, T., Noll, D. R., Allegra, J. R., Montgomery, R., Schreck, D. M., Grafstein, E., et al. (1999) · Clinical Therapeutics · doi:10.1016/s0149-2918(00)80024-7 · Cited by 41 · see citing works
Chung, F. F. (1999) · European Journal of Anaesthesiology · doi:10.1046/j.1365-2346.1999.00547.x · Cited by 37 · see citing works
Penagini, R., Bartesaghi, B., Zannini, P., Negri, G., & Bianchi, P. A. (1993) · Gut · doi:10.1136/gut.34.1.16 · Cited by 34 · see citing works
Differentiation between human ClC-2 and CFTR Cl − channels with pharmacological agents
Cuppoletti, J., Chakrabarti, J. L., Tewari, K. P., & Malinowska, D. H. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00077.2014 · Cited by 34 · see citing works
Poelaert, J., Koopmans-Klein, G., Dioh, A., Louis, F., Gorissen, M., Logé, D., den bosch, J. V. O., & van Megen, Y. J. B. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.02.010 · Cited by 33 · see citing works
Hellström, P. M., Saito, Y. A., Bytzer, P. M., Tack, J. F., Mueller‐Lissner, S., & Chang, L. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.78 · Cited by 31 · see citing works
Ruston, T. (2013) · Canadian Oncology Nursing Journal · doi:10.5737/1181912x234236240 · Cited by 26 · see citing works
Dürsteler, C., Mases, A., Fernandez, V., Pol, O., & Puig, M. M. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2005.10.002 · Cited by 26 · see citing works
Control mechanism of spontaneous in vitro contractions of the opossum sphincter of Oddi
Helm, J. F., Dodds, W. J., Christensen, J., & Sarna, S. K. (1985) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1985.249.5.g572 · Cited by 25 · see citing works
Koopmans-Klein, G., Simpson, K. H., Andrés, J. D., Lux, E. A., Wagemans, M. F. M., & van Megen, Y. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.971355 · Cited by 24 · see citing works
Skollerud, L. M., Fredheim, O. M. S., Svendsen, K., Skurtveit, S. O., & Borchgrevink, P. C. (2012) · Supportive Care in Cancer · doi:10.1007/s00520-012-1494-8 · Cited by 20 · see citing works
Human Pharmacology of the Opioid Neuropeptide Dynorphin A(1–13)
Greenwald, M. K., Stitzer, M. L., & Haberny, K. A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36704-7 · Cited by 19 · see citing works
Paterlini, M. (2005) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026053544579 · Cited by 13 · see citing works
Mehta, D. V. (2014) · Pain Physician · doi:10.36076/ppj.2014/17/415 · Cited by 13 · see citing works
Coyne, K. S., Poon, J. L., Thompson, C., Hu, Y., Datto, C. J., & Sostek, M. B. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.11.012 · Cited by 11 · see citing works
Cost Effectiveness of Naloxegol for Opioid-Induced Constipation in the UK
Lawson, R., Ryan, J., King, F. R., Goh, J. W., Tichy, E., & Marsh, K. (2016) · PharmacoEconomics · doi:10.1007/s40273-016-0454-4 · Cited by 10 · see citing works
Hunold, K. M., Smith, S. A., & Platts‐Mills, T. F. (2015) · Academic Emergency Medicine · doi:10.1111/acem.12745 · Cited by 10 · see citing works
Khemani, D., Camilleri, M., Roldan, A., Nelson, A. D., Park, S., Acosta, A. J., & Zinsmeister, A. R. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.13000 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [36]Williams JT Ingram SL Henderson G Regulation of mu-opioid receptors: desensitization, phosphorylation, internalization, and tolerance Pharmacol Rev 2013 65 223 254 23321159 PMC3565916
- [39]Penagini R Bartesaghi B Zannini P Lower oesophageal sphincter hypersensitivity to opioid receptor stimulation in patients with idiopathic achalasia Gut 1993 34 16 20 8381758 PMC1374093
- [104]Argoff CE Brennan MJ Camilleri M Consensus recommendations on initiating prescription therapies for opioid-induced constipation Pain Med 2015 16 2324 2337 26582720 PMC4738423
Cited by
Sorted by citations
Camilleri, M., Ford, A. C., Mawe, G. M., Dinning, P. G., Rao, S. S., Chey, W. D., Simrén, M., Lembo, A., Young-Fadok, T. M., & Chang, L. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.95 · Cited by 411 · see citing works
Camilleri, M., Chedid, V., Ford, A. C., Haruma, K., Horowitz, M., Jones, K. L., Low, P. A., Park, S.-Y., Parkman, H. P., & Stanghellini, V. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0038-z · Cited by 411 · see citing works
Drewes, A. M., Olesen, A. E., Farmer, A. D., Szigethy, E., Rebours, V., & Olesen, S. S. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0135-7 · Cited by 280 · see citing works
Colombel, J., Shin, A., & Gibson, P. R. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.001 · Cited by 209 · see citing works
Crockett, S. D., Greer, K. B., Heidelbaugh, J. J., Falck-Ytter, Y. T., Hanson, B., & Sultan, S. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.016 · Cited by 197 · see citing works
Pathophysiology, diagnosis, and management of opioid-induced constipation
Farmer, A. D., Holt, C. E. M. B., Downes, T. J., Ruggeri, E., Vecchio, S. D., & GIORGIO, R. D. (2018) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(18)30008-6 · Cited by 148 · see citing works
Management Options for Irritable Bowel Syndrome
Camilleri, M. (2018) · Mayo Clinic proceedings · doi:10.1016/j.mayocp.2018.04.032 · Cited by 121 · see citing works
Pharmacological Methods of Pain Management: Narrative Review of Medication Used
Alorfi, N. M. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s419239 · Cited by 148 · see citing works
Enteric Glia: A New Player in Abdominal Pain
Morales‐Soto, W., & Gulbransen, B. D. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.11.005 · Cited by 78 · see citing works
Opioid-induced endocrinopathies
Fountas, A., Van Uum, S., & Karavitaki, N. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30254-2 · Cited by 77 · see citing works
Risk Factors and Prevention Strategies for Postoperative Opioid Abuse
Zhao, S., Chen, F., Feng, A., Han, W., & Zhang, Y. (2019) · Pain Research and Management · doi:10.1155/2019/7490801 · Cited by 75 · see citing works
Postoperative ileus—An ongoing conundrum
Wattchow, D. A., Heitmann, P. T., Smolilo, D. J., Spencer, N. J., Parker, D. R., Hibberd, T. J., Brookes, S. J., Dinning, P. G., & Costa, M. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14046 · Cited by 69 · see citing works
Recent advances in dysphagia management
Triggs, J., & Pandolfino, J. E. (2019) · F1000Research · doi:10.12688/f1000research.18900.1 · Cited by 62 · see citing works
Drugs and Bugs: The Gut-Brain Axis and Substance Use Disorders
Simpson, S., Mclellan, R., Wellmeyer, E., Matalon, F., & George, O. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10022-7 · Cited by 61 · see citing works
KotliÅ„ska-Lemieszek, A., & Zylicz, Z. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s342409 · Cited by 56 · see citing works
The gut–brain interaction in opioid tolerance
Akbarali, H. I., & Dewey, W. L. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.10.012 · Cited by 54 · see citing works
Pharmacotherapy for Irritable Bowel Syndrome
Camilleri, M., & Ford, A. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6110101 · Cited by 44 · see citing works
Abdominal Pain in Inflammatory Bowel Diseases: A Clinical Challenge
Wils, P., Caron, B., D’Amico, F., Danese, S., & Peyrin‐Biroulet, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154269 · Cited by 48 · see citing works
Opioid-Induced Constipation in Oncological Patients: New Strategies of Management
Mesı́a, R., Echaburu, J. A. V., Gómez, J., Saurí, T., Serrano, G., & Pujol, E. (2019) · Current Treatment Options in Oncology · doi:10.1007/s11864-019-0686-6 · Cited by 44 · see citing works
A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health
Wiss, D. A. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00193 · Cited by 41 · see citing works
Chamie, K., Golla, V., Lenis, A. T., Lec, P. M., Rahman, S., & Viscusi, E. R. (2020) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-020-04671-x · Cited by 35 · see citing works
The placenta as a target of opioid drugs
Rosenfeld, C. S. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac003 · Cited by 31 · see citing works
Abdominal Pain in Inflammatory Bowel Disease: An Evidence-Based, Multidisciplinary Review
Coates, M. D., Clarke, K., Williams, E. D., Jeganathan, N., Yadav, S., Giampetro, D., Gordin, V., Smith, S. E., Vrana, K. E., Bobb, A. D., et al. (2023) · Crohn's & Colitis 360 · doi:10.1093/crocol/otad055 · Cited by 28 · see citing works
A concise review of opioid-induced esophageal dysfunction: is this a new clinical entity?
Ortiz, V., García‐Campos, M., González, E. S., delPozo, P., & Garrigues, V. (2018) · Diseases of the Esophagus · doi:10.1093/dote/doy003 · Cited by 26 · see citing works
Zheng, T., Vosoughi, K., Busciglio, I. A., Tebay, L., Burton, D. D., & Camilleri, M. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14386 · Cited by 24 · see citing works
Lacy, B. E., & Cangemi, D. J. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002887 · Cited by 24 · see citing works
Delphi consensus on strategies in the management of opioid-induced constipation in cancer patients
Working Group ActEIO Project, Sarrió, R. G., Calsina-Berna, A., García, A. G., Esparza-Miñana, J. M., Ferrer, E. F., & Porta-Sales, J. (2021) · BMC Palliative Care · doi:10.1186/s12904-020-00693-z · Cited by 23 · see citing works
Biliary Duct Dilatation: AJR Expert Panel Narrative Review
Ludwig, D. R., Itani, M., Childs, D. D., Revzin, M. V., Das, K. K., Anderson, M., Arif‐Tiwari, H., Lockhart, M. E., & Fulcher, A. S. (2023) · American Journal of Roentgenology · doi:10.2214/ajr.23.29671 · Cited by 23 · see citing works
Fernando, H., Shaw, J. A., Myles, P. S., Peter, K., & Stub, D. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107665 · Cited by 21 · see citing works
Goelen, N., Hoon, J. N. J. M. D., Morales, J., Varon, C., Huffel, S. V., Augustijns, P., Mols, R., Herbots, M., Verbeke, K., Vanuytsel, T., et al. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13733 · Cited by 20 · see citing works
Clinical Predictors of Rapid Gastric Emptying in Patients Presenting with Dyspeptic Symptoms
Cifuentes, J. D. G., Radetic, M., López, R., & Gabbard, S. L. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05620-8 · Cited by 21 · see citing works
Increasing Rates of Opioid Prescriptions for Gastrointestinal Diseases in the United States
LeBrett, W. G., Chen, F. W., Yang, L., & Chang, L. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001052 · Cited by 20 · see citing works
The Rise of Fentanyl: Molecular Aspects and Forensic Investigations
Barletta, C., Natale, V. D., Esposito, M., Chisari, M. G., Cocimano, G., Mauro, L. D., Salerno, M., & Sessa, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020444 · Cited by 20 · see citing works
Antonioli, L., Lucarini, E., Lambertucci, C., Fornai, M., Pellegrini, C., Benvenuti, L., Mannelli, L. D. C., Spinaci, A., Marucci, G., Blandizzi, C., et al. (2020) · Cells · doi:10.3390/cells9061509 · Cited by 19 · see citing works
μ-Opioid Receptor–Mediated Enteric Glial Activation Is Involved in Morphine-Induced Constipation
Gao, H., Zhang, Y., Li, Y., Chang, H., Cheng, B., Li, N., Yuan, W., Li, S., & Wang, Q. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02286-0 · Cited by 18 · see citing works
Implications of the Opioid Epidemic for the Clinical Gastroenterology Practice
Thapa, N., Kappus, M. R., Hurt, R. T., & Diamond, S. J. (2019) · Current Gastroenterology Reports · doi:10.1007/s11894-019-0712-7 · Cited by 18 · see citing works
Wild, J. E., Yamada, T., Ferreira, J. C. A., & Hale, M. E. (2019) · Pain · doi:10.1097/j.pain.0000000000001629 · Cited by 16 · see citing works
Crawford, J. A., Liu, S., Tao, R., Kramer, P. R., Bender, S. D., & Tao, F. (2024) · Pain · doi:10.1097/j.pain.0000000000003212 · Cited by 17 · see citing works
Effect of Opioid Use on Immune Activation and HIV Persistence on ART
Azzoni, L., Metzger, D. S., & Montaner, L. J. (2020) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-020-09959-y · Cited by 15 · see citing works
Pharmacologic treatments for gastroparesis
Camilleri, M., & Jencks, K. J. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2024.100019 · Cited by 14 · see citing works
Self-citationSaito, A., Alvi, S., Valant, C., Christopoulos, A., Carbone, S., & Poole, D. P. (2022) · British Journal of Pharmacology · doi:10.1111/bph.16023 · Cited by 14 · see citing works
Reduction in pain: Is it worth the gain? The effect of opioids on the GI tract
Nee, J. W., Rangan, V., & Lembo, A. J. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13367 · Cited by 14 · see citing works
Libero, M. L., Lucarini, E., Recinella, L., Ciampi, C., Veschi, S., Piro, A., Chiavaroli, A., Acquaviva, A., Nilofar, N., Orlando, G., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8270 · Cited by 13 · see citing works
Opioid-Induced Esophageal Dysfunction: An Emerging Entity with Sweeping Consequences
Patel, D. A., & Vaezi, M. F. (2018) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-018-0210-2 · Cited by 13 · see citing works
Lashgari, N.-A., Roudsari, N. M., Zandi, N., Pazoki, B., Rezaei, A., Hashemi, M., Momtaz, S., Rahimi, R., Shayan, M., Dehpour, A., et al. (2021) · Molecular Biology Reports · doi:10.1007/s11033-020-06095-x · Cited by 9 · see citing works
Kapural, L., Brown, B. K., Harandi, S., Rejeski, J., & Koch, K. L. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-06896-5 · Cited by 13 · see citing works
Hart, B., Viswanathan, S. K., & Jadcherla, S. R. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1469614 · Cited by 13 · see citing works
Cui, Y. R., Zhang, C., Zhang, H., Zhang, X., Tang, Y., Wu, Z., Wang, T., Chen, Q., Meng, Y., Wang, B., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25412 · Cited by 12 · see citing works
Citation Classics and Trends in the Field of Opioids: A Bibliometric Analysis
Akbar, H. F., Siddiq, K., & Nusrat, S. (2019) · Cureus · doi:10.7759/cureus.5055 · Cited by 12 · see citing works
International Differences in Outpatient Pain Management: A Survey of Sickle Cell Disease
El‐Amin, N., Nietert, P. J., & Kanter, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122136 · Cited by 12 · see citing works
The impact of opioid administration on the incidence of postanaesthetic colic in horses
Haralambus, R., Juri, M., Mokry, A., & Jenner, F. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1347548 · Cited by 11 · see citing works
Drug-induced osteoporosis and mechanisms of bone tissue regeneration through trace elements
da Costa, N. D. S., Lima, L. S., Galiciolli, M. E. A., Ribeiro, D. H. F., Ribeiro, M. M., Garica, G. D. P. J., Marçal, I. S., da Silva, J. F., Pereira, M. E., Oliveira, C. S., et al. (2024) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2024.127446 · Cited by 11 · see citing works
Neurophysiologic Mechanisms of Human Large Intestinal Motility ☆
Bharucha, A. E., & Brookes, S. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00023-2 · Cited by 12 · see citing works
Clinical utility of plecanatide in the treatment of chronic idiopathic constipation
Islam, B. N., Sharman, S. K., & Browning, D. D. (2018) · International Journal of General Medicine · doi:10.2147/ijgm.s125051 · Cited by 11 · see citing works
Opioid-Free Analgesia Provides Pain Control Following Thumb Carpometacarpal Joint Arthroplasty
Hysong, A. A., Odum, S. M., Lake, N. H., Hietpas, K. T., Michalek, C. J., Hamid, N., Gaston, R. G., Loeffler, B. J., & the CORE Study Group (2023) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.22.01278 · Cited by 10 · see citing works
Creating a bowel management plan for pediatric orthopaedic spine surgery patients
Seilhamer, C., Lorenzo, C. D., Holstine, J. B., & Samora, J. B. (2020) · Spine Deformity · doi:10.1007/s43390-020-00212-3 · Cited by 10 · see citing works
Long access heroin self-administration significantly alters gut microbiome composition and structure
Greenberg, J. M., Winters, A. D., Zagorac, B., Kracht, D. J., Francescutti, D. M., Cannella, N., Ciccocioppo, R., Woods, L. C. S., Mackle, J., Hardiman, G., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1369783 · Cited by 9 · see citing works
Fu, Z., Hu, B., Ma, T., Wang, Q., & Wang, D. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8481 · Cited by 9 · see citing works
Wang, D., Zhao, R., Duan, H., Zhang, M., He, L., Ye, X., Wei, D., & Wu, C. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaa054 · Cited by 9 · see citing works
The other side of the coin: Positive view on the role of opioids in cancer
Patrad, E., Khalighfard, S., Khori, V., & Alizadeh, A. M. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174888 · Cited by 9 · see citing works
Ahuja, D., Zou, G., Solitano, V., Syal, G., Lee, H. H., Ma, C., Jairath, V., & Singh, S. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.08.040 · Cited by 8 · see citing works
Greene, H., Dodd, A. E., Le, I. L. D., & LaMothe, J. (2024) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/jaaos-d-24-00500 · Cited by 8 · see citing works
Opioid induced constipation: mechanisms and management
Becker, E., Madi, M. Y., Magee, M., Ansari, N., Ruffle, J. K., Syn, W., Drewes, A. M., & Farmer, A. D. (2025) · Postgraduate Medical Journal · doi:10.1093/postmj/qgaf211 · Cited by 8 · see citing works
Lee, Y.-E., Wang, S.-Y., Chen, J., Chen, C. O., Shiue, Y., Soong, T., & Lam, C. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06502-9 · Cited by 8 · see citing works
Tan, J. Q., Wu, H.-L., Wang, Y.-C., Cata, J. P., Chen, J., Cherng, Y., & Tai, Y. (2023) · BMC Anesthesiology · doi:10.1186/s12871-023-02319-2 · Cited by 8 · see citing works
BouSaba, J., Sannaa, W., & Camilleri, M. (2022) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848221078638 · Cited by 8 · see citing works
Wu, Y. C., Chen, Z., Yao, C., Sun, H., Li, H., Du, X., Cheng, J., & Wan, X. (2023) · Scientific Reports · doi:10.1038/s41598-023-45022-5 · Cited by 7 · see citing works
Tan, W.-W., Liu, Z.-X., Liu, X.-Y., Zhang, W., Zheng, L., Zhang, Y.-L., & Dai, Y.-C. (2024) · Pain and Therapy · doi:10.1007/s40122-024-00672-9 · Cited by 9 · see citing works
Montgomery, D., Anand, J. P., Griggs, N. W., Fernández, T. J., Hartman, J. G., Sánchez-Santiago, A. A., Pogozheva, I. D., Traynor, J. R., & Mosberg, H. I. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00250 · Cited by 7 · see citing works
Deng, J., Hou, W., Dong, X., Hajagos, J., Saltz, M. M., Saltz, J. H., & Wang, F. (2021) · Drugs - Real World Outcomes · doi:10.1007/s40801-021-00253-8 · Cited by 7 · see citing works
Goudsward, H. J., Ruiz-Velasco, V., Stella, S., Willing, L. B., & Holmes, G. M. (2024) · Molecular Pharmacology · doi:10.1124/molpharm.123.000774 · Cited by 6 · see citing works
Esophageal Dysfunction in Post-lung Transplant: An Enigma
Jadcherla, A. V., Litzenberg, K. T., & Balasubramanian, G. (2022) · Dysphagia · doi:10.1007/s00455-022-10508-3 · Cited by 6 · see citing works
Cyclic Vomiting Syndrome and Cannabis Hyperemesis Syndrome
Lathrop, J. R., Rosen, S. N., Heitkemper, M. M., & Buchanan, D. T. (2023) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000730 · Cited by 6 · see citing works
LeBrett, W. G., & Chang, L. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14645 · Cited by 6 · see citing works
Stemboroski, L. N., & Schey, R. (2020) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2020.05.001 · Cited by 6 · see citing works
Ferrara, G., Kolli, V. S., Arnaudov, S., & Whiteley, G. (2018) · BMJ Case Reports · doi:10.1136/bcr-2017-223069 · Cited by 6 · see citing works
Cifuentes, J. D. G., Thota, P. N., & López, R. (2018) · Diseases of the Esophagus · doi:10.1093/dote/doy053 · Cited by 6 · see citing works
Advances of Microneedles for Cancer Diagnosis and Therapy
Yang, C., Zhang, L., Wang, S., Zhou, A., Tian, R., Xiang, M., Ya, R., Yu, Y., Li, R., & Gou, M. (2025) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.70018 · Cited by 5 · see citing works
Lee, H., Hossain, M. K., Kim, S.-H., Jeong, P.-Y., Lee, G., Kim, D., Chung, M. J., & Chae, H. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106444 · Cited by 6 · see citing works
Khunsriraksakul, C., Ziegler, O., Liu, D. J., Kulaylat, A. S., & Coates, M. D. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70147 · Cited by 5 · see citing works
Cash, B. D. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16702 · Cited by 5 · see citing works
Mohammed, C., Fuego, J. P., Garcia, K. V., Jamil, H., Rajesh, R. Y., Escobar, A. S., Hassan, M. J., & Rai, M. (2024) · Cureus · doi:10.7759/cureus.57055 · Cited by 5 · see citing works
Stoner, K., Preston, M. A., Mustain, W. C., Mizell, J. S., Mehaffey, G. R., & Laryea, J. A. (2020) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0000000000001873 · Cited by 5 · see citing works
Kim, G. H., & Jung, K. W. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19047 · Cited by 5 · see citing works
Barchi, A., Gupta, M., Warringa, N., Mandarino, F. V., Vespa, E., Passaretti, S. M., Danese, S., Bredenoord, A. J., & Masclee, G. M. C. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.70187 · Cited by 4 · see citing works
Longitudinal and Concurrent Changes in Brain and Gut due to Morphine Self‐Administration
Brunetti, K., Zhou, Z., Shuchi, S., Berry, R., White, S., Zhang, Y., Allen, M. S., Yang, S., Figueroa, J. D., & Colón-Pérez, L. M. (2025) · Addiction Biology · doi:10.1111/adb.70059 · Cited by 4 · see citing works
Nusrat, S., Syed, T., Saleem, R., Clifton, S. C., & Bielefeldt, K. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5308-9 · Cited by 4 · see citing works
Emerging Issues in Esophageal Motility Diseases
Kim, G. H., & Jung, K. W. (2019) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2019.73.6.322 · Cited by 4 · see citing works
High Opioid Prescribing Profiles Among Gastroenterologists: A Nationwide Analysis
LeBrett, W. G., Iyengar, P., Lee, A. H., Chen, F. W., & Chang, L. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.10.014 · Cited by 4 · see citing works
Facing the Opioid Crisis: Practical, Effective Actions We Can Take
Awsare, S. V., Havens, C., & Lippi, J. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.035 · Cited by 4 · see citing works
Medication use and polypharmacy in patients referred to a tertiary gastroenterology practice
Chris-Olaiya, A., Palmer, W. C., Stancampiano, F. F., Lacy, B. E., Heckman, M. G., Chirilă, R. M., Nikpour, N., McLeod, E., Ryan, T., Maillis, A. N., et al. (2020) · Romanian Journal of Internal Medicine · doi:10.2478/rjim-2020-0016 · Cited by 4 · see citing works
Dash, S. K., Rahman, M. A., Yi, B., Williams, B., Lim, G., Zhou, S., Zou, P., Li, Y., Mahler, G. J., & Zhang, T. (2025) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2025.103767 · Cited by 4 · see citing works
Constipation in critically ill adults
Kim, Y., & See, K. C. (2025) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v16.i4.112019 · Cited by 4 · see citing works
Treatment of Opioid-Induced Constipation
Mehta, N. D., Laitman, A. P., Brookfield, R. B., & Harris, L. A. (2025) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002185 · Cited by 3 · see citing works
Lee, J. B., Ognian, I., Park, J., Coggins, N., DeJulio, P. A., Ashenburg, N. G., & Ahern, T. L. (2025) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2025.08.038 · Cited by 3 · see citing works
Butt, M. F., Goodoory, V. C., Ng, C. E., Black, C. J., Ford, A. C., Corsetti, M., & Paine, P. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70400 · Cited by 3 · see citing works
Balbale, S. N., Cao, L., Trivedi, I., Stulberg, J. J., Suda, K. J., Gellad, W. F., Evans, C. T., Lambert, B. L., Keefer, L., & Jordan, N. (2021) · Military Medicine · doi:10.1093/milmed/usab095 · Cited by 3 · see citing works
Functional Gastrointestinal Disorders in Patients with Inflammatory Bowel Disease
Kim, K. O. (2022) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2022.001 · Cited by 3 · see citing works
Sadeghi, M., Zakariaei, Z., Yaghoubinia, A., Abbasi, A., & Ashrafi, M. (2023) · International Journal of Surgery Case Reports · doi:10.1016/j.ijscr.2023.109116 · Cited by 3 · see citing works
Innovations in Pain Management for Abdominoplasty Patients: A Systematic Review
Lim, B., Seth, I., Cevik, J., Ratnagandhi, A., Bulloch, G., Pentangelo, P., Ceccaroni, A., Alfano, C., Rozen, W. M., & Cuomo, R. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14111078 · Cited by 3 · see citing works
- Authors
- Camilleri, M., Lembo, A., & Katzka, D. A.
- Affiliations
- Mayo Clinic (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 15
- Issue
- 9
- Pages
- 1338-1349
- ISSN
- 1542-3565 (ISSN-L)
- PMC
- PMC5565678
- OpenAlex
- W2615758080
- Cited by
- 176
- References
- 117
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 21 · 2023: 19 · 2022: 14 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 16 · 2017: 4
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Centers for Disease Control and Prevention
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092179)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- opioids, opioid side effects, opioid-induced constipation, opioid-induced ileus, delayed gastric emptying, narcotic bowel syndrome, diarrhea-predominant irritable bowel syndrome, postoperative ileus
- MeSH terms
- Analgesics, Opioid, Gastroenterology, Gastrointestinal Diseases, Humans, United States
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review