Cited by 176Gastrointestinal motility and disordersOpioid Use Disorder TreatmentPain Management and Opioid Use

Opioids in gastroenterology: treating adverse effects and creating therapeutic benefits

Open access
Camilleri, Michael, Lembo, Anthony, Katzka, David A.·2017·Clinical Gastroenterology and Hepatology

Abstract

The use of opioid medications on both an acute and chronic basis is ubiquitous in the United States. As opioid receptors densely populate the gastrointestinal tract, symptoms and side effects can be expected in these patients. In the esophagus, dysmotility may result, manifesting with dysphagia and a syndrome indistinguishable from primary achalasia. In the stomach, a marked delay in gastric emptying may occur with postprandial nausea and early satiety. Postoperatively, particularly with abdominal surgery, opioid-induced ileus may ensue. In the colon, opioid-induced constipation is common. A unique syndrome termed narcotic bowel syndrome is characterized by chronic abdominal pain often accompanied by nausea and vomiting in the absence of other identifiable causes. With the recognition of the important role of opioids on gastrointestinal function, novel drugs have been developed that use this physiology. These medications include peripheral acting opioid agonists to treat opioid-induced constipation and combination agonist and antagonists used for diarrhea-predominant irritable bowel syndrome. This review summarizes the most recent data in these areas.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cgh.2017.05.014

Cites

117 of 117 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 3

  1. [36]Williams JT Ingram SL Henderson G Regulation of mu-opioid receptors: desensitization, phosphorylation, internalization, and tolerance Pharmacol Rev 2013 65 223 254 23321159 PMC3565916
  2. [39]Penagini R Bartesaghi B Zannini P Lower oesophageal sphincter hypersensitivity to opioid receptor stimulation in patients with idiopathic achalasia Gut 1993 34 16 20 8381758 PMC1374093
  3. [104]Argoff CE Brennan MJ Camilleri M Consensus recommendations on initiating prescription therapies for opioid-induced constipation Pain Med 2015 16 2324 2337 26582720 PMC4738423

Cited by

Sorted by citations

Authors
Camilleri, M., Lembo, A., & Katzka, D. A.
Affiliations
  • Mayo Clinic (US)
  • Beth Israel Deaconess Medical Center (US)
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2017-09
Volume
15
Issue
9
Pages
1338-1349
ISSN
1542-3565 (ISSN-L)
OpenAlex
W2615758080
Cited by
176
References
117
Citations by year
2026: 20 · 2025: 21 · 2024: 21 · 2023: 19 · 2022: 14 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 16 · 2017: 4
FWCI
2.91
Type
journal article
Language
en
Open access
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Centers for Disease Control and Prevention
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092179)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
opioids, opioid side effects, opioid-induced constipation, opioid-induced ileus, delayed gastric emptying, narcotic bowel syndrome, diarrhea-predominant irritable bowel syndrome, postoperative ileus
MeSH terms
Analgesics, Opioid, Gastroenterology, Gastrointestinal Diseases, Humans, United States

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review