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Cited by 130Hormonal and reproductive studiesSexual function and dysfunction studiesHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

ANDROTEST: A structured interview for the screening of hypogonadism in patients with sexual dysfunction

Corona, Giovanni, Mannucci, Edoardo, Petrone, Luisa, Balercia, Giancarlo, Fisher, Alessandra D., Chiarini, Valerio, Forti, Gianni, Maggi, Mario·2006·The Journal of Sexual Medicine
DOI 10.1111/j.1743-6109.2006.00262.x
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Abstract

Introduction: Detecting hypogonadism, which is important in the general population, becomes crucial in patients with sexual dysfunctions, because hypogonadism can have a causal role for them and testosterone (T) substitution represents a milestone for the therapy. Aim: No inventories are available for the screening of hypogonadism in patients with sexual dysfunction. We wished to set up a brief structured interview providing scores useful for detecting hypogonadism defined as low total T (<10.4 nmol/L, 300 ng/dL) in a symptomatic population (sexual dysfunction). Methods: A minimum set of items was identified within a larger structured interview through iterative receiver-operating characteristic curve analysis, with assessment of sensitivity and specificity for hypogonadism in a sample of 215 patients. Main Outcome Measures: Sensitivity and specificity were verified in a further sample of 664 patients. Correlation of test scores with prostate-specific antigen (PSA), testis volume, and others clinical and psychological parameters, was assessed for concurrent validity. Results: In the validation sample, the final 12-item version of the interview (ANDROTEST ©) had a sensitivity and specificity of 68% and 65%, in detecting low total T (<10.4 nmol/L) and of 71% and 65%, in the screening for low free T (<37 pmol/L). Furthermore, patients with a pathological test (i.e., score >8) showed higher prevalence of hypogonadism-related signs, such as lower testis volume and higher depressive symptoms. Finally, when only younger patients (<54 years, which represents the median age of the sample) were considered, Log10 [PSA] levels were significantly lower in those with ANDROTEST © score >8. Conclusion: ANDROTEST © is a quick and easy-to-administer interview that provides scores for the screening of male hypogonadism in patients with sexual dysfunction.

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Crossref · 10.1111/j.1743-6109.2006.00262.x

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Metadata

Authors
Corona, G., Mannucci, E., Petrone, L., Balercia, G., Fisher, A. D., Chiarini, V., Forti, G., & Maggi, M.
Affiliations
  • Ospedale Bellaria (IT)
  • University of Florence (IT)
  • Marche Polytechnic University (IT)
Corresponding author
Maggi, Mario
ORCID
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2006-07-01
Volume
3
Issue
4
Pages
706-715
ISSN
  • 1743-6095 (ISSN-L)
  • 1743-6109
DOI
10.1111/j.1743-6109.2006.00262.x
OpenAlex
W2114691422
Cited by
130
References
43
Citations by year
2026: 3 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 13 · 2012: 15
FWCI
7.70
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • The Journal of Sexual Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Funders
Programmi di ricerca di Rilevante Interesse Nazionale
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
male hypogonadism, sexual dysfunction, structured interviews, androgen deficiency, free testosterone, total testosterone, prostate-specific antigen, testicular volume, depressive symptoms, screening tool validation
MeSH terms
Adult, Androgens, Humans, Hypogonadism, Erectile Dysfunction, Male, Middle Aged, Surveys and Questionnaires, ROC Curve, Sensitivity and Specificity, Testosterone, Reproducibility of Results

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