Testosterone Undecanoate Restores Erectile Function in a Subset of Patients with Venous Leakage: A Series of Case Reports

Yassin, Aksam A.; Saad, Farid; Traish, Abdulmaged

doi:10.1111/j.1743-6109.2006.00267.x

Cited by 96Sexual function and dysfunction studiesHormonal and reproductive studiesUrological Disorders and Treatments

Testosterone Undecanoate Restores Erectile Function in a Subset of Patients with Venous Leakage: A Series of Case Reports

Yassin, Aksam A., Saad, Farid, Traish, Abdulmaged·2006·The Journal of Sexual Medicine

DOI 10.1111/j.1743-6109.2006.00267.x

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Abstract

Introduction: Androgens are critical for maintaining penile structure and function and androgen deficiency alters the function of the corporal veno-occlusive mechanism in animal models. However, there are limited research and data supporting this association in humans. Methods: Case reports of hypogonadal men (N = 12) with low plasma testosterone and moderate to severe erectile dysfunction are presented. Comorbidities varied, including diabetes mellitus type I or II, metabolic syndrome with possible related hypertension, dyslipidemia, or obesity. Oral phosphodiesterase type 5 (PDE5) inhibitor therapy did not improve erectile function. Each patient underwent baseline dynamic infusion pharmacocavernosometry and cavernosography revealing various degrees of corporal veno-occlusive dysfunction. The patients underwent treatment with 1,000 mg injectable testosterone undecanoate (NebidoR) on day 1, followed by another injection after 6 weeks and every 3 months thereafter. Dynamic infusion pharmacocavernosography was repeated in all 12 patients after 3 months of treatment. Results: Five of the 12 patients reported significant improvement in erectile function within 12–20 weeks of androgen treatment and are currently under follow-up. Compared with baseline pharmacocavernosography, repeat radiological studies in patients who reported improvement in erectile function did not show veins draining the corporal bodies. The patients who responded to androgens also noted improvement in sexual desire domain (International Index of Erectile Function [IIEF] scores increased from 4 ± 0.7 to 8 ± 0.3) and erectile function domain (IIEF scores increased from 6 ± 2 to 24 ± 1). Conclusion: The observations made in these limited series of case reports suggest that testosterone improved erectile function in hypogonadal patients by restoring veno-occlusive function. Prospective, multi-institutional, double-blind placebo-controlled trials in hypogonadal patients are indicated.

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Changes in erections and ejaculations may require up to 6 months.
“Changes in erections/ejaculations may require up to 6 months.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [71]
In patients with veno-occlusive dysfunction, testosterone undecanoate restores erectile function after a minimum of 3 months and a maximum of 11.5 months.
“In patients with veno-occlusive dysfunction, testosterone undecanoate restored erectile function after a minimum of 3 months and a maximum of 11.5 months (71).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [71]
Maximal effects of testosterone on erection and ejaculation are usually achieved after 3-6 months but may take up to 1 year in individual cases.
“Maximal effects are usually achieved after 3–6 months (72) but may take even up to 1 year in individual cases (71).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [71]

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Authors: Yassin, A. A., Saad, F., & Traish, A.
Affiliations: Gulf Medical University (AE)
Boston University (US)
Corresponding author: Yassin, Aksam A.
ORCID: Yassin, Aksam A.
Saad, Farid
Traish, Abdulmaged
Venue: The Journal of Sexual Medicine
Publisher: Oxford University Press (OUP)
Published: 2006-07-01
Volume: 3
Issue: 4
Pages: 727-735
ISSN: 1743-6095 (ISSN-L)
1743-6109
DOI: 10.1111/j.1743-6109.2006.00267.x
OpenAlex: W2013901810
Cited by: 96
References: 38
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 9 · 2012: 6
FWCI: 9.37
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: The Journal of Sexual Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords: testosterone undecanoate, erectile dysfunction, veno-occlusive dysfunction, hypogonadism, androgen therapy, phosphodiesterase-5 inhibitors, cavernosography, metabolic syndrome, diabetes mellitus, sexual desire
MeSH terms: Adult, Aged, Dose-Response Relationship, Drug, Humans, Hypogonadism, Male, Middle Aged, Penile Erection, Penis, Radiography, Regional Blood Flow, Testosterone, Ultrasonography, Vasodilation, Vasodilator Agents, Treatment Outcome, Impotence, Vasculogenic

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Testosterone Undecanoate Restores Erectile Function in a Subset of Patients with Venous Leakage: A Series of Case Reports

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