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Cited by 100Hormonal and reproductive studiesSperm and Testicular FunctionDiabetes, Cardiovascular Risks, and Lipoproteins

Diabetes mellitus is associated with subnormal serum levels of free testosterone in men

Rhoden, Ernani L., Ribeiro, Eduardo P., Teloken, Claudio, Souto, Carlos A.V.·2005·BJU International
DOI 10.1111/j.1464-410x.2005.05728.x
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Abstract

OBJECTIVE: To evaluate the relationship between diabetes mellitus (DM) and serum levels of free (FT) and total (TT) testosterone. PATIENTS AND METHODS: A cross‐sectional study was carried out including 746 men, of whom 116 (15.6%) were diabetics. Both groups, diabetic and nondiabetic, were paired according to age. Body mass index (BMI) and waist‐to‐hip ratio (WHR) were calculated, and a stratification analysis correlating DM and elevated BMI (>25 kg/m 2 ) and WHR (>1) with the presence of subnormal FT and TT levels was performed. RESULTS: FT and TT serum levels were subnormal in 46% and 34% of diabetics, respectively, and in 24% and 23% of nondiabetics. Subnormal FT levels were strongly correlated with DM (odds ratio (OR) 2.7; 95% confidence interval (CI) 1.8–4.1) but not with elevated BMI (OR 1.4; 95% CI 1.0–2.0). Subnormal TT levels were more strongly associated with elevated BMI and WHR (OR 2.6; 95% CI 1.7–3.9 and 2.0; 1.4–2.9) than with DM (1.7; 1.1–2.6 and 2.0; 1.3–3.2). CONCLUSION: These data strongly suggest that DM is associated with subnormal FT levels, and that TT levels are influenced more by obesity and central adiposity.

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  • Testosterone levels are linked to a variety of conditions and diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, obesity, stroke and osteoporosis.

    “Several studies have previously reported that testosterone levels are linked to a variety of conditions and diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, obesity, stroke and osteoporosis. 1-7”

    From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [1]

  • Age, BMI, fasting blood glucose, triglycerides, alcohol consumption and estradiol levels have all been reported to be associated with alteration in hormone levels.

    “Age, 11,14-17 body mass index (BMI), 12 fasting blood glucose, 1,35 triglycerides, 36 alcohol consumption 13,14 and estradiol levels, 13 which have all been reported to be associated with alteration in hormone levels, were chosen as potential confounding factors in this study.”

    From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [1]

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Authors
Rhoden, E. L., Ribeiro, E. P., Teloken, C., & Souto, C. A. V.
Corresponding author
Rhoden, Ernani L.
ORCID
Rhoden, Ernani L.
Venue
BJU International
Publisher
Wiley
Published
2005-09-09
Volume
96
Issue
6
Pages
867-870
ISSN
  • 1464-4096 (ISSN-L)
  • 1464-410X
DOI
10.1111/j.1464-410x.2005.05728.x
OpenAlex
W2087712225
Cited by
100
References
11
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 10 · 2013: 5 · 2012: 5
FWCI
2.57
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • British Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
diabetes mellitus, free testosterone, total testosterone, hypogonadism, male hypogonadism, obesity, abdominal obesity, waist-to-hip ratio, body mass index, sex hormone-binding globulin
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Humans, Male, Middle Aged, Obesity, Testosterone, Body Mass Index, Diabetes Complications

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