CoChat
Sign Up
Cited by 101Hormonal and reproductive studiesSexual function and dysfunction studiesHypothalamic control of reproductive hormones

Improvement of Sexual Function in Men with Late-Onset Hypogonadism Treated with Testosterone Only

Yassin, Aksam A., Saad, Farid·2007·The Journal of Sexual Medicine
DOI 10.1111/j.1743-6109.2007.00442.x
Open this paper in CoChat — free account

Abstract

Aim: Late-onset hypogonadism is associated with relatively mild testosterone deficiencies. This study investigated the effects of restoring testosterone levels to normal in men with complaints of low sexual desire and erectile dysfunction. Main Outcome Measures: Sexual function was assessed with the International Index of Erectile Function (IIEF) at baseline and after 24 weeks of testosterone administration. Methods: Twenty-two hypogonadal men (mean age 58 years) with erectile dysfunction were studied. Fifteen patients had serum testosterone below 6.9 nmol/L, and seven between 7.2 and 11.7 nmol/L (reference values in our laboratory ≥12.0 nmol/L); there were considerable comorbidities. The duration of sexual complaints was on average 3.8 years. Patients received intramuscular long-acting testosterone undecanoate. Results: In all patients, serum testosterone levels were restored to normal within 6–8 weeks. Twelve patients reported a significant improvement in the sexual desire domain (from 4.5 to 8.4) and experienced an improvement in the erectile function domain (from 12 to 25 [Questions 1–5 plus 15)], following treatment with this long-acting testosterone; in 9 of 12 patients, this occurred only after at least 12–24 weeks. The remaining 10 patients reported an improvement of sexual desire (from 4.5 to 7.5), but no significant improvement in the erectile function domain (from 12 to 14). No changes in serum prostate-specific antigen or prostate volume were noticed while receiving this long-acting testosterone preparation. Conclusion: Restoring testosterone levels to normal in men with proven subnormal testosterone levels improves libido in most subjects, and erectile function in more than 50% of these men. It may take 12–24 weeks before the effects of testosterone become manifest.

Integrity signals

Registry

Crossref · 10.1111/j.1743-6109.2007.00442.x

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Yassin, A. A., & Saad, F.
Affiliations
Gulf Medical University (AE)
Corresponding author
Yassin, Aksam A.
ORCID
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2007-03-01
Volume
4
Issue
2
Pages
497-501
ISSN
  • 1743-6095 (ISSN-L)
  • 1743-6109
DOI
10.1111/j.1743-6109.2007.00442.x
OpenAlex
W1936236392
Cited by
101
References
22
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 8 · 2012: 7
FWCI
11.45
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • The Journal of Sexual Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
andropause, testosterone replacement therapy, testosterone undecanoate, erectile dysfunction, low libido, sexual desire, sexual function, International Index of Erectile Function, serum testosterone levels, prostate-specific antigen, prostate volume
MeSH terms
Adult, Aged, Dose-Response Relationship, Drug, Humans, Hypogonadism, Erectile Dysfunction, Libido, Male, Middle Aged, Penile Erection, Prospective Studies, Surveys and Questionnaires, Severity of Illness Index, Testosterone, Patient Satisfaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review