The DOI matches its Crossref record; 65 of the 67 references it cites were found in a registry or an index.
Effects of Testosterone Supplementation on Depressive Symptoms and Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome
Abstract
Introduction: Low testosterone levels in men are associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality, and sexual dysfunction. Aim: To assess the effects of testosterone administration on these subjective symptoms, which have not extensively been studied in hypogonadal men with the MetS. Main Outcome Measures: The Beck Depression Inventory (BDI-IA), Aging Males’ Symptoms (AMS) scale, and International Index of Erectile Function 5-item (IIEF-5) scale at baseline, 18 and 30 weeks were analysed using multilevel analysis. Methods: In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identifier: NCT00696748), 184 men suffering from both the MetS and hypogonadism were included. They were treated for 30 weeks with either parenteral testosterone undecanoate (TU; 1,000 mg IM TU, at baseline, and after 6 and 18 weeks; Nebido®) or placebo injections, 105 (92.9%) men receiving TU and 65 (91.5%) receiving placebo completed the 30-week trial. Results: The 184 men were aged mean 52.1 years old (standard deviation [SD] 9.6; range 35–69), with a mean body mass index of 35.5 kg/m2 (SD 6.7; range 25.1–54.8), and a mean total testosterone level of 8.0 nmol/L (SD 4.0). There were significant improvements in BDI-IA (mean difference vs. placebo after 30 weeks: −2.5 points; 95% confidence interval [CI]: −0.9; −4.1; P = 0.003), AMS (−7.4 points; 95% CI: −4.3; −10.5; P <0.001), and IIEF-5 (+3.1 points; 95% CI: +1.8; +4.4; P <0.001). The effects on the BDI-IA, AMS, and IIEF-5 were strongest in men with baseline total testosterone levels <7.7 mmol/L (i.e., median value). Conclusions: TU administration may improve depressive symptoms, aging male symptoms and sexual dysfunction in hypogonadal men with the MetS. The beneficial effects of testosterone were most evident in men with the lowest baseline total testosterone levels.
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“Effects on depressive mood become detectable after 3–6 weeks with a maximum after 18–30 weeks.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [79]
In the citing paper
“It is remarkable that effects were more pronounced in men with the lowest baseline testosterone levels (79).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [79]
In the citing paper
“It is very likely that the positive effects of testosterone on depressive symptoms start as early as after 3–6 weeks, but will most likely take 18–30 weeks to find the patient with a significant improvement.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [79]
Citations
Cites
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Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation
Beck, A. T., Steer, R. A., & Carbin, M. G. (1988) · Clinical Psychology Review · doi:10.1016/0272-7358(88)90050-5 · Cited by 11,696
The metabolic syndrome—a new worldwide definition
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Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.3 · Cited by 853
Testosterone and Cardiovascular Disease
Kloner, R. A., Carson, C., Dobs, A., Kopecky, S., & Mohler, E. R. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.12.005 · Cited by 371
Isidori, A. M., Buvat, J., Corona, G., Goldstein, I., Jannini, E. A., Lenzi, A., Porst, H., Salonia, A., Traish, A. M., & Maggi, M. (2013) · European Urology · doi:10.1016/j.eururo.2013.08.048 · Cited by 315
Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men
Lunenfeld, B., Mskhalaya, G. J., Zitzmann, M., Arver, S., Kalinchenko, S. Y., Tishova, Y. A., & Morgentaler, A. (2015) · The Aging Male · doi:10.3109/13685538.2015.1004049 · Cited by 318
Self-citationTraish, A. M., Hassani, J., Guay, A. T., Zitzmann, M., & Hansen, M. L. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02157.x · Cited by 283
Metadata
- Authors
- Giltay, E. J., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J. G., Saad, F., & Kalinchenko, S. Y.
- Affiliations
- Leiden University Medical Center (NL)
- Peoples' Friendship University of Russia (RU)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Gulf Medical University (AE)
- Corresponding author
- Giltay, Erik J.
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-01
- Volume
- 7
- Issue
- 7
- Pages
- 2572-2582
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- OpenAlex
- W1706522822
- Cited by
- 140
- References
- 67
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2022: 10 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 19 · 2015: 11 · 2014: 13 · 2013: 12 · 2012: 9
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- The Journal of Sexual Medicine (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- testosterone undecanoate, testosterone supplementation, hypogonadism, metabolic syndrome, depressive symptoms, sexual dysfunction, erectile function, aging male symptoms, androgen deficiency, men's health, low energy, lack of motivation, low self-esteem, low self-confidence
- MeSH terms
- Adult, Age Factors, Aged, Aging, Androgens, Antidepressive Agents, Depression, Double-Blind Method, Humans, Hypogonadism, Infusions, Intravenous, Infusions, Parenteral, Male, Middle Aged, Psychometrics, Psychotropic Drugs, Surveys and Questionnaires, Regression Analysis, Statistics as Topic, Testosterone, Multivariate Analysis, Confidence Intervals, Statistics, Nonparametric, Metabolic Syndrome
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