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Cited by 141Hormonal and reproductive studiesSexual function and dysfunction studiesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 65 of the 67 references it cites were found in a registry or an index.

Effects of Testosterone Supplementation on Depressive Symptoms and Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome

Giltay, Erik J., Tishova, Yuliya A., Mskhalaya, George J., Gooren, Louis J.G., Saad, Farid, Kalinchenko, Svetlana Y.·2010·The Journal of Sexual Medicine
DOI 10.1111/j.1743-6109.2010.01859.x
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Abstract

Introduction: Low testosterone levels in men are associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality, and sexual dysfunction. Aim: To assess the effects of testosterone administration on these subjective symptoms, which have not extensively been studied in hypogonadal men with the MetS. Main Outcome Measures: The Beck Depression Inventory (BDI-IA), Aging Males’ Symptoms (AMS) scale, and International Index of Erectile Function 5-item (IIEF-5) scale at baseline, 18 and 30 weeks were analysed using multilevel analysis. Methods: In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identifier: NCT00696748), 184 men suffering from both the MetS and hypogonadism were included. They were treated for 30 weeks with either parenteral testosterone undecanoate (TU; 1,000 mg IM TU, at baseline, and after 6 and 18 weeks; Nebido®) or placebo injections, 105 (92.9%) men receiving TU and 65 (91.5%) receiving placebo completed the 30-week trial. Results: The 184 men were aged mean 52.1 years old (standard deviation [SD] 9.6; range 35–69), with a mean body mass index of 35.5 kg/m2 (SD 6.7; range 25.1–54.8), and a mean total testosterone level of 8.0 nmol/L (SD 4.0). There were significant improvements in BDI-IA (mean difference vs. placebo after 30 weeks: −2.5 points; 95% confidence interval [CI]: −0.9; −4.1; P = 0.003), AMS (−7.4 points; 95% CI: −4.3; −10.5; P <0.001), and IIEF-5 (+3.1 points; 95% CI: +1.8; +4.4; P <0.001). The effects on the BDI-IA, AMS, and IIEF-5 were strongest in men with baseline total testosterone levels <7.7 mmol/L (i.e., median value). Conclusions: TU administration may improve depressive symptoms, aging male symptoms and sexual dysfunction in hypogonadal men with the MetS. The beneficial effects of testosterone were most evident in men with the lowest baseline total testosterone levels.

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Crossref · 10.1111/j.1743-6109.2010.01859.x

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Metadata

Authors
Giltay, E. J., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J. G., Saad, F., & Kalinchenko, S. Y.
Affiliations
  • Leiden University Medical Center (NL)
  • Peoples' Friendship University of Russia (RU)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
  • Gulf Medical University (AE)
Corresponding author
Giltay, Erik J.
ORCID
Venue
The Journal of Sexual Medicine
Publisher
Oxford University Press (OUP)
Published
2010-07-01
Volume
7
Issue
7
Pages
2572-2582
ISSN
  • 1743-6095 (ISSN-L)
  • 1743-6109
DOI
10.1111/j.1743-6109.2010.01859.x
OpenAlex
W1706522822
Cited by
140
References
67
Citations by year
2026: 2 · 2025: 4 · 2024: 8 · 2022: 10 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 19 · 2015: 11 · 2014: 13 · 2013: 12 · 2012: 9
FWCI
8.47
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • The Journal of Sexual Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
testosterone undecanoate, testosterone supplementation, hypogonadism, metabolic syndrome, depressive symptoms, sexual dysfunction, erectile function, aging male symptoms, androgen deficiency, men's health, low energy, lack of motivation, low self-esteem, low self-confidence
MeSH terms
Adult, Age Factors, Aged, Aging, Androgens, Antidepressive Agents, Depression, Double-Blind Method, Humans, Hypogonadism, Infusions, Intravenous, Infusions, Parenteral, Male, Middle Aged, Psychometrics, Psychotropic Drugs, Surveys and Questionnaires, Regression Analysis, Statistics as Topic, Testosterone, Multivariate Analysis, Confidence Intervals, Statistics, Nonparametric, Metabolic Syndrome

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